Mohamed A Zebda, Sara R Elkins, R Anna Franklin, David F Curtis
{"title":"Posttraumatic Stress Disorder in Children and Adolescents.","authors":"Mohamed A Zebda, Sara R Elkins, R Anna Franklin, David F Curtis","doi":"10.1542/pir.2025-006778","DOIUrl":"10.1542/pir.2025-006778","url":null,"abstract":"<p><p>Traumatic events can affect children and adolescents in very unique and sometimes complex ways. Pediatricians in primary care settings are uniquely positioned to identify the influence traumatic experiences have upon their patients' general functioning and potential development of psychopathology. Thus, it is of vital importance for pediatricians to be able to recognize these influences and coordinate appropriate care for children and adolescents who are either presenting emerging symptoms or experiencing more definitive posttraumatic stress disorder (PTSD). To support these efforts, this article provides a review of key clinical features of PTSD and related conditions that are commonly presented in primary care, as well as best practices for screening, treatment, and coordination of care. By improving pediatricians' knowledge and awareness of common childhood reactions to adverse and traumatic experiences, the goal of this review is to promote a broader scope of trauma-informed practice considerations that will help clinicians prevent symptom progression and the development of PTSD for their child and adolescent patients.</p>","PeriodicalId":20007,"journal":{"name":"Pediatrics in review","volume":"47 7","pages":"361-370"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic Testing.","authors":"Kelly L Jones","doi":"10.1542/pir.2025-006982","DOIUrl":"https://doi.org/10.1542/pir.2025-006982","url":null,"abstract":"","PeriodicalId":20007,"journal":{"name":"Pediatrics in review","volume":"47 7","pages":"383-393"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luisanna M Sánchez, Ajibike Lapite, Alicia Chang, Titilope A Fasipe
{"title":"Long-Term Complications of Sickle Cell Disease.","authors":"Luisanna M Sánchez, Ajibike Lapite, Alicia Chang, Titilope A Fasipe","doi":"10.1542/pir.2024-006446","DOIUrl":"10.1542/pir.2024-006446","url":null,"abstract":"<p><p>SCD is a prevalent genetic disorder marked by chronic complications that impact quality of life and survival. Affecting approximately 100 000 individuals in the United States and millions globally, SCD results from a mutation in the β-globin gene, leading to sickle-shaped red blood cells and subsequent vaso-occlusive episodes, hemolysis, and multiorgan damage. Despite advancements such as newborn screening and disease-modifying therapies, individuals with SCD continue to face significant long-term challenges. This review focuses on the major long-term complications of SCD, including chronic pain, mental health diagnoses, neurological deficits, infection, alloimmunization, cardiopulmonary complications, and reproductive health concerns. Pain, often a hallmark of SCD, significantly affects quality of life and requires an individualized approach to management. Depression and anxiety are prevalent and impact both psychosocial well-being and disease outcomes. Neurological complications, including stroke and cognitive deficits, pose substantial risks and require ongoing monitoring. Reproductive health concerns, such as fertility and pregnancy complications, demand careful management. Alloimmunization, a potential consequence of transfusion exposure transfusion exposure, complicates future transfusion therapy and increases the risk of delayed hemolytic transfusion reactions. Cardiopulmonary complications, including pulmonary hypertension and restrictive lung disease secondary to recurrent acute chest syndrome, are associated with increased morbidity and warrant early recognition and monitoring. This review aims to bridge the knowledge gap for general pediatricians by providing comprehensive insights into these long-term complications and offering strategies for effective management. Understanding these aspects is essential for improving patient outcomes and ensuring that pediatricians can provide informed, empathetic, and proactive care for children with SCD.</p>","PeriodicalId":20007,"journal":{"name":"Pediatrics in review","volume":"47 7","pages":"394-403"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemangiomas: Beyond the Skin.","authors":"Nicole W Kittler, Ilona J Frieden, Maria C Garzon","doi":"10.1542/pir.2025-006913","DOIUrl":"10.1542/pir.2025-006913","url":null,"abstract":"<p><p>Infantile hemangiomas (IH) are common birthmarks. Their natural history of rapid growth during early infancy followed by gradual involution in the first few years of life is well recognized. Although the majority do not require additional evaluation or treatment, a significant minority need closer surveillance, imaging studies, and/or active intervention to prevent complications. This review will provide a focused examination of IH with a potential for extracutaneous involvement or associated structural anomalies. Although uncommon, these complications are not exceedingly rare, and pediatricians play a key role in early recognition. This review emphasizes the importance of the features of cutaneous IH, which should prompt evaluation for extracutaneous involvement, including their pattern on the skin surface, number of lesions, and specific anatomic sites that confer increased risk.</p>","PeriodicalId":20007,"journal":{"name":"Pediatrics in review","volume":"47 7","pages":"371-382"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Developmental Dysplasia of the Hip.","authors":"Connor Liggett, Nicole Martin, Joseph Lopreiato","doi":"10.1542/pir.2025-006798","DOIUrl":"https://doi.org/10.1542/pir.2025-006798","url":null,"abstract":"","PeriodicalId":20007,"journal":{"name":"Pediatrics in review","volume":"47 7","pages":"421-423"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis G Malca-Gomez, Claudia P Canepa-Livaque, José A Nombera-Mujica, Carmen A E Malca-Gomez
{"title":"Pediatric Multisystemic Illness With Cardiac Involvement: A Diagnostic Challenge.","authors":"Luis G Malca-Gomez, Claudia P Canepa-Livaque, José A Nombera-Mujica, Carmen A E Malca-Gomez","doi":"10.1542/pir.2025-006839","DOIUrl":"https://doi.org/10.1542/pir.2025-006839","url":null,"abstract":"","PeriodicalId":20007,"journal":{"name":"Pediatrics in review","volume":"47 7","pages":"414-417"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Isolated Leg Swelling in an Adolescent Boy.","authors":"Vanessa Victor-Linkenhoker, Vincent R Savarino","doi":"10.1542/pir.2025-007012","DOIUrl":"https://doi.org/10.1542/pir.2025-007012","url":null,"abstract":"","PeriodicalId":20007,"journal":{"name":"Pediatrics in review","volume":"47 7","pages":"410-413"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Visual Diagnosis: Term Infant With a Hemorrhagic Dermatologic Lesion.","authors":"Jack S Thomas, Divya Rana, Megan Derrer","doi":"10.1542/pir.2025-006971","DOIUrl":"https://doi.org/10.1542/pir.2025-006971","url":null,"abstract":"","PeriodicalId":20007,"journal":{"name":"Pediatrics in review","volume":"47 7","pages":"424-427"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electrolyte Imbalance and Growth Failure: Unravelling the Connection to Infantile Hyponatremia.","authors":"Shreshtha Banga, Samuel Engle","doi":"10.1542/pir.2025-006843","DOIUrl":"https://doi.org/10.1542/pir.2025-006843","url":null,"abstract":"","PeriodicalId":20007,"journal":{"name":"Pediatrics in review","volume":"47 6","pages":"332-336"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}