Pediatric pharmacology最新文献

{"title":"Objective and subjective barriers to the effective pediatric iron deficiency anemia control: results of questionnaire assessment of pediatricians and parents","authors":"I. Fisyun, T. A. Kuznetsova","doi":"10.15690/pf.v20i2.2554","DOIUrl":"https://doi.org/10.15690/pf.v20i2.2554","url":null,"abstract":"Background. Iron deficiency anemia (IDA) remains a pressing pediatric issue to date. Despite the availability of clinical guidelines and other publications that highlight the objective causes for the lack of effectiveness of treatment and prevention of IDA in children, the subjective reasons are unrenowned.Objective. The aim of the study is to evaluate health beliefs of pediatricians and parents on the problem of anemia in children to investigation into the objective and subjective causes for inadequate control of iron deficiency conditions in childhood.Materials and methods. In September 2022, single-step parallel survey of pediatricians and parents on the problem of IDA in children was conducted by random sampling technique using original questionnaires. The questions were formulated on five topics and related to a common understanding of the term “anemia”; priority reference sources; availability of diagnosis of IDA in medical institutions (MI); the position of pediatricians and parents on the treatment and prevention of IDA in children. Based on the results, the main subjective and objective barriers to the control of IDA in children are identified. The χ2 method was used for the comparative evaluation of the responses. The differences were considered significant at statistical significance of p < 0.05.Results. Pediatricians (n = 81) and parents (n = 363) from 23 members of the Russian Federation took the survey. Among the objective barriers to the IDA control in children, the low availability of serum ferritin in MI, difficulties of venous access in children, a shortage of a range of iron preparations for children on Russian market were revealed. The subjective barriers were the skepticism of pediatricians and parents about the necessity for conservative prevention of IDA; poor knowledge of the criteria for diagnosis IDA and completion of IDA therapy by pediatricians; insufficient independence and selectivity of pediatricians when prescribing iron preparations; orientation of the majority of parents (93.7%) to the opinion of doctors, along with the actual rarity of full-fledged conversations with a pediatrician (16.3%).Conclusion. The main limitation of this study was the random sample method inclusion of respondents due to the impossibility of conducting a full-fledged population study. Elimination of the revealed subjective and objective factors can contribute to improving the detection of IDA in children, early appointment and higher effectiveness of treatment, reducing the frequency of disease recurrences, as well as increasing the confidence of parents in pediatricians.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86915539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized Meningococcal Disease in the Newborn: Clinical Case and Literature Review","authors":"Irina Ya. Izvekova","doi":"10.15690/pf.v20i2.2544","DOIUrl":"https://doi.org/10.15690/pf.v20i2.2544","url":null,"abstract":"Neisseria meningitidis is one of the main etiological factors of meningitis and sepsis in children and adults, however, it is rarely diagnosed in the neonatal period. Clinical definition of neonatal meningococcal disease is complicated, the disease outcome is commonly lethal, and therefore its timely diagnosis and adequate therapy are crucial. This article describes clinical case of the newborn with meningococcal sepsis hospitalized on the 5th day after birth and provides the literature review of the data from the late 19th century until the present.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85493435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"XXIV Congress of pediatricians of Russia with international participation \"Current Topics of Pediatrics\"","authors":"A. Editorial","doi":"10.15690/pf.v20i2.2559","DOIUrl":"https://doi.org/10.15690/pf.v20i2.2559","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75120152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative approach to the target therapy of atopic diseases in children","authors":"A. Editorial","doi":"10.15690/pf.v20i2.2551","DOIUrl":"https://doi.org/10.15690/pf.v20i2.2551","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85981450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatricians on guard of children's health: empiric therapy, but not antibiotics","authors":"A. Editorial","doi":"10.15690/vsp.v22i2.2546","DOIUrl":"https://doi.org/10.15690/vsp.v22i2.2546","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78687133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symposium “Frequent Clinical Cases at the Pediatrician's Appointment”","authors":"A. Editorial","doi":"10.15690/pf.v20i2.2545","DOIUrl":"https://doi.org/10.15690/pf.v20i2.2545","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"111 3S 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75608659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant and anniversary dates of the history of pediatrics in 2023","authors":"A. Editorial","doi":"10.15690/pf.v20i2.2562","DOIUrl":"https://doi.org/10.15690/pf.v20i2.2562","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80241344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evgeny V. Karpukhin (to the 80th anniversary of his birth)","authors":"A. Editorial","doi":"10.15690/pf.v20i2.2565","DOIUrl":"https://doi.org/10.15690/pf.v20i2.2565","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75348275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatologic toxicity of high doses of tiothepa in children. Case report","authors":"T. Z. Aliev, T. I. Potemkina, T. Belysheva, T. Valiev, K. Sergeenko, I. A. Kostareva, L. Kudaeva, E. Machneva, T. Ushakova, V. Polyakov, K. Kirgizov, S. Varfolomeeva","doi":"10.15690/pf.v20i2.2543","DOIUrl":"https://doi.org/10.15690/pf.v20i2.2543","url":null,"abstract":"Hematopoietic stem cell transplantation (HSCT) is a treatment modality for a number of severe malignant and non-neoplastic diseases. Autologous hematopoietic stem cell transplantation (auto-HSCT) improves outcomes in patients with solid and hematological malignancies. Skin lesions at the auto-HSCT stage are quite common and represent an important diagnostic and therapeutic problem. The most significant causes of skin lesions in auto-HSCT are drug toxicity, infectious and viral lesions. Each of the complications can manifest itself to varying degrees as well as combine with others, having a significant negative on the patient’s condition, posing a threat to the patient’s life in severe cases.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88899506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Approach to Developing Baseline Reference Ranges for Platelet Function","authors":"O. Gordeeva, M. S. Karaseva, V. A. Lastovka, N. Vashakmadze, M. Soloshenko, G. V. Revunenkov, Kirill A. Valyalov, Viktor V. Altunin","doi":"10.15690/pf.v20i2.2530","DOIUrl":"https://doi.org/10.15690/pf.v20i2.2530","url":null,"abstract":"Background. Thrombocytopathies are topical issues of pediatrics. Platelet dysfunction clinically manifests as thrombotic and hemorrhagic events of various severity and location. Platelet function can be evaluated via aggregatometry. Specified parameters for aggregatometry can be used in pediatrics as a standard for evaluating platelet function in peripheral blood. There were no similar studies in children in Russian Federation.Objective. The aim of the study is — to justify the significance of reference ranges (RR) development for platelet aggregatometry in pediatrics.Methods. The study included 30 relatively healthy patients aged from 1 to 18 years. Laboratory tests included complete blood count via automatic hematological analyzer; platelet aggregation in whole blood was evaluated via impedance aggregometer; plasmic hemostasis component (Quick prothrombin), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen were evaluated on automatic coagulation analyzer; molecular genetic study of platelet genes polymorphisms was performed via real-time PCR. Several inducers were used to study platelet aggregation: thrombin receptor activating peptide (TRAP), adenosine diphosphate (ADP), arachidonic acid (ASPI). Instrumental methods included electrocardiography, ultrasound of abdomen, urinary system, and thyroid gland.Results. The study included 16 girls and 14 boys. The median age was 9.4, interquartile range (IQR) was 6.5; 14,1. RR for platelet aggregation indicators were determined for all aggregation inducers (thrombin, ADP, arachidonic acid) as a result of the study.Conclusion. The obtained data will allow to improve the diagnosis approach for platelet dysfunction regarding the established reference ranges. The results of further research may contribute in the development of the algorithm for controlling antiplatelet therapy in patients with contraindications or with genetically determined low sensitivity to thrombocyte aggregation inhibitors based on acetylsalicylic acid.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"244 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80568272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}