Journal of Internal Medicine Research & Reports最新文献

{"title":"COVID-19 Severity Among Non-Vaccinated Pregnant Women During the Delta Wave in Tunisia: A Retrospective Monocentric Study","authors":"Manel Kammoun, A. Jarraya, Yosra Mejdoub","doi":"10.47363/jimrr/2022(1)118","DOIUrl":"https://doi.org/10.47363/jimrr/2022(1)118","url":null,"abstract":"Introduction: Pregnant women are vulnerable to SARS-CoV2 infection, particularly with the Delta variant. The aim of our study is to describe the COVID-19 syndrome among non-vaccinated pregnant women during the delta wave and to investigate risk factors for severe forms. Methods: In this study, we included all non-vaccinated pregnant women who tested positive for COVID-19 and who required hospital admission at any stage of gestation during the Delta wave in the maternity of Sfax, Tunisia. Patients were divided into 2 groups according to the mode of delivery in case of completed pregnancies and according to the severity of the disease. Severe COVID-19 is considered when the pregnant woman requires advanced oxygen support or intensive care unit referral. We performed univariate and multivariate logistic regression models to investigate the predictors of severe maternal outcomes among infected pregnant women. The significance level was set top ≤ 0.05. Results: one hundred patients were included. Severe adverse outcomes were observed in 23 patients (group1). The mortality rate during the Delta wave was 6%. The mode of delivery had not influenced the maternal and perinatal outcomes. Age >35 years old [OR 3.16, 95% CI 1.13- 8.84], BMI>30 kg/m2 [OR 2.63, 95% CI 1.0 -6.95], preeclampsia [OR 4.0, CI 95% 1.04- 15.32], dyspnea [OR 7.55, 95% CI 2.62- 21.7], cytolysis [ OR 4.6, 95% CI 1.48- 14.2], and lung injury in CT Scan > 50% [OR9.6, 95%CI 1.48-62.1] were significantly associated with an increased risk of severe maternal outcomes. Conclusions: During the delta wave in Tunisia, non-vaccinated pregnant women seem to be at higher risk of severe maternal outcomes and maternal deaths. The main risk factors for severe outcomes were age 35, obesity, preeclampsia, cytolysis, and severe lung damage in the CT scan.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research & Reports","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124973637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Anti-Inflammatory Activity of the Leaf Extract and Fractions of Ipomoea Quamoclit in Albino Wistar Rats","authors":"O. Aziakpono, Okoye Delphine Ogechukwu","doi":"10.47363/jimrr/2022(1)117","DOIUrl":"https://doi.org/10.47363/jimrr/2022(1)117","url":null,"abstract":"Background: Medicinal plants have been shown to contain intrinsic active ingredients that can be used for curative purpose for some diseases. Ipomoea quamoclit is one of such ethnomedicinal plants of reported health benefits. Aim of Study: This study was aimed at evaluating the anti-inflammatory activity of ethanol extract and fractions of the leaves of Ipomoea quamoclit Mill. Materials and Methods: Ipomoea quamoclit leaves were harvested and extracted with 80% ethanol by cold maceration for 48 hours and the crude extract was fractionated to obtain n-hexane, n-butanol and ethyl acetate fraction, respectively. The crude extract and its fractions were screened to unveil the resident phytochemical constituents. The ethanol extract was tested for acute toxicity (LD50). The systemic acute inflammation of the crude extract and fractions of Ipomoea quamoclit was studied using the water (fluid) displacement method after inducing inflammation with egg albumin, using rats. The effect of the crude extract and fractions of Ipomoea quamoclit on arthritis was studied using the formaldehyde-induced arthritis model in rats. Results: The results of the qualitative phytochemical evaluation of the plant confirmed the presence of these phytoconstituents such as alkaloids, flavonoids, saponins, tannins, steroids, terpenoids, glycosides, carbohydrates, proteins, and coumarins. There were no deaths recorded for acute toxicity study for both phases of the test. In the acute anti-inflammation assay, significant (P<0.05) anti-inflammatory activities were observed from the 5th hour for the ethyl acetate fraction (150 and 400 mg/kg) and the butanol fraction (400 mg/kg). The anti-arthritic activity of the crude extract (150 mg/kg), ethyl acetate fraction (150 and 400 mg/kg), n-hexane fraction (150 mg/kg) and butanol fraction (150 and 400 mg/kg) was obvious from the second day after administration. By the 10th day the crude extract (50, 150, and 400 mg/kg) and ethyl acetate fraction (150 and 400 mg/kg) brought about a significant reduction of chronic inflammation (arthritis) in the test animals to normal basal levels. Conclusions: This study thus provides scientific information and validates the ethnobotanical use of Ipomoea quamoclit leaves in management of diseases and inflammation inclusive. The findings of this study also reveal that potentially Ipomoea quamoclit could be a source of pharmacologically active compounds of pharmaceutical importance.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131699393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial Bleeding as Primary Manifestation of Antiphospholipid Syndrome: Case Report","authors":"Dominique Zöld, J. Végh","doi":"10.47363/jimrr/2022(1)116","DOIUrl":"https://doi.org/10.47363/jimrr/2022(1)116","url":null,"abstract":"Antiphospholipid syndrome (APS) is a systemic autoimmune disorder usually resulting in an increased risk of blood clots in the arterial-, venous-, or microvascular system. Various antibodies have been identified causing the activation and aggregation of thrombocytes and endothelial dysfunction resulting in a wide range of symptoms. Frequent manifestation may be arterial or venous clots in extremities or internal organs, neurological manifestation or pregnancy morbidities. Rarely, APS can manifest in the form of hemorrhage. We discuss the case of a 40-year-old male presenting with a severe headache, fatigue and fever. Head CT confirmed a subdural hematoma. Laboratory findings showed anemia, thrombocytopenia and elongated coagulation times. Immunoserology found the strong presence of lupus anticoagulant, anti-cardiolipin-, and anti-β2glycoprotein-I IgG antibodies confirming the diagnosis of primary antiphospholipid syndrome, specifically LA - hypoprothrombinemia syndrome. Following the administration of high dose glucocorticoids, we chose to give intravenous immunoglobulin followed by rituximab. Although his symptoms regressed and there was no further hemorrhaging, we chose to perform plasmapheresis due to continuously high concentration of anti- phospholipid antibodies to lower the antibody titer, which proved to be effective. Antithrombotic treatment can be challenging in such cases due to the co-occurrence of hypoprothrombinemia and prothrombotic antibodies. We decided to administer low-dose aspirin, with which the patient has no bleeding or blood clots for over 6 years. We find the case worth presenting due to the rare occurance of bleeding as primary manifestation of APS and due to the challenging treatment.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121625472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Transplant Indication in Acute Heart Insufficiency with COVID-19","authors":"A. Gasparoto, R. Martínez","doi":"10.47363/jimrr/2022(1)114","DOIUrl":"https://doi.org/10.47363/jimrr/2022(1)114","url":null,"abstract":"The report shows the evolution of a 29yr old woman who eas admitted to the hospitals because of her recent heart condition with pulmonary symptoms aswell. It was found that her COVID-19 tests were positive. As her evolution only worsened having kidney function aggravated it was decided that she had indication for a successful heart transplant. She has now 20 months of post-surgery and is being monitored by all clinical, la oratory and image exams thus being considered a successful case of serious and lifesaving heart condition due to COVID-19.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131929436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaemia and Its Correlates in Haart Naïve Patients in Port Harcourt, Nigeria","authors":"B. Oyan, H. Omunakwe","doi":"10.47363/jimrr/2022(1)115","DOIUrl":"https://doi.org/10.47363/jimrr/2022(1)115","url":null,"abstract":"Introduction: Anemia is one of the complications of HIV infection, a multifactorial marker of bone marrow dysfunction, and an indicator of poor prognosis. Methods: A retrospective assessment of electronic data and case notes of HAART naïve patients in our hospital between January 2016 and December 2018 was done. Data on age, sex, packed cell volume (PCV) and CD4 at diagnosis was collected. Continuous variables were compared with the students’ t-test while categorical parameters were compared with the chi-square. Spearman’s correlation was used to assess the association between anaemia and the CD 4 count. Risk factors for the outcome variable were determined with logistic regression and a p-value of ≤0.05 was considered statistically significant. Results: The records of three hundred and twenty-one (321) new registrants in the Antiretroviral Therapy (ART) Clinic in Rivers State University Teaching Hospital (RSUTH) were evaluated. Their mean age was 40.43 ±10.51 years (range 19 – 76 years). Anemia was prevalent in 280(87.2%) patients. The CD4 count was normal in 102 (32.6%) patients. Female gender (p=0.001) and WHO clinical stage (p<0.001) were found to be the strongest predictors of anemia in this study. Conclusion: The findings from this study shows that a significant proportion of people infected with HIV present with severe immunosuppression and low hemoglobin. There is a need to strengthen the pathways for early diagnosis, prompt treatment by trained physicians and supportive care by hematologists to reduce the severity and impact of anemia in this group of patients.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123119686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression Among Health Workers in Kuwait","authors":"Khaled Alsaadi, Ahmad Alobaid","doi":"10.47363/jimrr/2022(1)113","DOIUrl":"https://doi.org/10.47363/jimrr/2022(1)113","url":null,"abstract":"Introduction: People with depression have persistent sadness which interferes with productivity and daily activity. Subsequently decreasing work accuracy or increasing the medical errors in the medical field. The increasing amount of medical errors that was suggestive of depression encouraged us to estimate the extensiveness of depression among health workers in the hospitals in Kuwait. Aim: To provide basic data that will contribute to the design of preventive measures that will reduce the prevalence of Depression among health workers. Study Design: Cross sectional study. Materials and Methods: The research was conducted in AlFarwaniya Hospital & Mubarak AlKabeer Hospital in 2016. Data was performed using IPad and analyzed using SPSS. Results: The highest percentage of depression is among the ones whose ages are between 30 to 39 which is 12% (37) out of 52.4 % (162). It shows that females had depressive symptoms more than males, 7.1% of males were depressed compared to the 12.2% who were females. It seems that Kuwaiti health workers show depressive symptoms more than the non-Kuwaiti. It shows that doctors have highest depression rate (28%) then the nurse and finally the other careers. Married individuals show 68% are depressed which is the highest, single individuals with (28%) and divorced with (1.7%). Smokers were with 25% and nonsmokers with (19%) of depression. Chronic diseases don’t show significant effect on depression. Conclusion: This study showed that there is a difference in the prevalence of depression between the genders as well as the social status. Establishment of new rules to decrease working hours and held workshops and seminars on overcoming depression are great solutions to reduce stress among health workers.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117146495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Medical Cannabis in Palliative & Supportive Care","authors":"Ioannis P Capos","doi":"10.47363/jimrr/2022(1)112","DOIUrl":"https://doi.org/10.47363/jimrr/2022(1)112","url":null,"abstract":"","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131510149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Hemolytic Anemia","authors":"A. Taksande, Snehi Kumar","doi":"10.47363/jimrr/2022(1)105","DOIUrl":"https://doi.org/10.47363/jimrr/2022(1)105","url":null,"abstract":"The diagnosis of autoimmune haemolytic anaemia (AIHA) is a challenge for both the immune-haematology laboratory and the clinician as the laboratory investigation can be troublesome and often requires extensive time-consuming serological testing, especially when a blood transfusion is needed. Frequently, there is a need to start therapy rapidly. Autoantibodies directed to epitopes on red blood cell (RBC) consisting in sugar and/or protein structures are crucial in the pathogenesis of AIHA. The isotype is important for the clinical significance of an autoantibody. Frequently, patients are icteric and suffer from clinical signs of anaemia, such as pallor, fatigue, shortness of breath and palpitations, on examination hepatosplenomegaly can be present. If there is no vital indication for a transfusion it is prudent to wait for the results of the immune-haematological tests and the ensuing transfusion advice based on this. Focus of treatment should be stoppage of hemolysis or at least be attenuated via an inhibition of autoantibody production and/or inhibition of premature RBC destruction. Successful treatment of secondary AIHA is only possible when the underlying disease is treated.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116735305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Tuberculosis and Lung Cancer: A Case Report","authors":"Laure Stella Ghoma Linguissi, A. Mabiala","doi":"10.47363/jimrr/2022(1)106","DOIUrl":"https://doi.org/10.47363/jimrr/2022(1)106","url":null,"abstract":"Lung cancer and pulmonary tuberculosis (TB) are two major public health problems associated with similar clinical and radiological presentations thus leading to misdiagnosis and inappropriate initiation of treatment. We investigated the case of a patient presenting symptoms for Tuberculosis and who was finally diagnosed as having probable lung cancer. Lung cancer may be the cause of some of the symptoms in TB suspected patients and this calls for vigilance on clinicians to know what appropriate tests are needed for patients presenting symptoms suspicious of TB in order to differentially diagnose TB and /or lung cancer.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"1999 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113966427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Rhythms, Disorders and their Energetic : A Review","authors":"Asif Bilal, Nimra Naveed","doi":"10.47363/jimrr/2022(1)104","DOIUrl":"https://doi.org/10.47363/jimrr/2022(1)104","url":null,"abstract":"Body rhythms are recurring molecular, hormonal, or psychological phenomena that occur in all living organisms. There are five types of body rhythms such as diurnal, circadian, ultradian, infradian, and circannual rhythms. The present review aims to discuss body rhythms, body rhythms disorders, and their energetics. Diurnal rhythms occur during the day and in resting, or inactivity at night, circadian rhythms complete one cycle in 24 hours and known as midday activity, ultradian are recurrent or repeated cycle in 24 hours, infradian rhythms complete one cycle more than one day, and circannual rhythms complete their cycle in 24 hours or one year. Body rhythms are following disorders like delayed sleep phase syndrome, altered Sleep, phase Shift Work Dysfunction, and circadian rhythm nap defects. Body rhythm control stress, lighten body load, exercise, avoid smoking, restrict sleeping, avoid napping during the day, provide energy for eating, and limit alcohol consumption. Body rhythms play an important role to regulate the body, while disturbance in body rhythms leads to several disorders.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130472110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}