Journal of Internal Medicine Research & Reports最新文献

{"title":"The Association between Urinary Alcohol Metabolites on Hepatitis C Treatment and Response","authors":"Aaron Gerard Issac, Yun Han Hannah Wang, Anand S. Shah, Emily J. Cartwright","doi":"10.47363/jimrr/2024(3)128","DOIUrl":"https://doi.org/10.47363/jimrr/2024(3)128","url":null,"abstract":"Background: Direct-acting antiviral (DAA) medications for the treatment of chronic hepatitis C virus (HCV) infection has achieved higher rates of sustained virologic response (SVR) with shorter treatment durations and no alcohol abstinence prerequisite. Previous therapies required alcohol abstinence for at least 6 months. Methods: Our retrospective cohort study in Veterans with chronic HCV infection presenting for care at the Joseph Maxwell Cleland Atlanta VA medical center (AVAMC) between 1/1/2015 – 11/29/2017 examined the relationship between alcohol use, DAA initiation, and SVR. Results: The cohort included 1763 people that were mostly males (97%) with a mean age of 63 years and 70% Black. In multivariate analysis, the odds of receiving DAA were 0.7 (95% CI: 0.674, 0.9; p=0.0013) in those with “detectable” alcohol metabolites compared with those who had “undetectable” alcohol metabolites. The odds of achieving SVR were 0.7 (95% CI: 0.5, 1.0; p=0.0525) in those with “detectable” alcohol metabolites. Overall, 86% of patients who received DAA therapy achieved SVR. Conclusions: Alcohol use categorized using urine alcohol metabolite testing, during the study period was associated with a significantly lower odds of receiving DAA therapy but had no statistical significance on the odds of achieving SVR. While patients with chronic hepatitis C should be counseled on the risks of alcohol use, it is not associated with lower likelihood of achieving SVR and should not preclude the initiation of DAA therapy","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research & Reports","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140415930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Diagnostic Challenges: Chronic Anemia Leading to the Diagnosis of Gastric Antral Vascular Ectasia (GAVE) in the Absence of Typical Symptoms","authors":"Abraamyan F, Bobolis K","doi":"10.47363/jimrr/2024(3)129","DOIUrl":"https://doi.org/10.47363/jimrr/2024(3)129","url":null,"abstract":"Gastric antral vascular ectasia (GAVE) is a rare acquired vascular dysplasia usually associated with portal hypertension or CREST syndrome. Here we present a case of a 62-year-old female with no significant related comorbidities who presented to our clinic due to severe acute on chronic anemia. On initial review of systems, the only complaint the patient had was fatigue, shortness of breath and being lightheaded. Patient denied hematochezia or melena, no hematemesis or other gastrointestinal complaints, no history of NSAIDs or aspirin use. Initial labs were significant for iron-deficiency anemia with hemoglobin of 8.5 g/ dL. Recent colonoscopy was non diagnostic for the cause of anemia as well. Due to unrevealing previous workup patient was referred to gastroenterologist and undergone esophagogastroduodenoscopy (EGD) with findings of ecstatic vessels in stomach antrum suggestive of GAVE, successfully treated with argon plasma coagulation. Total in a span of 4 years due to recurrence of anemia patient required 3 EGDs, while GAVE was successfully treated each time with argon plasma coagulation. Due to absence of gastrointestinal (GI) complaints patient was recommended to have regular laboratory workup to monitor for silent blood loss. This atypical presentation of upper GI bleeding warrants physicians to refer patients to gastroenterologists to perform EGD for further evaluation and treatment in cases of unknown etiology of iron deficiency anemia even in the absence of gastrointestinal (GI) complaints and non-revealing previous GI workup with colonoscopy","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research & Reports","volume":"20 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmodium Falciparum Malaria and Concomitant High-Risk Pulmonary Thromboembolism: Case Report","authors":"Mauro Capuepue, Oliveira Siquito","doi":"10.47363/jimrr/2023(2)126","DOIUrl":"https://doi.org/10.47363/jimrr/2023(2)126","url":null,"abstract":"The authors describe a case of a patient admitted due to a previous condition of osteomyoarthralgia, headache, fever, malaise, which worsened with sudden onset dyspnea, chest pain, syncope, the plasmodium test was positive, the EKG performed at the Emergency department presented the classic pattern of acute cor pulmonale (S1Q3 T3 ). The echocardiogram demonstrated changes compatible with pulmonary thromboembolism. Chest X-ray showed an increase in the cardiothoracic index and dilation of the right pulmonary artery (Fleischner ‘s sign). Computed angiotomography (angioCT) of the chest confirmed the diagnosis, showing the presence of thrombi in the main, segmental and subsegmental branches. The patient underwent fibrinolytic therapy and progressed favorably.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research & Reports","volume":"97 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139131539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of an Internet-Hospital-Community-Home Linked Health Management Model in Patients with Osteoporotic Vertebral Compression Fractures Who Received Conservative Treatment: A Quasi-Experimental Study","authors":"Tingye Hu","doi":"10.47363/jimrr/2023(2)127","DOIUrl":"https://doi.org/10.47363/jimrr/2023(2)127","url":null,"abstract":"Objective: To evaluate the effect of an internet-hospital-community-home (IHCH) linked health management model in the management of patients with osteoporotic vertebral compression fractures (OVCF) who undergoing conservative treatment. Methods: This quasi-experimental study enrolled patients with OVCF who undergoing conservative treatment and visited to xx hospital between April 2022 and September 2022. Patients were divided into two group based on their time of visit to receive the IHCH linked health management (IHCH group) or routine management (control group). The outcomes were activities of daily living (ADL) scores, quality of life [measured by SF-36 Health Survey (SF36) scores], functional disability [measured by Roland-Morris Disability Questionnair (RMDQ) score], pain assessment [measured by Visual Analog Scale (VAS) score] at acute stage, 1 month, 3-month, 6 months after intervention; and pressure injuries, medication adherence, and health service satisfaction at 6 months after intervention. Results: Sixty-two patients completed the follow-up, with 31 cases in each group. The baseline information between the two groups were comparable (all P>0.05). After intervention, repeated measures ANOVA showed that the ADL (P time < 0.001, P group = 0.045, P time x group < 0.001), SF-36 (P time < 0.001, P group = 0.008, P time x group < 0.001), and RMDQ scores (P time < 0.001, P group = 0.014, P time x group < 0.001) in IHCH group were significantly improved compared to the control group, which were interacted with time. Furthermore, at the 6-month follow-up, the IHCH group exhibited significantly lower incidence of pressure injuries [2 (6.67) vs 8 (26.67), P = 0.038], higher medication adherence [16 (53.33) vs 9(30.00), P = 0.031], and greater satisfaction with health services [Total satisfaction: 27 (90.00) vs 19 (63.33), P = 0.015] compared to the control group. Conclusion: The IHCH linked health management model might improve the effectiveness of conservative treatment for OVCF patients, reduce the occurrence of complications, and enhance satisfaction with health services.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"62 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139130660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxic Respiratory Failure Due to Three Hits: Pulmonary Embolism, Rasburicase-Induced Methaemoglobinaemia And Haemolytic Anaemia In A Patient with Previously Undiagnosed Glucose-6-Phosphate Dehydrogenase Deficiency","authors":"Y.T. Vincent Aw, A. Ekladious","doi":"10.47363/jimrr/2023(2)124","DOIUrl":"https://doi.org/10.47363/jimrr/2023(2)124","url":null,"abstract":"We present a 35-year-old male patient who developed hypoxic respiratory failure from three concurrent pathologies–acute pulmonary embolism, methemoglobinemia and oxidative haemolytic anaemia from previously undiagnosed glucose-6-phosphate dehydrogenase deficiency, precipitated by rasburicase therapy for tumour lysis syndrome following chemotherapy for non-Hodgkin’s lymphoma. Hypoxia resolved upon treating all pathologies, highlighting the need to consider these rare differential diagnoses.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132583231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GAD-65 Antibody Mimics Cocaine Induced Limbic Encephalopathy","authors":"Tyler G Chin, J. Colombo, S. Soloway","doi":"10.47363/jimrr/2023(2)121","DOIUrl":"https://doi.org/10.47363/jimrr/2023(2)121","url":null,"abstract":"Glutamic Acid Decarboxylase 65-kilodalton isoform (GAD-65) is associated with cocaine induced limbic encephalopathy mimicking GAD-65 limbic encephalopathy in humans. A 20-year-old white female presented with a clinical picture of a limbic encephalopathy and a positive ANA. She has a hypermobility disorder with dysautonomia with POTS. Her workup revealed a GAD-65 antibody greater than 250 nmol/L, a normal lumbar puncture, and a normal brain MRI. Her GAD-65 associated limbic encephalopathy was treated with IVIG 2 g per kilogram per month. She received three treatments with no improvement. Due to arthralgias, a soft tissue rheumatic pain, she was referred to pain management. The patient admitted to using cocaine. Her IVIG was discontinued. A repeat test for GAD-65 antibody remained elevated. After a stint in drug rehabilitation and cessation of cocaine her symptoms of limbic encephalopathy abated and GAD-65 normalized. This is the 1st case report of GAD-65 antibody mimicking cocaine induced limbic encephalopathy. While GAD65 related autoimmune neuropathies are rare, one must consider cocaine toxicity as a mimic of both autoimmunity and immune neuropathies, including the spectrum of GAD-65-related disorders.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122550634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ileal Conduit Necrosis Secondary to Spontaneous Retroperitoneal Hematoma","authors":"Cuenca Ramirez MD, Botto Lugo SM","doi":"10.47363/jimrr/2023(2)120","DOIUrl":"https://doi.org/10.47363/jimrr/2023(2)120","url":null,"abstract":"Case Presentation: A fifty-nine years old woman with previous muscle-invasive bladder cancer treated five years prior in another medical center with radical cystectomy and Bricker’s ureteroileostomy diversion, presented to the Emergency Room (ER) describing general discomfort, diarrhea, arterial hypotension and tachycardia. After conducting an imaging test, ileal conduit ischemia and mesenteric ischemia was diagnosed secondary to retroperitoneal hematoma. Ileal reservoir resection, resection of the ischemic intestine, and bilateral cutaneous ureterostomy were performed. Relevance: In patients with previous urinary diversion and acute abdominal pain, it is imperative to dismiss conduit involvement. Clinical Implications: In cases of acute abdomen with history of urinary diversion, physical examination and imaging tests can detect if the ileal reservoir has been compromised and, therefore, guide the adequate therapeutic approach. Conclusions: Identifying the complications of the urinary diversion in early stages in order to treat the underlying cause is advisable.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134078251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on The Impact of Climate Change on Approach to Epidemiology of Livestock Diseases Control","authors":"M. Getachew, Henok Mulatu","doi":"10.47363/jimrr/2023(2)122","DOIUrl":"https://doi.org/10.47363/jimrr/2023(2)122","url":null,"abstract":"The livestock sector globally is highly dynamic. In developing countries, it is evolving in response to rapidly increasing demand for livestock products. In developed countries, demand for livestock products is stagnating, while many production systems are increasing their efficiency and environmental sustainability. Currently, the world is facing a number of challenges, of which Global climate change is a priority area. Agriculture and livestock are amongst the most climate sensitive economic sectors in the developing countries. Climates comprises many factors including temperature, rainfall, humidity, winds and altitude hat can have both direct and indirect effects on animal production and health. It can also affect the quality and quantity of feedstuffs such as pasture, forage and grain and the severity and distribution of livestock diseases and parasites. Infectious diseases of animals are of huge socioeconomic and public health importance. The earth’s temperature has risen at an average of 0.3 to 0.7 °C since 1900 & 20-30% of all vertebrate animals are expected to get extinct if the average temperature rises by 2-3 °C. The early consequences of global climate change (GCC) are well documented. However, future impacts on ecosystem health, and on the health of humans, domestic animals, and wildlife, are much less well understood. A two-pronged approach must be adapted to tackle the alarming situation arising out of climate change impacts. Adaptation may involve the measures for future adaptation to the disease onslaught and the Mitigation focuses on reducing the level of agents/factors leading to the climate change. One health concept in one health triad needs to be followed in spirit to avert the otherwise sure to come impacts of climate change.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115335371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Solitary Rectal Ulcer Syndrome from Twenty-Four Iraqi Patients","authors":"Kamal Breesam Lafta, Muntadher Abdulkareem Abdullah","doi":"10.47363/jimrr/2023(2)123","DOIUrl":"https://doi.org/10.47363/jimrr/2023(2)123","url":null,"abstract":"Background: Solitary rectal ulcer syndrome (SRUS) is a rare benign rectal disorder that can present with bleeding, mucus passage, straining during defecation, constipation, rectal prolapse, and a feeling of incomplete evacuation. It is characterized by a combination of clinical findings, histological abnormalities, and symptoms. Since patients frequently come with lesions that are neither solitary nor ulcerated, the nomenclature of the syndrome is deceptive. Multiple factors may be implicated in the etiology and pathogenesis of the illness, which is usually linked to pelvic floor abnormalities. Objectives: To study the distribution of age and sex for this syndrome among a sample of Iraqi patients and to further characterize this syndrome in our population. Materials and Methods: A retro-prospective, descriptive single-center study with this research design was carried out at the Baghdad Gastroenterology and Hepatology Teaching Hospital involved reading reports from (1784) lower gastrointestinal endoscopies (sigmoidoscopy and colonoscopy) performed at the Baghdad Gastroenterology and Hepatology hospital over the course of fourteen months. Of those, twenty-four patients who met the requirements for the clinical, endoscopic, and histological diagnosis of SRUS were examined and monitored. Results: Sixteen patients were female and eight patients were male, mean age was (26.5±9.69), mean duration of symptoms until diagnosis was 12.083 months ±11.5. The most frequent symptom was bleeding per rectum (95.8%).All patients(100%) were subjected to several treatment options, they were advised on normal defecatory behavior and bowel habits, Sulfasalazine enema1-2gm/day for(3-6 months),sucralfate enema(2gm/day for 3months), only four patients(16.6%)ended with endoscopic treatment and two patients(8.3%)ended with surgery. Conclusion: SRUS is a chronic, benign disorder in young adults, often related to straining or abnormal defecation. SRUS remains a well-defined but nonspecific entity with varied presentation, characterized by a rectal lesion caused by straining during defecation. Clinicians, surgeons, and pathologists should be aware of the features of SRUS so that it is not confused with other conditions.","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"197 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132155790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and Predictors of COVID-19 Worsening Among Patients Initially Managed on An Outpatient Basis: An Observational Study in Sfax Governorate; Tunisia","authors":"Maamri Hanen, Issaoui Fadhila, H. Rania","doi":"10.47363/jimrr/2022(1)119","DOIUrl":"https://doi.org/10.47363/jimrr/2022(1)119","url":null,"abstract":"","PeriodicalId":199879,"journal":{"name":"Journal of Internal Medicine Research &amp; Reports","volume":"6 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126022109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}