{"title":"Novartis’ Sandoz to Become Largest Generic Dermatology Company with US$1.53 B Fougera Pharmaceuticals Acquisition","authors":"Heather Cartwright","doi":"10.3833/pdr.v2012i5.1741","DOIUrl":"https://doi.org/10.3833/pdr.v2012i5.1741","url":null,"abstract":"Novartis’ generic drug unit Sandoz has agreed to acquire Fougera Pharmaceuticals, the former US dermatology business of Nycomed, for US$1.53 B in cash in order to become the leading player in the global generic dermatology market. Fougera reported sales of US$429 M in 2011, most of which came from the US, and Novartis aims to expand the company’s product sales globally. The acquisition will also provide the Swiss company with in-house expertise in topical dermatological products.","PeriodicalId":19951,"journal":{"name":"Pharmadeals Review","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78162661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Celgene Gains Buyout Option with VentiRx Cancer Collaboration","authors":"Heather Cartwright","doi":"10.3833/PDR.V2012I10.1825","DOIUrl":"https://doi.org/10.3833/PDR.V2012I10.1825","url":null,"abstract":"Celgene has formed a global collaboration with the virtual company VentiRx Pharmaceuticals to fund Phase II trials of VentiRx’s TLR8 (Toll-like receptor 8) agonist VTX-2337 in ovarian and head-and-neck cancers. Celgene will provide US$35 M upfront for further development of the drug through predefined clinical endpoints and in return retains an exclusive option to acquire VentiRx at a predetermined price. VentiRx is also eligible to receive additional funding during the option period, including a potential equity investment by Celgene. VentiRx in-licensed Array BioPharma’s TLR8 programme in 2007.","PeriodicalId":19951,"journal":{"name":"Pharmadeals Review","volume":"100 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91455895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Janssen Biotech Licenses Ex-Japan Rights to Astellas’ Oral JAK Inhibitor ASP015K","authors":"Heather Cartwright","doi":"10.3833/PDR.V2012I10.1821","DOIUrl":"https://doi.org/10.3833/PDR.V2012I10.1821","url":null,"abstract":"In a bid to strengthen its autoimmune disease franchise, Johnson & Johnson’s Janssen Biotech has licensed worldwide rights, excluding Japan, to develop and commercialise Astellas Pharma’s ASP015K, a Janus kinase (JAK) inhibitor in Phase IIb development for moderate-to-severe rheumatoid arthritis (RA). J&J already markets the anti-TNF-alpha (anti-tumour necrosis factor alpha) agents Remicade® (infliximab) and Simponi® (golimumab). Pfizer’s tofacitinib is poised to be the first JAK inhibitor to be approved for the treatment of RA with a regulatory decision expected from the US FDA in November 2012.","PeriodicalId":19951,"journal":{"name":"Pharmadeals Review","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74437881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bayer and Evotec Collaborate to Develop Three Endometriosis Drug Candidates","authors":"Heather Cartwright","doi":"10.3833/pdr.v2012i10.1820","DOIUrl":"https://doi.org/10.3833/pdr.v2012i10.1820","url":null,"abstract":"Bayer Pharma and Evotec have entered into a 5-year partnership aimed at developing three clinical candidates for the treatment of endometriosis. Both companies will contribute drug targets and will be jointly responsible for early research and preclinical characterisation. Bayer will then undertake any subsequent clinical development and commercialisation. Bayer already markets the progesterone receptor agonist Visanne® (dienogest) for the treatment of endometriosis and the deal could help strengthen the company’s women’s healthcare business in the long term.","PeriodicalId":19951,"journal":{"name":"Pharmadeals Review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86981156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"BASF Aims for Top Spot in Omega-3 API Market with Pronova BioPharma Acquisition","authors":"Heather Cartwright","doi":"10.3833/PDR.V2012I12.1858","DOIUrl":"https://doi.org/10.3833/PDR.V2012I12.1858","url":null,"abstract":"In order to attain a leading position in the global omega-3 API market, the German chemical company BASF has made a voluntary offer to acquire Pronova BioPharma, the originator of the blockbuster omega-3 derived drug Lovaza®/Omacor® (omega-3-acid ethyl esters), for a total enterprise value of NOK4845 M (US$844 M). The deal follows BASF’s May 2012 acquisition of Equateq, a UK-based manufacturer of concentrated omega-3 fatty acids.","PeriodicalId":19951,"journal":{"name":"Pharmadeals Review","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74812742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Start-Up Tolero Pharmaceuticals Licenses MannKind’s Btk Programme in US$130 M Deal","authors":"Heather Cartwright","doi":"10.3833/PDR.V2012I5.1740","DOIUrl":"https://doi.org/10.3833/PDR.V2012I5.1740","url":null,"abstract":"In a deal worth approximately US$130 M, start-up Tolero Pharmaceuticals has licensed worldwide rights to develop and commercialise compounds from MannKind’s Btk (Bruton’s tyrosine kinase) programme, which are being developed for the treatment of haematological malignancies and inflammatory diseases. Interestingly, MannKind retains the right to reacquire the Btk assets at prespecified terms up to 60 days after completion of the first Phase I study.","PeriodicalId":19951,"journal":{"name":"Pharmadeals Review","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85692415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Forma Therapeutics and Boehringer Ingelheim Partner to Target Oncology-Relevant Protein-Protein Interactions","authors":"Heather Cartwright","doi":"10.3833/PDR.V2012I2.1677","DOIUrl":"https://doi.org/10.3833/PDR.V2012I2.1677","url":null,"abstract":"Forma Therapeutics has landed a 4-year cancer drug discovery deal with Boehringer Ingelheim that is potentially worth up to US$815 M to discover small molecule therapeutics against oncology-relevant protein-protein interactions. With this deal, Boehringer Ingelheim will join Forma’s list of big pharma partners, which includes Roche, Eisai and Novartis.","PeriodicalId":19951,"journal":{"name":"Pharmadeals Review","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87412662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Forma Therapeutics and Janssen Biotech Target Tumour Metabolism with US$700 M Drug Discovery Alliance","authors":"Heather Cartwright","doi":"10.3833/PDR.V2012I2.1676","DOIUrl":"https://doi.org/10.3833/PDR.V2012I2.1676","url":null,"abstract":"Forma Therapeutics has secured another big pharma deal by forming a cancer drug discovery alliance with Johnson & Johnson’s Janssen Biotech. Forma will discover and develop drugs against a panel of tumour metabolism targets and could receive up to US$700 M in project funding and milestone payments plus royalties. In a first for the company and contingent upon the achievement of certain milestones during the initial phase of the collaboration, Forma has an option to co-develop and retain North American rights to one of the collaboration programmes, to be selected by Janssen.","PeriodicalId":19951,"journal":{"name":"Pharmadeals Review","volume":"296 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73201301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Xenon and Genentech Partner to Develop Pain Therapeutics and Companion Diagnostics","authors":"Heather Cartwright","doi":"10.3833/PDR.V2012I2.1678","DOIUrl":"https://doi.org/10.3833/PDR.V2012I2.1678","url":null,"abstract":"Canadian Xenon Pharmaceuticals has formed its sixth major partnership by agreeing to collaborate with Roche’s Genentech on the discovery and development of novel compounds and companion diagnostics for the potential treatment of pain. The agreement is interesting in that Genentech will gain an exclusive licence to compounds and a non-exclusive licence to diagnostics for future development and commercialisation. The deal is potentially worth up to US$646 M to Xenon in research, development and commercialisation milestones for multiple products and indications.","PeriodicalId":19951,"journal":{"name":"Pharmadeals Review","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85739775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Baxter Expands its Oncology Pipeline by Licensing European Rights to Onconova Therapeutics’ Rigosertib","authors":"Heather Cartwright","doi":"10.3833/PDR.V2012I9.1811","DOIUrl":"https://doi.org/10.3833/PDR.V2012I9.1811","url":null,"abstract":"In return for US$50 M upfront and up to US$515 M in precommercialisation milestone payments, Baxter International has licensed European commercialisation rights to Onconova Therapeutics’ lead anticancer therapy rigosertib. The drug candidate is currently in Phase III development for myelodysplastic syndromes, for which it has been granted Orphan Drug Designation in the US and Europe, and is the subject of a Phase II/III study in pancreatic cancer. Baxter, which has an existing US$50 M equity position in Onconova, also has the option to develop rigosertib in additional indications.","PeriodicalId":19951,"journal":{"name":"Pharmadeals Review","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89039787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}