Parasite Immunology最新文献

Murine immune responses to Schistosoma haematobium and the vaccine candidate rSh28GST 小鼠对血吸虫和候选疫苗 rSh28GST 的免疫反应

IF 2.2 4区医学

Parasite Immunology Pub Date : 2024-09-13 DOI: 10.1111/j.1365-3024.1998.tb00001.x

A. LANE, D. BOULANGER, G. RIVEAU, A. CAPRON, R.A. WILSON

{"title":"Murine immune responses to Schistosoma haematobium and the vaccine candidate rSh28GST","authors":"A. LANE, D. BOULANGER, G. RIVEAU, A. CAPRON, R.A. WILSON","doi":"10.1111/j.1365-3024.1998.tb00001.x","DOIUrl":"https://doi.org/10.1111/j.1365-3024.1998.tb00001.x","url":null,"abstract":"SUMMARYLongitudinal studies of Schistosoma haematobium infection in CBA mice revealed a progressive down‐regulation of cellular immune responses, as measured by mitogenic and antigenic stimulation of in vitro lymphocyte cultures. Antigen‐stimulated production of the Th1 cytokine IFN‐γ by splenocytes increased progressively up to 14 weeks post infection, (four weeks after the onset of parasite egg production), before declining swiftly. Levels of the Th2 cytokine IL‐4 in the same cultures remained low until 14 weeks, after which they rose rapidly as IFN‐γ declined. High levels of IL‐10 coincided with the peak in IFN‐γ production, suggesting a non Th2‐restricted role for this cytokine. Both total and antigen‐specific immunoglobulin production confirmed parasite egg deposition as being a major stimulus for host humoral responses. The S. haematobium tobium infection failed to elicit detectable T cell responses to the antifecundity vaccine candidate rSh28GST. However, low levels of antibody were detectable in infected mouse serum and strong IgG and IgA production was induced by vaccination with rSh28GST plus adjuvant.","PeriodicalId":19931,"journal":{"name":"Parasite Immunology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SEA Alleviates Hepatic Ischaemia-Reperfusion Injury by Promoting M2 Macrophage Polarisation. SEA 通过促进 M2 巨噬细胞极化缓解肝脏缺血再灌注损伤

IF 1.4 4区医学

Parasite Immunology Pub Date : 2024-08-01 DOI: 10.1111/pim.13061

Shudong Xie, Chen Guo, Pengpeng Zhang, Junhui Li, Yu Zhang, Chen Zhou, Xiaofei Fan, Yingzi Ming

{"title":"SEA Alleviates Hepatic Ischaemia-Reperfusion Injury by Promoting M2 Macrophage Polarisation.","authors":"Shudong Xie, Chen Guo, Pengpeng Zhang, Junhui Li, Yu Zhang, Chen Zhou, Xiaofei Fan, Yingzi Ming","doi":"10.1111/pim.13061","DOIUrl":"https://doi.org/10.1111/pim.13061","url":null,"abstract":"Hepatic ischaemia-reperfusion (I/R) injury is a frequent and nearly inevitable pathophysiological process without widely accepted effective therapy. Soluble egg antigen (SEA) of Schistosoma japonicum (S. japonicum) is the main mediators capable of regulating immunological activities and has received increased attention in immune-mediated diseases. But its role in hepatic I/R injury has not been well defined. This study aimed to elucidate whether SEA protects liver against hepatic I/R injury and explore underlying mechanism. After intraperitoneal injecting SEA three times a week for 4 weeks, mice underwent 70% hepatic I/R injury. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), haematoxylin-eosin (HE) and TdT-mediated dUTP nick-end labelling (TUNEL) staining were used to evaluate liver injury. The severity related to the inflammatory response was also investigated. Furthermore, immunofluorescence was used to detect macrophage polarisation. Compared with the hepatic I/R injury group, SEA pretreatment significantly alleviated hepatic I/R injury induced liver damage, apoptosis and inflammatory. Interestingly, SEA enhanced the polarisation of macrophages towards M2 macrophages in vivo. We are the first to investigate the therapeutic efficacy of S. japonicum SEA in a hepatic I/R injury model in mice. We provided the first direct evidence that SEA attenuated hepatic I/R injury by promoting M2 macrophage polarisation.","PeriodicalId":19931,"journal":{"name":"Parasite Immunology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leishmania donovani Modulates Macrophage Lipidome During Infection. 唐氏利什曼原虫在感染过程中调节巨噬细胞脂质体

IF 1.4 4区医学

Parasite Immunology Pub Date : 2024-08-01 DOI: 10.1111/pim.13066

Shams Tabrez, Zeeshan Fatima, Sajjadul Kadir Akand, Areeba Rahman, Saif Hameed, Mohammed Saleem, Yusuf Akhter, Subhash Kumar Yadav, Mohammad Z Ahmed, Yashwant Kumar, Surajit Bhattacharjee, Abdur Rub

{"title":"Leishmania donovani Modulates Macrophage Lipidome During Infection.","authors":"Shams Tabrez, Zeeshan Fatima, Sajjadul Kadir Akand, Areeba Rahman, Saif Hameed, Mohammed Saleem, Yusuf Akhter, Subhash Kumar Yadav, Mohammad Z Ahmed, Yashwant Kumar, Surajit Bhattacharjee, Abdur Rub","doi":"10.1111/pim.13066","DOIUrl":"https://doi.org/10.1111/pim.13066","url":null,"abstract":"Obligate intracellular protozoan parasite, Leishmania donovani, causative agent of visceral leishmaniasis, led to impaired macrophage functions. It is well documented that many of these changes were induced by parasite-mediated reduction in macrophage cholesterol content. Leishmania-mediated alteration in the other lipids has not been explored in detail yet. Here, we found that the expression of key cholesterol biosynthetic genes and total cellular cholesterol were reduced during L. donovani infection. Further, we have also identified that this reduction in the cholesterol led to increased membrane fluidity and inhibition of antigen-presenting potential of macrophages. In addition to this, we studied the relative changes in different lipids in THP-1-derived macrophages during L. donovani infection through liquid chromatography-mass spectrometry. We found that Sphingomyelin (16:0) and ceramide (20:1, 26:0 and 26:1) were significantly reduced in infected macrophages. We further observed that the majority of different sub-classes of phospholipids were downregulated significantly. Overall ratio of phosphatidylcholine versus phosphotidylethanolamine was decreased which indicated the compensatory mechanism of cell in response to cholesterol reduction. The observed Leishmania-mediated alteration in macrophage-lipidome provided the novel insights into mechanism of host-pathogen interactions.","PeriodicalId":19931,"journal":{"name":"Parasite Immunology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142293031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generation of Devil Facial Tumour Cells Co-Expressing MHC With CD80, CD86 or 41BBL to Enhance Tumour Immunogenicity. 生成与 CD80、CD86 或 41BBL 共同表达 MHC 的魔鬼面部肿瘤细胞，以增强肿瘤免疫原性。

IF 1.4 4区医学

Parasite Immunology Pub Date : 2024-08-01 DOI: 10.1111/pim.13062

Chrissie E B Ong, A Bruce Lyons, Gregory M Woods, Andrew S Flies

{"title":"Generation of Devil Facial Tumour Cells Co-Expressing MHC With CD80, CD86 or 41BBL to Enhance Tumour Immunogenicity.","authors":"Chrissie E B Ong, A Bruce Lyons, Gregory M Woods, Andrew S Flies","doi":"10.1111/pim.13062","DOIUrl":"https://doi.org/10.1111/pim.13062","url":null,"abstract":"The major histocompatibility complex (MHC) molecules play an integral role in the adaptive immune response to transmissible cancers through tumour antigen presentation and recognition of allogeneic MHC molecules. The transmissible devil facial tumours 1 and 2 (DFT1 and DFT2) modulate MHC-I antigen presentation to evade host immune responses and facilitate transmission of tumours cells to new Tasmanian devil (Sarcophilus harrisii) hosts. To enhance T-cell-driven tumour immunogenicity for vaccination and immunotherapy, DFT1 and DFT2 cells were co-transfected with (i) NLRC5 for MHC-I expression or CIITA for MHC-I and MHC-II expression, and (ii) a co-stimulatory molecule, either CD80, CD86 or 41BBL. The co-transfected DFT cells presented enhanced expression of MHC-I and/or MHC-II. As few devil-specific monoclonal antibodies exist, we used recombinant CTLA4 and 41BB fused to a fluorescent protein to confirm expression of cell surface CD80, CD86 and 41BBL. The capacity for these cells to induce T-cell responses including PD1 and IFNG expression was evaluated in in vitro co-culture assays with captive devil peripheral blood mononuclear cells (PBMCs). Although PBMC viability had increased, there was no evidence of enhanced T-cell activation. This system can be used to identify additional factors required to promote activation of naïve devil T-cells in vitro.","PeriodicalId":19931,"journal":{"name":"Parasite Immunology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mass Spectrometry Identifies Taenia solium Proteins in Sera of Patients With and Without Parenchymal Neurocysticercosis. 质谱法鉴定神经囊虫病患者和非神经囊虫病患者血清中的疟原虫蛋白

IF 1.4 4区医学

Parasite Immunology Pub Date : 2024-07-01 DOI: 10.1111/pim.13058

Betcy Evangeline Pamela, Chhaya Patole, Subashini Thamizhmaran, Ranjith K Moorthy, Josephin Manoj, Anupriya Thanigachalam, James R S Hocker, Douglas A Drevets, Anna Oommen, Vedantam Rajshekhar, Hélène Carabin, Prabhakaran Vasudevan

{"title":"Mass Spectrometry Identifies Taenia solium Proteins in Sera of Patients With and Without Parenchymal Neurocysticercosis.","authors":"Betcy Evangeline Pamela, Chhaya Patole, Subashini Thamizhmaran, Ranjith K Moorthy, Josephin Manoj, Anupriya Thanigachalam, James R S Hocker, Douglas A Drevets, Anna Oommen, Vedantam Rajshekhar, Hélène Carabin, Prabhakaran Vasudevan","doi":"10.1111/pim.13058","DOIUrl":"10.1111/pim.13058","url":null,"abstract":"Neurocysticercosis (NCC), a major cause of global acquired epilepsy, results from Taenia solium larval brain infection. T. solium adult worms release large numbers of infective eggs into the environment contributing to high levels of exposure in endemic areas. This study identifies T. solium proteins in the sera of individuals with and without NCC using mass spectrometry to examine exposure in endemic regions. Forty-seven patients (18-51 years), 24 parenchymal NCC (pNCC), 8 epilepsy of unknown aetiology, 7 glioma, 8 brain tuberculoma, and 7 healthy volunteers were studied. Trypsin digested sera were subject to liquid chromatography-tandem mass spectrometry and spectra of 375-1700 m/z matched against T. solium WormBase ParaSite database with MaxQuant software to identify T. solium proteins. Three hundred and nineteen T. solium proteins were identified in 87.5% of pNCC and 56.6% of non-NCC subjects. Three hundred and four proteins were exclusive to pNCC sera, seven to non-NCC sera and eight in both. Ten percent, exhibiting immune-modulatory properties, originated from the oncosphere and cyst vesicular fluid. In conclusion, in endemic regions, T. solium proteins are detected in sera of individuals with and without pNCC. The immunomodulatory nature of these proteins may influence susceptibility and course of infection.","PeriodicalId":19931,"journal":{"name":"Parasite Immunology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Immunological and Neuropsychobehavioral Effects of Latent Toxoplasmosis on Humans. 潜伏弓形虫对人类免疫和神经心理行为影响的综述。

IF 1.4 4区医学

Parasite Immunology Pub Date : 2024-07-01 DOI: 10.1111/pim.13060

Mohammad Kazemi Arababadi, Seyyed Hossein Abdollahi, Mahnaz Ramezani, Mohammad Zare-Bidaki

{"title":"A Review of Immunological and Neuropsychobehavioral Effects of Latent Toxoplasmosis on Humans.","authors":"Mohammad Kazemi Arababadi, Seyyed Hossein Abdollahi, Mahnaz Ramezani, Mohammad Zare-Bidaki","doi":"10.1111/pim.13060","DOIUrl":"https://doi.org/10.1111/pim.13060","url":null,"abstract":"Toxoplasmosis as a zoonotic disease has a worldwide distribution and can infect a wide range of animal hosts, as well as at least one third of the world's human population. The disease is usually mild or asymptomatic in immunocompetent individuals, but dormant tissue cysts survive especially in the brain for the host lifespan, known as latent toxoplasmosis (LT). Recent studies suggest that LT can have certain neurological, immunological psychological and behavioural effects on human including schizophrenia, bipolar disorder, Alzheimer's disease, depression, suicide anxiety and sleeping disorders. LT effects are controversial, and their exact mechanisms of action is not yet fully understood. This review aims to provide an overview of the potential effects, their basic mechanisms including alteration of neurotransmitter levels, immune activation in the central nervous system and induction of oxidative stress. Additionally, beneficial effects of LT, and an explanation of the effects within the framework of manipulation hypothesis, and finally, the challenges and limitations of the current research are discussed.","PeriodicalId":19931,"journal":{"name":"Parasite Immunology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Secretome of Adult Murine Hookworms Is Shaped by Host Expression of STAT6. 成年小鼠钩虫的分泌组受宿主表达 STAT6 的影响

IF 1.4 4区医学

Parasite Immunology Pub Date : 2024-07-01 DOI: 10.1111/pim.13056

Annabel A Ferguson, Heather L Rossi, De'Broski R Herbert

{"title":"The Secretome of Adult Murine Hookworms Is Shaped by Host Expression of STAT6.","authors":"Annabel A Ferguson, Heather L Rossi, De'Broski R Herbert","doi":"10.1111/pim.13056","DOIUrl":"10.1111/pim.13056","url":null,"abstract":"Co-evolutionary adaptation of hookworms with their mammalian hosts has been selected for immunoregulatory excretory/secretory (E/S) products. However, it is not known whether, or if so, how host immunological status impacts the secreted profile of hematophagous adult worms. This study interrogated the impact of host Signal transducer and activator of transcription 6 (STAT6) expression during the experimental evolution of hookworms through the sequential passage of the life cycle in either STAT6 deficient or WT C57BL/6 mice. Proteomic analysis of E/S products by LC-MS showed increased abundance of 15 proteins, including myosin-3, related to muscle function, and aconitate hydratase, related to iron homeostasis. However, most E/S proteins (174 of 337 unique identities) were decreased, including those in the Ancylostoma-secreted protein (ASP) category, and metallopeptidases. Several identified proteins are established immune-modulators such as fatty acid-binding protein homologue, cystatin, and acetylcholinesterase. Enrichment analysis of InterPro functional categories showed down-regulation of Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 proteins (CAP), Astacin-like metallopeptidase, Glycoside hydrolase, and Transthyretin-like protein groups in STAT6 KO-adapted worms. Taken together, these data indicate that in an environment lacking Type 2 immunity, hookworms alter their secretome by reducing immune evasion proteins- and increasing locomotor- and feeding-associated proteins.","PeriodicalId":19931,"journal":{"name":"Parasite Immunology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Somatic Antigens of Adult Toxocara helminthes for Detection of Human Toxocariasis. 评估用于检测人类弓形虫的成虫体细胞抗原

IF 1.4 4区医学

Parasite Immunology Pub Date : 2024-07-01 DOI: 10.1111/pim.13055

Zahra Navi, Reza Falak, Mehdi Mohebali, Mohammad Bagher Molairad, Zabihollah Zarei, Mojgan Aryaeipour, Abbas Rahimi Foroushani, Mohammad Zibaei, Mohammad Bagher Rokni

{"title":"Evaluation of Somatic Antigens of Adult Toxocara helminthes for Detection of Human Toxocariasis.","authors":"Zahra Navi, Reza Falak, Mehdi Mohebali, Mohammad Bagher Molairad, Zabihollah Zarei, Mojgan Aryaeipour, Abbas Rahimi Foroushani, Mohammad Zibaei, Mohammad Bagher Rokni","doi":"10.1111/pim.13055","DOIUrl":"https://doi.org/10.1111/pim.13055","url":null,"abstract":"We aimed to develop an indirect enzyme-linked immunosorbent assay (ELISA) to evaluate the presence of specific IgG against Toxocara canis and Toxocara cati somatic antigens on the serum of patients with toxocariasis. The sensitivity, specificity, positive and negative predictive values for indirect-ELISA were calculated by receiver operating characteristic curve (ROC) analysis and Youden's J using Likelihood ratio. All statistics were analysed and graphs are plotted using GraphPad Prism version 8.4.3 (Graph Pad Software, La Jolla, CA, USA), with 95% confidence interval (CI). The sensitivity, specificity, positive and negative predictive values for T. canis were 100%, 82%, 79% and 100%, respectively. The mentioned variables for T. cati were 97%, 82%, 78% and 98%, respectively. Five immune reactive bands of 38, 40, 72, 100 and 250 kDa were common in both species. Toxocara crude antigens were highly immunogenic in human sera. Immunoreactive bands against T. canis compared to T. cati somatic antigen were about two times more. Unlike Toxocara excretory-secretory antigen, that was homologue in two species, somatic antigens of T. canis and T. cati showed different immunoreactive bands in our western blot.","PeriodicalId":19931,"journal":{"name":"Parasite Immunology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of Anti-Strongyloides Antibodies in the Serum of Liver Transplant Recipients: Need of Screening for This Neglected Helminthiasis. 在肝移植受者血清中检测到抗链尾丝虫抗体：筛查这种被忽视的蠕虫病的必要性。

IF 1.4 4区医学

Parasite Immunology Pub Date : 2024-07-01 DOI: 10.1111/pim.13059

Marcelo Andreetta Corral, Dirce Mary Correia Lima Meisel, Michele Soares Gomes Gouvêa, Mario Guimarães Pessoa, Edson Abdala, Debora Raquel Benedita Terrabuio, Idessania Nazareth da Costa, Fabiana Martins de Paula, Ronaldo Cesar Borges Gryschek

引用次数: 0

Nonsteroidal Anti-Inflammatory Drugs and Experimental Chagas Disease: An Unsolved Question. 非甾体抗炎药与实验性南美锥虫病：一个悬而未决的问题

IF 1.4 4区医学

Parasite Immunology Pub Date : 2024-07-01 DOI: 10.1111/pim.13057

Scheila Thaís Nicolau, Daniela Patrícia Tres, Thaís Soprani Ayala, Rafael Andrade Menolli

{"title":"Nonsteroidal Anti-Inflammatory Drugs and Experimental Chagas Disease: An Unsolved Question.","authors":"Scheila Thaís Nicolau, Daniela Patrícia Tres, Thaís Soprani Ayala, Rafael Andrade Menolli","doi":"10.1111/pim.13057","DOIUrl":"10.1111/pim.13057","url":null,"abstract":"Chagas disease is a parasitic disease caused by the protozoan Trypanosoma cruzi with an acute, detectable blood parasites phase and a chronic phase, in which the parasitemia is not observable, but cardiac and gastrointestinal consequences are possible. Mice are the principal host used in experimental Chagas disease but reproduce the human infection depending on the animal and parasite strain, besides dose and route of administration. Lipidic mediators are tremendously involved in the pathogenesis of T. cruzi infection, meaning the prostaglandins and thromboxane, which participate in the immunosuppression characteristic of the acute phase. Thus, the eicosanoids inhibition caused by the nonsteroidal anti-inflammatory drugs (NSAIDs) alters the dynamic of the disease in the experimental models, both in vitro and in vivo, which can explain the participation of the different mediators in infection. However, marked differences are founded in the various NSAIDs existing because of the varied routes blocked by the drugs. So, knowing the results in the experimental models of Chagas disease with or without the NSAIDs helps comprehend the pathogenesis of this infection, which still needs a better understanding.","PeriodicalId":19931,"journal":{"name":"Parasite Immunology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0