Journal of Pineal Research最新文献_第9页

Melatonin Defends Against the Oxidative Stress by Preventing the Uptake of Nanoplastics and Activating the Antioxidant System in Paeonia ostii 褪黑素通过阻止纳米塑料的摄取和激活白芍抗氧化系统来防御氧化应激。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-23 DOI: 10.1111/jpi.70117

Zhipeng Sheng, Zhaoyu Hou, Jiasong Meng, Daqiu Zhao, Jun Tao

{"title":"Melatonin Defends Against the Oxidative Stress by Preventing the Uptake of Nanoplastics and Activating the Antioxidant System in Paeonia ostii","authors":"Zhipeng Sheng, Zhaoyu Hou, Jiasong Meng, Daqiu Zhao, Jun Tao","doi":"10.1111/jpi.70117","DOIUrl":"10.1111/jpi.70117","url":null,"abstract":"<div>\u0000 \u0000 As emerging pollutants of global concern, the toxicity of polystyrene nanoplastics (PS-NPs) in plants has received widespread attention, but little is known about how to alleviate their adverse impacts on wood plants. In Paeonia ostii, PS-NPs could be uptood by roots, transported and accumulated in stems and leaves, and induced oxidative stress and negatively affected plant growth. Exogenous melatonin application has for the first time shown to reduce the cell wall porosity to prevent PS-NPs from entering the cells via inhibiting the expression of genes associated with expansins, ultimately decreasd PS-NPs accumulation. And exogenous melatonin also activated the antioxidant system to scavenge reactive oxygen species (ROS) and alleviated the adverse impacts of PS-NPs on plant growth. Moreover, increasing endogenous melatonin by overexpressing N-acetylserotonin-O-methyltransferase gene obtained the similar results as mentioned above. And the transgenic plants uptook and accumulated relatively lower levels of PS-NPs by reducing the cell wall porosity, and induced lower ROS accumulation by activating the antioxidant system. Collectively, these results suggested that melatonin could defend against the oxidative stress caused by PS-NPs via preventing their uptake and activating the antioxidant system in P. ostii, which highlighted that melatonin can be used to protect plants in the nanoplastic-polluted environments.</div>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESSION OF CONCERN: Melatonin Protects Against the Pathological Cardiac Hypertrophy Induced by Transverse Aortic Constriction Through Activating PGC-1β: In Vivo and In Vitro Studies 关注表达：褪黑素通过激活PGC-1β来保护横断主动脉收缩引起的病理性心肌肥大：体内和体外研究。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-19 DOI: 10.1111/jpi.70119

{"title":"EXPRESSION OF CONCERN: Melatonin Protects Against the Pathological Cardiac Hypertrophy Induced by Transverse Aortic Constriction Through Activating PGC-1β: In Vivo and In Vitro Studies","authors":"","doi":"10.1111/jpi.70119","DOIUrl":"10.1111/jpi.70119","url":null,"abstract":"EXPRESSION OF CONCERN: M. Zhai, Z. Liu, B. Zhang, L. Jing, B. Li, K. Li, X. Chen, M. Zhang, B. Yu, K. Ren, Y. Yang, W. Yi, J. Yang, J. Liu, D. Yi, H. Liang, Z. Jin, R. J. Reiter, W. Duan, and S. Yu, “Melatonin Protects Against the Pathological Cardiac Hypertrophy Induced by Transverse Aortic Constriction Through Activating PGC-1β: In Vivo and In Vitro Studies,” Journal of Pineal Research 63, no. 3 (2017): e12433, https://doi.org/10.1111/jpi.12433.This Expression of Concern is for the above article, published online on 14 July 2017 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. A third party raised concerns of image overlap between the 4 wk TAC image and the 8 wk Sham + Mel image in Figure 2D. An investigation by the publisher confirmed this concern and also found overlap between the Perivascular (8 wk) and Interstitial (8 wk) images in Figure 4A. The authors did not respond to an inquiry and request for original data by the publisher, and as such the data in this article related to the concerns cannot be validated. This Expression of Concern has been published in order to inform and alert readers about the concerns of image overlap in Figures 2D and 4A. The authors were informed of this Expression of Concern.","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146224626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESSION OF CONCERN: Melatonin Promotes Angiogenesis During Protection and Healing of Indomethacin-Induced Gastric Ulcer: Role of Matrix Metaloproteinase-2 关注表达：褪黑素在吲哚美辛诱导的胃溃疡的保护和愈合过程中促进血管生成：基质金属蛋白酶-2的作用。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-19 DOI: 10.1111/jpi.70123

{"title":"EXPRESSION OF CONCERN: Melatonin Promotes Angiogenesis During Protection and Healing of Indomethacin-Induced Gastric Ulcer: Role of Matrix Metaloproteinase-2","authors":"","doi":"10.1111/jpi.70123","DOIUrl":"10.1111/jpi.70123","url":null,"abstract":"EXPRESSION OF CONCERN: K. Ganguly, A. V. Sharma, R. J. Reiter, and S. Swarnakar, “Melatonin Promotes Angiogenesis During Protection and Healing of Indomethacin-Induced Gastric Ulcer: Role of Matrix Metaloproteinase-2,” Journal of Pineal Research 49, no. 2 (2010): 130-140, https://doi.org/10.1111/j.1600-079X.2010.00776.xThis Expression of Concern is for the above article, published online on 02 August 2010 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. A third party raised concerns that bands in lanes within Figure 4A (gelatin zymography) and within Figure 5B (Western blot) were highly similar and may have been duplicated. The authors responded to an inquiry by the publisher about these concerns, but they were not able to provide original data.Following this inquiry, an investigation by the publisher found further concerns of similarity between the MMP-2 gel in Figure 4C and the VEGF gel in Figure 4D, similarities of bands within Figure 6B, similarities in lanes within Figure 6C, and similarities in lanes within Figure 6D. However, the concerns could not be validated due to the condition of the image data.Because original data are no longer available, the experimental results related to these concerns cannot be validated. This Expression of Concern has been published in order to inform and alert readers about concerns with Figures 4, 5, and 6. The authors were informed of this Expression of Concern.","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146224639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESSION OF CONCERN: Melatonin Alleviates Brain Injury in Mice Subjected to Cecal Ligation and Puncture via Attenuating Inflammation, Apoptosis, and Oxidative Stress: The Role of SIRT1 Signaling 关注表达：褪黑素通过减轻炎症、细胞凋亡和氧化应激，减轻盲肠结扎和穿刺小鼠的脑损伤：SIRT1信号的作用。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-19 DOI: 10.1111/jpi.70118

{"title":"EXPRESSION OF CONCERN: Melatonin Alleviates Brain Injury in Mice Subjected to Cecal Ligation and Puncture via Attenuating Inflammation, Apoptosis, and Oxidative Stress: The Role of SIRT1 Signaling","authors":"","doi":"10.1111/jpi.70118","DOIUrl":"10.1111/jpi.70118","url":null,"abstract":"EXPRESSION OF CONCERN: L. Zhao, R. An, Y. Yang, X. Yang, H. Liu, L. Yue, X. Li, Y. Lin, R. J. Reiter, and Y. Qu, “Melatonin Alleviates Brain Injury in Mice Subjected to Cecal Ligation and Puncture via Attenuating Inflammation, Apoptosis, and Oxidative Stress: The Role of SIRT1 Signaling,” Journal of Pineal Research 59, no. 2 (2015): 230-239, https://doi.org/10.1111/jpi.12254.This Expression of Concern is for the above article, published online on 10 June 2015 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. A third party raised concerns that the AC-Fox01 and Bax bands in Figure 3 were duplicated. An investigation by the publisher confirmed that the bands had been duplicated. The authors did not respond to an inquiry and request for original data by the publisher, and as such the data related to the concerns cannot be validated. This Expression of Concern has been published in order to inform and alert readers about the concerns in Figure 3. The authors were informed of this Expression of Concern.","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146224685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESSION OF CONCERN: Mechanisms of Isoproterenol-Induced Cardiac Mitochondrial Damage: Protective Actions of Melatonin 关注的表达：异丙肾上腺素诱导心脏线粒体损伤的机制：褪黑激素的保护作用。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-18 DOI: 10.1111/jpi.70121

引用次数: 0

EXPRESSION OF CONCERN: Simultaneous Modulation of COX-2, p300, Akt, and Apaf-1 Signaling by Melatonin to Inhibit Proliferation and Induce Apoptosis in Breast Cancer Cells 表达关注：褪黑激素同时调节COX-2、p300、Akt和Apaf-1信号，抑制乳腺癌细胞增殖并诱导凋亡。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-18 DOI: 10.1111/jpi.70122

{"title":"EXPRESSION OF CONCERN: Simultaneous Modulation of COX-2, p300, Akt, and Apaf-1 Signaling by Melatonin to Inhibit Proliferation and Induce Apoptosis in Breast Cancer Cells","authors":"","doi":"10.1111/jpi.70122","DOIUrl":"10.1111/jpi.70122","url":null,"abstract":"EXPRESSION OF CONCERN: J. Wang, X. Xiao, Y. Zhang, D. Shi, W. Chen, L. Fu, L. Liu, F. Xie, T. Kang, W. Huang, and W. Deng, “Simultaneous Modulation of COX-2, p300, Akt, and Apaf-1 Signaling by Melatonin to Inhibit Proliferation and Induce Apoptosis in Breast Cancer Cells,” Journal of Pineal Research 53, no. 1 (2012): 77–90, https://doi.org/10.1111/j.1600-079X.2012.00973.x.This Expression of Concern is for the above article, published online on 03 January 2012 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. A third party raised concerns that a FACS plot had been duplicated between Figures 1B and 6C, while both are intended to represent different treatments and quantification. An investigation by the publisher confirmed this duplication and also found evidence of image duplication between Figures 3D and 4A involving western blot data, as well as a panel mismatch in Figure 6D involving fluorescence data.The authors responded to an inquiry by the publisher with an explanation and some additional data, but they could not supply all of the original raw data for the article. The Expression of Concern has been agreed to because the concerns of image and data duplication in the article cannot be resolved. The authors were informed of the Expression of Concern.","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESSION OF CONCERN: Melatonin Treatment Protects Against Spinal Cord Injury Induced Functional and Biochemical Changes in Rat Urinary Bladder 表达关注：褪黑素治疗可预防脊髓损伤引起的大鼠膀胱功能和生化变化。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-18 DOI: 10.1111/jpi.70124

引用次数: 0

EXPRESSION OF CONCERN: Melatonin Protects Against Isoproterenol-Induced Alterations in Cardiac Mitochondrial Energy-Metabolizing Enzymes, Apoptotic Proteins, and Assists in Complete Recovery From Myocardial Injury in Rats 关注的表达：褪黑素可以防止异丙肾上腺素诱导的心肌线粒体能量代谢酶和凋亡蛋白的改变，并有助于大鼠心肌损伤后的完全恢复。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-18 DOI: 10.1111/jpi.70125

{"title":"EXPRESSION OF CONCERN: Melatonin Protects Against Isoproterenol-Induced Alterations in Cardiac Mitochondrial Energy-Metabolizing Enzymes, Apoptotic Proteins, and Assists in Complete Recovery From Myocardial Injury in Rats","authors":"","doi":"10.1111/jpi.70125","DOIUrl":"10.1111/jpi.70125","url":null,"abstract":"EXPRESSION OF CONCERN: D. Mukherjee, A. K. Ghosh, A. Bandyopadhyay, et al., “Melatonin Protects Against Isoproterenol-Induced Alterations in Cardiac Mitochondrial Energy-Metabolizing Enzymes, Apoptotic Proteins, and Assists in Complete Recovery From Myocardial Injury in Rats,” Journal of Pineal Research 53, no. 2 (2012): 166–179, https://doi.org/10.1111/j.1600-079X.2012.00984.x.This Expression of Concern is for the above article, published online on 20 February 2012 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. A third party raised concerns that the beta-actin control bands in Figures 3A, 4A, 4B, 5A, 5B, 6A, 6B, 7A, and 7B were duplicates and had also been used in an earlier article by most of the same authors [Mukherjee et al. 2010 (https://doi.org/10.1111/j.1600-079X.2010.00749.x)].The authors responded to an inquiry by the publisher and stated that the studies reported in both articles were part of a single experimental project conducted between 2008 and 2009, which used identical sample sets processed under uniform conditions. Most of the original data were no longer available. As such, the publisher is not able to validate the data related to these concerns. Additionally, this article did not adequately indicate that both articles derived from the same experimental procedure and did not declare the re-use of beta-actin control bands. This Expression of Concern has been published in order to inform and alert readers about these concerns. The authors were informed of this Expression of Concern.","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin Improves Diabetic-Accelerated Experimental Osteoarthritis by Inhibiting NLRP3-Mediated Chondrocyte Pyroptosis via PKG/Nrf2 褪黑素通过PKG/Nrf2抑制nlrp3介导的软骨细胞热亡，改善糖尿病加速实验性骨关节炎。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-17 DOI: 10.1111/jpi.70113

Wenyue Yang, Hong Chen, Yukun Zhang, Shuya Wang, Xue Miao, Zongsheng Qiu, Di Qiu, Bo Gu, Luyao Zhang, Jiantao Zhang, Tianwen Ma

{"title":"Melatonin Improves Diabetic-Accelerated Experimental Osteoarthritis by Inhibiting NLRP3-Mediated Chondrocyte Pyroptosis via PKG/Nrf2","authors":"Wenyue Yang, Hong Chen, Yukun Zhang, Shuya Wang, Xue Miao, Zongsheng Qiu, Di Qiu, Bo Gu, Luyao Zhang, Jiantao Zhang, Tianwen Ma","doi":"10.1111/jpi.70113","DOIUrl":"10.1111/jpi.70113","url":null,"abstract":"<div>\u0000 \u0000 Recent evidence suggests a potential link between diabetes and the worsening and severity of osteoarthritis (OA) symptoms. Melatonin (MLT) has a strong ability to scavenge reactive oxygen species and lipid peroxidation, and plays a vital role in the treatment of OA. However, the role and mechanism of MLT in diabetic OA are still unclear. This study aimed to confirm that diabetes aggravates OA cartilage degeneration and to explore the specific mechanism by which MLT inhibits cell pyroptosis and alleviates OA. In this study, a model of OA combined with type 2 diabetes was established, and it was found that hyperglycemia would exacerbate the degradation of OA cartilage tissue. Secondly, we investigated the effect of MLT on OA under hyperglycemic conditions and the underlying molecular mechanisms in vivo and in vitro experiments. The results show that MLT inhibits the activation of the NLRP3 inflammasome in chondrocytes by activating PKG to mediate the Nrf2/HO-1 antioxidant defense system, thereby exerting anti-inflammatory, anti-pyroptosis, and anti-degradation effects on the cartilage extracellular matrix (ECM). Further verification revealed that silencing PKG or inhibiting Nrf2 would partially reduce the protective effect of MLT. MLT can also reduce the pain sensitivity of rats, decrease the degree of subchondral bone remodeling, and improve the microstructure of the bone. This suggests that MLT therapy may be a promising new approach for treating OA, particularly in patients with diabetes.\u0000 </div>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin's Sex-Specific Protection Against High-Salt Diet and Irradiation-Induced Multi-Organ Injury Through Microbiota–Metabolite Interactions 褪黑素通过微生物-代谢物相互作用对高盐饮食和辐射诱导的多器官损伤的性别特异性保护。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-16 DOI: 10.1111/jpi.70116

Xudong Ding, Jia Du, Zhaoyu Wang, Lu Lu, Saijun Fan

{"title":"Melatonin's Sex-Specific Protection Against High-Salt Diet and Irradiation-Induced Multi-Organ Injury Through Microbiota–Metabolite Interactions","authors":"Xudong Ding, Jia Du, Zhaoyu Wang, Lu Lu, Saijun Fan","doi":"10.1111/jpi.70116","DOIUrl":"10.1111/jpi.70116","url":null,"abstract":"<div>\u0000 \u0000 With the evolution of dietary habits and the widespread application of radiation therapy, high-salt diet (HSD) and irradiation (IR) have become significant public health concerns. This study aims to investigate the protective effects of melatonin (MLT) against multi-organ damage induced by HSD combined with whole-abdominal irradiation (WAI), with a focus on its gender-specific mechanisms. Using a C57BL/6 J mouse model of HSD and IR injury, we employed a multi-omics approach to evaluate MLT's therapeutic effects. Results demonstrated that both oral and intraperitoneal administration of MLT significantly mitigated HSD and WAI-induced damage to renal and intestinal tissues while restoring expression of intestinal tight junction proteins and mucin-2 (MUC2), which is the main intestinal mucin forming the mucus barrier. Further investigations revealed that MLT showed sex-dependent associations with the gut microbiota–metabolite axis. Under HSD conditions, it primarily regulates microbial balance via the tryptophan metabolic pathway, whereas post-IR exposure, its regulation shifts toward specific metabolites. Additionally, MLT alleviates cognitive impairment. These findings provide crucial experimental evidence for developing personalized radiation protection strategies.</div>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146199742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0