Journal of Nanotechnology in Diagnosis and Treatment最新文献

Mechanical Characterization Study of Additive as Nanofiller in Poly (ε-Caprolactone) Nanocomposite 聚(ε-己内酯)纳米复合材料中添加剂作为纳米填料的力学特性研究

Journal of Nanotechnology in Diagnosis and Treatment Pub Date : 2023-03-01 DOI: 10.12974/2311-8792.2023.09.1

Prarthana U. Dhanvijay

引用次数: 0

Synthesis of Silver Nanoparticles Using Novel Chemical Solution Method as Antibacterial Applied on Cosmetic Cotton Balls 新型化学溶液法合成纳米银抗菌化妆品棉球

Journal of Nanotechnology in Diagnosis and Treatment Pub Date : 2023-02-24 DOI: 10.12974/2311-8792.2023.09.2

Sizam A. M. Mahgoub, M. Karahan, Hind A. M. Elsanosi, Malaz S. A. Bader, Sitana H. O. Mohamed, Hasabo Abdelbagi Mohamed Ahmed, A. Ari

引用次数: 0

Virtual Screening of Kinase Based Drugs: Statistical Learning Towards Drug Repositioning 基于激酶的药物虚拟筛选:对药物重新定位的统计学习

Journal of Nanotechnology in Diagnosis and Treatment Pub Date : 2022-12-12 DOI: 10.12974/2311-8792.2022.08.03

M. T. Mustapha, D. Flower, A. Chattopadhyay

{"title":"Virtual Screening of Kinase Based Drugs: Statistical Learning Towards Drug Repositioning","authors":"M. T. Mustapha, D. Flower, A. Chattopadhyay","doi":"10.12974/2311-8792.2022.08.03","DOIUrl":"https://doi.org/10.12974/2311-8792.2022.08.03","url":null,"abstract":"Kinases are phosphate catalysing enzymes that have traditionally proved difficult to target against ligands,and hence inefficacious in drug development. There are two colluding reasons for this. First is the issue of specificity. The homogeneity that exists between the kinase ATP-binding pockets makes it a non-realisable target to developcompounds that would inhibit only one out of 538 protein kinases encoded by the human genome, without inhibitingsome of the others. Second, producing compounds with the required efficacy to rival the millimolar ATP concentrations present in cells is stoichiometrically inefficient. This study uses a recently propounded computational strategy based onStructure Based Virtual Screening (SBVS) that was previously benchmarked on 999 DUD-E protein decoys(Chattopadhyay et al, Int Sc. Comp. Life Sciences 2022), to rank potential ligands, or by extension rank kinase-ligand pairs, identifying best matching ligand:kinase docking pairs. The results of the SBVS campaign employing severalcomputational algorithms reveal variations in the preferred top hits. To address this, we introduce a novel consensusscoring algorithm by sampling statistics across four independent statistical universality classes, statistically combining docking scores from ten docking programs (DOCK, Quick Vina-W, Vina Carb, PLANTS, Autodock, QuickVina2,QuickVina21, Smina, Autodock Vina and VinaXB) to create a holistic SBVS formulation that can identify active ligandsfor any target. Our results demonstrate that CS provides improved ligand:kinase docking fidelity when compared to individual docking platforms, requiring only a small number of docking combinations, and can serve as a viable andthrifty alternative to expensive docking platforms.","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131344085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Damage Properties of Woven Carbon-Epoxy Composites Modified with CNT Fillers 碳纳米管改性机织碳-环氧复合材料损伤性能研究

Journal of Nanotechnology in Diagnosis and Treatment Pub Date : 2022-06-24 DOI: 10.12974/2311-8792.2022.08.1

M. Karahan, Nevin Karahan

引用次数: 0

Towards Phenotyping Suppressed Anger in Perimenopausal Women with Lyfas Biomedical Application: A Comprehensive Diagnostic Reliability Study Lyfas生物医学应用对围绝经期妇女抑制愤怒表型的综合诊断可靠性研究

Journal of Nanotechnology in Diagnosis and Treatment Pub Date : 2022-06-15 DOI: 10.12974/2311-8792.2022.08.2

S. Chattopadhyay, Rupam Das

{"title":"Towards Phenotyping Suppressed Anger in Perimenopausal Women with Lyfas Biomedical Application: A Comprehensive Diagnostic Reliability Study","authors":"S. Chattopadhyay, Rupam Das","doi":"10.12974/2311-8792.2022.08.2","DOIUrl":"https://doi.org/10.12974/2311-8792.2022.08.2","url":null,"abstract":"Biomedical applications are gaining popularity in decoding human emotion. Anger causes sympathetic overdrive and is a normal emotion, which is either expressed or kept suppressed. Suppressed anger (SA) is a major health issue often causing serious cardiometabolic and mental diseases due to cardiac autonomic neuropathy (CAN), where the sympathovagal homeostasis is compromised to compensate for it. Lyfas is a smartphone-based biomedical application that captures CAN through short (120 sec) heart rate variability (HRV) and its associated cardiovascular optical biomarkers (COBs). This paper attempts to diagnose SA with the help of Lyfas COBs and a few important physical parameters in a cohort of Indian perimenopausal women (N=415; case 205 and control 210), who suffer from mood dysregulation due to the depletion of natural estradiol (E2) in the brain. The clinical Anger Scale (CAS), a gold-standard anger assessment tool is taken into consideration as a reference scale. The strength of correlations of each COB and physical parameter with CAS and its reliability is calculated using Spearman’s correlation and Bland-Altman’s reliability assessment, respectively. The paper concludes that COBs such as SDNN, RMSSD, and LF/HF along with physical parameters (BMI) are hallmark biomarkers for SA phenotypes with 71% of accuracy, 74% of j-statistics, as well as 92% of precision. Early diagnosis of SA with Lyfas would facilitate early treatment, and thereby improve the quality of life.","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126062477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards Cardiac Risk Monitoring of Duchene Muscular Dystrophy using Lyfas 应用Lyfas监测杜氏肌营养不良患者心脏风险的研究

Journal of Nanotechnology in Diagnosis and Treatment Pub Date : 2021-10-31 DOI: 10.12974/2311-8792.2021.07.3

Rupam Das, S. Chattopadhyay

引用次数: 5

Polymeric Coatings for Drug Delivery by Medical Devices 医疗器械给药用聚合物涂层

Journal of Nanotechnology in Diagnosis and Treatment Pub Date : 2021-10-31 DOI: 10.12974/2311-8792.2021.07.4

Sanziana Anghel, M. A. Mahmood, C. Matei, A. Visan

{"title":"Polymeric Coatings for Drug Delivery by Medical Devices","authors":"Sanziana Anghel, M. A. Mahmood, C. Matei, A. Visan","doi":"10.12974/2311-8792.2021.07.4","DOIUrl":"https://doi.org/10.12974/2311-8792.2021.07.4","url":null,"abstract":"An analysis of the current landscape of therapeutics and delivery methods was conducted, aiming the field of drug delivery systems. Drug delivery biodistribution characteristics should be systematically understood, in order to maximize the function of these delivery systems. As a result, this review covers a history of the drug delivery systems, as well as the basic terminology associated with them, with a focus on the usage of polymers in the drug administration systems (particularly in form of coatings) and their application. \u0000New trends in nanomaterials-based drug delivery systems, primarily for cancer treatment, were presented, involving a technology designed to maximize therapeutic efficacy of drugs by controlling their biodistribution profile. \u0000There is a justified need to investigate drug delivery systems in form of thin films because, in comparation to bulk drug delivery system, which have a long and comprehensive history, there is still insufficient and fragmented understanding about the delivery of thin polymeric films, with research limited in general to very specific cases. Our efforts have been concentrated on these specifically polymeric drug delivery systems in the form of coatings. Understanding the dynamic changes that occur in a biodegradable polymeric thin film can aid in the prediction of the future performance of synthesized films designed to be used as implantable medical devices. \u0000Extensive research is required to continuously develop new therapeutic systems in order to achieve an optimal concentration of a specific drug at its site of action for an appropriate duration.","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125091987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Case Fatality of Dengue Epidemic: Statistical Machine Learning Towards a Virtual Doctor 预测登革热病死率:面向虚拟医生的统计机器学习

Journal of Nanotechnology in Diagnosis and Treatment Pub Date : 2021-10-15 DOI: 10.12974/2311-8792.2021.07.2

S. Chattopadhyay, A. Chattopadhyay, E. Aifantis

{"title":"Predicting Case Fatality of Dengue Epidemic: Statistical Machine Learning Towards a Virtual Doctor","authors":"S. Chattopadhyay, A. Chattopadhyay, E. Aifantis","doi":"10.12974/2311-8792.2021.07.2","DOIUrl":"https://doi.org/10.12974/2311-8792.2021.07.2","url":null,"abstract":"Dengue fever is a self-limiting communicable viral disease, transmitted through mosquito bites. Its Case Fatality Grade (CFG) varies across population due to variations in viral load, immunity of the patient, early diagnosis, and availability of high-end treatment facility. This study describes an initial effort to automate the process of Dengue CFG predictions. Two established Statistical Machine Learning (SML) algorithms, Multiple Linear Regressions (MLR) and Multinomial Logistic Regressions (MnLR), are combined to substitute the existing Deep Learning methods for clinical decision making. We consider a vector of eleven sign-symptoms (independent variables), each weighted between [0,1] on a 3-point scale - ‘Mild’ (CFG<=0.33), ‘Moderate’ (0.330.66). Results show that both classifiers are effective in early screening with similar accuracy levels (68% for MLR versus 72% for MnLR) although precision levels are far superior with MnLR (88%) than MLR (61%). This study is a futuristic step towards Machine Learning (ML) aided clinical diagnostic paradigms, as an alternative to computationally intensive Artificial Intelligence.","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134258691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Comparative Study of Water Dispersible Orange-Emitting Mn-Doped ZnSe/ZnS and CdTe/CdS Core/Shell Quantum Dots 水分散橙色发光mn掺杂ZnSe/ZnS与CdTe/CdS核壳量子点的比较研究

Journal of Nanotechnology in Diagnosis and Treatment Pub Date : 2021-06-02 DOI: 10.12974/2311-8792.2021.07.1

Aboulaich Abdelhay, C. Merlin, R. Schneider

引用次数: 0

Integration of Microfluidics in a Smartphone Microscopy Device for Particles Imaging 微流控技术在智能手机颗粒成像显微设备中的集成

Journal of Nanotechnology in Diagnosis and Treatment Pub Date : 2018-12-20 DOI: 10.12974/2311-8792.2018.06.1

D. Kotsifaki

引用次数: 0