Pathophysiology最新文献_第10页

Safety and Efficacy of Buprenorphine-Naloxone in Pregnancy: A Systematic Review of the Literature. 丁丙诺啡-纳洛酮在妊娠期的安全性和有效性:文献系统综述。

Pathophysiology Pub Date : 2023-02-11 DOI: 10.3390/pathophysiology30010004

Alice Ordean, Meara Tubman-Broeren

{"title":"Safety and Efficacy of Buprenorphine-Naloxone in Pregnancy: A Systematic Review of the Literature.","authors":"Alice Ordean, Meara Tubman-Broeren","doi":"10.3390/pathophysiology30010004","DOIUrl":"https://doi.org/10.3390/pathophysiology30010004","url":null,"abstract":"The prevalence of opioid use among pregnant people has been increasing over the past few decades, with a parallel increase in the rate of neonatal abstinence syndrome. Opioid agonist treatment (OAT) including methadone and buprenorphine is the recommended management method for opioid use disorders during pregnancy. Methadone has been extensively studied during pregnancy; however, buprenorphine was introduced in the early 2000s with limited data on the use of different preparations during pregnancy. Buprenorphine-naloxone has been incorporated into routine practice; however, only a few studies have investigated the use of this medication during pregnancy. To determine the safety and efficacy of this medication, we conducted a systematic review of maternal and neonatal outcomes among buprenorphine-naloxone-exposed pregnancies. The primary outcomes of interest were birth parameters, congenital anomalies, and severity of neonatal abstinence syndrome. Secondary maternal outcomes included the OAT dose and substance use at delivery. Seven studies met the inclusion criteria. Buprenorphine-naloxone doses ranged between 8 and 20 mg, and there was an associated reduction of opioid use during pregnancy. There were no significant differences in gestational age at delivery, birth parameters, or prevalence of congenital anomalies between buprenorphine-naloxone-exposed neonates and those exposed to methadone, buprenorphine monotherapy, illicit opioids, or no opioids. In studies comparing buprenorphine-naloxone to methadone, there were reduced rates of neonatal abstinence syndrome requiring pharmacotherapy. These studies demonstrate that buprenorphine-naloxone is a safe and effective opioid agonist treatment for pregnant people with OUD. Further large-scale, prospective data collection is required to confirm these findings. Patients and clinicians may be reassured about the use of buprenorphine-naloxone during pregnancy.","PeriodicalId":19852,"journal":{"name":"Pathophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10753596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Multiple Sclerosis in Mongolia; the First Study Exploring Predictors of Disability and Depression in Mongolian MS Patients. 蒙古多发性硬化症；探索蒙古多发性硬化症患者残疾和抑郁预测因素的首次研究。

Pathophysiology Pub Date : 2023-01-20 DOI: 10.3390/pathophysiology30010003

Myadagmaa Jaalkhorol, Oyunbileg Dulamsuren, Amarsaikhan Dashtseren, Enkh-Amgalan Byambajav, Nansalmaa Khaidav, Badrangui Bat-Orgil, Anar Bold, Enkhdulguun Amgalan, Anujin Chuluunbaatar, Ikuo Tsunoda

{"title":"Multiple Sclerosis in Mongolia; the First Study Exploring Predictors of Disability and Depression in Mongolian MS Patients.","authors":"Myadagmaa Jaalkhorol, Oyunbileg Dulamsuren, Amarsaikhan Dashtseren, Enkh-Amgalan Byambajav, Nansalmaa Khaidav, Badrangui Bat-Orgil, Anar Bold, Enkhdulguun Amgalan, Anujin Chuluunbaatar, Ikuo Tsunoda","doi":"10.3390/pathophysiology30010003","DOIUrl":"10.3390/pathophysiology30010003","url":null,"abstract":"Mongolia is located at 45° north latitude in the center of the Asian continent, and about 80% of the territory is at 1000 m above sea level. Epidemiologically, multiple sclerosis (MS) has not been investigated in Mongolia, although there have been a few MS case reports. We investigated the characteristics of MS in Mongolia for the first time, focusing on the association between MS-related parameters and depression levels. We initiated cross-sectional analyses, using data from 27 MS patients aged 20 to 60 years in Ulaanbaatar, Mongolia. The patients completed a questionnaire on their lifestyles and clinical information. We classified the MS patients on the basis of disability levels using the expanded disability status scale (EDSS) scores: 11.1% mild disability and 88.9% moderate to severe disability (median EDSS score, 5.5). We also classified the patients on the basis of depression levels using the 9-item patient health questionnaire (PHQ-9) scores: 44.4% mild depression, 40.7% moderate depression, and 14.8% severe depression (mean PHQ-9's score, 9.96 ± 5.05). We used multivariate logistical regression analyses to identify predictors of EDSS or PHQ-9 scores. Disability levels were associated with vision and balance problems. Depression levels were associated with corticosteroid treatment; no patients were treated with disease-modifying drugs (DMDs). The odds ratios for disease onset age and treatment duration were associated with EDSS scores. In conclusion, MS onset age and treatment duration were independent predicting factors influencing the level of disability. Appropriate DMD treatment would lower the disability and depression levels.","PeriodicalId":19852,"journal":{"name":"Pathophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10764930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgment to the Reviewers of Pathophysiology in 2022. 向2022年病理生理学审稿人致谢。

Pathophysiology Pub Date : 2023-01-16 DOI: 10.3390/pathophysiology30010002

Pathophysiology Editorial Office

引用次数: 0

LMP1-EBV Gene Deletion Mutations and HLA Genotypes of Nasopharyngeal Cancer Patients in Vietnam. 越南鼻咽癌患者的 LMP1-EBV 基因缺失突变和 HLA 基因型

IF 2.7

Pathophysiology Pub Date : 2023-01-11 DOI: 10.3390/pathophysiology30010001

Cua Thi Hong Trinh, Dung Ngoc Tran, Linh Thi Thao Nguyen, Nghia Tin Tran, Minh Trinh Gia Nguyen, Vy Tran Phuong Nguyen, Nhung Thi Hong Vu, Khanh Duy Dang, Kha Van Vo, Hoa Chieu Chau, Phi Thi Phi Phan, Mai Huynh Truc Phuong

{"title":"LMP1-EBV Gene Deletion Mutations and HLA Genotypes of Nasopharyngeal Cancer Patients in Vietnam.","authors":"Cua Thi Hong Trinh, Dung Ngoc Tran, Linh Thi Thao Nguyen, Nghia Tin Tran, Minh Trinh Gia Nguyen, Vy Tran Phuong Nguyen, Nhung Thi Hong Vu, Khanh Duy Dang, Kha Van Vo, Hoa Chieu Chau, Phi Thi Phi Phan, Mai Huynh Truc Phuong","doi":"10.3390/pathophysiology30010001","DOIUrl":"10.3390/pathophysiology30010001","url":null,"abstract":"Nasopharyngeal carcinoma (NPC) is the most common cancer among head and neck cancers in Vietnam. We aimed to identify the rate of a 30 bp deletion mutation of the LMP1-EBV gene in nasopharyngeal biopsy tissue samples, the HLA genotypes of NPC patients, and the relationship between these two targets. Patients with NPC at Can Tho Oncology Hospital from September 2014 to December 2018 were selected. A length of 30 bp of the del-LMP1-EBV gene was analyzed using a PCR technique, and the HLA genotypes in patients' blood samples were analyzed with PCR-SSO technology. HLA-B*15 gene carriers had the highest risk of 30 bp LMP1-EBV gene deletion mutation, which was found in 51 out of 70 patients (72.9%). Carriers of the HLA-B*15 allele had a 4.6-fold increased risk of a 30 bp del-LMP1-EBV gene compared with non-carriers of this allele. The initial identification of NPC was related to the 30 bp del-LMP1-EBV gene and high frequencies of the -A*02, -B*15, -DRB1*12, -DQB1*03, and -DQA1*01 HLA alleles. Our study results suggest an association of the 30 bp del-LMP1-EBV gene and the HLA-B*15 allele with NPC susceptibility.","PeriodicalId":19852,"journal":{"name":"Pathophysiology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10541402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Endothelial Glycocalyx and Retinal Hemodynamics. 内皮糖萼与视网膜血流动力学。

Pathophysiology Pub Date : 2022-12-17 DOI: 10.3390/pathophysiology29040052

Gaganpreet Kaur, Wendy Leskova, Norman R Harris

{"title":"The Endothelial Glycocalyx and Retinal Hemodynamics.","authors":"Gaganpreet Kaur, Wendy Leskova, Norman R Harris","doi":"10.3390/pathophysiology29040052","DOIUrl":"https://doi.org/10.3390/pathophysiology29040052","url":null,"abstract":"Purpose: Previous studies suggest that the endothelial glycocalyx adds to vascular resistance, inhibits thrombosis, and is critical for regulating homogeneous blood flow and ensuring uniform red blood cell (RBC) distribution. However, these functions and consequences of the glycocalyx have not been examined in the retina. We hypothesize that the endothelial glycocalyx is a critical regulator of retinal hemodynamics and perfusion and decreases the propensity for retinal thrombus formation.Methods: Hyaluronidase and heparinase, which are endothelial glycocalyx-degrading enzymes, were infused into mice. Fluorescein isothiocyanate-dextran (2000 kDa) was injected to measure lumen diameter, while RBC velocity and distribution were measured using fluorescently labeled RBCs. The diameters and velocities were used to calculate retinal blood flow and shear rates. Mean circulation time was calculated by measuring the difference between arteriolar and venular mean transit times. Rose Bengal dye was infused, followed by illumination with a green light to induce thrombosis.Results: The acute infusion of hyaluronidase and heparinase led to significant increases in both arteriolar (7%) and venular (16%) diameters in the retina, with a tendency towards increased arteriolar velocity. In addition, the degradation caused a significant decrease in the venular shear rate (14%). The enzyme infusion resulted in substantial increases in total retinal blood flow (26%) and retinal microhematocrit but no changes in the mean circulation time through the retina. We also observed an enhanced propensity for retinal thrombus formation with the removal of the glycocalyx.Conclusions: Our data suggest that acute degradation of the glycocalyx can cause significant changes in retinal hemodynamics, with increases in vessel diameter, blood flow, microhematocrit, pro-thrombotic conditions, and decreases in venular shear rate.","PeriodicalId":19852,"journal":{"name":"Pathophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10741441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Candida albicans in Oral Carcinogenesis. 白色念珠菌在口腔癌变中的作用。

Pathophysiology Pub Date : 2022-12-07 DOI: 10.3390/pathophysiology29040051

Nurina Febriyanti Ayuningtyas, Fatma Yasmin Mahdani, Togu Andrie Simon Pasaribu, Muhammad Chalim, Visilmi Kaffah Putri Ayna, Arvind Babu Rajendra Santosh, Luigi Santacroce, Meircurius Dwi Condro Surboyo

{"title":"Role of Candida albicans in Oral Carcinogenesis.","authors":"Nurina Febriyanti Ayuningtyas, Fatma Yasmin Mahdani, Togu Andrie Simon Pasaribu, Muhammad Chalim, Visilmi Kaffah Putri Ayna, Arvind Babu Rajendra Santosh, Luigi Santacroce, Meircurius Dwi Condro Surboyo","doi":"10.3390/pathophysiology29040051","DOIUrl":"https://doi.org/10.3390/pathophysiology29040051","url":null,"abstract":"Oral carcinogenesis is also dependent on the balance of the oral microbiota. Candida albicans is a member oral microbiota that acts as an opportunistic pathogen along with changes in the epithelium that can predispose to premalignancy and/or malignancy. This systematic review uses the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines to analyze the role of Candida albicans in the process of oral carcinogenesis. Eleven articles qualified inclusion criteria, matched keywords, and provided adequate information about the carcinogenesis parameters of Candida albicans in oral cancer. Candida albicans in oral carcinogenesis can be seen as significant virulent factors for patients with oral squamous cell carcinoma (OSCC) or potentially malignant disorder (OPMD) with normal adjacent mucosa. Candida albicans have a role in the process of oral carcinogenesis concerning morphological phenotype changes in cell structure and genotype and contribute to the formation of carcinogenic substances that can affect cell development towards malignancy.","PeriodicalId":19852,"journal":{"name":"Pathophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10435190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The Effect of TGFβ1 in Adipocyte on Inflammatory and Fibrotic Markers at Different Stages of Adipocyte Differentiation. 脂肪细胞中tgf - β1对脂肪细胞分化不同阶段炎症和纤维化标志物的影响

Pathophysiology Pub Date : 2022-11-23 DOI: 10.3390/pathophysiology29040050

Babu Raja Maharjan, Susan V McLennan, Stephen M Twigg, Paul F Williams

{"title":"The Effect of TGFβ1 in Adipocyte on Inflammatory and Fibrotic Markers at Different Stages of Adipocyte Differentiation.","authors":"Babu Raja Maharjan, Susan V McLennan, Stephen M Twigg, Paul F Williams","doi":"10.3390/pathophysiology29040050","DOIUrl":"https://doi.org/10.3390/pathophysiology29040050","url":null,"abstract":"Transforming growth factor beta (TGFβ) is a versatile cytokine. Although a profibrotic role of TGFβ is well established, its effect on tissue inhibitor of metalloproteinase (TIMPs) and inflammatory mediators are incompletely described. This study investigates the profibrotic and pro-inflammatory role of TGFβ1 during adipocyte differentiation. NIH3T3L1 cells were used for the in vitro study and were differentiated by adding a standard differentiation mix either with rosiglitazone (R-Diff) or without (S-Diff). Recombinant TGFβ1 (2 ng/mL) was added to the undifferentiated preadipocyte during the commitment stage and at the terminal differentiation stage. TGFβ1 treatment significantly decreased adiponectin mRNA at both early commitment (>300 fold) and terminal differentiated cells [S-Diff (~33%) or R-Diff (~20%)]. TGFβ1 upregulated collagen VI mRNA and its regulators connective tissue growth factor (CCN2/CTGF), TIMP1 and TIMP3 mRNA levels in undifferentiated preadipocytes and adipocytes at commitment stage. But in the terminal differentiated adipocytes, changes in mRNA and protein of collagen VI and TIMP3 mRNA were not observed despite an increase in CCN2/CTGF, TIMP1 mRNA. Although TGFβ1 upregulated interleukin-6 (IL6) and monocyte chemoattractant protein-1 (MCP1) mRNA at all stages of differentiation, decreased tumor necrosis factor-α (TNFα) mRNA was observed early in adipocyte differentiation. This study highlights the complex role of TGFβ1 on extracellular matrix (ECM) remodeling and inflammatory markers in stimulating both synthetic and inhibitory markers of fibrosis at different stages of adipocyte differentiation.","PeriodicalId":19852,"journal":{"name":"Pathophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10844424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Supplementation with D-Ribose-L-Cysteine Prevents Hepatic Stress and Pro-Inflammatory Responses in Male Wistar Rats Fed a High-Fructose High-Fat Diet. 饲粮中补充d -核糖- l -半胱氨酸可预防饲喂高果糖高脂肪饮食的雄性Wistar大鼠的肝脏应激和促炎反应。

Pathophysiology Pub Date : 2022-10-31 DOI: 10.3390/pathophysiology29040049

Abodunrin Adebayo Ojetola, Jerome Ndudi Asiwe, Wale Johnson Adeyemi, Dare Joshua Ogundipe, Adesoji Adedipe Fasanmade

{"title":"Dietary Supplementation with D-Ribose-L-Cysteine Prevents Hepatic Stress and Pro-Inflammatory Responses in Male Wistar Rats Fed a High-Fructose High-Fat Diet.","authors":"Abodunrin Adebayo Ojetola, Jerome Ndudi Asiwe, Wale Johnson Adeyemi, Dare Joshua Ogundipe, Adesoji Adedipe Fasanmade","doi":"10.3390/pathophysiology29040049","DOIUrl":"https://doi.org/10.3390/pathophysiology29040049","url":null,"abstract":"Diets rich in fats and fructose are associated with the pathogenesis of oxidative stress-induced non-alcoholic fatty liver disease. Therefore, we investigated the effect of D-ribose-L-cysteine (DRLC) in high-fructose high-fat (HFHF) diet-fed rats. Twenty rats (n = 5), divided into four groups, were simultaneously exposed to HFHF and/or DRLC (250 mg/kg) orally during the 8 weeks of the study. Results showed that HFHF precipitated pro-inflammation and selective disruption of the oxidative stress markers. There were significant decreases in the level of antioxidants such as superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), hepatic SOD and GPX. Significant increases in serum levels of uric acid (UA), tumour necrosis factor-alpha (TNF-α), C-reactive protein (CRP) and hepatic Xanthine oxidase (XO) were observed in the HFHF compared to the control. In the HFHF + DRLC group, oxidative stress was mitigated due to differences in serum levels of SOD, GPX, TAC, TNF-α, liver SOD, and XO relative to control. The administration of DRLC alone caused significant reductions in malondialdehyde, UA and CRP and a significant increase in SOD compared to the control. DRLC prevents hepatic and systemic oxidative stress and pro-inflammatory events in HFHF diet-fed rats.","PeriodicalId":19852,"journal":{"name":"Pathophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10689969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Conservative Management of Spontaneous Left Main Coronary Artery Dissection (SCAD) Triggered by Emotional Stress in the Late Postpartum Period: Case Report and Pathophysiology. 产后后期情绪应激诱发自发性左主干冠状动脉剥离(SCAD)的保守治疗:病例报告及病理生理学

Pathophysiology Pub Date : 2022-10-26 DOI: 10.3390/pathophysiology29040047

Jaksa Zanchi, Dino Miric, Lovel Giunio, Anteo Bradaric Slujo, Mislav Lozo, Duje Erceg, Duje Orsulic, Josip A Borovac

{"title":"Conservative Management of Spontaneous Left Main Coronary Artery Dissection (SCAD) Triggered by Emotional Stress in the Late Postpartum Period: Case Report and Pathophysiology.","authors":"Jaksa Zanchi, Dino Miric, Lovel Giunio, Anteo Bradaric Slujo, Mislav Lozo, Duje Erceg, Duje Orsulic, Josip A Borovac","doi":"10.3390/pathophysiology29040047","DOIUrl":"https://doi.org/10.3390/pathophysiology29040047","url":null,"abstract":"A spontaneous coronary artery dissection (SCAD) during the postpartum period is a serious medical emergency and the most important non-atherosclerotic cause of coronary artery disease (CAD) in this population. While conservative management is recommended in most SCAD scenarios, cases complicated by hemodynamic instability or cardiogenic shock are particularly challenging and might be amenable only with invasive percutaneous or cardiothoracic surgical management. Herein, we present a case of a 35-year-old otherwise healthy woman that suffered an intense emotional stress event and was subsequently admitted with crushing chest pain to the emergency department. The initial electrocardiogram showed dynamic changes suggesting anterolateral ST-elevation myocardial infarction. She gave birth to a healthy child 3 months before the current presentation. Diagnostic angiography found no occlusive CAD but instead an extensive intramural hematoma originating from the left main artery dissection and extending to the whole left coronary circulation was observed. Hemodynamic instability and hypotension soon followed, and the patient went into cardiogenic shock. The heart team opted for conservative and supportive intensive care management without surgical or percutaneous intervention. This decision ultimately led to the successful extubation of the patient and the achievement of hemodynamic stability. The patient was eventually safely discharged home without any permanent disability.","PeriodicalId":19852,"journal":{"name":"Pathophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10689971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Player Sex and Playing Surface Are Individual Predictors of Injuries in Professional Soccer Players. 球员性别和比赛场地是职业足球运动员受伤的个体预测因子。

Pathophysiology Pub Date : 2022-10-26 DOI: 10.3390/pathophysiology29040048

Zakariya H Nawasreh, Mohammad A Yabroudi, Ahmad A Darwish, Wesam A Debes, Khaldoon M Bashaireh

{"title":"Player Sex and Playing Surface Are Individual Predictors of Injuries in Professional Soccer Players.","authors":"Zakariya H Nawasreh, Mohammad A Yabroudi, Ahmad A Darwish, Wesam A Debes, Khaldoon M Bashaireh","doi":"10.3390/pathophysiology29040048","DOIUrl":"https://doi.org/10.3390/pathophysiology29040048","url":null,"abstract":"Background: The factors contributing to soccer injuries and their influence on the occurrence of injury are controversial and inconclusive. This study aimed to determine the association between player characteristics and playing factors with injuries in professional soccer players. Methods: One hundred and fifty-two professional soccer players completed a self-administered questionnaire that asked about demographic information and injury profile, the type of playing surface on which they sustained their injury, medical treatment, and the time lost due to soccer injury at the end of the soccer season. Results: The injury rate was 44.74% (n = 68; males: 61.50% (n = 56), females: 19.70% (n = 12)). Players’ age (OR: 1.15, 95%CI: 1.05−1.25, p < 0.002) and BMI (OR: 1.21, 95%CI: 1.06−1.38, p < 0.003) were significantly associated with soccer injuries. After adjusting for age and BMI, players’ sex (OR: 5.39, 95%CI: 2.11−13.75, p < 0.001), previous soccer injury (OR: 3.308, 95%CI: 2.307−29.920, p < 0.001), and playing surfaces (OR: 11.07, 95%CI: 4.53−27.03, p < 0.001) were the significant predictors of soccer injuries. Conclusion: Players’ age, BMI, sex, previous soccer injury, and playing surface were associated with injuries among professional soccer players. Old male athletes with high BMI, previous soccer injuries, and playing on natural grass were more likely to sustain soccer injuries than young female players with low BMI who had no previous injuries and played on synthetic surfaces.","PeriodicalId":19852,"journal":{"name":"Pathophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10867483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0