Panminerva medica最新文献_第4页

MiR-30d inhibits cardiomyocytes autophagy promoting ferroptosis after myocardial infarction. MiR-30d 可抑制心肌细胞自噬，促进心肌梗死后的铁蛋白沉积。

IF 4.3 4区医学

Panminerva medica Pub Date : 2024-09-01 Epub Date: 2020-07-27 DOI: 10.23736/S0031-0808.20.03979-8

Shilin Tang, Yang Wang, Tanya Ma, Shijuan Lu, Kang Huang, Qiang Li, Miao Wu, Hui Yang, Jianghua Zhong

{"title":"MiR-30d inhibits cardiomyocytes autophagy promoting ferroptosis after myocardial infarction.","authors":"Shilin Tang, Yang Wang, Tanya Ma, Shijuan Lu, Kang Huang, Qiang Li, Miao Wu, Hui Yang, Jianghua Zhong","doi":"10.23736/S0031-0808.20.03979-8","DOIUrl":"10.23736/S0031-0808.20.03979-8","url":null,"abstract":"Background: The aim of this study was to investigate the effect of microRNA-30d (miR-30d) on autophagy and reveal the mechanism of autophagy promoting ferroptosis in H9C2 cells.Methods: First, we detected miR-30d expression of myocardial tissue in the sham and myocardial infarction (MI) group, and then analyzed by biochemical analysis and luciferase Genetic experiments to confirm its downstream target gene of. After using Lentivirus-ATG5 (LV-sh-ATG5) to effectively inhibit autophagy, in order to further clarify the possible mechanism of autophagy leading to ferroptosis in H9C2 cells, we have tested the relevant indicators ferroptosis.Results: We first found that miR-30d expression was down-regulated in myocardial tissue after MI, while autophagy increased, and autophagy was reduced when miR-30d was overexpressed, and then analyzed by biochemical analysis and luciferase Genetic experiments confirmed that ATG5 was a downstream target gene of miR-30d. After using Lentivirus-ATG5 (LV-shATG5) to effectively inhibit autophagy and up-regulate the expression of FTH1 and GSH peroxidase (GPX4) in H9C2 cells, reduce the content of MDA, increase the content of GSH, and increase the activity of GPX4, suggesting that autophagy after MI may promote ferroptosis in H9C2 cells.Conclusions: The expression of miR-30d decreased in cardiomyocytes after MI and which can inhibit autophagy by binding to ATG5. Furthermore, autophagy after MI may promote ferroptosis.","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"249-255"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38200280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect and mechanism of CDK11 in promoting breast cancer cell proliferation, migration, and doxorubicin resistance by regulating EGFR. CDK11 通过调控表皮生长因子受体促进乳腺癌细胞增殖、迁移和多柔比星耐药性的作用和机制

IF 4.3 4区医学

Panminerva medica Pub Date : 2024-09-01 Epub Date: 2023-12-21 DOI: 10.23736/S0031-0808.23.04983-2

Zhe Yang, Tianze Cao, Kaiqing Yang, Zhe Ren, Quancheng Kan, Yubing Zhou

引用次数: 0

Mediating role of self-advocacy in the correlation between depression and health-related quality of life among elderly patients with diabetes mellitus. 自我主张在老年糖尿病患者抑郁与健康相关生活质量之间的相关性中的中介作用。

IF 4.3 4区医学

Panminerva medica Pub Date : 2024-09-01 Epub Date: 2023-09-15 DOI: 10.23736/S0031-0808.23.04963-7

Nannan Xi, Chen Wei, Qiangqiang Chu, Sasa Fu, Tingting Dai, Lunfang Xie, Aihong Pan

引用次数: 0

The effect and exploration of continuous positive pressure ventilation combined with upper limb robot training on upper limb function in stroke patients with OSAHS. 持续正压通气联合上肢机器人训练对脑卒中OSAHS患者上肢功能的影响及探讨

IF 4.3 4区医学

Panminerva medica Pub Date : 2024-09-01 Epub Date: 2023-11-30 DOI: 10.23736/S0031-0808.23.05021-8

Danxia Huang, Xiaoqiang Liu, Zhisheng Wu, Yihong Zhuang, Yang Liu

引用次数: 0

An update of the literature about rehabilitation tools used in the treatment of COVID-19-related disabilities: a systematic review of literature. 关于用于治疗 COVID-19 相关残疾的康复工具的最新文献：系统性文献综述。

IF 4.3 4区医学

Panminerva medica Pub Date : 2024-09-01 Epub Date: 2024-06-05 DOI: 10.23736/S0031-0808.24.05098-5

Gianpaolo Ronconi, Sefora Codazza, Mariantonietta Ariani, Fabiana LA Cagnina, Roberta Scrima, Daniele Coraci, Paola E Ferrara

{"title":"An update of the literature about rehabilitation tools used in the treatment of COVID-19-related disabilities: a systematic review of literature.","authors":"Gianpaolo Ronconi, Sefora Codazza, Mariantonietta Ariani, Fabiana LA Cagnina, Roberta Scrima, Daniele Coraci, Paola E Ferrara","doi":"10.23736/S0031-0808.24.05098-5","DOIUrl":"10.23736/S0031-0808.24.05098-5","url":null,"abstract":"Introduction: The role of rehabilitation during and after the COVID-19 pandemia was influenced by the progressive acquisition of knowledge on the pathology with the adaptation of the rehabilitative instruments to the heterogeneous impairments of the patients. The aim of this systematic review is to describe the effects of the rehabilitation tools applied in the last three years in the different phases of the COVID-19 disease.Evidence acquisition: A literature search of MEDLINE (PubMed), Scopus and Physiotherapy Evidence Database (PEDro) was conducted. 2994 participants were included in this systematic review: 1225 patients for acute-COVID, 1331 patients for post-COVID, 438 patients for long-COVID.Evidence synthesis: Of the initial 907 hits only 45 randomized controlled trials were included. The Cochrane library assessment tool was used to evaluate the risk of bias. The trials selected studied the effects of respiratory rehabilitation alone or in association with exercises, tele-rehabilitation, endurance training, virtual reality, electrostimulations in different settings and phases of the infection with the evaluation of clinical, quality of life and impairment outcome measures.Conclusions: All the rehabilitations tool were used based on the experts' opinion and on the rules of good clinical practice, during and after the pandemic period. Despite the heterogeneity of the studies, the different outcome measures and the small sample sizes, pulmonary rehabilitation, tele-rehabilitation and low/moderate intensity aerobic and endurance exercises seemed to improve clinical and quality of life outcomes at short (8 weeks) and mean time (2 months) after treatments in all phases of the infection.","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"309-316"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on the expression and prognostic value of copper death related genes in liver cancer. 铜死亡相关基因在肝癌中的表达及预后价值的研究进展。

IF 4.3 4区医学

Panminerva medica Pub Date : 2024-09-01 Epub Date: 2024-01-24 DOI: 10.23736/S0031-0808.23.05012-7

Yuping Yang, Di Xiao, Jianqing Liang, Yongqiang Duan

引用次数: 0

Experimental study on prevention and treatment of postmenopausal osteoporosis by antioxidant stress of Mongolian medicine blue thorn regulating FoxO/Wnt/ β-catenin pathway. 调控FoxO/Wnt/β-catenin通路的蒙药蓝刺抗氧化应激预防和治疗绝经后骨质疏松症的实验研究

IF 4.3 4区医学

Panminerva medica Pub Date : 2024-09-01 Epub Date: 2021-09-21 DOI: 10.23736/S0031-0808.21.04476-1

Chongyang Dong, Yu Fang, Jianping Shi, Xiongyao Wang, Yan Liu, Jun Zhao, Xiaoming Gao

引用次数: 0

The early predictive value of multimodal ultrasound in the assessment of neoadjuvant chemotherapy efficacy. 多模式超声在新辅助化疗疗效评估中的早期预测价值。