Pakistan Journal of Medical and Health Sciences最新文献

{"title":"Family Screening of Thalassemic Patients and Effectiveness of Education in Providing Knowledge about Prevention of Thalassemia","authors":"Rameez Iqbal, Sidrah, Asfahan Akhtar, Kiran Memon, Muhammad Rahil Khan, Muhammad Anique, Kiran Aamir, Aamir Ramzan","doi":"10.53350/pjmhs2023176253","DOIUrl":"https://doi.org/10.53350/pjmhs2023176253","url":null,"abstract":"Objective: To identify the carriers in the families of Beta Thalassemia patients and to determine the effectiveness of education about the prevention of thalassemia. Methods: The Observational - Cross-Sectional study was carried out in 6 months from 01-09-2021 to 31-03-2022 on a sample of 73 thalassemia patients and their families, after taking informed written consent. This study was conducted via non-probability, convenient sampling and was carried out at the Department of Pathology & Diagnostic and Research Laboratory - LUMHS Hyderabad/Jamshoro. The data was analyzed via SPSS 21.0 Results: The mean age of patients was found to be 17.34 + 7.32 years. 52% of participants were males with mean age of 15.23 + 9.67 years and 48% participants were females with mean age of 13.48 + 5.7 years. Most of the patients were having fortnightly blood transfusion i.e. 42.8% followed by 32.9% patients with monthly transfusion. Bi-monthly transfusion were found to be least reported. Consanguineous marriage among parents was found in 87.70% of patients. Hb electrophoresis pattern among siblings of thalassemia patients showed 4.1% occurrence of thalassemia major and 32.8% occurrence of thalassemia minor while 63% patients were found to be having normal electrophoresis pattern. The mean hemoglobin was found to be 09.23 + 3.65 mg/dl among siblings of thalassemia patients with 63.86 + 8.41 mg/dl mean MCV. Conclusion: The study found out that the around 2/3rd of the families were having positive history of thalassemia with around 1/4th of the patients had history of blood transfusion. The educational session was found to effective in improving the knowledge regarding the thalassemia. Keywords: Thalassemia, carriers, family history, effectiveness of educational awareness","PeriodicalId":19842,"journal":{"name":"Pakistan Journal of Medical and Health Sciences","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of Post Partum Urinary Retention after Vaginal Delivery","authors":"Shahnilah Zafar, Muniba Maqbool, Sheeba Rehman, Sara Gulbaz, Javaria Aslam, Iram Aslam","doi":"10.53350/pjmhs2023176231","DOIUrl":"https://doi.org/10.53350/pjmhs2023176231","url":null,"abstract":"Objective: To determine the factors responsible for postpartum urinary retention after vaginal delivery in women. Materials and methods: This is an observational study conducted in the department of obstetrics and gynecology Rai medical College Sargodha. Study was completed in six months duration from July 2022 to December 2022. Patients undergoing spontaneous vaginal delivery and experienced urinary retention till six hours postpartum were labelled as case of postpartum urinary retention (PPUR). Total 120 cases of PPUR were included in this study after following inclusion and exclusion criteria. Results: Frequency of PPUR after vaginal delivery was 10(8.3%). Main factors causing PPUR include epidural analgesia in 3(37.5%) and prolong duration of labor in 2(25%) cases. Mean age of the study cases was 27.8 ± 4.2 years. Mean gestational age was 38.12 ± 2.2 weeks. Practical Implication: In this study our aim was to assess risk factors developing postpartum urinary retention (PPUR) in women who underwent vaginal delivery in order to identify women with increased risk of developing symptomatic PPUR so that this problem may be noted in post natal care and may be managed properly. There is no previously sufficient data related to this problem in our population so this study will help us to understand the disease burden in our society. Conclusion: Main risk factors of postpartum urinary retention after vaginal delivery include prolonged labor and epidural analgesia. Keywords: Postpartum hemorrhage, Vaginal delivery, Risk factors, Urinary retention, Prolong labor,","PeriodicalId":19842,"journal":{"name":"Pakistan Journal of Medical and Health Sciences","volume":"140 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Fenestration Technique for Lumbar Disc Excision in Pain Relief","authors":"Jawad Jan Arif, Subhan Shahid, Tanveer Afzal, Muhammad Abubakar, Ali Irfan","doi":"10.53350/pjmhs2023176225","DOIUrl":"https://doi.org/10.53350/pjmhs2023176225","url":null,"abstract":"Objective: To determine the outcomes of lumbar disc excision by fenestration technique for pain relief in lumbar radiculopathy due to prolapsed intervertebral disc. Methodology: This is a descriptive study conducted in a joint venture of orthopedic and neurosurgeons in a private hospital of Lahore. Study was completed in six months duration from July to December 2022. All patients presenting with lower back pain, straight leg raise test positive on <60 degrees and prolapsed disc at the level of L4/L5 or L5/S1 L discs on MRI. Those with multilevel disc prolapse, previous history of spinal surgery, cauda equine syndrome and patients with lumbar stenosis were excluded from the study. All study patients were operated under general anesthesia in knee chest position. Efficacy of the procedure was determined using Dennis Pain Scale. Important findings were documented when patient was discharged. SPSS version 20 was used for statistical analysis. Results: 125 patients were studied including 73(58.4%) males and 52(41.6%) females. Patients with the age of 20-60 years were included in this study with the mean age of 47.3 ± 5.2 years. Most commonly involved disc level was L4-L5 in 77(61.6%) and L5-S1 in 48(38.4%) cases. Unilateral radicular pain was present in 94(75.2%) cases and bilateral pain was present in 31(24.8%) cases. According to Dennis Pain Scale out of 125 cases 78(62.4%) patients presented in Dennis pain scale P4 and among them complete recovery achieved in 70(89.7%) cases. Conclusion: Surgical intervention is necessary in selected patients with prolapsed intervertebral disc with chronic unilateral or bilateral radicular pain. Fenestration technique for disc excision is a very good procedure for prolapsed disc. Keywords: Sciatica, Disc Excision, Prolapsed Disc, Radiculopathy","PeriodicalId":19842,"journal":{"name":"Pakistan Journal of Medical and Health Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Education in Providing Knowledge about Thalassemia Prevention and Family Screening of Thalassemic Patients","authors":"Rameez Iqbal, Kiran Memon, Suresh Kumar, Muhammad Rahil Khan, Shabnam Shabnam, A. Bhutto, Kiran Aamir, Aamir Ramzan","doi":"10.53350/pjmhs2023176257","DOIUrl":"https://doi.org/10.53350/pjmhs2023176257","url":null,"abstract":"Objective: The purpose of this study was to track out Beta Thalassemia carriers in affected households and evaluate the efficacy of thalassemia awareness campaigns. Study Design: Observational - Cross-Sectional study Place and Duration: Department of Pathology & Diagnostic and Research Laboratory - LUMHS Hyderabad/Jamshoro. 01-09-2021 to 31-03-2022 Methods: A total of 55 thalassemia patients and families included in the study after providing written consent; the research was conducted at the Department of Pathology and Diagnostic and Research Laboratory. Demographic information such as age, gender, education level, and family history of thalassemia was recorded, and SPSS 24.0 was used for statistical analysis. Results: In 55 patients, majority 33 (60%) were males and 22 (40%) were females. The frequency of bimonthly blood transfusions was found to be the lowest, and consanguineous marriage between parents was found in 46 (83.6%) of patients. Three (5.5%) siblings of thalassemia patients were found to have thalassemia major, and seventeen (34.5%) siblings were found to have thalassemia minor. Thirty-five (63.6% of patients) were found to have a normal electrophoresis pattern. Conclusion: The research showed that roughly 50% of families were impacted by thalassemia and that 25% of individuals had previously received a blood transfusion. The instructional event was evaluated positively for its impact on participants' understanding of thalassemia. Keywords: Effectiveness of Educational Awareness, Carriers, Thalassemia, family history","PeriodicalId":19842,"journal":{"name":"Pakistan Journal of Medical and Health Sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effectiveness of Low-Level Laser Therapy and Quantum Acoustic Waves in Patients with Chronic Low Back Pain","authors":"Sidra Shaban, Samraiz Mughal, Jawad Haider, Rehan Yaqoob, Muhammad Taha Javed, Laraib Shehzadi","doi":"10.53350/pjmhs2023176243","DOIUrl":"https://doi.org/10.53350/pjmhs2023176243","url":null,"abstract":"Background: Low Back pain (LBP) is a primary source of years lived with bad health condition, with an expected 70–85 percentage of the people to experience LBP at some moments in their lives. It is typically defined as backache, muscle tightness above the inferior gluteal folds and below the costal border with or without radiating pain in leg. The most prevalent issue and a major contributor to morbidity in adults is low back pain (LBP). Acute LBP is pain that lasts less than 3 months, while chronic LBP is pain that lasts more than 3 months. Nearly two thirds of adults experience it at some point in their lives. LDH, or lumbar disc herniation, is one of the most frequent causes of LBP. Objective: This study was intended to relate the effects of low-level-laser therapy and quantum acoustic waves on low-back-pain (LBP). Methods: It was a quasi-experimental study conducted at KKT orthopedic spine center and laser pain management rehab clinic, Multan from February, 2023, to April, 2023. There were two groups in total. One group was provided with low-level-laser therapy along with routine physiotherapy and the other with quantum acoustic wave along with routine physiotherapy. Assessment on 6th and 12th session was taken and measurements of Numeric Pain Rating Scale, Oswestry low back pain questionnaire and range of motion with goniometry were recorded before and after the treatment. SPSS-27 was used to analyze the data. Results: There were a total of 48 patients. 24 patients were given to low level laser group and 24 patients to quantum acoustic waves group. The mean age of patients was 30-70, Severity of pain in quantum acoustic waves group decline considerably related to low-level-laser therapy group at the end of the treatment session (p-value=<0.01). Conclusion: Mutually low-level-laser therapy and quantum acoustic waves lessens severity of pain but quantum acoustic waves caused lessening of pain severity more than low-level-laser therapy whereas, both presented major effects on range of motion ROM. Keywords: Back Disability Index; Khan Kinetic Treatment; Low level laser therapy; Low back pain","PeriodicalId":19842,"journal":{"name":"Pakistan Journal of Medical and Health Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urdu Translation and Psychometric Validation of Manual Ability Measure (MAM-36) in Patients with Neurological Disease","authors":"Hafsa Mushtaq","doi":"10.53350/pjmhs2023176218","DOIUrl":"https://doi.org/10.53350/pjmhs2023176218","url":null,"abstract":"Background: The pathophysiological underpinnings of lifelong impairment in a variety of acute and chronic neurological illnesses include neuronal loss and destruction. Upon neuroaxonal injury, levels of neurofilament proteins rise in the blood and cerebrospinal fluid (CSF). The Manual Ability Measure (MAM-36) is a questionnaire about the perceived ease or difficulty individuals may experience when performing unilateral and bilateral ADL tasks. The objective o was to translate and validate the Urdu version of manual ability measure for patients with neurological disorders Methods: A standardized step by step forward and backward translation procedure was followed. Data was collected from 108 patients with neurological diseases. Researcher employed Urdu version of self-administered MAM-36 questionnaire for data collection. Data was analysed by using SPSS.25. in this study test retest reliability was found through alpha Cronbach and Intra class Coefficient and construct validity was assess in relation to MusiQOL Results: The reliability analysis of the Manual Ability Measure (MAM-36) questionnaire demonstrated a high level of internal consistency, with both readings having a Cronbach's alpha reliability coefficient of 0.987. The sample consisted of 45 males (41.7%) and 63 females (58.3%), and the majority had a middle socioeconomic status (66.7%). Descriptive statistics showed that the sample had a mean age of 56±4 years, a mean height of 1.68±0.1 meters, a mean weight of 86.5±11.0 kg, a mean body mass index of 30.7±4, a mean grip strength of dominant hand of 24.6±1.9, and a mean grip strength of non-dominant hand of 22.9±0.7. Practical Implication: The reliability statistics indicate that the MAM-36 questionnaire is a reliable and valid tool for measuring manual ability in individuals with neurological diseases. The strong positive correlation between the variable of interest and the reference variable supports the construct validity of the measure. Conclusion: Hence it was concluded that, the reliability statistics indicate that the MAM-36 questionnaire is a reliable and valid tool for measuring manual ability in individuals with neurological diseases. The strong positive correlation between the variable of interest and the reference variable supports the construct validity of the measure. Keywords: Psychometric validation, Manual Ability Measure (MAM-36), Neurological disease","PeriodicalId":19842,"journal":{"name":"Pakistan Journal of Medical and Health Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension in Pregnant Females Promotes Thrombocytopenia","authors":"A. Naz, A. Bhutto, Ghulam Fatima, Shabnam, Yasmeen Rasheed Bhutto, Aamir Ramzan, Kiran Aamir","doi":"10.53350/pjmhs2023176261","DOIUrl":"https://doi.org/10.53350/pjmhs2023176261","url":null,"abstract":"Objective: To determine how often pregnant hypertensive women get thrombocytopenia during the pregnancy. Study Design: Retrospective study Place and Duration: People university of Medical and Health Sciences for Women Nawabshah. January 2022 to December 2022. Methods: Total 63 pregnant females were presented. All the presented females had pregnancy induced hypertension with age group 18-46 years. All cases included platelet estimate, and thrombocytopenia was diagnosed in individuals with a reported platelet count of less than 1,50,000/cumm. All data were analyzed with SPSS 24.0. Results: Pregnant females had mean age 28.6±4.35 years and had mean BMI 26.4±3.29 kg/m2. Frequency of primigravida was 27 (42.9%) and 36 (57.1%) cases were multi-gravida. Majority of the patients 55 (87.3%) had blood pressure 140-160/90-110 mmHg and 8 (12.7%) cases had Bp > 160/110 mmHg. Frequency of thrombocytopenia was found in 17 (26.98%) cases. Among 17 cases of thrombocytopenia mild PIH was found in 3 cases, moderate in 5 cases and 8 cases had severe PIH. Conclusion: In particular, in third-trimester hypertensive pregnant women, gestational thrombocytopenia (GT) is recognized as a primary cause of thrombocytopenia. For those women, careful monitoring both during and after pregnancy is advised. Keywords: Thrombocytopenia, Gestational hypertension, Pregnancy","PeriodicalId":19842,"journal":{"name":"Pakistan Journal of Medical and Health Sciences","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of TIMI Risk Score and GRACE Risk Score with Lesion of Coronary Artery Disease in Patients with Non-ST Segment Elevation Acute Coronary Syndrome","authors":"Maroof Hassan, Ghulam Kubra, Mehwish Sabeen, Deebaj Nadeem, Asma Murtaza, Faiza Sikandari","doi":"10.53350/pjmhs2023176205","DOIUrl":"https://doi.org/10.53350/pjmhs2023176205","url":null,"abstract":"Objective: To compare the correlation of “thrombolysis in myocardial infarction (TIMI)” and “Global Registry of Acute Coronary Events (GRACE)” risk score with lesion of coronary artery disease in patients with non-ST segment elevation acute coronary syndrome. Study Design: Cross-sectional study. Place and Duration: The Department of adult cardiology, “National Institute of Cardiovascular Diseases (NICVD)”, Karachi, Pakistan, from January 2021 to July 2021. Methodology: Demographics, weight, height, risk factors along with the required information needed for TIMI and GRACE score were obtained at the time of presentation in emergency department as per the scoring criteria. SYNTAX score was calculated after performing conventional angiography of the patients, using SYNTAX.com calculator. Results: In a total of 104 patients, the mean age was 57.21±12.22 years while 56 (53.8%) patients were male. Hypercholesterolemia was found in 33 (31.7%) patients. Mean score of TIMI was calculated as 4.680±2.064 while SYNTAX score was calculated as 26.45±12.94 and the correlation between TIMI risk score and SYNTAX score was noted as (r=0.109) and P value was found to be non-significant i.e. (P=0.270). Mean score of GRACE was noted as 135.38±90.88 while SYNTAX score was noted as 26.45±12.94 and the correlation between GRACE risk score and SYNTAX score was documented as (r=0.179) and P value was found to be non-significant i.e. (P=0.068). Practical Implications: Both TIMI and GRACE risk scoring systems showed weak correlations with SYNTAX scores. Conclusion: There is a weak correlation between TIMI risk score and SYNTAX score as well as GRACE risk score and SYNTAX score. Keywords: Acute coronary syndrome, coronary artery disease, GRACE score, myocardial infarction, thrombolysis.","PeriodicalId":19842,"journal":{"name":"Pakistan Journal of Medical and Health Sciences","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a Five Minute Counseling Session of Proper Inhaler Technique on Control of Asthma in Patients Presenting to Tertiary Care Hospital","authors":"Rashid Iqbal, Khawar Shoaib, Hassan Farooq","doi":"10.53350/pjmhs2023176237","DOIUrl":"https://doi.org/10.53350/pjmhs2023176237","url":null,"abstract":"Objectives: To determine the effectiveness of counseling session of inhaler technique in improving control of symptoms in asthma patients, the factors affecting the improper inhaler technique and association of inhaler use with control of asthma. It has been observed that patients coming to tertiary care hospitals have poor asthma control and patients does not know exactly how to use inhaler in asthma symptoms. Study design: A facility based Observational, Prospective, Cross-sectional study conducted on patient with asthma symptoms and signs. Settings: This study was done in Department of Medicine, Sir Ganga Ram hospital Lahore. Timings: From 24-1-2023 to 23-5-2023. Methods: A facility based Observational, Prospective, Cross-sectional study was conducted on patient with asthma symptoms and signs. This study described the improvement in asthma symptoms by counseling sessions of using inhaler techniques in asthma patients. This study was done in Department of Medicine, Sir Ganga Ram hospital, Lahore. Patients who come to Out patient department of the hospital were selected who had asthma symptoms and signs. Sample size: A total of eighty Patients were selected with asthma symptoms and signs. Patients history were recorded and they were asked to use inhaler and there inhaler use technique were scored. Sample Selection: Inclusion Criteria: Patients age 16 years above, Both male and female patients, new onset asthma symptoms and signs, previously uncontrolled asthma on corticosteroid inhalers and meter dose inhaler devices. Exclusion criteria: Patients with history of chronic bronchitis and Patient with history of emphysema, Patients age less than 16 years. Data Collection procedure: A questionnaire was given to doctors who filled the data and record of patients with asthma symptoms and signs. A proper five minutes counseling of inhaler technique was done in asthma patients who came to Out Patient department of hospital. A questionnaire was filled and used for interpretation of results. We separated patients in two groups. One group of patients did not know how to use inhaler and other group knew how to use inhalers. Improper technique for use of inhaler defined as less than 75 percent of corrected steps done for use of inhaler device. Then we scored patient about the level of effective use of inhaler in asthma patients. We did a five minute counseling session to teach them how to use inhalers properly. We followed these patients in out patients department of tertiary care of hospital and see the improvement in control of asthma symptoms. We observed that patients asthma were controlled, if symptoms and signs improved, reduce nocturnal awakening of patients with cough and shortness of breath, improved quality of life and daily activities. We did the comparison of both group of patients coming to tertiary care hospital and see the impact of five minute counseling of proper inhaler techniques in improving asthma control in these patients. Results: A tot","PeriodicalId":19842,"journal":{"name":"Pakistan Journal of Medical and Health Sciences","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Controlled Trial of Labetalol Versus Hydralazine, for Severe Hypertension in Obstetric Patients, at Tertiary Care Hospital of Karachi","authors":"S. Siddiqui, Farah Shabih Ul Hasnain, R. Jaleel","doi":"10.53350/pjmhs2023176249","DOIUrl":"https://doi.org/10.53350/pjmhs2023176249","url":null,"abstract":"Background: Blood pressure ≥160/110 mm Hg, is indication for urgent drug therapy in obstetric women, to prevent complications and deaths. There is limited data for comparison of Labetalol to Hydralazine in emergent treatment of severe pregnancy related hypertension. Methods: Randomized controlled trial, analyzed 184 women with severe hypertension at ≥28 weeks of pregnancy or within 72 hours after delivery, from October 2012 to September 2014. Ninety-two patients in each group received intravenous Labetalol or Hydralazine boluses, repeated every 10 or 20 minutes respectively (maximum 5 boluses). Outcome measures comprised blood pressure reduction <160/110 mm Hg, mean arterial pressure, severe persistent hypertension, number of boluses, maternal hypotension, tachycardia, adverse effect on fetal heart, still birth and neonatal bradycardia. Data was collected on a semi -structured proforma and analyzed through SPSS version 20. Numeric outcome measures were compared by Mann Whitney U test or independent sample t test according to normality distribution. Qualitative measures were compared by Chi square or Fisher’s exact test. Level of significance was <0.05 Results: There was no significant difference in reduction of systolic, diastolic blood pressure and severe persistent hypertension, between Labetalol and Hydralazine (p>0.05). Tachycardia, palpitation, headache, were significantly higher (p <0.05) in Hydralazine group. Adverse effects on fetal heart were not statistically significant. Numbers of boluses were significantly lower in labetalol group. Conclusion: Labetalol is equal to hydralazine in reducing severe pregnancy related hypertension. Maternal side effect profile of Labetalol is better, and it achieves blood pressure control with reduced boluses. Keywords: Pregnancy-induced hypertension, Hypertensive crisis, Labetalol, Hydralazine, Pregnancy, Preeclampsia, Antihypertensive agent.","PeriodicalId":19842,"journal":{"name":"Pakistan Journal of Medical and Health Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}