Pediatric Surgery International最新文献

{"title":"The timing of surgery for congenital diaphragmatic hernia in infants receiving extracorporeal membrane oxygenation: a meta-analysis.","authors":"Minhua Lin, Hao Wu, Jiachi Liao, Ziyin Lyu, Le Li","doi":"10.1007/s00383-025-06146-z","DOIUrl":"10.1007/s00383-025-06146-z","url":null,"abstract":"<p><p>There is controversy regarding the timing of congenital diaphragmatic hernia surgery in infants receiving extracorporeal membrane oxygenation (ECMO). We conducted a meta-analysis of trials examining the optimal timing of surgery for congenital diaphragmatic hernia (CDH) in infants receiving ECMO. Compared to late surgery with ECMO, early repair surgery with ECMO reduced mortality (OR, 0.51; 95% CI 0.30-0.87; P = 0.01) and postoperative bleeding rates (OR, 0.25; 95% CI 0.11-0.54; P = 0.0004) and shortened ECMO duration (MD, - 2.15; 95% Cl, - 3.20 to - 1.09; P < 0.0001) and duration of hospitalization (MD, - 29.07; 95% Cl, - 44.55 to - 12.59; P = 0.0005). There were no significant differences in ventilator duration (MD, - 15.98; 95% CI, - 35.76 to 3.80; P = 0.11). For infants with CDH receiving ECMO, we recommend early repair surgery. Levels of evidence: Level III.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"245"},"PeriodicalIF":1.6,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of gender on pediatric surgical access and outcomes in Africa.","authors":"Sacha Williams, Olivia Serhan, Jenny Wang, Christian Guindi, Elena Guadagno, Maeve Trudeau, Emmanuel Ameh, Kokila Lakhoo, Dan Poenaru","doi":"10.1007/s00383-025-06144-1","DOIUrl":"10.1007/s00383-025-06144-1","url":null,"abstract":"<p><strong>Introduction: </strong>Girls, whose care is often affected by barriers steeped in gender inequity, may be at higher risk of poor surgical outcomes. This study explored the impact of gender on pediatric surgical care in Africa.</p><p><strong>Methods: </strong>Differences in access to care and clinical outcomes for boys and girls were examined for pediatric surgical conditions that do not differ by physiological sex. A systematic review of African pediatric surgical studies ensued, followed by a random effects meta-analysis, and risk of bias assessment.</p><p><strong>Results: </strong>Of the 12,281 records retrieved, 54 were selected for review. Most studies were retrospective (57.4%), single-site (94.4%), from Egypt, Nigeria, Ghana, or Ethiopia (55.6%), focused on gastrointestinal conditions (63.0%), published in 2010 or sooner (85.1%), had study durations of 5 years or less (68.5%), and cohorts of less than 200 children (57.4%). Sixty percent reported the outcome of mortality. Meta-analysis odds ratios revealed surgery was performed 3.6 times more often on boys (95% CI 2.6, 4.9); and mortality was 1.6 times greater for girls (95% CI 1.3, 2.0).</p><p><strong>Conclusion: </strong>African girls appear to face gender inequities in pediatric surgical care. Findings will be further explored in a mixed-methods study.</p><p><strong>Level of evidence: </strong>I.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"243"},"PeriodicalIF":1.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical and nutritional outcomes of extremely low birth weight infants with enterostomy: a single-center retrospective study in China.","authors":"Huijia Lin, Jiajing Ge, Guoqiang Qi, Jinfa Tou, Xiaolu Ma, Zheng Chen","doi":"10.1007/s00383-025-06139-y","DOIUrl":"https://doi.org/10.1007/s00383-025-06139-y","url":null,"abstract":"<p><strong>Background: </strong>We investigated the outcomes of extremely low birth weight (ELBW) infants who underwent intestinal enterostomy.</p><p><strong>Methods: </strong>This retrospective study included ELBW infants who were hospitalized from January 1, 2019, to December 31, 2023, and underwent enterostomy. Data regarding demographic information, complications, and outcomes were collected.</p><p><strong>Results: </strong>In total, 52 ELBW infants who underwent enterostomy were enrolled. Among them, 30 (57.7%) had necrotizing enterocolitis (NEC) and 10 (19.2%) had spontaneous intestinal perforation. Forty-seven infants survived at discharge. Twenty-nine infants developed intestinal failure, while 36 developed short bowel syndrome. The median gestational age in the intestinal failure group was 26.9 (1.9) weeks, lower than that of 27.2 (1.5) weeks in the non-intestinal failure group (p = 0.024). Infants with intestinal failure achieved full enteral nutrition at an average age of 112(32) days; this was significantly greater than the age of 71(41) days in the non-intestinal failure group (p < 0.001).</p><p><strong>Conclusion: </strong>NEC was the main disease in ELBW infants undergoing intestinal enterostomy, with a high incidence of SBS and IF postoperatively. Infants with IF have a lower gestational age and a longer parenteral nutrition duration. This finding highlights the need for more rational nutritional strategies.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"244"},"PeriodicalIF":1.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual nephrogenic rests affect the long-term prognosis of Wilms tumor with bilateral nephrogenic rests.","authors":"Xiaofeng Chang, Jinghao Yan, Shen Yang, Hong Qin, Wei Yang, Yang Yang, Yanchao Qu, Jianguo Zhang, Jiatong Xu, Tong Yu, Han Liu, Hongcheng Song, Huanmin Wang","doi":"10.1007/s00383-025-06142-3","DOIUrl":"https://doi.org/10.1007/s00383-025-06142-3","url":null,"abstract":"<p><strong>Background/objectives: </strong>The progression of nephrogenic rests (NRs) can lead to the development of Wilms tumor (WT). The aim is to explore the factors affecting the poor prognosis associated with WT combined with bilateral NRs.</p><p><strong>Methods: </strong>We retrospectively analyzed the clinical data of patients with WT combined bilateral NRs admitted to our center from January 2008 to December 2022. The enrolled patients were divided into two groups according to whether they had residual NRs at the end of standard therapy or not.</p><p><strong>Results: </strong>57 patients were finally enrolled in this study, of which 23 patients were in the non-residual NRs group and 34 patients were in the residual NRs group. In the residual NRs group, 15 patients (44.1%) ultimately progressed to WT, and 3 patients died of tumor. In the non-residual NRs group, 1 patient (4.3%) experienced WT development (P < 0.01). The 5-year EFS of the non-residual group was 95.6%, which was significantly higher than that of the residual group (70.5%) (p < 0.01). Univariate and multivariate Cox analysis revealed that residual NRs was the risk factor for WT progression in the WT patients with bilateral NRs.</p><p><strong>Conclusion: </strong>The residual NRs increased the risk of WT development and led to poor prognosis. Future multicenter prospective studies may need to further assess the conditions of patients with residual NRs to guide further treatment.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"242"},"PeriodicalIF":1.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of surgical site infection in pediatric patients using NSQIP-P data during COVID-19 pandemic and non-pandemic periods.","authors":"Simin Park, Zidong Zhang, Shin Miyata","doi":"10.1007/s00383-025-06147-y","DOIUrl":"https://doi.org/10.1007/s00383-025-06147-y","url":null,"abstract":"<p><strong>Introduction: </strong>Surgical site infections (SSIs) remain a significant post-operative complication, with rates varying across populations. The COVID-19 pandemic led to heightened infection control measures, which were expected to lower SSI rates. However, existing studies mainly focus on adult populations, leaving a gap in understanding the pandemic's impact on pediatric surgeries.</p><p><strong>Methods: </strong>We used the National Surgical Quality Improvement Program in Pediatric Surgery (NSQIP-P) database to analyze SSI rates and lengths of stay (LOS) for pediatric patients from 2018 to 2021. We compared data from pre-pandemic (2018-2019) and pandemic (2020-2021) periods, adjusting for confounding variables, such as patient demographics, comorbidities, and surgical specialties.</p><p><strong>Results: </strong>Among 472,581 cases analyzed, SSI rates increased from 2.5% pre-pandemic to 2.88% during the pandemic. While the percentage of patients with LOS exceeding 2 days slightly decreased, SSI rates for those with prolonged LOS increased, highlighting a strong association between extended hospitalization and SSI risk. Pediatric Otolaryngology had the highest adjusted odds ratio (OR) for SSI (1.393), while pediatric surgery had the lowest (1.097).</p><p><strong>Discussion: </strong>Despite enhanced infection control protocols, SSI rates in pediatric surgeries increased during the COVID-19 pandemic. These findings emphasize that infection control measures alone may have been insufficient to mitigate SSIs in pediatric populations, even with efforts to reduce LOS. Further research is needed to explore the pandemic's broader impact on pediatric surgical outcomes and the relationship between LOS and SSIs.</p><p><strong>Levels of evidence: </strong>Observational study, Level III.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"241"},"PeriodicalIF":1.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of second-layer coverages on complication rates in primary tubularized incised plate urethroplasty (TIPU) for distal and midpenile hypospadias repair: a systematic review.","authors":"Marta Pezzoli, Mattia Lo Re, Virginia Carletti, Lorenzo Masieri, Alberto Mantovani","doi":"10.1007/s00383-025-06134-3","DOIUrl":"10.1007/s00383-025-06134-3","url":null,"abstract":"<p><p>This systematic review assesses the impact of different second-layer coverage techniques on complication rates following primary tubularized incised plate urethroplasty (TIPU) for distal and midpenile hypospadias. A systematic search of PubMed, EMBASE, Cochrane Central, and Scopus was conducted in August 2024. Studies were included if they reported outcomes of single- or double-layer neourethral coverage in primary TIPU for distal or midpenile hypospadias. A narrative synthesis was performed due to study heterogeneity. Forty studies met inclusion criteria. In distal hypospadias, single-layer coverage yielded urethrocutaneous fistula (UCF) rates below 10% in most cases. Meatal stenosis reached 33.3% but was uncommon with dorsal dartos (DD) flaps. Double-layer coverage, especially with double DD flaps, showed lower UCF rates (0-12)% and minimal stenosis. For midpenile hypospadias, single-layer coverage showed higher UCF rates (0-36.4%), with DD flaps performing worse (12.5-36.4%) than tunica vaginalis (TV) flaps (0-3.1%). Double-layer techniques consistently reduced UCF to < 5%, with double DD flaps showing no fistula or stenosis. In conclusion, second-layer coverage, particularly double layer, reduces complications in TIPU. The DD flap remains most commonly used due to its accessibility, while the technically demanding TV flap shows promising results. Further high-quality data are needed to identify the optimal technique.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"240"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in morbidity and mortality in children with burns.","authors":"Serap Samut Bülbül, Sevda Akdeniz, Alper Ceylan, Ahmet Saraç, Murat Güzel, Metin Ocak, Selim Görgün","doi":"10.1007/s00383-025-06145-0","DOIUrl":"https://doi.org/10.1007/s00383-025-06145-0","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to investigate whether neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) rates have a role in morbidity and mortality in children who were hospitalized due to burns.</p><p><strong>Methods: </strong>A total of 282 patients between the ages of 0-18 who were hospitalized due to deep partial thickness and full thickness burns between 2018 and 2023 were included in the study.</p><p><strong>Results: </strong>The mean NLR value in deceased patients was found to be significantly higher than that in survivors (p < 0.036). The NLR value was found to be significantly positively associated with the duration of hospital stay (p < 0.001). The sensitivity and specificity of the 8.775 cutoff value for NLR in predicting mortality were determined to be 66.7% and 74.7%, respectively. There was no statistically significant difference between the PLR values of survivors and non-survivors (p = 0.926).</p><p><strong>Conclusion: </strong>Despite PLR, the study indicates that the risk of morbidity and mortality is significantly higher in pediatric patients with high NLR values at the time of admission to the hospital, and that the NLR value provides important information about the clinical course and mortality in these patients.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"239"},"PeriodicalIF":1.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excision versus division of Müllerian duct remnants in male disorders of sexual development and differentiation: a prospective study to generate anatomical assessment criteria.","authors":"Mohamed Sayed Abd El-Monsif, Ahmed Mohamed Kadry Wishahy, Noha Arafa, Mohamed Magdy Elbarbary, Gamal Eltagy, Mahmoud Marei Marei","doi":"10.1007/s00383-025-06079-7","DOIUrl":"10.1007/s00383-025-06079-7","url":null,"abstract":"<p><strong>Background: </strong>Müllerian duct remnants (MDRs) in male disorders of sexual development (DSD) exhibit variable degrees of development and Wolffian duct relations, influencing surgical decision-making.</p><p><strong>Objectives: </strong>This study introduces the G-V_D-M_DR classification to guide excision versus division decisions. It also examines the correlation between the external masculinisation score (EMS) and surgical approach for improved preoperative planning.</p><p><strong>Methods: </strong>A cohort of 18 male-reared DSD patients with MDRs was prospectively managed laparoscopically, out of 20 initially considered cases. Surgical approaches included either longitudinal splitting/division or near-total excision. G-V_D-M_DR classification was introduced, which categorises MDRs based on three anatomical parameters: (A) gonadal status (G0-G3), (B) relation to the vasa deferentia (V0-V2), and (C) degree of Müllerian development (M1-M5). In addition, the predictive value of the EMS in determining surgical feasibility was evaluated.</p><p><strong>Results: </strong>Patients with higher EMS (≥ 8.5) were more likely to require MDR division due to complex MDR-vas deferens relations, while those with EMS ≤ 5.5 underwent excision. Bilateral MDR-vas deferens relations favoured division (83.3%), whereas unilateral or absent MDR-vas deferens relations were more common in the excision group (41.6% and 50%, respectively). A significant correlation was found between EMS and surgical approach (p = 0.004).</p><p><strong>Conclusion: </strong>The G-V_D-M_DR classification, combined with EMS assessment, offers a structured and predictive framework for optimising MDR surgical management. The need to achieve single-stage, tension-free orchidopexy and the anatomical relationship between MDRs and the vas deferens govern the choice between excision and division.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"238"},"PeriodicalIF":1.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of glanular decompression and expansion surgery in proximal hypospadias with hypoplastic glans penis.","authors":"Yue Wang, Shengli Gu, Yuan Ding, Zhengbo Yu, Ruiqi Chen","doi":"10.1007/s00383-025-06141-4","DOIUrl":"10.1007/s00383-025-06141-4","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of glanular decompression and expansion surgery in repairing proximal hypospadias accompanied by hypoplastic glans penis.</p><p><strong>Methods: </strong>Clinical data from pediatric patients with proximal hypospadias and hypoplastic glans penis admitted to the pediatric surgery department of First People's Hospital, Zunyi City from January 2020 to June 2023 were retrospectively analyzed. Patients were divided into two groups according to surgical approach: a conventional glanuloplasty group (n = 26) and a glanular decompression and expansion group (n = 28). Surgical outcomes, postoperative complications, penile growth, and satisfaction with postoperative penile appearance were compared and analyzed between the groups.</p><p><strong>Results: </strong>No statistically significant differences existed between the two groups in preoperative baseline clinical data(P > 0.05).In the conventional glanuloplasty group, complications occurred in 10 cases (38.46%),including glanular dehiscence in 4 cases (15.38%), urethral stenosis in 2 cases (7.69%), urethral fistula in 3 cases (11.54%), and recurrent penile curvature in 1 case (3.85%). In the glanular decompression and expansion group, 6 cases (21.43%) experienced complications, comprising urethral fistula in 3 cases (10.71%), urethral stenosis in 2 cases (7.14%), urethral diverticulum in 1 case (3.57%),and no cases of glanular dehiscence. The incidence of postoperative glanular dehiscence was significantly lower in the decompression and expansion group compared with the conventional group (P = 0.047),There were no statistically significant differences in the overall complication rate, incidence of urethral fistula, or urethral diverticulum between the groups (P > 0.05).One year postoperatively, the glanular width in the decompression and expansion group was significantly greater than that in the conventional group (1.34 ± 0.13 cm vs 1.40 ± 0.08 cm; P = 0.031).</p><p><strong>Conclusion: </strong>Glanular decompression and expansion surgery effectively reduces the incidence of postoperative glanular dehiscence in proximal hypospadias patients with hypoplastic glans penis. Additionally, this technique enhances glanular size and improves the satisfaction of physicians and patients' families regarding penile appearance. However, its efficacy in reducing urethral fistula and overall complication rates remains limited.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"237"},"PeriodicalIF":1.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in self-reported quality of life and bowel function among patients with anorectal malformation and Hirschsprung's disease compared to a healthy population: a multicenter cross-sectional study.","authors":"Mei Yee Aw, Suganthi Rajasegaran, Nur Aini Ahmad, Shung Ken Tan, Abhirrami Lechmiannandan, Yew-Wei Tan, Anand Sanmugam, Shireen Anne Nah","doi":"10.1007/s00383-025-06140-5","DOIUrl":"10.1007/s00383-025-06140-5","url":null,"abstract":"<p><strong>Purpose: </strong>Anorectal malformations (ARM) and Hirschsprung's disease (HD) are congenital conditions that impact quality of life (QoL) and bowel function. Understanding gender-specific differences in these domains is essential for tailored clinical care and patient support. This study aimed to explore gender differences in QoL and bowel function among patients with ARM and HD compared to healthy controls.</p><p><strong>Method: </strong>Patients with ARM and HD aged 5-17 years at four tertiary referral centres, who had primary corrective surgery done > 12 months prior, were recruited between December 2020 and February 2023. Quality of life was assessed using the Pediatric Quality of Life Inventory (PedsQL ™) Generic Core Scales 4.0 and General Well-Being Scale 3.0., while bowel function was evaluated using the Rintala Bowel Function Score (BFS). Statistical analysis was performed, with p < 0.05 significance.</p><p><strong>Results: </strong>A total of 202 participants aged between 5 and 17 years were enrolled: 65 ARM patients, 54 HD patients, and 83 healthy controls. Participants were grouped by gender and age (5-7, 8-12, and 13-17 years). No significant gender differences in QoL scores were found in ARM or control groups. However, among HD patients aged 8-12 years, males reported significantly higher physical health scores than females (p = 0.01), but no significant gender differences were found in other domains. Healthy controls consistently reported higher QoL scores, regardless of gender. Bowel Function Scores were comparable between genders in ARM and HD patients, while healthy controls uniformly reported the highest scores.</p><p><strong>Conclusion: </strong>Our study did not reveal gender differences in QoL and bowel function outcomes in ARM and HD patients, except in physical health scores of HD patients aged 8-12, possibly due to low sampling of females. Healthy controls consistently demonstrated superior outcomes. The use of generic QoL tools may be inadequate to draw out gender-related concerns. Larger studies should integrate gender-specific considerations to inform holistic clinical care and long-term management of ARM and HD patients.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"235"},"PeriodicalIF":1.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}