Pharmaceutica acta Helvetiae最新文献_第9页

Development of an abdominal magnetic resonance (MR) contrast agent formulation with Oral Magnetic Particles (OMP, Ferristene) 口服磁性颗粒(OMP、铁烯)腹腔磁共振造影剂配方的研制

Pharmaceutica acta Helvetiae Pub Date : 1998-12-01 Epub Date: 1999-01-23 DOI: 10.1016/S0031-6865(98)00024-7

Manabu Matsumura, Hiroaki Nakagami, Chu-Jun Chen, Shigekazu Ito, Tsutomu Konno

{"title":"Development of an abdominal magnetic resonance (MR) contrast agent formulation with Oral Magnetic Particles (OMP, Ferristene)","authors":"Manabu Matsumura, Hiroaki Nakagami, Chu-Jun Chen, Shigekazu Ito, Tsutomu Konno","doi":"10.1016/S0031-6865(98)00024-7","DOIUrl":"10.1016/S0031-6865(98)00024-7","url":null,"abstract":"<div>A formulation for fast dispersible granules with the magnetic resonance (MR) contrast agent, Oral Magnetic Particles (OMP), was developed. The formulation contained viscosity-increasing agents (xanthan gum and a mixture of microcrystalline cellulose and sodium carboxymethylcellulose). The granules were dispersed easily in water when stirred by hand and became a viscous OMP suspension with apparent homogeneity, but does not form granule aggregates (lump), within 10 min. The dispersibility was greatly affected by the binder type and addition of disintegrant. Hydroxypropylcellulose and low-substituted hydroxypropylcellulose were preferable. The preparation method to incorporate OMP into the granules also greatly influenced the dispersibility of the granules. A fluidized bed granulation of the base granules containing additives and subsequent coating of OMP onto the granules was eventually utilized. The formulation was able to control the viscosity of the suspension by regulating the content of viscosity-increasing agent while maintaining dispersibility. The developed formulation gave a good MR contrast image in rats and no magnetic susceptibility artifact was observed.</div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 4","pages":"Pages 205-213"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00024-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20770137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

High-performance liquid chromatographic assay of quinapril in tablets 高效液相色谱法测定喹奈普利片剂中的含量

Pharmaceutica acta Helvetiae Pub Date : 1998-12-01 DOI: 10.1016/S0031-6865(98)00019-3

A. Gumieniczek, H. Hopkała

引用次数: 7

High-performance liquid chromatographic assay of quinapril in tablets 高效液相色谱法测定喹奈普利片剂中的含量

Pharmaceutica acta Helvetiae Pub Date : 1998-12-01 Epub Date: 1999-01-23 DOI: 10.1016/S0031-6865(98)00019-3

Anna Gumieniczek, Hanna Hopkala

引用次数: 7

Preparation of casein–chitosan microspheres containing diltiazem hydrochloride by an aqueous coacervation technique 水凝聚法制备盐酸地尔硫卓酪蛋白-壳聚糖微球

Pharmaceutica acta Helvetiae Pub Date : 1998-12-01 Epub Date: 1999-01-23 DOI: 10.1016/S0031-6865(98)00020-X

M.A. Bayomi, S.A. Al-Suwayeh, A.M. El-Helw, A.F. Mesnad

{"title":"Preparation of casein–chitosan microspheres containing diltiazem hydrochloride by an aqueous coacervation technique","authors":"M.A. Bayomi, S.A. Al-Suwayeh, A.M. El-Helw, A.F. Mesnad","doi":"10.1016/S0031-6865(98)00020-X","DOIUrl":"10.1016/S0031-6865(98)00020-X","url":null,"abstract":"<div>Sustained release casein–chitosan microspheres containing diltiazem hydrochloride (DTZ) were prepared with colloidal coacervation technique in a completely aqueous environment. The interaction between chitosan solution in dilute acetic acid (5% v/v) and casein solution in 0.5 M sodium hydroxide was the basis for the microspheres formation. Formaldehyde was used for the surface hardening of the droplets by cross-linking and thus fixing the shape and surface morphology of the formed microspheres. The entrapment efficiencies of the microspheres were variables (14.5–53.7%) depending on the preparation conditions. The prepared microspheres exhibited an angle of repose values between 31.9–42.0° indicating good free flowing nature, whereas DTZ powder as such was non-flowable. The dissolution profiles of DTZ from casein–chitosan microspheres showed retarded release pattern of the drug into distilled water. Casein and chitosan concentrations, initial drug concentration and stirring time were found to be the main parameters that affect the properties and the performance of the prepared microspheres. The retarded release of DTZ was increased by increasing casein concentration, and stirring time. On the other hand, increasing chitosan concentration and using high initial drug loading showed a fast drug release.</div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 4","pages":"Pages 187-192"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00020-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20770135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 89

PMR assay of vincamine and formulations 长春胺及其制剂的PMR测定

Pharmaceutica acta Helvetiae Pub Date : 1998-12-01 Epub Date: 1999-01-23 DOI: 10.1016/S0031-6865(98)00022-3

Elsayed A. Aboutabl , Aida A. El-Azzouny , Manal S. Afifi

引用次数: 5

From peptides to peptidomimetics: design of nonpeptide ligands for major histocompatibility proteins 从多肽到多肽拟物:主要组织相容性蛋白的非多肽配体设计

Pharmaceutica acta Helvetiae Pub Date : 1998-12-01 Epub Date: 1999-01-23 DOI: 10.1016/S0031-6865(98)00021-1

Stefan Krebs , Didier Rognan

引用次数: 15

Pharmacodynamic and pharmacokinetic evaluation of lipid microspheres of indomethacin 吲哚美辛脂质微球的药效学及药动学评价

Pharmaceutica acta Helvetiae Pub Date : 1998-12-01 Epub Date: 1999-01-23 DOI: 10.1016/S0031-6865(98)00023-5

P. Srinath, P.V. Diwan

{"title":"Pharmacodynamic and pharmacokinetic evaluation of lipid microspheres of indomethacin","authors":"P. Srinath, P.V. Diwan","doi":"10.1016/S0031-6865(98)00023-5","DOIUrl":"10.1016/S0031-6865(98)00023-5","url":null,"abstract":"<div>Lipid microspheres (LM) of indomethacin were prepared using phosphatidyl choline and soya bean oil. LM of required size (<1 μm) were obtained by intermittent microscopic observation while homogenization. Anti-inflammatory activity of lipo-indomethacin was compared with free indomethacin by carrageenan induced rat paw edema model. It was found that at 30% edema inhibitory dose, lipo-indomethacin was about 1.5 times more potent than free indomethacin, indicating possible localization of LM at the inflammatory site. Biodistribution studies were performed in rats at the dose of 12 mg/kg. After 2 h of the treatment, concentration of the drug was 0.31 μg/g of inflammatory tissue with lipo-indomethacin, whereas, only 0.05 μg/g of the tissue was found with free indomethacin. Maximum difference in drug concentrations between the above two formulations was observed in lungs. LM were found not to cross the BBB as drug concentration in the brain after lipo-indomethacin treatment was below the detectable level. Thus, the pharmacokinetic data gave a quantitative evidence for high anti-inflammatory potential of lipo-indomethacin.</div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 4","pages":"Pages 199-203"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00023-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20770136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity 4-氨基苯乙酮芳基缩氨基脲的合成及其抗hiv活性研究

Pharmaceutica acta Helvetiae Pub Date : 1998-12-01 Epub Date: 1999-01-23 DOI: 10.1016/S0031-6865(98)00028-4

Vibha Mishra , S.N. Pandeya , E. DeClercq , Christophe Pannecouque , Myriam Witvrouw

引用次数: 15

Spectrophotometric determination of Fe(II) in pharmaceutical multivitamin preparations by azo-dye derivatives of heteroazopyrocatechine 杂氮儿茶素偶氮染料衍生物分光光度法测定复合维生素制剂中的铁(II)

Pharmaceutica acta Helvetiae Pub Date : 1998-08-01 Epub Date: 1999-09-15 DOI: 10.1016/S0031-6865(98)00013-2

S Zaręba, K Szarwiło, H Hopkała

引用次数: 0

Effect of vehicles on yohimbine permeation across excised hairless mouse skin 载药对育亨宾在切除的无毛小鼠皮肤中渗透的影响

Pharmaceutica acta Helvetiae Pub Date : 1998-08-01 Epub Date: 1999-09-15 DOI: 10.1016/S0031-6865(98)00007-7

V Carelli, G Di Colo, E Nannipieri, M.F Serafini

{"title":"Effect of vehicles on yohimbine permeation across excised hairless mouse skin","authors":"V Carelli, G Di Colo, E Nannipieri, M.F Serafini","doi":"10.1016/S0031-6865(98)00007-7","DOIUrl":"10.1016/S0031-6865(98)00007-7","url":null,"abstract":"<div>Turchi et al. [Turchi, P., Canale, D., Ducci, M., Nannipieri, E., Serafini, M.F., Menchini Fabris, G.F. (1992). The transdermal route in the treatment of male sexual impotence: preliminary data on the use of yohimbine. Int. J. Impotence Res. 4, 45–50.] showed that the application on penile skin of an oil-in-water cream (cream I.G) containing yohimbine (YO) was successful in the treatment of male sexual impotence. The components of the cream were stearyl alcohol, isopropyl lanolate, white petrolatum, liquid petrolatum, sodium lauryl sulphate (NaLS), propylene glycol (PG) and water. In the present study, a number of creams were derived from the cream I.G by adding, eliminating or replacing one or more constituents, and the effects of such changes on YO permeation through excised hairless mouse skin were investigated. From the data emerged the possibility of improving YO permeation even through slight changes in I.G composition. The stratum corneum-vehicle interactions were investigated by analyzing samples of isolated hairless mouse stratum corneum by DSC.</div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 3","pages":"Pages 127-134"},"PeriodicalIF":0.0,"publicationDate":"1998-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00007-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20628561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7