PMR assay of vincamine and formulations

Abstract

An accurate and specific PMR method for the determination of vincamine in the bulk drug, as well as solid and liquid dosage forms has been developed. The determination is based on the integration of the three methyl protons of the CH₂–CH₃ group of vincamine, relative to that of the two noncarboxylic protons of maleic acid (internal standard). The method furnishes a specific means of identification of vincamine as well as the simultaneous detection of the possible presence of other alkaloids.