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Pflügers Archiv - European Journal of Physiology最新文献

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Determinants of hypokalemia following hypertonic sodium bicarbonate infusion 高渗碳酸氢钠输注后低钾血症的决定因素
Pflügers Archiv - European Journal of Physiology Pub Date : 2022-03-11 DOI: 10.1007/s00424-022-02677-9
H. Adrogue, A. Awan, N. Madias
{"title":"Determinants of hypokalemia following hypertonic sodium bicarbonate infusion","authors":"H. Adrogue, A. Awan, N. Madias","doi":"10.1007/s00424-022-02677-9","DOIUrl":"https://doi.org/10.1007/s00424-022-02677-9","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"11 1","pages":"603 - 612"},"PeriodicalIF":0.0,"publicationDate":"2022-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73079694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potentiation of force by extracellular potassium and posttetanic potentiation are additive in mouse fast-twitch muscle in vitro 细胞外钾的力增强作用和破伤风后增强作用在小鼠体外快速收缩肌中是可加性的
Pflügers Archiv - European Journal of Physiology Pub Date : 2022-03-09 DOI: 10.1007/s00424-022-02681-z
K. Overgaard, William Gittings, R. Vandenboom
{"title":"Potentiation of force by extracellular potassium and posttetanic potentiation are additive in mouse fast-twitch muscle in vitro","authors":"K. Overgaard, William Gittings, R. Vandenboom","doi":"10.1007/s00424-022-02681-z","DOIUrl":"https://doi.org/10.1007/s00424-022-02681-z","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"36 1","pages":"637 - 646"},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83096286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Insights into permeability control of the fenestrated endothelium of the jejunal microvasculature 空肠微血管开孔内皮通透性调控的研究
Pflügers Archiv - European Journal of Physiology Pub Date : 2022-03-03 DOI: 10.1007/s00424-022-02680-0
D. V. van Helden
{"title":"Insights into permeability control of the fenestrated endothelium of the jejunal microvasculature","authors":"D. V. van Helden","doi":"10.1007/s00424-022-02680-0","DOIUrl":"https://doi.org/10.1007/s00424-022-02680-0","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"20 1","pages":"485 - 486"},"PeriodicalIF":0.0,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74741389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ion channel long non-coding RNAs in neuropathic pain 离子通道长非编码rna在神经性疼痛中的作用
Pflügers Archiv - European Journal of Physiology Pub Date : 2022-03-02 DOI: 10.1007/s00424-022-02675-x
R. Felix, David Muñoz-Herrera, Alejandra Corzo-López, Miriam Fernández-Gallardo, M. Leyva-Leyva, R. González-Ramírez, Alejandro Sandoval
{"title":"Ion channel long non-coding RNAs in neuropathic pain","authors":"R. Felix, David Muñoz-Herrera, Alejandra Corzo-López, Miriam Fernández-Gallardo, M. Leyva-Leyva, R. González-Ramírez, Alejandro Sandoval","doi":"10.1007/s00424-022-02675-x","DOIUrl":"https://doi.org/10.1007/s00424-022-02675-x","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"4 1","pages":"457 - 468"},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78414617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Discordant Ca2+ release in cardiac myocytes: characterization and susceptibility to pharmacological RyR2 modulation 心肌细胞中不一致的Ca2+释放:表征和对RyR2药理学调节的敏感性
Pflügers Archiv - European Journal of Physiology Pub Date : 2022-03-02 DOI: 10.1007/s00424-022-02678-8
L. Sommese, María Florencia Racioppi, Xin Shen, A. Orlowski, C. Valverde, W. Louch, M. Vila Petroff, L. Gonano
{"title":"Discordant Ca2+ release in cardiac myocytes: characterization and susceptibility to pharmacological RyR2 modulation","authors":"L. Sommese, María Florencia Racioppi, Xin Shen, A. Orlowski, C. Valverde, W. Louch, M. Vila Petroff, L. Gonano","doi":"10.1007/s00424-022-02678-8","DOIUrl":"https://doi.org/10.1007/s00424-022-02678-8","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"207 1","pages":"625 - 636"},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80466441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Electrophysiology of nociception: understanding of signaling pathways forms a basis for potential treatment 痛觉的电生理学:对信号通路的理解是潜在治疗的基础
Pflügers Archiv - European Journal of Physiology Pub Date : 2022-02-28 DOI: 10.1007/s00424-022-02679-7
Ľ. Lacinová
{"title":"Electrophysiology of nociception: understanding of signaling pathways forms a basis for potential treatment","authors":"Ľ. Lacinová","doi":"10.1007/s00424-022-02679-7","DOIUrl":"https://doi.org/10.1007/s00424-022-02679-7","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"93 1","pages":"365 - 366"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74749152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Triclosan is a KCNQ3 potassium channel activator 三氯生是KCNQ3钾通道活化剂
Pflügers Archiv - European Journal of Physiology Pub Date : 2021-10-01 DOI: 10.1101/2021.09.30.462664
Victor De la Rosa, M. Guzmán-Hernández, Elisa Carrillo
{"title":"Triclosan is a KCNQ3 potassium channel activator","authors":"Victor De la Rosa, M. Guzmán-Hernández, Elisa Carrillo","doi":"10.1101/2021.09.30.462664","DOIUrl":"https://doi.org/10.1101/2021.09.30.462664","url":null,"abstract":"KCNQ channels participate in the physiology of several cell types. In neurons of the central nervous system, the primary subunits are KCNQ2, 3, and 5. Activation of these channels silence the neurons, limiting action potential duration and preventing high-frequency action potential burst. Loss-of-function mutations of the KCNQ channels are associated with a wide spectrum of phenotypes characterized by hyperexcitability. Hence, pharmacological activation of these channels is an attractive strategy to treat epilepsy and other hyperexcitability conditions as are the evolution of stroke and traumatic brain injury. In this work we show that triclosan, a bactericide widely used in personal care products, activates the KCNQ3 channels but not the KCNQ2. Triclosan induces a voltage shift in the activation, increases the conductance, and slows the closing of the channel. The response is independent of PIP2. Molecular docking simulations together with site-directed mutagenesis suggest that the putative binding site is in the voltage sensor domain. Our results indicate that triclosan is a new activator for KCNQ channels.","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"71 1","pages":"721 - 732"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77848888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Gerhard Giebisch (1927–2020): a pioneer of kidney physiology 格哈德·吉比希(1927-2020):肾脏生理学的先驱
Pflügers Archiv - European Journal of Physiology Pub Date : 2020-06-01 DOI: 10.1007/s00424-020-02409-x
H. Murer, Carsten A. Wagner
{"title":"Gerhard Giebisch (1927–2020): a pioneer of kidney physiology","authors":"H. Murer, Carsten A. Wagner","doi":"10.1007/s00424-020-02409-x","DOIUrl":"https://doi.org/10.1007/s00424-020-02409-x","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"69 1","pages":"637 - 638"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84317439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of skeletal muscle IL-6 on subcutaneous and visceral adipose tissue metabolism immediately after high- and moderate-intensity exercises 高强度和中等强度运动后骨骼肌IL-6对皮下和内脏脂肪组织代谢的影响
Pflügers Archiv - European Journal of Physiology Pub Date : 2019-11-28 DOI: 10.1007/s00424-019-02332-w
Lærke Bertholdt, Anders Gudiksen, S. Ringholm, H. Pilegaard
{"title":"Impact of skeletal muscle IL-6 on subcutaneous and visceral adipose tissue metabolism immediately after high- and moderate-intensity exercises","authors":"Lærke Bertholdt, Anders Gudiksen, S. Ringholm, H. Pilegaard","doi":"10.1007/s00424-019-02332-w","DOIUrl":"https://doi.org/10.1007/s00424-019-02332-w","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"1 1","pages":"217 - 233"},"PeriodicalIF":0.0,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82380008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Now a Nobel gas: oxygen 现在来看看诺贝尔气体:氧
Pflügers Archiv - European Journal of Physiology Pub Date : 2019-11-22 DOI: 10.1007/s00424-019-02334-8
J. Fandrey, J. Schödel, K. Eckardt, D. Katschinski, Roland H. Wenger
{"title":"Now a Nobel gas: oxygen","authors":"J. Fandrey, J. Schödel, K. Eckardt, D. Katschinski, Roland H. Wenger","doi":"10.1007/s00424-019-02334-8","DOIUrl":"https://doi.org/10.1007/s00424-019-02334-8","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"126 1","pages":"1343 - 1358"},"PeriodicalIF":0.0,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76701553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 36
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