{"title":"Investigation Of Structure-Activity Relationships With Molecular Docking For Some Antiepileptic Drugs And Voltage-Gated Calcium (CaV) Channels","authors":"E. Çakmak, M. Gür, B. Kiran","doi":"10.55385/kastamonujes.1094129","DOIUrl":"https://doi.org/10.55385/kastamonujes.1094129","url":null,"abstract":"In the study, the active drugs molecules used in the treatment of convulsive seizures occurring in epilepsy disease were used. These molecules; Vigabatrin, Lokosamidin, Zonisamide, Oxcarbazepine, Levetiracetam, Tiagabin, Topiramate, Lamotrigine, Gabapentin, Felbamate, Ethosuximide, Valproic Acid, Mesuximide, Ethotoin, Primidone, Trimethadion, Phenytoin, Remasemide, Mephenytoin. These molecules have been selected considering the physiopathological mechanisms of action of epilepsy. Since the selected molecules are used as a potential antiepileptic agent, they were deemed suitable for molecular insertion studies. In addition, voltage-gated calcium channels, which play an important role in epilepsy, are emphasized. Voltage-gated calcium channels (CaV) act by providing the flow of Ca+ ions during the action potential that triggers seizure formation, and among the ten subtypes of voltage-gated calcium (CaV) channels, CaV3.1- CaV3.3, T-type or abnormal activities are associated with epilepsy, psychiatric form the associated low-voltage-activated subfamily. For this reason, the PDB ID: 6KZP receptor, which acts as an antagonist according to its activity on the channel in the formation of epileptic seizures, was chosen for the molecular insertion study. As a result of molecular placement studies; Oxcarbazepine and Phenytoin gave the best binding affinity for 6KZP with a value of -7.5 kcal/mol. Other results are in descending order (in kcal/mol); Tiagabine (-7.4), Mesuximide (-7.3), Primidone (-7.1), Remasemide (-7.0), Topiramate (-6.9) Mephenytoin (-6.7), Lomotrigine and Ethotoin (-6.4), Locosamide and Zonisamide (-6.1) , Felbamate (-6.0), Levetiracetam and Gabapentin (-5.4), Esuximide (-5.1), Valproic Acid (-4.9), Trimethadione (-4.7), Vigabatrin (-4.4) determined as.","PeriodicalId":197560,"journal":{"name":"Kastamonu University Journal of Engineering and Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133799068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Determining the Biocomfort Zones in Near Future in Antalya Province Depending on the Global Climate Change Scenarios","authors":"Ismail Koc","doi":"10.55385/kastamonujes.1091122","DOIUrl":"https://doi.org/10.55385/kastamonujes.1091122","url":null,"abstract":"Climate is a factor that affects the entire life of humans such as physiological development and characteristics, housing and house structures, food and cloth selections, and distribution on land. It is projected that global climate change would cause important changes in climate parameters in near future and affect the lives of all organisms on the earth directly or indirectly. It is estimated that these changes would cause significant changes in biocomfort zones. Thus, it is important to determine the biocomfort zones depending on the climate change scenarios and to use them in urban planning studies. In this study, it was aimed to determine the change in bioclimatic comfort zones in Antalya depending on the projected climate change scenarios. Within the scope of this study, considering the SSPs 245 and SSPs 585 scenarios of Coupled Model Intercomparison Project Phase 6, that is the 6th assessment report of IPCC, it was aimed to determine the current status and possible changes in biocomfort zones in Antalya in years 2040, 2060, 2080, and 2100. The results showed that the comfort zones in Antalya will generally shift from cold to hot towards the year 2100, that this shift will be at important level, and that the highest level of increase will be seen in southern regions with high population density and intense touristic activities.","PeriodicalId":197560,"journal":{"name":"Kastamonu University Journal of Engineering and Sciences","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134324519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SAMSUN KENT MERKEZİNDE YETİŞEN BAZI BİTKİLERDE B ve Ag KONSANTRASYONLARININ TRAFİK YOĞUNLUĞUNA BAĞLI DEĞİŞİMİ","authors":"İlknur ZEREN ÇETİN","doi":"10.55385/kastamonujes.1093979","DOIUrl":"https://doi.org/10.55385/kastamonujes.1093979","url":null,"abstract":"Artan nüfus ve sanayileşme, hava kirliliğini de beraberinde getirmiş, hava kirliliği bazı şehirlerde insan sağlığını tehdit edecek düzeyde artmış ve günümüzün en önemli gündem konularından birisi haline gelmiştir. Kent içerisinde egzoz gazları, araba tekerleri, araçlar ve araç aşınmalarından kaynaklanan pek çok kirletici madde ortaya çıkmaktadır. Bunlar arasında özellikle ağır metaller büyük öneme sahiptir. Zira ağır metaller doğada bozulmadan uzun süre kalabilmekte ve çevredeki konsantrasyonu da sürekli artmaktadır. Ayrıca biyobirikme eğilimindedir. Bundan dolayı ağır metal konsantrasyonunun belirlenmesi, riskli bölgelerin ve risk düzeyinin tespit edilmesi açısından büyük öneme sahiptir. Ağır metal kirliliğinin atmosferdeki konsantrasyonunun değişimini gösteren en önemli belirteçler biyomonitörlerdir. Bu çalışmada da trafik kaynaklı ağır metal konsantrasyonunun izlenmesinde kullanılabilen Eonymus japonica (Ej), Juniperus sabina (Js) ve Buxus sempervirens (Bs) türlerinde B ve Ag elementlerin konsantrasyonlarının organ bazında yıkama durumu ve trafik yoğunluğuna bağlı değişimi belirlenmeye çalışılmıştır. Çalışma kapsamında çalışmaya konu bitki türlerinin, trafiğin yoğun olduğu, az yoğun olduğu ve trafiğin bulunmadığı alanlarda yetişen bireylerinden yaprak ve dal örnekleri toplanmış, örneklerin bir kısmında yıkama işlemi gerçekleştirilmiş ve hazırlanan örneklerde ağır metal analizleri yapılarak B ve Ag elementlerinin konsantrasyonları belirlenmiştir. Çalışma sonucunda farklı türlerin ağır metalleri farklı düzeyde biriktirdiği, elementlerin konsantrasyonlarındaki değişimin de tür bazında organ ve trafik yoğunluğuna bağlı olarak değişiklik gösterdiği belirlenmiştir.","PeriodicalId":197560,"journal":{"name":"Kastamonu University Journal of Engineering and Sciences","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125518458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}