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SARS-CoV-2 variant identification using a genome tiling array and genotyping probes. 利用基因组拼接阵列和基因分型探针鉴定SARS-CoV-2变异。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2023-01-01 DOI: 10.2217/pme-2022-0013
Ryota Shimada, Emily N Alden, Kendall Hoff, Xun Ding, Jiayi Sun, Adam M Halasz, Wei Zhou, Jeremy S Edwards
{"title":"SARS-CoV-2 variant identification using a genome tiling array and genotyping probes.","authors":"Ryota Shimada,&nbsp;Emily N Alden,&nbsp;Kendall Hoff,&nbsp;Xun Ding,&nbsp;Jiayi Sun,&nbsp;Adam M Halasz,&nbsp;Wei Zhou,&nbsp;Jeremy S Edwards","doi":"10.2217/pme-2022-0013","DOIUrl":"https://doi.org/10.2217/pme-2022-0013","url":null,"abstract":"<p><p>With over 5.5 million deaths worldwide attributed to the respiratory disease COVID-19 caused by the novel coronavirus SARS-CoV-2, it is essential that continued efforts be made to track the evolution and spread of the virus globally. The authors previously presented a rapid and cost-effective method to sequence the entire SARS-CoV-2 genome with 95% coverage and 99.9% accuracy. This method is advantageous for identifying and tracking variants in the SARS-CoV-2 genome compared with traditional short-read sequencing methods which can be time-consuming and costly. Herein, the addition of genotyping probes to a DNA chip that targets known SARS-CoV-2 variants is presented. The incorporation of genotyping probe sets along with the advent of a moving average filter improved the sequencing coverage and accuracy of the SARS-CoV-2 genome.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"20 1","pages":"13-25"},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350312/pdf/nihms-1907630.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9780379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Knowledge, attitudes and practice regarding pharmacovigilance and adverse drug reaction reporting among physicians and pharmacists in Egypt: a step toward personalized medicine implementation. 埃及医生和药剂师关于药物警戒和药物不良反应报告的知识、态度和做法:向个性化医疗实施迈出的一步。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-11-01 Epub Date: 2022-10-14 DOI: 10.2217/pme-2022-0030
Alaa Abdel Aziz, Sara Rogers, Omneya Hassanien, Lobna Shalaby, Mohamed Nagy
{"title":"Knowledge, attitudes and practice regarding pharmacovigilance and adverse drug reaction reporting among physicians and pharmacists in Egypt: a step toward personalized medicine implementation.","authors":"Alaa Abdel Aziz,&nbsp;Sara Rogers,&nbsp;Omneya Hassanien,&nbsp;Lobna Shalaby,&nbsp;Mohamed Nagy","doi":"10.2217/pme-2022-0030","DOIUrl":"https://doi.org/10.2217/pme-2022-0030","url":null,"abstract":"<p><p><b>Aim:</b> To assess the knowledge, attitudes, and practices of the healthcare professionals working at Children's Cancer Hospital Egypt regarding pharmacovigilance (PV) and adverse drug reaction (ADR) reporting, in addition to the ADR reporting barriers. <b>Materials & methods:</b> A cross-sectional study was conducted at Children's Cancer Hospital Egypt from July to September 2021 using a validated questionnaire. <b>Results:</b> About 37 physicians (20.3%) and 145 pharmacists (79.7%) responded to the survey. Overall, the knowledge (median: 40%) and practice (median: 50%) of PV and the reporting of ADRs were low; however, attitudes were mostly positive. The main barrier to reporting ADRs was The difficulty of determining whether or not ADRs occurred (42.3%). <b>Conclusion:</b> Understanding of PV and ADR reporting could improve the huge gap between ADRs experienced and ADRs reported. In order to be able to assess the impact of personalized medicine implementation, adequate ADR reporting should be well established.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":"495-507"},"PeriodicalIF":2.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33512316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical geneticists, genetic diseases and services in Brazil in the age of personalized medicine. 医学遗传学家，遗传疾病和服务在巴西的个性化医疗时代。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-11-01 DOI: 10.2217/pme-2021-0153
Carolina Bonilla, Vinicius Albuquerque Sortica, Lavinia Schuler-Faccini, Alicia Matijasevich, Mário C Scheffer
{"title":"Medical geneticists, genetic diseases and services in Brazil in the age of personalized medicine.","authors":"Carolina Bonilla,&nbsp;Vinicius Albuquerque Sortica,&nbsp;Lavinia Schuler-Faccini,&nbsp;Alicia Matijasevich,&nbsp;Mário C Scheffer","doi":"10.2217/pme-2021-0153","DOIUrl":"https://doi.org/10.2217/pme-2021-0153","url":null,"abstract":"<p><p><b>Aim:</b> In anticipation of the implementation of personalized medicine in Brazil the authors assessed the characteristics of its medical genetics workforce together with the distribution of genetic diseases and services across the country. <b>Materials & methods:</b> The authors used demographic data on medical specialties, and summarized data from the public and private healthcare systems on live births, hospitalization and mortality, for the years 2019 and 2020. <b>Results:</b> The distribution of medical geneticists (MGs) overlapped the country-wide distribution of genetic diseases and services examined, indicating that ∼30% of the patient population has access to a MG specialist. Graduate specialism in medical genetics, registered MGs and suitable workplaces were concentrated in the south and southeast regions, leaving the north and northeast deeply underserved. <b>Conclusion:</b> MGs are concentrated in the wealthiest and most populated areas, while other regions have very limited services. These inequalities should be addressed for a successful transition to personalized medicine.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":"549-563"},"PeriodicalIF":2.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40674377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
miR-516a-3P, a potential circulating biomarker in hepatocellular carcinoma, correlated with rs738409 polymorphism in PNPLA3. miR-516a-3P是肝细胞癌中一种潜在的循环生物标志物，与PNPLA3中rs738409多态性相关。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-11-01 Epub Date: 2022-10-14 DOI: 10.2217/pme-2022-0005
Samar Samir Youssef, Rana Ahmed Youness, Eman Abd El-Razek Abbas, Noha Mohamed Osman, Asmaa ELFiky, Mohamed El-Kassas
{"title":"miR-516a-3P, a potential circulating biomarker in hepatocellular carcinoma, correlated with <i>rs738409</i> polymorphism in <i>PNPLA3</i>.","authors":"Samar Samir Youssef,&nbsp;Rana Ahmed Youness,&nbsp;Eman Abd El-Razek Abbas,&nbsp;Noha Mohamed Osman,&nbsp;Asmaa ELFiky,&nbsp;Mohamed El-Kassas","doi":"10.2217/pme-2022-0005","DOIUrl":"https://doi.org/10.2217/pme-2022-0005","url":null,"abstract":"<p><p><b>Aim:</b> The aim was to investigate the expression profile of miR-516a-3P and its correlation with the <i>PNPLA3</i> <i>rs738409</i> polymorphism in Egyptian hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) patients. <b>Materials & methods:</b> miR-516a-3P was quantified and <i>rs738409</i> was genotyped by quantitative reverse transcription PCR. <b>Results:</b> miR-516a-3P was significantly upregulated in HCC patients compared with HCV patients (p = 0.001). Receiver operating characteristic curve analysis confirmed that miR-516a-3P discriminates HCC from HCV (p = 0.001). A significant (p = 0.015) correlation between miR-516a-3p level and <i>PNPLA3</i> <i>rs738409</i> genotypes was recorded in HCV patients, yet it was not recorded in either healthy individuals or HCC patients. miR-516a-3p level was significantly (p = 0.001) higher in HCV patients carrying the <i>rs738409 GG</i> genotype than in those carrying the <i>CC</i> genotype. <b>Conclusion:</b> miR-516a-3P is a potential biomarker in HCC. <i>PNPLA3</i> <i>rs738409</i> <i>GG</i> carriers affect miR-516a-3P expression in HCV, and this may highlight a new mechanism in liver disease.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":"483-493"},"PeriodicalIF":2.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33510686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Whole-exome sequencing reveals novel variants associated with abnormal uterine bleeding caused by copper intrauterine device. 全外显子组测序揭示了与铜质宫内节育器引起的异常子宫出血相关的新变异。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-11-01 Epub Date: 2022-10-17 DOI: 10.2217/pme-2022-0060
Yupei Shen, Xiaoli Liu, Linfen Xu, Weiqiang Zhu, Zhaofeng Zhang, Junwei Liu, Lifang Jiang, Yanyan Mao, Jianhua Xu, Xiaoqin Yan, Junjie Sun, Fang Liu, Xiumei Xiong, Xiujuan Chen, Yan Che, Jing Du
{"title":"Whole-exome sequencing reveals novel variants associated with abnormal uterine bleeding caused by copper intrauterine device.","authors":"Yupei Shen,&nbsp;Xiaoli Liu,&nbsp;Linfen Xu,&nbsp;Weiqiang Zhu,&nbsp;Zhaofeng Zhang,&nbsp;Junwei Liu,&nbsp;Lifang Jiang,&nbsp;Yanyan Mao,&nbsp;Jianhua Xu,&nbsp;Xiaoqin Yan,&nbsp;Junjie Sun,&nbsp;Fang Liu,&nbsp;Xiumei Xiong,&nbsp;Xiujuan Chen,&nbsp;Yan Che,&nbsp;Jing Du","doi":"10.2217/pme-2022-0060","DOIUrl":"https://doi.org/10.2217/pme-2022-0060","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to explore the genetic risk factors and validate variants of abnormal uterine bleeding after copper intrauterine device insertion. <b>Methods:</b> Whole-exome sequencing was performed and several variants were validated by Sequenom MassARRAY. <b>Results:</b> Eight variants showed potential clinical damage according to American College of Medical Genetics and Genomics criteria. By combined analysis of screening and validation, <i>NFASC</i> <i>RS2802808</i> <i>C>G</i> p.Ile971Met (P<sub>allele</sub> = 0.009 and P<sub>genotype</sub> = 0.027) and <i>PIGR</i> <i>RS2275531</i> <i>C>T</i> p.Gly365Ser (P<sub>allele</sub> = 0.009 and P<sub>genotype</sub> = 0.013) variants were identified as significantly associated with abnormal uterine bleeding with a false discovery rate <0.05. <i>NFASC</i> and <i>PIGR</i> may play a role in abnormal uterine bleeding by regulating coagulation fibrinolysis and endometrial epithelium inflammation functions. <b>Conclusion:</b> These findings provide a genetic basis for clinical individualization and precision of intrauterine device implantation.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":"523-534"},"PeriodicalIF":2.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33519401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preferences for pharmacogenomic testing in polypharmacy patients: a discrete choice experiment. 多重用药患者对药物基因组学检测的偏好：离散选择实验。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-11-01 DOI: 10.2217/pme-2022-0056
Cheng Chen, Melissa H Roberts, Dennis W Raisch, Todd A Thompson, Amy Bachyrycz, Matthew E Borrego
{"title":"Preferences for pharmacogenomic testing in polypharmacy patients: a discrete choice experiment.","authors":"Cheng Chen, Melissa H Roberts, Dennis W Raisch, Todd A Thompson, Amy Bachyrycz, Matthew E Borrego","doi":"10.2217/pme-2022-0056","DOIUrl":"10.2217/pme-2022-0056","url":null,"abstract":"<p><p><b>Aim:</b> To elicit preferences for pharmacogenomic (PGx) testing in polypharmacy patients. <b>Materials & methods:</b> A face-to-face discrete choice experiment survey was designed and administered to adult polypharmacy patients recruited at a local retail pharmacy in Albuquerque (NM, USA). <b>Results:</b> A total of 128 eligible polypharmacy patients completed the discrete choice experiment survey and significantly preferred a PGx test with lower cost, better confidentiality and higher certainty of identifying best medication/dose and side effects and one that can be used to advocate for their treatment needs (all p < 0.01). <b>Conclusion:</b> This is the first study eliciting preferences for PGx testing among polypharmacy patients. The study found most polypharmacy patients were willing to take a PGx test and their preferences were mostly influenced by test cost.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 6","pages":"535-548"},"PeriodicalIF":2.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10859042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10828352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, attitudes and practices of Egyptian healthcare professionals toward therapeutic drug monitoring service as a principal component of personalized medicine. 知识，态度和做法，埃及卫生保健专业人员对治疗药物监测服务作为个性化医疗的主要组成部分。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-10-26 DOI: 10.2217/pme-2022-0031
S. Hassan, Omneya Hassanain, S. Kamal, L. Shalaby, M. Nagy
{"title":"Knowledge, attitudes and practices of Egyptian healthcare professionals toward therapeutic drug monitoring service as a principal component of personalized medicine.","authors":"S. Hassan, Omneya Hassanain, S. Kamal, L. Shalaby, M. Nagy","doi":"10.2217/pme-2022-0031","DOIUrl":"https://doi.org/10.2217/pme-2022-0031","url":null,"abstract":"Aim: To assess pharmacists' and physicians' knowledge, attitudes and practices toward therapeutic drug monitoring (TDM) service at the Children's Cancer Hospital Egypt 57357. Materials & methods: This was a single-site cross-sectional study where all practicing pharmacists and physicians were eligible to participate. Results: A statistically significant difference in the knowledge scores between pharmacists and physicians (p = 0.022) was found. In general, attitudes toward TDM among pharmacists and physicians were positive. Regarding practices, pharmacists were more likely than physicians to agree or strongly agree that they have studied some scientific references on TDM (p = 0.034), but more physicians recommend the TDM service (p = 0.046). Conclusion: A multidisciplinary educational program in Egypt for TDM for both medicine and pharmacy staff will improve interprofessional collaboration in the clinical setting, leading to better personalized medication management.","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42598508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Conference Report: NHGRI Research Training and Career Development Annual Meeting. 会议报告:NHGRI研究培训与职业发展年会。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-10-18 DOI: 10.2217/pme-2022-0095
S. Haga
{"title":"Conference Report: NHGRI Research Training and Career Development Annual Meeting.","authors":"S. Haga","doi":"10.2217/pme-2022-0095","DOIUrl":"https://doi.org/10.2217/pme-2022-0095","url":null,"abstract":"Since 2016, the National Human Genome Research Institute of the US NIH has convened a meeting for their trainees. Training programs supported by the Institute are located throughout the US and provide funding to trainees from the undergraduate to the postdoctoral and junior faculty levels. The annual training meeting provides trainees with a novel opportunity to network, learn about a wide range of genomic research and gain skills and information to support their educational and career path in genomic research. The pandemic forced a transition to virtual meetings in 2020 and 2021, but the 2022 meeting was convened as a hybrid format, with 383 attendees (59% in-person) in Durham, NC, US.","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42714121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guanylyl cyclase C as a diagnostic and therapeutic target in colorectal cancer. 作为结直肠癌诊断和治疗靶点的鸟苷酸环化酶 C。
IF 1.7 4区 医学
Personalized medicine Pub Date : 2022-09-01 Epub Date: 2022-08-03 DOI: 10.2217/pme-2022-0026
Adi Caspi, Ariana A Entezari, Madison Crutcher, Adam E Snook, Scott A Waldman
{"title":"Guanylyl cyclase C as a diagnostic and therapeutic target in colorectal cancer.","authors":"Adi Caspi, Ariana A Entezari, Madison Crutcher, Adam E Snook, Scott A Waldman","doi":"10.2217/pme-2022-0026","DOIUrl":"10.2217/pme-2022-0026","url":null,"abstract":"<p><p>Colorectal cancer remains a major cause of mortality in the USA, despite advances in prevention and screening. Existing therapies focus primarily on generic treatment such as surgical intervention and chemotherapy, depending on disease severity. As personalized medicine and targeted molecular oncology continue to develop as promising treatment avenues, there has emerged a need for effective targets and biomarkers of colorectal cancer. The transmembrane receptor guanylyl cyclase C (GUCY2C) regulates intestinal homeostasis and has emerged as a tumor suppressor. Further, it is universally expressed in advanced metastatic colorectal tumors, as well as other cancer types that arise through intestinal metaplasia. In this context, GUCY2C satisfies many characteristics of a compelling target and biomarker for gastrointestinal malignancies.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 5","pages":"457-472"},"PeriodicalIF":1.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40577583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 telehealth preparedness: a cross-sectional assessment of cardiology practices in the USA. COVID-19远程医疗准备:美国心脏病学实践的横断面评估
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-09-01 Epub Date: 2022-08-01 DOI: 10.2217/pme-2021-0179
Carly E Waldman, Jean H Min, Heba Wassif, Andrew M Freeman, Anne K Rzeszut, Jack Reilly, Paul Theriot, Ahmed M Soliman, Ritu Thamman, Ami Bhatt, Sanjeev P Bhavnani
{"title":"COVID-19 telehealth preparedness: a cross-sectional assessment of cardiology practices in the USA.","authors":"Carly E Waldman,&nbsp;Jean H Min,&nbsp;Heba Wassif,&nbsp;Andrew M Freeman,&nbsp;Anne K Rzeszut,&nbsp;Jack Reilly,&nbsp;Paul Theriot,&nbsp;Ahmed M Soliman,&nbsp;Ritu Thamman,&nbsp;Ami Bhatt,&nbsp;Sanjeev P Bhavnani","doi":"10.2217/pme-2021-0179","DOIUrl":"https://doi.org/10.2217/pme-2021-0179","url":null,"abstract":"<p><p><b>Aim:</b> The COVID-19 pandemic forced medical practices to augment healthcare delivery to remote and virtual services. We describe the results of a nationwide survey of cardiovascular professionals regarding telehealth perspectives. <b>Materials & methods:</b> A 31-question survey was sent early in the pandemic to assess the impact of COVID-19 on telehealth adoption & reimbursement. <b>Results:</b> A total of 342 clinicians across 42 states participated. 77% were using telehealth, with the majority initiating usage 2 months after the COVID-19 shutdown. A variety of video-based systems were used. Telehealth integration requirements differed, with electronic medical record integration being mandated in more urban than rural practices (70 vs 59%; p < 0.005). Many implementation barriers surfaced, with over 75% of respondents emphasizing reimbursement uncertainty and concerns for telehealth generalizability given the complexity of cardiovascular diseases. <b>Conclusion:</b> Substantial variation exists in telehealth practices. Further studies and legislation are needed to improve access, reimbursement and the quality of telehealth-based cardiovascular care.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 5","pages":"411-422"},"PeriodicalIF":2.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40672906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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