Patient Related Outcome Measures最新文献

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RE: Health Workers' Practice Towards Smoking Cessation Intervention Based on 5A's Model and Associated Factors in Public Hospitals, Hadiya Zone, Southern Ethiopia [Letter]. RE:埃塞俄比亚南部Hadiya区公立医院卫生工作者戒烟干预的5A模型及相关因素分析[Letter]。
IF 2.1
Patient Related Outcome Measures Pub Date : 2021-10-11 eCollection Date: 2021-01-01 DOI: 10.2147/PROM.S341524
Navandeep Kaur Thumber, Prerana Bhandari
{"title":"RE: Health Workers' Practice Towards Smoking Cessation Intervention Based on 5A's Model and Associated Factors in Public Hospitals, Hadiya Zone, Southern Ethiopia [Letter].","authors":"Navandeep Kaur Thumber, Prerana Bhandari","doi":"10.2147/PROM.S341524","DOIUrl":"https://doi.org/10.2147/PROM.S341524","url":null,"abstract":"","PeriodicalId":19747,"journal":{"name":"Patient Related Outcome Measures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/0e/prom-12-313.PMC8524260.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39560469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of PROMIS® in an Optometry Clinic. PROMIS®在验光诊所的实施。
IF 2.1
Patient Related Outcome Measures Pub Date : 2021-10-07 DOI: 10.2147/PROM.S329345
Randall S Porter, Kathleen Holt, Rajeev S Ramchandran
{"title":"Implementation of PROMIS<sup>®</sup> in an Optometry Clinic.","authors":"Randall S Porter,&nbsp;Kathleen Holt,&nbsp;Rajeev S Ramchandran","doi":"10.2147/PROM.S329345","DOIUrl":"10.2147/PROM.S329345","url":null,"abstract":"<p><strong>Purpose: </strong>The full utility of general health Patient-Reported Outcomes Measurement Information System<sup>®</sup> (PROMIS) surveys in the eye care setting has not been previously demonstrated. This report demonstrates the feasibility of implementing PROMIS in an eye care clinic.</p><p><strong>Patients and methods: </strong>Over 2 months, general health and functioning PROMIS surveys were offered to all patients in an optometric clinic in Rochester, NY. Demographic and clinical variables were recorded along with percent completion and time to completion of the survey.</p><p><strong>Results: </strong>Across 651 patients, 258 chose to attempt PROMIS. Patients with low visual acuity were less likely to attempt the survey (<i>p</i>=0.049), and younger patients were more likely to complete the survey (<i>p</i>=0.025); no other patient characteristics were found to differ between those who did and did not participate in, nor complete, PROMIS. A total of 193 patients completed the survey (74.8%) in a mean time of 6.36 minutes (range = [1.43, 51.92] minutes; standard deviation = 5.62 minutes). Time to completion did not vary significantly across any groups.</p><p><strong>Conclusion: </strong>Our relatively high completion rate among those who attempted PROMIS indicates that PROMIS surveys are feasible to implement in an optometry clinic. While most patients completed the survey in little time, the large range of time to completion may indicate that some patients had difficulty completing the survey. Furthermore, the significant difference in visual acuity between those who participated in the survey and those who did not highlights the need to address the way PROMIS is delivered in order to foster greater inclusion.</p>","PeriodicalId":19747,"journal":{"name":"Patient Related Outcome Measures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/69/prom-12-307.PMC8504709.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39538964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Minimal Clinically Important Differences (MCID) for the Western Ontario Osteoarthritis of the Shoulder Index (WOOS) and the Oxford Shoulder Score (OSS). 西安大略骨关节炎肩关节指数(WOOS)和牛津肩关节评分(OSS)的最小临床重要差异(MCID)。
IF 2.1
Patient Related Outcome Measures Pub Date : 2021-09-22 eCollection Date: 2021-01-01 DOI: 10.2147/PROM.S316920
Marc Randall Kristensen Nyring, Bo Sanderhoff Olsen, Alexander Amundsen, Jeppe Vejlgaard Rasmussen
{"title":"Minimal Clinically Important Differences (MCID) for the Western Ontario Osteoarthritis of the Shoulder Index (WOOS) and the Oxford Shoulder Score (OSS).","authors":"Marc Randall Kristensen Nyring,&nbsp;Bo Sanderhoff Olsen,&nbsp;Alexander Amundsen,&nbsp;Jeppe Vejlgaard Rasmussen","doi":"10.2147/PROM.S316920","DOIUrl":"https://doi.org/10.2147/PROM.S316920","url":null,"abstract":"<p><strong>Background: </strong>The minimal clinically important difference (MCID) is an important instrument in the interpretation of changes in patient-reported outcome measures (PROM). To our knowledge, no MCID of the Western Ontario Osteoarthritis of the Shoulder Index (WOOS) score has ever been reported and no studies have reported an MCID for the Oxford Shoulder Score (OSS) based on patients with glenohumeral osteoarthritis, treated with an anatomical total shoulder arthroplasty (aTSA). The aim of this study was to determine MCID for WOOS and OSS in a cohort of patients with glenohumeral osteoarthritis treated with an aTSA.</p><p><strong>Methods: </strong>All patients treated with an aTSA for glenohumeral osteoarthritis at our institution between March 2017 and February 2019 were included. Each patient completed the WOOS and the OSS preoperatively and one year postoperatively. At one year, the patients were asked to rate their overall improvement on a 7-point scale. We used an anchor-based method as our primary method to calculate the MCID, supported by two different distribution-based methods.</p><p><strong>Results: </strong>A total of 45 primary aTSA were included. The MCID of WOOS was 12.3 according to the anchor-based method and 14.2 and 10.3 according to the two distribution-based methods. The MCID of OSS was 4.3 according to the anchor-based method and 5.8 and 4.3 according to the two distribution-based methods.</p><p><strong>Conclusion: </strong>The anchor-based method is considered superior to the distribution-based method, and therefore we advocate to use this as MCID. For patients with glenohumeral osteoarthritis treated with an aTSA, the MCID values were 12.3 points for WOOS and 4.3 points for OSS. To our knowledge, this is the first study to report a MCID value for WOOS and the first study to report a MCID value for OSS in this subgroup of patients.</p>","PeriodicalId":19747,"journal":{"name":"Patient Related Outcome Measures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/19/prom-12-299.PMC8473013.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39470749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Health Workers' Practice Towards Smoking Cessation Intervention Based on 5A's Model and Associated Factors in Public Hospitals, Hadiya Zone, Southern Ethiopia. 埃塞俄比亚南部Hadiya区公立医院卫生工作者基于5A模型的戒烟干预实践及相关因素
IF 2.1
Patient Related Outcome Measures Pub Date : 2021-09-16 eCollection Date: 2021-01-01 DOI: 10.2147/PROM.S322049
Temesgen Tamirat
{"title":"Health Workers' Practice Towards Smoking Cessation Intervention Based on 5A's Model and Associated Factors in Public Hospitals, Hadiya Zone, Southern Ethiopia.","authors":"Temesgen Tamirat","doi":"10.2147/PROM.S322049","DOIUrl":"https://doi.org/10.2147/PROM.S322049","url":null,"abstract":"<p><strong>Background: </strong>The tobacco pandemic is one of the world's most serious public health concerns, killing more than 8 million lives per year. The worst burden is in low- and middle-income countries. Unless appropriate action is taken, the burden may worsen. Health workers are among the actors to implement smoke cessation interventions. However, the level of intervention practices towards smoke cessation was not defined.</p><p><strong>Objective: </strong>To determine health workers' practice towards smoke cessation interventions based on 5A's model and associated factors in public hospitals.</p><p><strong>Methods: </strong>Facility-based cross-sectional design was used. All public hospitals found in the Hadiya zone were included in the study. From each public hospital, representative number of health workers, who fulfil inclusion criteria, were included in the study. A total of 323 sample size of health workers were used. A self-administered questionnaire was employed to collect data. Both descriptive and advanced analyses were performed using SPSS software version 20.0. In bivariable analysis, variables with p-value < 0.25 were considered for multivariable analysis. Finally, odds ratio with 95% CI and p-value < 0.05 were used to declare factors as significantly associated with the outcome variable.</p><p><strong>Results: </strong>About 97% of health care workers had poor practice on smoking cessation interventions. About 7.4% (23) health workers reported as they were current smokers. Moreover, only 28% of health workers asked their patients about smoking status. Being females, having <10 years of service, training and having good knowledge was significantly associated with the outcome variable.</p><p><strong>Conclusion: </strong>Majority of the healthcare workers surveyed did not provide smoking cessation interventions. Identified statistically significant factors with the practice of smoke cessation interventions in this study were sex, knowledge, training and service years. Therefore, strategies should be designed and implemented to improve and equip the health workers towards practising of smoke cessation interventions by instituting smoke cessation programs.</p>","PeriodicalId":19747,"journal":{"name":"Patient Related Outcome Measures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/a9/prom-12-291.PMC8453442.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39443497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Health-Related Quality of Life Among Heart Failure Patients Attending an Outpatient Clinic in the University of Gondar Comprehensive Specialized Hospital Northwest, Ethiopia, 2020: Using Structural Equation Modeling Approach. 埃塞俄比亚贡达尔大学西北综合专科医院门诊心力衰竭患者与健康相关的生活质量:使用结构方程建模方法
IF 2.1
Patient Related Outcome Measures Pub Date : 2021-08-28 eCollection Date: 2021-01-01 DOI: 10.2147/PROM.S322421
Gebrekidan Ewnetu Tarekegn, Lemma Derseh Gezie, Tilahun Yemanu Birhan, Frew Ewnetu
{"title":"Health-Related Quality of Life Among Heart Failure Patients Attending an Outpatient Clinic in the University of Gondar Comprehensive Specialized Hospital Northwest, Ethiopia, 2020: Using Structural Equation Modeling Approach.","authors":"Gebrekidan Ewnetu Tarekegn,&nbsp;Lemma Derseh Gezie,&nbsp;Tilahun Yemanu Birhan,&nbsp;Frew Ewnetu","doi":"10.2147/PROM.S322421","DOIUrl":"https://doi.org/10.2147/PROM.S322421","url":null,"abstract":"<p><strong>Background: </strong>Chronic heart failure is one of the most important public health concerns in the industrialized and developing world having increasing prevalence. Measuring quality of life using rigorous statistical methods may be helpful to provide input for decision-makers and the development of guidelines. This study aimed to assess health-related quality of life and associated factors among heart failure patients attending the University of Gondar Specialized Hospital.</p><p><strong>Methods: </strong>A cross-sectional study was employed to select 469 heart failure patients who have follow-up at the University of Gondar Specialized Hospital consecutively from March 01 to 30, 2020. Data were entered to Epi Info 7 and exported to STATA version 15 for further statistical analysis. The quality-of-life domains were measured with World Health Organization Quality of Life BREF. Structural equation modeling was employed to estimate the relationships among exogenous, mediating, and endogenous variables simultaneously.</p><p><strong>Results: </strong>Chronic heart failure patients had a significantly lower mean score in physical health domain (31.70 mean score), environmental health domain (38.35 mean score), and in overall quality of life domain (41.61 mean score) moderate in social relation domain (46.22 mean score), and in psychological health domain (50.21 mean score) of health-related quality of life (p-value <0.0001). Age had a direct positive effect on health-related quality of life. Residency also had a direct negative effect on both physical and environmental health-related quality of life domain. Duration of heart failure had a direct negative effect on psychological health.</p><p><strong>Conclusion: </strong>The finding of this study indicated that poor health-related quality of life in the physical health domain, moderately poor in overall health-related quality of life, and moderate health-related quality of life in the psychological health domain among Chronic heart failure patients. Age, residence, marital status, income, and duration of HF were significantly associated factors for quality of life among HF patients.</p>","PeriodicalId":19747,"journal":{"name":"Patient Related Outcome Measures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/49/prom-12-279.PMC8409769.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39403009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Incidence and Risk Factors of Emergence Delirium After Anesthesia in Elderly Patients at a Postanesthesia Care Unit in Ethiopia: Prospective Observational Study [Removal]. 埃塞俄比亚麻醉后护理病房老年患者麻醉后出现谵妄的发生率和危险因素:前瞻性观察研究[移除]。
IF 2.1
Patient Related Outcome Measures Pub Date : 2021-08-10 eCollection Date: 2021-01-01 DOI: 10.2147/PROM.S330479
{"title":"Incidence and Risk Factors of Emergence Delirium After Anesthesia in Elderly Patients at a Postanesthesia Care Unit in Ethiopia: Prospective Observational Study [Removal].","authors":"","doi":"10.2147/PROM.S330479","DOIUrl":"https://doi.org/10.2147/PROM.S330479","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.2147/PROM.S297871.].</p>","PeriodicalId":19747,"journal":{"name":"Patient Related Outcome Measures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/39/prom-12-277.PMC8383473.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39356004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacotherapy Pattern and Treatment Outcomes of Stroke Patients Admitted to Jimma University Medical Center, Ethiopia. 埃塞俄比亚吉马大学医学中心卒中患者的药物治疗模式和治疗效果
IF 2.1
Patient Related Outcome Measures Pub Date : 2021-08-07 eCollection Date: 2021-01-01 DOI: 10.2147/PROM.S307291
Nigatu Beyene, Korinan Fanta, Ramanjireddy Tatiparthi
{"title":"Pharmacotherapy Pattern and Treatment Outcomes of Stroke Patients Admitted to Jimma University Medical Center, Ethiopia.","authors":"Nigatu Beyene,&nbsp;Korinan Fanta,&nbsp;Ramanjireddy Tatiparthi","doi":"10.2147/PROM.S307291","DOIUrl":"https://doi.org/10.2147/PROM.S307291","url":null,"abstract":"<p><strong>Background: </strong>Despite the fact that stroke has been reported as one of the top three leading causes of death and morbidity in Ethiopia, there are limited data regarding the management of stroke and clinical outcomes. Hence, the present study aimed to evaluate the pharmacotherapy of stroke and factors associated with poor treatment outcomes.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted at Jimma University Medical Center (JUMC) among adult stroke patients managed from 2014 to 2017. Clinical characteristics, treatment, and outcomes data were analyzed by using SPSS version 21. Multivariable logistic regression was performed to identify the predictors of poor treatment outcomes. Two-sided P < 0.05 was accepted as statistically significant.</p><p><strong>Results: </strong>A total of 153 illegible patient cases were included in this study. The majority, 111 (72.5%), were male and the mean age of the patients was 57±13.7 years. Among 153 stroke patients, 112 (73.2%) patients presented with ischemic stroke. Aspirin and statins (78.6%) were the most commonly used treatment among ischemic stroke patients, whereas enalapril was used in about (43%) of stroke patients to treat high blood pressure. About 61 (40%) stroke patients had poor treatment outcomes; of this, 36 (23.5%) died in hospital. Older age (AOR = 1.034; 95% CI: 1.003-1.069), history of heart failure (AOR = 4.26; 95% CI: 1.58-11.48), loss of consciousness diabetes (AOR = 3.05 95% CI: 1.25-7.44), and aspiration pneumonia (AOR = 5.94; 95% CI: 2.46-14.32) were significantly associated with poor treatment outcomes.</p><p><strong>Conclusion: </strong>Overall, treatment of stroke patients was sub-optimal and almost half of the patients had poor treatment outcomes. Availing of thrombolytic therapy, devising appropriate preventive measures of risk factors (hypertension), and decreasing preventable complication such as aspiration pneumonia could improve patient outcomes.</p>","PeriodicalId":19747,"journal":{"name":"Patient Related Outcome Measures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/53/72/prom-12-267.PMC8357615.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39311862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Monitoring Severity of Respiratory Syncytial Virus (RSV) in Infants and Young Children Using the Pediatric RSV Electronic Severity and Outcome Rating System (PRESORS): Results of Initial Quantitative Validation. 使用儿科RSV电子严重程度和结局评分系统(PRESORS)监测婴幼儿呼吸道合胞病毒(RSV)严重程度:初步定量验证的结果
IF 2.1
Patient Related Outcome Measures Pub Date : 2021-07-23 eCollection Date: 2021-01-01 DOI: 10.2147/PROM.S298736
Christine de la Loge, Fatoumata Fofana, Paul Williams, Sarah Rusch, Marita Stevens, Jane Scott
{"title":"Monitoring Severity of Respiratory Syncytial Virus (RSV) in Infants and Young Children Using the Pediatric RSV Electronic Severity and Outcome Rating System (PRESORS): Results of Initial Quantitative Validation.","authors":"Christine de la Loge,&nbsp;Fatoumata Fofana,&nbsp;Paul Williams,&nbsp;Sarah Rusch,&nbsp;Marita Stevens,&nbsp;Jane Scott","doi":"10.2147/PROM.S298736","DOIUrl":"https://doi.org/10.2147/PROM.S298736","url":null,"abstract":"<p><strong>Purpose: </strong>PRESORS ClinRO completed by clinicians and ObsRO completed by caregivers were developed to characterize the clinical course of respiratory syncytial virus (RSV) infection. This study describes preliminary analysis of PRESORS' measurement properties using clinical trial data.</p><p><strong>Patients and methods: </strong>PRESORS ClinRO and ObsRO data were collected in a 28-day randomized, double-blind, Phase 1b trial of JNJ-53718678 or placebo in infants and children ≤24 months of age treated for RSV infection in hospitals. PRESORS data were scored and key psychometric properties of scores were evaluated, including ability to discriminate between known groups and to detect change over time. Time to resolution of RSV signs was explored using two responder definitions.</p><p><strong>Results: </strong>Daily completion rates for PRESORS ClinRO and ObsRO were high for the 44 children in the study (median: 100% and 93%, respectively). Large floor effects were observed at baseline for signs of severe RSV infection that were either absent (cyanosis, fever, apnea) or rarely reported (reduced urination/dehydration, vomiting). Implausible ObsRO ratings suggested some caregivers could not accurately measure heart rate. Known-group validity was confirmed: children in poor health based on baseline ClinRO had mean baseline composite scores that were significantly worse for both ObsRO (p=0.001) and ClinRO (p<0.001) compared to those with better overall health. ObsRO (p=0.009) and ClinRO (p<0.001) composite scores were responsive to change in overall health status from baseline to Day 3. Mean scores for RSV sign dimensions decreased rapidly from baseline to Day 7 except for coughing and sleep ratings by caregivers. Time to recovery varied greatly depending on definitions used.</p><p><strong>Conclusion: </strong>PRESORS ClinRO and ObsRO can inform endpoints and enable monitoring the clinical course of RSV in pediatric trials. Improved alignment between ClinRO and ObsRO and revisions ensuring caregivers can assess all signs will be addressed in revised PRESORS.</p>","PeriodicalId":19747,"journal":{"name":"Patient Related Outcome Measures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/60/87/prom-12-247.PMC8315813.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39257225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Eliciting Health State Utilities for Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency: A Vignette Study in France. 激发芳香族 L-Amino 酸脱羧酶 (AADC) 缺乏症的健康状态效用:法国小故事研究。
IF 2.1
Patient Related Outcome Measures Pub Date : 2021-07-12 eCollection Date: 2021-01-01 DOI: 10.2147/PROM.S306228
Adam B Smith, Andria Hanbury, Igor Beitia Ortiz de Zarate, Florence Hammes, Gerard de Pouvourville, Katharina Buesch
{"title":"Eliciting Health State Utilities for Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency: A Vignette Study in France.","authors":"Adam B Smith, Andria Hanbury, Igor Beitia Ortiz de Zarate, Florence Hammes, Gerard de Pouvourville, Katharina Buesch","doi":"10.2147/PROM.S306228","DOIUrl":"10.2147/PROM.S306228","url":null,"abstract":"<p><strong>Purpose: </strong>Health-related quality of life (HRQoL) is difficult to measure in rare diseases, especially in paediatric populations, yet capturing HRQoL is critical to evaluating treatment, including the cost-effectiveness of treatments. Given the ultra-rare nature of AADC deficiency indirect elicitation of HRQoL data through proxy caregiver/parent ratings is not feasible. In these circumstances, HRQoL data may be derived through vignette studies using the general population. The aim of the study was to generate health utility values specific for France for AADC deficiency using vignettes.</p><p><strong>Methods: </strong>The study was completed online by panel participants from a French representative sample. Five health state vignettes, reflecting key milestones in the eladocagene exuparvovec clinical trials and economic model, were presented to the participants: \"bedridden\", \"head control\", \"sitting unsupported\", \"standing with assistance\" and \"walking with assistance\". The vignettes had been previously developed with input from parents of patients with AADC deficiency, patients and expert opinion. Participants also completed the Health Utilities Index-3 for the \"bedridden\" health state.</p><p><strong>Results: </strong>A total of 1001 participants (51% females; mean age 46 years) completed the vignettes. Utilities increased linearly as the health state improved for both the time trade-off (TTO): 0.47 (standard deviation, SD 0.36) to 0.54 (SD 0.36) and standard gamble (SG): 0.61 (SD 0.29) to 0.67 (SD 0.27). A significant minority had incongruent responses (high utilities for the bedridden compared to walking health states) for the vignette (27%). When these were removed, the TTO health utilities (N=729) ranged from 0.39 (SD 0.36) to 0.56 (SD 0.38) and 0.61 (SD 0.30) to 0.69 (SD 0.27) for the SG.</p><p><strong>Conclusion: </strong>Health utilities were derived for AADC deficiency which will be used for a cost-effectiveness model of an AADC deficiency treatment.</p>","PeriodicalId":19747,"journal":{"name":"Patient Related Outcome Measures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/16/prom-12-237.PMC8285298.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39203179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indications, Outcome and Risk Factors of Cesarean Delivery Among Pregnant Women Utilizing Delivery Services at Selected Public Health Institutions, Oromia Region, South West Ethiopia. 埃塞俄比亚西南部奥罗米亚地区选定公共卫生机构分娩服务孕妇剖宫产的适应症、结果和危险因素
IF 2.1
Patient Related Outcome Measures Pub Date : 2021-07-07 eCollection Date: 2021-01-01 DOI: 10.2147/PROM.S304672
Belete G/Mariam, Temesgen Tilahun, Elias Merdassa, Desalew Tesema
{"title":"Indications, Outcome and Risk Factors of Cesarean Delivery Among Pregnant Women Utilizing Delivery Services at Selected Public Health Institutions, Oromia Region, South West Ethiopia.","authors":"Belete G/Mariam,&nbsp;Temesgen Tilahun,&nbsp;Elias Merdassa,&nbsp;Desalew Tesema","doi":"10.2147/PROM.S304672","DOIUrl":"https://doi.org/10.2147/PROM.S304672","url":null,"abstract":"<p><strong>Background: </strong>Approximately 10% of deliveries are considered as high risk, which may require cesarean section. Besides, a rise in cesarean section delivery is a real public health concern; cesareans are costly and carry 8-12 and 8 times higher feto-maternal morbidity and mortality, respectively, as compared to vaginal delivery. Like in other countries where unnecessary cesarean delivery is performed, it is also rising in our country, posing potential risk to the mothers and their newborns.</p><p><strong>Objective: </strong>To assess the indications and outcome of cesarean section delivery among pregnant women utilizing delivery services in selected hospitals.</p><p><strong>Methods: </strong>A case-control study design was used among 488 randomly selected pregnant women attending delivery services in Bedelle and Mettu-Kharl Hospitals. Data were collected by interviewer-administered questionnaire and entered into EPI-data version 3.1 and exported to SPSS version 20 for cleaning and analyses. Binary logistic regression analysis was used to control for possible confounders. Association was declared at 95% CI and <i>P</i>-value <0.05 to assess the association between dependent and independent variables. Variables with <i>P</i>-values <0.05 at bivariate analysis were entered to final logistic regression model.</p><p><strong>Results: </strong>Nearly 30% and 24.6% of fetuses had been exposed to unfavorable outcome among those delivered following cesarean and vaginal delivery, respectively. The mean age of study participants was 25.79 (SD 6.76) for mothers who underwent cesarean delivery and 24.76 (SD 4.956) for their counterparts. Unfavorable maternal outcome was experienced by 20.5% and 14.7% of pregnant women who gave birth by cesarean and vaginal delivery, respectively. Those not having antenatal care follow-up were five times more likely to encounter unfavorable outcome than attendees (AOR 5.22, 95% CI 1.85-14.69), while mothers of newborns with low 5th minute Apgar score were 3 times (AOR 2.96, 95% CI 1.07, 8.16), multi-parity 7 times (AOR 7.22, 95% CI 1.45, 36.05) and rural residence were 1.29 times (AOR 1.29, 95% CI 5.09, 12.88) more likely to develop unfavorable feto-maternal outcome.</p><p><strong>Conclusion: </strong>Vaginal delivery results in more favorable feto-maternal outcomes than does cesarean delivery.</p>","PeriodicalId":19747,"journal":{"name":"Patient Related Outcome Measures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/75/prom-12-227.PMC8274704.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39184195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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