Pediatric Hematology and Oncology最新文献

Premature treatment cessation in pediatric acute myeloid leukemia due to excessive toxicity: clinical experiences and patient outcomes - a case series. 儿童急性髓性白血病因毒性过大而过早停止治疗：临床经验和患者结果-一个病例系列。

IF 1.4 4区医学

Pediatric Hematology and Oncology Pub Date : 2026-10-19 DOI: 10.1080/08880018.2026.2742887

Coen van de Groep, Merlijn van Hamel, Noa Wijnen, Kim Klein, Bianca F Goemans, Michel Zwaan, Gertjan J L Kaspers

{"title":"Premature treatment cessation in pediatric acute myeloid leukemia due to excessive toxicity: clinical experiences and patient outcomes - a case series.","authors":"Coen van de Groep, Merlijn van Hamel, Noa Wijnen, Kim Klein, Bianca F Goemans, Michel Zwaan, Gertjan J L Kaspers","doi":"10.1080/08880018.2026.2742887","DOIUrl":"https://doi.org/10.1080/08880018.2026.2742887","url":null,"abstract":"Although survival in pediatric acute myeloid leukemia (AML) has improved over the past decades, intensive chemotherapy may be associated with severe and life-threatening toxicities. This case series describes pediatric AML patients in whom therapy was discontinued due to excessive toxicity. Patients were identified through a national database of two consecutive AML treatment protocols in the Netherlands (2010-2023). Seven patients were included; discontinuation of treatment was because of a severe fungal infection in five out of seven cases. Five out of seven patients had a favorable genetic profile; four harboring RUNX1::RUNX1T1 and one with a CEBPA-bZIP mutation. All seven patients remain in continuous complete remission with a median follow-up of 6,7 years. This case series shows that selected children with AML who discontinue chemotherapy early due to treatment-related toxicity may still achieve long-term survival and possibly cure. The high incidence of invasive fungal infections highlights a critical cause of treatment-limiting toxicity. This series could inform clinical practice in future similar cases.","PeriodicalId":19746,"journal":{"name":"Pediatric Hematology and Oncology","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: Horner Syndrome as a Complication of Neuroblastoma Treatment. 致编辑的信：霍纳综合征是神经母细胞瘤治疗的并发症。

IF 1.4 4区医学

Pediatric Hematology and Oncology Pub Date : 2026-09-01 Epub Date: 2026-07-21 DOI: 10.1080/08880018.2026.2703639

Burak Ardıçlı, Saniye Ekinci

引用次数: 0

Clinical and microbiological characteristics of viridans group streptococcal bacteremia in pediatric and adolescent patients with cancer. 儿童和青少年癌症患者翠绿组链球菌菌血症的临床和微生物学特征。

IF 1.4 4区医学

Pediatric Hematology and Oncology Pub Date : 2026-09-01 Epub Date: 2026-06-23 DOI: 10.1080/08880018.2026.2692081

Natsuko Yoshikawa, Suguru Uemura, Shinsuke Mizuno, Saki Tanaka, Natsumi Kikuchi, Nanako Nino, Aiko Kozaki, Atsuro Saito, Toshiaki Ishida, Takeshi Mori, Masashi Kasai, Daiichiro Hasegawa

{"title":"Clinical and microbiological characteristics of viridans group streptococcal bacteremia in pediatric and adolescent patients with cancer.","authors":"Natsuko Yoshikawa, Suguru Uemura, Shinsuke Mizuno, Saki Tanaka, Natsumi Kikuchi, Nanako Nino, Aiko Kozaki, Atsuro Saito, Toshiaki Ishida, Takeshi Mori, Masashi Kasai, Daiichiro Hasegawa","doi":"10.1080/08880018.2026.2692081","DOIUrl":"10.1080/08880018.2026.2692081","url":null,"abstract":"Viridans group streptococci (VGS) are an important cause of bacteremia inpediatric oncology patients and hematopoietic stem cell transplantation (HSCT) recipients, with the potential to viridans streptococcal shock syndrome (VSSS). Increasing β-lactam resistance has raised concerns about the adequacy of current empiric treatment strategies, which typically avoid routine glycopeptide use. We retrospectively analyzed 53 episodes of VGS bacteremia (VGSB) in 42 pediatric and adolescent patients who underwent chemotherapy or HSCT at Kobe Children's Hospital from May 2016 to August 2024. Clinical characteristics, antimicrobial susceptibility, inflammatory markers, and recurrence patterns were assessed. Acute myeloid leukemia (AML) accounted for 49% of episodes, and 60% occurred during cytarabine-containing chemotherapy. Seven patients experienced repeated episodes of VGSB-all with AML; among them, five developed cefepime resistance, and three showed a transition from susceptible to intermediate or resistant isolates during subsequent episodes. Cefepime susceptibility was 64%, whereas all isolates remained susceptible to vancomycin. Exposure to prophylactic antibiotics was significantly associated with the isolation of cefepime-intermediate or resistant strains (10/19 vs. 9/36, p = 0.03). Routine glycopeptide prophylaxis is not justified; however, our findings suggest that AML patients with recurrent VGSB or prior cefepime-nonsusceptible VGS may represent a high-risk subgroup for cefepime-nonsusceptible VGS infection. Further studies are needed to validate risk-adapted antimicrobial strategies in this population.","PeriodicalId":19746,"journal":{"name":"Pediatric Hematology and Oncology","volume":" ","pages":"307-318"},"PeriodicalIF":1.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromuscular Changes During the Six-Minute Walk Test in Pediatric Sickle Cell Disease. 小儿镰状细胞病6分钟步行试验中的神经肌肉变化

IF 1.4 4区医学

Pediatric Hematology and Oncology Pub Date : 2026-09-01 Epub Date: 2026-07-05 DOI: 10.1080/08880018.2026.2694449

Victoria G Marchese, Simon K Ho, Vicki L Gray

{"title":"Neuromuscular Changes During the Six-Minute Walk Test in Pediatric Sickle Cell Disease.","authors":"Victoria G Marchese, Simon K Ho, Vicki L Gray","doi":"10.1080/08880018.2026.2694449","DOIUrl":"10.1080/08880018.2026.2694449","url":null,"abstract":"Children/adolescents with sickle cell disease (SCD) experience muscle-related impairments and declines in physical function. These deficits result from chronic anemia and impaired oxygen delivery, limiting the development of safe and effective exercise-based interventions. To better understand the effects of SCD on sustained activity, this study aimed to compare the physical function of children/adolescents with SCD to normative values and evaluate changes in neuromuscular function and muscle oxygenation during the 6-min walk test (6MWT). Each child/adolescent underwent a standardized 6MWT while measuring vastus lateralis muscle activity and oxygenation using surface electromyography (EMG) and Near-infrared spectroscopy. Heart rate was also continuously monitored. Compared to age- and sex-matched norms (625.9 ± 55.1 m), children/adolescents with SCD had a higher resting heart rate (108.5 ± 11.7 vs. 90.3 ± 5.0 bpm; p = 0.023), covered less distance (482.7 ± 91.9 m; p = 0.002), but no difference in heart rate at the End of the 6MWT (p = 1.0). Heart rate rose steadily throughout the 6MWT, 121.3 ± 11.1 bpm at the Start (p = 0.17), 139.0 ± 20.3 bpm at Mid (p = 0.009), and 142.1 ± 24.2 bpm at the End (p = 0.009). EMG median frequency decreased significantly from pre-start (82.7 ± 11.7 Hz) to the Start of walking (68.5 ± 21.7 Hz; p = 0.028), and remained low at Mid (68.0 ± 22.4 Hz; p = 0.047) and End (65.7 ± 21.5 Hz; p = 0.047). Children/adolescents with SCD had reduced functional walking capacity, with an elevated resting heart rate and expected increases, sustained changes in neuromuscular activation during submaximal, sustained activities. This suggests that routine activities may place greater physiologic demands on children/adolescents with SCD, and that clinical assessments may require more than just walking distance.","PeriodicalId":19746,"journal":{"name":"Pediatric Hematology and Oncology","volume":" ","pages":"319-329"},"PeriodicalIF":1.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with early death among children and adolescents with cancer in Brazil: a nationwide registry-based study. 巴西儿童和青少年癌症患者早期死亡的相关因素：一项全国性的基于登记的研究。

IF 1.4 4区医学

Pediatric Hematology and Oncology Pub Date : 2026-09-01 Epub Date: 2026-09-16 DOI: 10.1080/08880018.2026.2733752

Carlos Fabián Amigo Mendoza, Luiz Claudio Santos Thuler, Eloá Moreira-Marconi, Suzana Sales de Aguiar, Ivana Leao Ribeiro, Anke Bergmann

{"title":"Factors associated with early death among children and adolescents with cancer in Brazil: a nationwide registry-based study.","authors":"Carlos Fabián Amigo Mendoza, Luiz Claudio Santos Thuler, Eloá Moreira-Marconi, Suzana Sales de Aguiar, Ivana Leao Ribeiro, Anke Bergmann","doi":"10.1080/08880018.2026.2733752","DOIUrl":"10.1080/08880018.2026.2733752","url":null,"abstract":"This study aimed to identify sociodemographic, clinical, and care-related factors associated with early death in childhood and adolescent cancer patients in Brazil. A retrospective cohort study was conducted using data from the Brazilian Hospital Cancer Registry Integrator Database (IntegradorRHC). All cancer cases diagnosed in individuals aged 0-19 years between 2000 and 2023 were included. Early death was defined as death at the end of the first treatment or within 12 months after diagnosis. Associations were assessed using multivariable logistic regression, and results were expressed as adjusted odds ratios (aOR) with 95% confidence intervals (CI). Among 102,430 eligible cases, early death occurred in 24.7%. Increased risk of early death was independently associated with older age at diagnosis (aOR = 1.006), non-white race/skin color (aOR = 1.467), missing information on race/skin color (aOR = 3.177), unknown referral origin (aOR = 3.507), residence in the Southeast region (aOR = 1.921), and receipt of chemotherapy (aOR = 1.624). Central nervous system tumors (aOR = 2.430), soft tissue sarcomas, bone tumors, and leukemias showed the highest risk of early death. Surgery (aOR = 0.636) and radiotherapy (aOR = 0.750) were associated with reduced risk, while lymphomas (aOR =0.70) showed a protective association. Early death among pediatric cancer patients in Brazil is strongly influenced by tumor type and marked social, regional, and informational disparities.","PeriodicalId":19746,"journal":{"name":"Pediatric Hematology and Oncology","volume":" ","pages":"429-444"},"PeriodicalIF":1.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of plasma coagulation deficiencies and antiphospholipid antibodies positivity in the pediatric population of the Małopolska region: A single-center study from a pediatric hospital in Kraków. Małopolska地区儿童人群中血浆凝血功能缺陷和抗磷脂抗体阳性的患病率：Kraków儿科医院的单中心研究

IF 1.4 4区医学

Pediatric Hematology and Oncology Pub Date : 2026-09-01 Epub Date: 2026-07-10 DOI: 10.1080/08880018.2026.2695382

Aleksandra Zima, Joanna Zdziarska, Teresa Iwaniec, Marta Olszewska, Zbigniew Żuber

{"title":"Prevalence of plasma coagulation deficiencies and antiphospholipid antibodies positivity in the pediatric population of the Małopolska region: A single-center study from a pediatric hospital in Kraków.","authors":"Aleksandra Zima, Joanna Zdziarska, Teresa Iwaniec, Marta Olszewska, Zbigniew Żuber","doi":"10.1080/08880018.2026.2695382","DOIUrl":"10.1080/08880018.2026.2695382","url":null,"abstract":"Plasma coagulation disorders in children present with diverse and often subtle clinical manifestations, contributing to frequent underrecognition and delayed diagnosis. Data on the prevalence of bleeding disorders in Polish children are lacking. This study aimed to estimate the prevalence of plasma coagulation disorders and antiphospholipid antibodies positivity in 120 children aged 3-10 years from the Małopolska region. The study was conducted at a single pediatric center in Kraków, recruiting participants from hospital inpatients, outpatients, and primary care clinics. All children underwent clinical evaluation-including medical history, physical examination, and a standardized questionnaire-and were assigned to study or control groups. During the study, we assessed plasma coagulation factors I, II, V, VII, VIII, IX, X, XI, XII, and XIII, von Willebrand factor antigen (vWF:Ag), and von Willebrand factor ristocetin cofactor activity (vWF:RCo). Decreased activity of one or more coagulation factors (including Hageman anomaly) was identified in 28.33% of participants-33.33% in the study group and 23.33% in controls. A positive family history of bleeding significantly increased the likelihood of a coagulation disorder (OR 5.25, p = 0.002), whereas a personal bleeding history was not statistically significant. Routine screening assays (activated partial thromboplastin time [APTT] and prothrombin time [PT]) showed low sensitivity and did not reliably exclude mild hemostatic abnormalities. These findings highlight the high probability of underestimating bleeding disorder prevalence in children. Detailed family history remains a crucial diagnostic tool, while standard screening tests are insufficient. Population-based studies and educational initiatives are needed to improve recognition and diagnosis of pediatric hemostatic disorders.","PeriodicalId":19746,"journal":{"name":"Pediatric Hematology and Oncology","volume":" ","pages":"330-343"},"PeriodicalIF":1.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148423004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Feasibility and Acceptability of Bright IDEAS Problem-Solving Skills Training Among Uganda Professionals Caring for Children with Cancer: A Single-Arm Pilot Study. 评估乌干达护理癌症儿童的专业人员解决问题技能培训的可行性和可接受性：一项单臂试点研究。

IF 1.4 4区医学

Pediatric Hematology and Oncology Pub Date : 2026-09-01 Epub Date: 2026-09-04 DOI: 10.1080/08880018.2026.2721638

Nicole M Schneider, Joyeeta Talukdar, Rachel Kansiime

{"title":"Evaluating the Feasibility and Acceptability of Bright IDEAS Problem-Solving Skills Training Among Uganda Professionals Caring for Children with Cancer: A Single-Arm Pilot Study.","authors":"Nicole M Schneider, Joyeeta Talukdar, Rachel Kansiime","doi":"10.1080/08880018.2026.2721638","DOIUrl":"10.1080/08880018.2026.2721638","url":null,"abstract":"Bright IDEAS is a problem-solving skills intervention designed to aid caregivers of children with cancer. While this paradigm has been well-studied in high-income settings, the feasibility and utility of this intervention in low-resource settings has been largely unexplored. This pilot study examined whether Bright IDEAS was perceived as workable, usable, and useful by professionals in Uganda caring for patients and caregivers within pediatric oncology settings. A single-arm pilot feasibility study design was utilized in this study. Participants included 24 Ugandan health and psychosocial professionals trained in the Bright IDEAS model. Quantitative data was obtained from 14 participants, using a post-training survey of usability, feasibility, comfort, practicality, and perceived utility on a 5-point Likert scale (1 = Poor to 5 = Excellent). Open-ended items assessed barriers, enablers, and experiences of implementation. Descriptive statistics and thematic content analysis were conducted. Respondents rated both overall feasibility and usability highly (M = 4.3, SD = 0.6). They reported comfort in teaching caregivers about the intervention (M = 4.1) and reported Bright IDEAS strategies were easy for caregivers to understand (M = 4.4). The major qualitative themes were perceived empowerment of caregivers, strengthened problem-solving skills, and enhanced therapeutic engagement. Relevant challenges included lack of support from institutions, time constraints, and inadequate resources. Bright IDEAS was widely believed to be valuable for Ugandan professionals and the study demonstrated strong perceived impact on caregiver coping and communication. These results support additional contextual refinement and robust testing of Bright IDEAS in Ugandan oncology and psychosocial care contexts.","PeriodicalId":19746,"journal":{"name":"Pediatric Hematology and Oncology","volume":" ","pages":"373-382"},"PeriodicalIF":1.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute kidney injury during ruxolitinib therapy in pediatric patients with graft-versus-host disease: incidence, associated factors, and histopathological findings in a retrospective cohort study. 儿童移植物抗宿主病患者鲁索利替尼治疗期间的急性肾损伤：发生率、相关因素和回顾性队列研究的组织病理学结果

IF 1.4 4区医学

Pediatric Hematology and Oncology Pub Date : 2026-09-01 Epub Date: 2026-09-12 DOI: 10.1080/08880018.2026.2731106

Beyza Ural Koluaçık, Sinem Durdaş, Nilden Ünsal, Gülşah Kaya Aksoy, Funda Tayfun Küpesiz, Zeyneb Merve Küçük, Mustafa Koyun, Elif Çomak, Havva Serap Toru, Bahar Akkaya, Osman Alphan Küpesiz, Elif Güler

{"title":"Acute kidney injury during ruxolitinib therapy in pediatric patients with graft-versus-host disease: incidence, associated factors, and histopathological findings in a retrospective cohort study.","authors":"Beyza Ural Koluaçık, Sinem Durdaş, Nilden Ünsal, Gülşah Kaya Aksoy, Funda Tayfun Küpesiz, Zeyneb Merve Küçük, Mustafa Koyun, Elif Çomak, Havva Serap Toru, Bahar Akkaya, Osman Alphan Küpesiz, Elif Güler","doi":"10.1080/08880018.2026.2731106","DOIUrl":"10.1080/08880018.2026.2731106","url":null,"abstract":"Ruxolitinib is a cornerstone treatment for steroid-refractory graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (HSCT) in children, yet longitudinal data on kidney function during such therapy remain limited. We retrospectively analyzed 38 pediatric patients (0-18 years) receiving ruxolitinib for acute or chronic GVHD between January 2018 and December 2025, assessing kidney function at six timepoints from baseline to month 6. Mean serum creatinine rose from 0.34 ± 0.16 mg/dL at baseline to 0.50 ± 0.34 mg/dL at month 3 (p < 0.001) and remained mildly elevated at month 6 (0.48 ± 0.23 mg/dL; p < 0.001). Acute kidney injury (AKI) occurred in 7 patients (18.4%) at a median of 2.36 months after ruxolitinib initiation, with 4 (57.1%) progressing to acute kidney disease; biopsies excluded BK virus nephropathy. BK virus reactivation, BKV-related hemorrhagic cystitis, CMV reactivation, older age at transplantation, and higher baseline creatinine were significantly associated with AKI, whereas ruxolitinib dose was not. Post-transplant AKI in this setting appears multifactorial; controlled studies including a ruxolitinib-unexposed comparator group are needed to clarify the specific contribution of the drug.","PeriodicalId":19746,"journal":{"name":"Pediatric Hematology and Oncology","volume":" ","pages":"409-428"},"PeriodicalIF":1.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early discharge for low-risk pediatric febrile neutropenia: safe only in selected centers. 低风险儿童发热性中性粒细胞减少症的早期出院：仅在选定的中心安全。

IF 1.4 4区医学

Pediatric Hematology and Oncology Pub Date : 2026-09-01 Epub Date: 2026-06-27 DOI: 10.1080/08880018.2026.2695386

Orkun Dinç

{"title":"Early discharge for low-risk pediatric febrile neutropenia: safe only in selected centers.","authors":"Orkun Dinç","doi":"10.1080/08880018.2026.2695386","DOIUrl":"10.1080/08880018.2026.2695386","url":null,"abstract":"Marathe et al. report encouraging results from a step-down pathway for low-risk fever and neutropenia in pediatric and adolescent-young adult oncology patients, with reduced hospitalization and no sepsis or infection-related mortality. Their work is an important contribution to risk-adapted supportive care. This Article Commentary argues, however, that early discharge is not a universally portable intervention. Its safety depends not only on patient biology and initial clinical stability, but also on the surrounding health-care infrastructure: rapid microbiology, timely antibiotics, 24-h oncology consultation, reliable transport, informed caregivers, and guaranteed urgent reassessment. From the perspective of pediatric hematology-oncology practice in Van, eastern Türkiye, the distance from tertiary care, variability in after-hours pediatric oncology expertise, and uneven access to rapid reassessment can make direct adoption of such a pathway nearly impossible without explicit safeguards. The central issue is therefore not whether low-risk patients can ever be discharged early, but which patients, families, centers, and regional systems can do so safely. Future studies and guidelines should define an auditable infrastructure threshold and report implementation outcomes alongside clinical outcomes, so that early-discharge pathways reduce hospitalization without shifting avoidable risk onto families and geographically remote services. This distinction is essential for equitable implementation in real-world oncology practice.","PeriodicalId":19746,"journal":{"name":"Pediatric Hematology and Oncology","volume":" ","pages":"366-370"},"PeriodicalIF":1.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148339557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.4 4区医学

Pediatric Hematology and Oncology Pub Date : 2026-09-01 Epub Date: 2026-09-08 DOI: 10.1080/08880018.2026.2729160

Beatriz Andrade, Marta Lourenço, Joana Valente Dias, Marta Contreiras

{"title":"Health-related quality of life in pediatric sickle cell disease: insights from a Portuguese hospital-based study.","authors":"Beatriz Andrade, Marta Lourenço, Joana Valente Dias, Marta Contreiras","doi":"10.1080/08880018.2026.2729160","DOIUrl":"10.1080/08880018.2026.2729160","url":null,"abstract":"Sickle cell disease (SCD) significantly affects health-related quality of life (HRQoL) in children and adolescents, with pain being a major contributor. We conducted a cross-sectional study of 27 patients aged 5-17 years attending pediatric outpatient clinics at a secondary-level hospital in Lisbon, Portugal. HRQoL was assessed using the Portuguese version of the Pediatric Quality of Life Inventory™ Sickle Cell Disease Module 3.0 (PedsQL™ SCD), encompassing domains such as pain, pain impact, emotions, treatment, and communication. The total score indicated intermediate HRQoL, with the pain impact domain showing the lowest scores, highlighting the importance of systematic pain management. Associations were observed between age, disease complications, household composition, and specific HRQoL domains, suggesting that both clinical burden and family context influence patient-reported outcomes. These findings underscore the multifactorial nature of HRQoL in pediatric SCD and support the development of standardized outpatient and emergency pain management protocols, alongside family-centered care, to improve quality of life in this population.","PeriodicalId":19746,"journal":{"name":"Pediatric Hematology and Oncology","volume":" ","pages":"395-408"},"PeriodicalIF":1.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0