Nuclear Medicine Communications最新文献

{"title":"Assessment of surface contamination of low-dose radioactive iodine ( 131 I) treatment container.","authors":"Chan-Ju Ryu","doi":"10.1097/MNM.0000000000001939","DOIUrl":"10.1097/MNM.0000000000001939","url":null,"abstract":"<p><p>With the advancement of radiotherapy technology in the medical field, the amount of radioactive waste has rapidly increased, and the International Atomic Energy Agency (IAEA) has proposed waste deregulation standards based on individual dose, collective dose, and nuclide concentration. The purpose of this study is to define the standard period (1 day) required to measure collected radioactive waste using direct and indirect methods with a radioactivity meter, ensure that the radiation dose remains below the allowable level, and transport the waste safely. In this study, 131 I low-dose (30 mCi) radioactive waste discarded after radioiodine treatment at a medical institution was collected, and a measuring container was prepared to measure radioactivity concentration according to IAEA standards. The experiments showed that the minimum number of days required for the contamination levels of the inner and outer parts of containers and therapeutic plastics to fall below the tolerance limit were 6, 1, and 5 days, respectively. Conversely, the contamination levels measured immediately after 131 I treatments in the cases of Styrofoam and paper boxes were below the tolerance limit. The study emphasizes the need for a safe disposal process and active radioactive waste management operations by radioactive waste transporters by specifying the scope for safe transportation beyond the permissible limit.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"187-192"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic markers derived from 18 F-FDG PET/CT in suspected recurrent ovarian carcinoma: predictive value for disease burden and prognosis.","authors":"Bela Jain, Yogita Khandelwal, Manish Ora, Prabhakar Mishra, Punita Lal, Sanjay Gambhir","doi":"10.1097/MNM.0000000000001944","DOIUrl":"10.1097/MNM.0000000000001944","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the role of 18 F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) in suspected recurrent ovarian carcinoma. Several clinical and PET parameters were assessed to evaluate disease burden and prognosis.</p><p><strong>Methods: </strong>We did a single-center, retrospective study in patients with suspected recurrent ovarian carcinoma who underwent 18 F-FDG PET/CT. The disease burden on the scan was evaluated. We calculated several semiquantitative markers, including standard uptake values (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Survival analysis was done with clinical parameters, CA-125 levels, disease distribution, and metabolic markers.</p><p><strong>Results: </strong>Fifty-two patients were included in the study. Half of the patients had suspected recurrence within 12 months of primary diagnosis. PET/CT scan suggested disease in 35 (67.3%) patients. Multiple metastatic sites were noted in 21 (40.4%) patients. Extra-abdominal metastases were seen in 15 (28.8%) patients. Eight patients had 18 F-FDG avid disease despite a low CA-125 level (<35 IU). Young patients (<50 years), extra-abdominal disease, multiple metastases, and higher restaging were associated with poor outcomes. Meanwhile, treatment history, CA-125 level, and post-PET/CT treatment had no significant effect on survival. MTV@40% SUV (>17.21) and TLG@40% SUV (>68.7) had the sensitivity of 87.5% and 75% for predicting disease outcome.</p><p><strong>Conclusion: </strong>Recurrent ovarian carcinoma commonly presents with multiple metastasis and extra-abdominal metastases. 18 F-FDG PET/CT-guided patterns of disease distribution were significant markers for poor prognosis. Disease burden on PET/CT-derived semiquantitative parameters was associated with poor outcomes.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"268-275"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of cerebral technetium-99m-ethyl cysteinate dimer perfusion in patients with dementia with Lewy bodies and Parkinson's disease dementia.","authors":"Aili Toyli, Guang-Uei Hung, Chen Zhao, Qiuying Sha, Pai-Yi Chiu, Weihua Zhou","doi":"10.1097/MNM.0000000000001946","DOIUrl":"10.1097/MNM.0000000000001946","url":null,"abstract":"<p><strong>Objective: </strong>Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are closely related neurodegenerative conditions within the Lewy body spectrum. The relationship between DLB and PDD remains debated, with ongoing discussion about whether they are distinct diseases or different manifestations of the same disorder. This study aimed to identify differences in cerebral perfusion patterns between DLB and PDD patients.</p><p><strong>Methods: </strong>Single-photon emission computed tomography (SPECT) ethyl cysteinate dimer (ECD) imaging was performed on patients diagnosed with DLB ( n  = 46) and PDD ( n  = 30). The data were acquired by two SPECT/computed tomography systems from two affiliated centers and were retrospectively recruited under the local ethics approval. Relative tracer uptake levels were calculated across 47 automatically determined regions of interest and 240 subregions. A two-sided Welch's t -test was employed to evaluate mean perfusion differences, with results further confirmed through a voxel-wise t -test mapping. The Benjamini-Hochberg procedure was used to adjust P -values for multiple comparisons.</p><p><strong>Results: </strong>The greatest difference in perfusion was in the left associative visual cortex in planes 34 and 36 and the right primary visual cortex in plane 34, with lower mean perfusion observed in PDD patients than those with DLB ( P  = 0.005).</p><p><strong>Conclusion: </strong>No statistically significant differences in ECD perfusion were found between DLB and PDD patients. The greatest difference was in the visual cortices, where PDD patients suffered a greater loss of perfusion.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"218-222"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of quantitative Krenning Scores with visual assessment in 99mTc-EDDA/HYNIC-TOC SPECT-CT.","authors":"Alastair J Gemmell, Colin M Brown, Surajit Ray, Alexander Small","doi":"10.1097/MNM.0000000000001967","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001967","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study is to assess inter-observer variability of the Krenning Score for 99mTc-EDDA/HYNIC-TOC single photon emission computed tomography (SPECT)-computed tomography (CT) images and compare against quantitative metrics obtained from tumour and physiological uptake measurements.</p><p><strong>Methods: </strong>Thirty-two patients with 117 lesions visible on 99mTc-EDDA/HYNIC-TOC SPECT-CT were scored by two expert observers using the Krenning Score. Five observers with less extensive experience also scored the lesions on visual assessment. Inter-observer agreement and comparison to the expert consensus was tested. Three observers made quantitative measurements of the lesions and physiological uptake, with intra-observer and inter-observer variation investigated. Assessment of agreement between quantitative metrics and the expert visual consensus was also made.</p><p><strong>Results: </strong>Inter-observer agreement for visual assessment was 44.3% for proportions of agreement and 0.576 for Fleiss' Kappa, whilst for the best-performing quantitative metric the inter-observer Fleiss' Kappa was equal to 1. The agreement with expert consensus for the best-performing visual observer was 89.8% for percentage of agreement and 0.914 for Cohen's Kappa, similar to the best-performing quantitative metric (a derived quantitative Krenning Score) at 86.4% and κ = 0.877. Standardised uptake value maximum (SUVmax) also showed similar levels of agreement at 85.1% and κ = 0.871.</p><p><strong>Conclusion: </strong>A derived quantitative Krenning Score, or alternatively SUVmax, can provide similar levels of agreement with an expert consensus Krenning Score as visual assessment, with reduced inter-observer variability. Quantification can deliver greater consistency in scoring of 99mTc-EDDA/HYNIC-TOC images over visual assessment, an important factor when imaging is used to determine patient eligibility for peptide receptor radiotherapy.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of visual interpretation of [I-123] FP-CIT SPECT scans versus reference-based quantitative analysis utilizing a Japanese normal database.","authors":"Ryo Yamakuni, Shiro Ishii, Kenji Fukushima, Takeyasu Kakamu, Masanori Yusa, Katsuyuki Kikori, Tensho Yamao, Noriyuki Takahashi, Hirofumi Sekino, Shuntaro Itagaki, Itaru Miura, Hiroshi Ito","doi":"10.1097/MNM.0000000000001968","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001968","url":null,"abstract":"<p><strong>Objective: </strong>Dopamine transporter single-photon emission computed tomography (DAT-SPECT) plays an important role in diagnosing parkinsonism. Recently, a reference-based quantitative analysis utilizing a Japanese normal database for DAT-SPECT was developed. This study aimed to investigate the frequency and trends of cases wherein the analysis- and physician-based diagnoses diverged.</p><p><strong>Methods: </strong>Two physicians performed an interpretation task twice on 195 DAT-SPECT scans. After assessing intra- and intertester agreements, disagreements were resolved by consensus. For the reference-based quantitative analysis, the calibrated specific binding ratio (cSBR), calibrated asymmetry index (cAI), and Z-scores were measured. Images were grouped according to physician consensus and the negative-positive difference from thresholds (Z-score of less than -2.0 and/or cAI of more than 12.22) as follows: group 1 (physician, normal; quantitative analysis, normal; n = 70), group 2 (abnormal; normal; n = 4), group 3 (normal; abnormal; n = 31), and group 4 (abnormal; abnormal; n = 90).</p><p><strong>Results: </strong>Median cSBRs and Z-scores decreased in order from group 1 to group 4. Median cAI values increased in the order of groups 1, 3, 2, and 4. Significant differences were observed between groups 1 and 2 for cSBRs and cAIs; groups 2 and 3 for Z-scores; groups 2 and 4 for cSBRs and Z-scores; and groups 1 and 3, 1 and 4, and 3 and 4 for all parameters (Kruskal-Wallis and Steel-Dwass tests).</p><p><strong>Conclusion: </strong>In approximately 18% of cases, the visual interpretation of physicians diverged from the reference-based quantitative analysis based on a Japanese normal database. It is crucial to appropriately utilize DAT-SPECT reference-based quantitative analysis as a diagnostic aid.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of tubarial salivary gland function detected through 68Ga-prostate-specific membrane antigen PET/computed tomography to total salivary gland function.","authors":"İhsan Kaplan, Ömer Yeprem, Halil Kömek, Ferat Kepenek, Yunus Güzel, Hüseyin Karaoğlan, Mehmet Serdar Yildirim, Veysi Şenses, Ridvan Kiliç, Fulya Kaya İpek, Emine Budak, Ahmet Yanarateş, Canan Can","doi":"10.1097/MNM.0000000000001970","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001970","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine the contribution of tubarial salivary glands to total salivary gland function using quantitative parameters obtained from 68Ga-prostate-specific membrane antigen (PSMA) PET/computed tomography (PET/CT), including salivary gland volume (SV) and salivary gland function (SF).</p><p><strong>Method: </strong>This retrospectively designed study included 102 patients with prostate cancer (PCa) who had undergone 68Ga-PSMA PET/CT for staging purposes between January 2022 and December 2023. Patients with missing data, those with tumors in the head and neck region, those who received radiotherapy to the head and neck region, those who underwent surgery in the head and neck region, those with any salivary gland-related disease, those previously treated with radioactive iodine, and those who received lutetium-177 (177Lu) therapy were excluded from the study.</p><p><strong>Results: </strong>All 102 patients included in the study were male and diagnosed with PCa. The mean age of the patients was calculated as 72.53 ± 7.58 years. Patients' tubarial SV% and tubarial SF% values were calculated as 7.76 ± 4.01 and 2.58 ± 1.34, respectively. The percentage volume of tubarial glands was found to be statistically significantly higher than that of sublingual glands (P < 0.001, Wilcoxon signed-rank test). No statistical difference, however, was observed in their contributions to total function (P = 0.506).</p><p><strong>Conclusion: </strong>When examining the volume ratios of salivary glands showing PSMA expression, it was found that the tubarial salivary glands had a higher volumetric ratio but a lower contribution to total function. We recommend considering these ratios when administering treatments that affect salivary gland functions.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic value of left ventricular diastolic dyssynchrony combined with myocardial perfusion, systolic dyssynchrony, and cardiovascular risk factors in patients with normal left ventricular ejection fraction.","authors":"Jingwen Wang, Bao Liu, Feifei Zhang, Jianfeng Wang, Wenji Yu, Yurui Hu, Zhimin Yang, Peng Wan, Xiaoyu Yang, Yuetao Wang","doi":"10.1097/MNM.0000000000001969","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001969","url":null,"abstract":"<p><strong>Objective: </strong>Major adverse cardiovascular events (MACE) still occur in the normal left ventricular ejection fraction (LVEF) patients with coronary artery disease (CAD). Currently, there are no studies related to the prognostic value of left ventricular diastolic dyssynchrony (LVDD) in combination with perfusion, systolic dyssynchrony, and cardiovascular risk factors in patients with normal LVEF. Therefore, we aimed to investigate the incremental prognostic value of LVDD in patients with normal LVEF and to establish a model to predict MACE.</p><p><strong>Methods: </strong>This study included 239 suspected or known CAD patients with a normal LVEF who underwent gated single-photon emission computerized tomography myocardial perfusion imaging. Clinical data such as age, sex, and cardiovascular risk factors were collected. Myocardial perfusion, and left ventricular dyssynchrony parameters were assessed using QPS and Emory Toolbox software, respectively. The least absolute shrinkage and selection operator and multivariable Cox regression were used to select the variables.</p><p><strong>Results: </strong>The subjects were followed up for a total of 73.2±16.4 months and MACE occurred in 28 patients. In multivariate Cox regression, rest diastolic bandwidth (BW) was closely related to MACE [hazard ratio (95% confidence interval), 10.78 (1.65-70.35); P=0.013]. The C-index of the model was increased from 0.748 to 0.783 by increasing the rest diastolic BW on the basis of summed difference score (SDS), stress systolic SD, age, hypertension, and chest pain (P<0.001). A final model for predicting MACE was constructed based on age, hypertension, chest pain, SDS, stress systolic SD, and rest diastolic BW. The C-index of the model was 0.783, and the area under the curves of the model predicting the occurrence of 3-year and 5-year MACE events were 0.766 and 0.827, respectively. The calibration curve showed a good calibration of the model.</p><p><strong>Conclusion: </strong>LVDD is associated with MACE in patients with normal LVEF. In addition, based on SDS, stress systolic SD, age, hypertension, and chest pain, rest diastolic BW had an incremental predictive value for MACE.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of the association between baseline [18F] fluorodeoxyglucose uptake and axillary pathological complete response in node-positive breast cancer patients: focus on clinical subtypes.","authors":"Melissa Lenaerts, Florien J G van Amstel, Felix M Mottaghy, Sandra M E Geurts, Vivianne C G Tjan-Heijnen, Marjolein L Smidt, Thiemo J A van Nijnatten","doi":"10.1097/MNM.0000000000001964","DOIUrl":"10.1097/MNM.0000000000001964","url":null,"abstract":"<p><p>The objective is to assess whether the degree of metabolic uptake of the primary tumor and axillary lymph nodes (ALNs) on baseline [18F] fluorodeoxyglucose ([18F]FDG) PET/CT is associated with the probability to achieve axillary pathologic complete response (pCR) in clinically node-positive (cN+) breast cancer patients treated with neoadjuvant systemic therapy (NST), overall and per clinical subtype. Studies that assessed the maximum standardized uptake value (SUVmax) in the primary tumor and ALNs on baseline [18F]FDG PET/CT and reported axillary pCR rates in patients diagnosed with cN+ invasive breast cancer treated with NST, followed by surgery, were searched. Area under the curve (AUC) values were obtained. A total of seven studies (561 patients) were included. The mean baseline SUVmax of the primary tumor ranged from 8.1 (±4.3) to 9.8 (±7.2). Mean baseline axillary SUVmax ranged from 6.0 (±5.6) to 7.3 (±6.2). The axillary pCR rate ranged from 38.0% to 48.1%. Considering the primary tumor, no study reported on the association between baseline SUVmax and the axillary pCR rate. Considering the ALNs, the AUC value for baseline axillary SUVmax to predict axillary pCR ranged from 0.52 [95% confidence interval (CI): 0.39-0.65; all subtypes included] to 0.74 (95% CI: 0.53-0.95; only human epidermal growth factor receptor 2+ and triple negative). In conclusion, no association between the primary tumor SUVmax on baseline [18F]FDG PET/CT and axillary pCR was found. Concerning the axilla, based on limited scientific evidence, the axillary SUVmax on baseline [18F]FDG PET/CT may be associated with axillary pCR after NST in cN+ breast cancer patients, however, potential differences between clinical subtypes should be considered.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of preoperative 18F-flurodeoxyglucose PET/CT scanning in preoperative evaluation and surgical planning for pulmonary tuberculosis.","authors":"Lei-Lei Li, Lin Wang, Hong-Wei Li, Hui Chen, Lei Shi, Lai-Yi Wan, Yan-Zheng Song","doi":"10.1097/MNM.0000000000001930","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001930","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to investigate the utility of preoperative 18F-FDG PET/CT scanning in preoperative evaluation and surgical planning for pulmonary tuberculosis.</p><p><strong>Methods: </strong>The study involved a retrospective analysis of clinical data and preoperative chest 18F-FDG PET/CT data of 24 patients with pulmonary tuberculosis who underwent pneumonectomy at the Shanghai Public Health Clinical Center between December 2017 and January 2022.</p><p><strong>Results: </strong>All 24 patients successfully underwent chest 18F-FDG PET/CT imaging, and complete data pertaining to the maximum standardized uptake value, mean standardized uptake value, minimum standardized uptake value, total lesion glycolysis, and metabolic tumor volume were obtained. Surgical excision plans were finalized using the chest 18F-FDG PET/CT findings along with the conventional chest CT scans. Pneumonectomy was successfully completed in all 24 patients, and these included 13 cases of pulmonary lobectomy, two cases of total pneumonectomy, one case of combined pulmonary lobectomy, one case of segmentectomy, and seven cases of pulmonary wedge resection. The actual surgical procedures had a conformity rate of 100% to the preoperative surgical plans that were made. The intraoperative bronchial stump embedding rate was 69% (11/18 cases), the incidence rate of postoperative air leakage was 3.8% (1/24 cases), and there were no reported cases of postoperative bronchopleural fistula or death.</p><p><strong>Conclusion: </strong>Preoperative 18F-FDG PET/CT scans had significant utility in surgical planning, the selection of surgical methods, and the formulation of postoperative antituberculosis treatment courses for patients with pulmonary tuberculosis. The use of 18F-FDG PET/CT shows considerable promise in being promoted clinically for the surgical management of patients with pulmonary tuberculosis.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":"46 2","pages":"180-186"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of thyroglobulin after radioiodine therapy for excellent response to treatment in postoperative thyroid cancer.","authors":"Yuan Zhu, Xiaoying Yang, Zhao Liu, Qinghua Zhang, Zhiyong Li, Xiancun Hou, Hui Zhu","doi":"10.1097/MNM.0000000000001933","DOIUrl":"10.1097/MNM.0000000000001933","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the usefulness of thyroglobulin (Tg) after radioiodine (RAI) therapy in predicting excellent response (ER) to therapy in postoperative differentiated thyroid cancer (DTC).</p><p><strong>Methods: </strong>A retrospective observational study was conducted on postoperative DTC patients who underwent RAI from August 2018 to December 2022. Various factors were analyzed to predict ER to treatment. This involved Tg under stimulation (sTg) before RAI, Tg immediately (imTg) 112 h post-RAI and imTg/sTg(rTg). Based on the efficacy of RAI, patients were categorized into two groups: ER and non-ER (NER). Univariate logistic analysis was utilized to compare parameters between the two groups, followed by binary logistic regression analysis on factors associated with ER. Receiver operating characteristic (ROC) curves were employed to evaluate the sensitivity, specificity, and optimal diagnostic cutoff points for parameters affecting ER.</p><p><strong>Results: </strong>The analysis included 45 ER patients and 56 NER patients. Statistical significance was found in the binary logistic regression analysis for the number of lymph nodes in the lateral cervical region ( P  = 0.016), sTg ( P  = 0.021), and rTg ( P  ≤ 0.001) concerning ER. ROC curve analysis revealed that the rTg area under the curve was 0.845, with an optimal cutoff value of 11.78, sensitivity of 82.6%, and specificity of 74.5%.</p><p><strong>Conclusion: </strong>Post-RAI therapy, significant value is demonstrated by rTg with high sensitivity and specificity. This provides a foundation for the evaluation and decisions about DTC treatment in advance.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"146-151"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}