Pacific Medical Journal最新文献

{"title":"Effect of various pharmacotherapy regimens on the state of carbohydrate metabolism in patients with urination disorders","authors":"V. V. Danilov, E. V. Eliseeva, V. V. Danilov, I. Volnykh, A. V. Tyrtyshnikova, M. M. Piskun, V. V. Danilov","doi":"10.34215/1609-1175-2023-4-77-81","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-4-77-81","url":null,"abstract":"Aim. To evaluate the efficacy and safety of various pharmacotherapy regimens in patients with urination disorders and type 2 diabetes mellitus during their preparation for surgery.Materials and methods. In total, 130 people (56 men and 74 women) aged from 18 to 81 years (average 65 years) were included in the research. All the patients were on standardized hypoglycemic therapy in combination with alpha1-blockers (doxazosin, terazosin) and vitamin-like drugs (alpha-lipoic acid, levocarnitine). Patients were divided into male and female subgroups, as well as into age subgroups, including under 65 years and over 65 years. Tabular methods of assessing the clinical symptoms of urinary disorders were used, along with instrumental, laboratory, and statistical methods (Mann-Whitney test, Spearman rank correlation coefficient).Results. The duration of therapy averaged 16± 2 months. The observation found that alpha1-blockers lead to a number of positive changes in the composition of carbohydrate metabolism, i.e., the level of serum glucose and insulin. In the general observation group, a significant decrease in blood glucose from 6.64 to 6.27 mmol/L, insulin from 18.07 to 14.03 mU/mL, and C-peptide from 3.67 to 2.98 ng/mL was detected. In the male subgroup, glucose levels decreased from 6.45 to 6.00 mmol/L, insulin from 18.92 to 13.99 mU/mL, and C-peptide from 3.76 to 2.97 ng/mL. In the female subgroup, blood glucose levels decreased from 6.98 to 6.77 mmol/L, insulin from 16.41 to 14.1 mU/mL, and C-peptide from 3.51 to 2.99 ng/mL. In the group of patients younger than 65 years of age, a decrease in glucose from 6.22 to 5.93 mmol/L, insulin from 17.87 to 14.36 mU/mL, and C-peptide from 3.49 to 3.01 ng/mL were also observed. In the group of patients older than 65 years of age, similar dynamics of the above parameters was established.Conclusions. The data obtained suggest that alpha1-blockers in combination with vitamin-like drugs contribute to reducing the level of serum glucose, insulin, and C-peptide during a long-term (at least 1 year) therapy, which may be promising in the correction of metabolic disorders during preparation of patients for surgery.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"43 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139809968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health dynamics of children and adolescents in the Far Eastern federal district in 2013–2020","authors":"O. Gritsina, A. Yatsenko, L. V. Trankovskaya, Yu. V. Maistrovskaya, D. A. Ermakova, S. D. Shestakova","doi":"10.34215/1609-1175-2023-4-72-76","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-4-72-76","url":null,"abstract":"Aim. To identify trends in the primary morbidity of children and adolescents in the Far Eastern Federal District.Materials and methods. A retrospective analytical study of the dynamics of primary morbidity in children and adolescents by disease class was conducted.Results. Among the children population, a very high and high stability of the decrease in morbidity rates was established (R = -0.714– (-1.0)) for all classes of diseases. Among the adolescent population, a weak stability in the decrease in morbidity rates was characteristic of VII Diseases of the eye and adnexa (R = -0.262) and X Respiratory diseases (R = -0.262); a moderate stability of IV Diseases of the endocrine system, nutritional disorders, and metabolic disorders (R = -0.333); a moderate stability of IX Diseases of the circulatory system (R = -0.623); and a high stability among all other classes (R= -0.738 – (-0.928)). In the older age group, weak resistance to growth dynamics was determined in classes III Diseases of the blood, hematopoietic organs, and certain disorders involving the immune mechanism (R = 0.024) and VIII Diseases of the ear and mastoid process (R = 0.095).Conclusion. The data obtained forms a basis for further research into regional risk factors that contribute to poor health of the population. The findings can also be used to predict the health status of younger generations.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"56 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139871258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of various pharmacotherapy regimens on the state of carbohydrate metabolism in patients with urination disorders","authors":"V. V. Danilov, E. V. Eliseeva, V. V. Danilov, I. Volnykh, A. V. Tyrtyshnikova, M. M. Piskun, V. V. Danilov","doi":"10.34215/1609-1175-2023-4-77-81","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-4-77-81","url":null,"abstract":"Aim. To evaluate the efficacy and safety of various pharmacotherapy regimens in patients with urination disorders and type 2 diabetes mellitus during their preparation for surgery.Materials and methods. In total, 130 people (56 men and 74 women) aged from 18 to 81 years (average 65 years) were included in the research. All the patients were on standardized hypoglycemic therapy in combination with alpha1-blockers (doxazosin, terazosin) and vitamin-like drugs (alpha-lipoic acid, levocarnitine). Patients were divided into male and female subgroups, as well as into age subgroups, including under 65 years and over 65 years. Tabular methods of assessing the clinical symptoms of urinary disorders were used, along with instrumental, laboratory, and statistical methods (Mann-Whitney test, Spearman rank correlation coefficient).Results. The duration of therapy averaged 16± 2 months. The observation found that alpha1-blockers lead to a number of positive changes in the composition of carbohydrate metabolism, i.e., the level of serum glucose and insulin. In the general observation group, a significant decrease in blood glucose from 6.64 to 6.27 mmol/L, insulin from 18.07 to 14.03 mU/mL, and C-peptide from 3.67 to 2.98 ng/mL was detected. In the male subgroup, glucose levels decreased from 6.45 to 6.00 mmol/L, insulin from 18.92 to 13.99 mU/mL, and C-peptide from 3.76 to 2.97 ng/mL. In the female subgroup, blood glucose levels decreased from 6.98 to 6.77 mmol/L, insulin from 16.41 to 14.1 mU/mL, and C-peptide from 3.51 to 2.99 ng/mL. In the group of patients younger than 65 years of age, a decrease in glucose from 6.22 to 5.93 mmol/L, insulin from 17.87 to 14.36 mU/mL, and C-peptide from 3.49 to 3.01 ng/mL were also observed. In the group of patients older than 65 years of age, similar dynamics of the above parameters was established.Conclusions. The data obtained suggest that alpha1-blockers in combination with vitamin-like drugs contribute to reducing the level of serum glucose, insulin, and C-peptide during a long-term (at least 1 year) therapy, which may be promising in the correction of metabolic disorders during preparation of patients for surgery.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139869729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Software application for predicting the efficacy of rehabilitation treatment in patients with discirculatory encephalopathy","authors":"E. V. Moroz, O. V. Perelomova, V. V. Knyshоva","doi":"10.34215/1609-1175-2023-4-86-88","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-4-86-88","url":null,"abstract":"Aim. To develop a software application for determining the rehabilitation potential and predicting the efficacy of rehabilitation treatment in elderly and senile patients with stage III discirculatory encephalopathy (DE).Methods. A database of 185 patients with stage III DE was used. The indicators were assessed in dynamics, i.e., prior to the rehabilitation treatment and following three and six months from the onset of treatment course. The software application was developed using the Visual Basic for Applications (VBA) programming language built into Microsoft Excel 2010.Results. The developed application comprises several first-order subroutines to assess the patient’s neurological status, memory, attention, functional activity in everyday life, as well as second-order subroutines to calculate the rehabilitation potential and predict the treatment efficacy. At the first stage, personal data and characteristics of neurological disorders, cognitive functions, scale of instrumental activities in daily living (IADL) are entered. At the second stage, the indicator of rehabilitation potential is automatically calculated and its qualitative assessment is provided. On the basis of prediction of the efficacy of the three complexes, further rehabilitation tactics for a particular patient is determined.Conclusions. The developed software application is useful for automating and optimizing the work of rehabilitation neurologists.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139811287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined application of exercise therapy and reflexotherapy for ischemic stroke patients in the acute period","authors":"E. V. Pavlushchenko, L. Y. Petrova, L. I. Kisel, L. A. Klersfeld","doi":"10.34215/1609-1175-2023-4-64-68","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-4-64-68","url":null,"abstract":"Aim. Search for new effective methods of physical rehabilitation for patients with ischemic stroke.Materials and methods. In total, 60 ischemic stroke patients aged from 51 to 80 years in the acute period were included in the rehabilitation program. All patients showed motor and speech disorders, problems with self-care and mobility, and reduced quality of life indicators. The program of early rehabilitation included the combination of reflexotherapy (RT) and differentiated choice of exercise therapy (ET).Results. The comparative analysis of the results of three therapeutic programs for rehabilitation of patients with acute cerebral circulation disorders (ACCD) in the acute period showed the high efficacy of a combined use of RT and ET with a differentiated approach to method selection.Conclusions. The combined application of neurorehabilitation methods for ischemic stroke patients has confirmed its high efficacy. The developed rehabilitation programs may improve the quality of life of patients after acute cerebral circulation disorders and increase their independence in everyday life.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139871013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morbidity of circulatory diseases among the working-age population in the Far Eastern federal district in 2012–2021","authors":"A. A. Vazhenina, A. Shastin, L. V. Trankovskaya, I. L. Ivanova, E. Anishchenko, V. G. Panov, V. Gazimova, S. O. Zolotareva","doi":"10.34215/1609-1175-2023-4-57-63","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-4-57-63","url":null,"abstract":"Aim. To study the indicators and regional features of circulatory disease morbidity among the able-bodied population in the Far Eastern Federal District for the 2012–2021 period.Material and methods. A descriptive statistical study was conducted. The indicators of incidence and prevalence rates of circulatory system diseases, including ischemic heart diseases and cerebrovascular diseases, were calculated according to the data published by the Russian Research Institute of Health. To assess the statistical significance of differences in the incidence rate in 2020 and 2021 relative to the 2012–2019 period, a 95% CI for the average incidence rate in 2012–2019 was used by generating repeated samples. Differences in the incidence and prevalence rates in 2020 and 2021 above the upper or below the lower CI boundary for the average values in 2012–2019 were considered statistically significant.Results. An analysis of the incidence and prevalence rates of circulatory system diseases among the working-age population in the Far Eastern Federal District in 2012–2021 was carried out. The obtained data are characterized by a significant variability and heterogeneity of indicators, showing significant differences from the all-Russian data for the 2012–2019 period. Changes in the incidence and prevalence rates of circulatory system diseases in the Far Eastern Federal District during the spread of COVID-19 in 2020–2021 were found to be multidirectional. In general, the statistically significant increase in the incidence of coronary heart disease in the Far Eastern Federal District in 2020 and 2021 is largely associated with the growth of indicators in the Khabarovsk Krai.Conclusions. The obtained characteristics of the incidence and prevalence rates of circulatory system diseases, including ischemic heart diseases and cerebrovascular diseases, indicate the presence of pronounced regional characteristics. The revealed multiple differences in the morbidity rates in the subjects of the Far Eastern Federal District require further research to determine their priority and significance for monitoring the health of the population.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"80 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139810802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training program for primary care physicians in medical rehabilitation at the Pacifi c Medical University","authors":"T. N. Kuzmina, G. V. Kuznetsova, L. Y. Petrova","doi":"10.34215/1609-1175-2023-4-93-96","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-4-93-96","url":null,"abstract":"This article describes the experience of training primary care physicians in the field of medical rehabilitation. The existing procedure for the arrangement of medical rehabilitation prescribes its rules and order of implementation in medical primary health care organizations both in outpatient and day patient settings. The Pacific State Medical University (PSMU) runs training programs for primary care physicians within the 31.05.01 educational program “General Medicine”, direction “02 Healthcare”. In accordance with the curriculum, a training program “Medical Rehabilitation” that includes both lectures and training sessions was developed. This program is aimed at forming the necessary competencies of future primary care physicians in implementing and monitoring the effectiveness of the patient’s medical rehabilitation. Training is carried out at the facilities of the PSMU Institute of Clinical Neurology and Rehabilitation Medicine by specialists having experience in medical rehabilitation and having completed the program “Modern aspects of specialist training in the field of physical and rehabilitation medicine”.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"46 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139869109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of pediatric and adolescent rehabilitation in the department of rehabilitation of the regional children’s oncohematological center, Vladivostok","authors":"G. V. Kuznetsova, L. M. Minkina, T. N. Kuzmina, I. A. Obukhova, A. V. Voskresenskaya, E. V. Prosekova","doi":"10.34215/1609-1175-2023-4-89-92","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-4-89-92","url":null,"abstract":"The development of modern treatment technologies in oncology has reduced the mortality of children and adolescents from malignant neoplasms and hematological diseases. As a result, the issue of organizing rehabilitation care has become urgent. In this article, we describe the experience of organizing and developing pediatric rehabilitation in the oncology/hematology profile in Primorsky Krai for the period from 1995 to 2022. Various medical, psychological, social, and environmental aspects are outlined along with rehabilitation technologies used. The effectiveness of rehabilitation and the peculiarities of its implementation in children with oncological and hematological diseases are shown. The expediency of carrying out stages of rehabilitation in the region of residence of patients is substantiated.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"19 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139870819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morbidity of circulatory diseases among the working-age population in the Far Eastern federal district in 2012–2021","authors":"A. A. Vazhenina, A. Shastin, L. V. Trankovskaya, I. L. Ivanova, E. Anishchenko, V. G. Panov, V. Gazimova, S. O. Zolotareva","doi":"10.34215/1609-1175-2023-4-57-63","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-4-57-63","url":null,"abstract":"Aim. To study the indicators and regional features of circulatory disease morbidity among the able-bodied population in the Far Eastern Federal District for the 2012–2021 period.Material and methods. A descriptive statistical study was conducted. The indicators of incidence and prevalence rates of circulatory system diseases, including ischemic heart diseases and cerebrovascular diseases, were calculated according to the data published by the Russian Research Institute of Health. To assess the statistical significance of differences in the incidence rate in 2020 and 2021 relative to the 2012–2019 period, a 95% CI for the average incidence rate in 2012–2019 was used by generating repeated samples. Differences in the incidence and prevalence rates in 2020 and 2021 above the upper or below the lower CI boundary for the average values in 2012–2019 were considered statistically significant.Results. An analysis of the incidence and prevalence rates of circulatory system diseases among the working-age population in the Far Eastern Federal District in 2012–2021 was carried out. The obtained data are characterized by a significant variability and heterogeneity of indicators, showing significant differences from the all-Russian data for the 2012–2019 period. Changes in the incidence and prevalence rates of circulatory system diseases in the Far Eastern Federal District during the spread of COVID-19 in 2020–2021 were found to be multidirectional. In general, the statistically significant increase in the incidence of coronary heart disease in the Far Eastern Federal District in 2020 and 2021 is largely associated with the growth of indicators in the Khabarovsk Krai.Conclusions. The obtained characteristics of the incidence and prevalence rates of circulatory system diseases, including ischemic heart diseases and cerebrovascular diseases, indicate the presence of pronounced regional characteristics. The revealed multiple differences in the morbidity rates in the subjects of the Far Eastern Federal District require further research to determine their priority and significance for monitoring the health of the population.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"77 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139870875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Аnalysis of clinical cases of diabetic retinopathy progression in pregnant women with type 1 diabetes","authors":"N. Pomytkina","doi":"10.34215/1609-1175-2023-4-69-71","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-4-69-71","url":null,"abstract":"This paper presents clinical cases of diabetic retinopathy (DR) progression in pregnant women with type 1 diabetes. In preproliferative DR, the formation of focal macular edema in both eyes with nonperfusion areas of perimacular localization was observed. Both eyes were subjected to laser coagulation of the retina. After one month, a regression of macular edema in the left eye and hemorrhagic phenomena in both eyes was established with the emergence of new nonperfusion zones. DR progression during pregnancy and in the postpartum period is determined by a number of factors, including diabetes mellitus compensation, retinopathy stabilization, and the presence of concomitant pathologies. In the aggressive course of proliferative DR, local traction retinal detachment and partial hemophthalmos of the left eye were revealed. In this case, three stages of panretinal laser coagulation of both eyes and endovitreal intervention with silicone tamponade on the left eye were performed. At 28 weeks of gestation, progression of retinal neovascularization was observed in the right eye, extensive areas of nonperfusion in the posterior pole. The areas of laser coagulation of the retina were compacted in the right eye.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"41 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139870059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}