Journal of Internal Medicine最新文献

{"title":"Higher circulating FGF21, lower protein intake, and lower muscle mass: Associations with a higher risk of mortality","authors":"Adrian Post,&nbsp;Wendy A. Dam,&nbsp;Dion Groothof,&nbsp;Casper F. M. Franssen,&nbsp;Stephan J. L. Bakker,&nbsp;Robin P. F. Dullaart","doi":"10.1111/joim.20099","DOIUrl":"10.1111/joim.20099","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objectives</h3>\u0000 \u0000 <p>This population-based study explores associations of fibroblast growth factor 21 (FGF21), a key modulator of processes linked to protein metabolism, with protein intake and muscle mass, and their relationships with all-cause mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In 6395 participants (mean age 54 years; 50% women), circulating FGF21 (immunoassay), protein intake (Maroni equation using 24-h urinary urea excretion; low intake defined as &lt;0.8 g/kg/day), and muscle mass (24-h creatinine excretion rate indexed to height squared (CERI)) were documented.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>FGF21 concentration was 896 (540–1384) pg/mL, protein intake was 1.01 (0.85–1.19) g/kg/day, and CERI was 4.1 ± 0.9 mmol/day/m². Higher FGF21 was associated with higher odds of low protein intake (odds ratio per doubling: 1.48; 95% confidence interval [CI]: 1.38–1.58; <i>p</i> &lt; 0.0001) and lower muscle mass (standardized beta: −0.08; 95% CI: −0.10; −0.06; <i>p</i> &lt; 0.001). Over 10.4 years of follow-up, 955 deaths were registered. Higher FGF21 was associated with increased mortality (hazard ratio (HR) per doubling: 1.09; 95% CI: 1.02–1.16; <i>p</i> = 0.009). Conversely, higher protein intake (HR per doubling: 0.67; 95% CI: 0.56–0.81; <i>p</i> &lt; 0.0001) and higher CERI (HR per standard deviation increase: 0.83; 95% CI: 0.76–0.90; <i>p</i> &lt; 0.0001) were associated with a lower risk of mortality, independent of potential confounders. However, the FGF21-mortality association became non-significant after adjusting for protein intake.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Higher FGF21 was associated with higher odds of low protein intake. The observed association of higher FGF21 concentrations and risk mortality was predominantly attributable to lower protein intake. In contrast, both higher protein intake and higher muscle mass were independently associated with lower mortality risk, highlighting the potential relevance of protein intake and maintenance of muscle mass in long-term health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":196,"journal":{"name":"Journal of Internal Medicine","volume":"298 1","pages":"2-15"},"PeriodicalIF":9.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/joim.20099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standard and advanced echocardiographic study of patients with Paget's disease of bone: Evidence of a pagetic heart disease?","authors":"Alfonso Giaquinto,&nbsp;Veronica Abate,&nbsp;Anita Vergatti,&nbsp;Riccardo Muscariello,&nbsp;Adelaide Iervolino,&nbsp;Martina Pucci,&nbsp;Guido Cavati,&nbsp;Filippo Pirrotta,&nbsp;Gianpaolo De Filippo,&nbsp;Roberta Esposito,&nbsp;Lanfranco D'Elia,&nbsp;Daniela Merlotti,&nbsp;Luigi Gennari,&nbsp;Domenico Rendina","doi":"10.1111/joim.20069","DOIUrl":"10.1111/joim.20069","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Paget's disease of the bone (PDB) is a metabolic bone disorder involving one or more skeletal sites. Cardiovascular diseases (CVDs) have been described in patients with PDB but have not been systematically analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to compare standard and advanced (speckle-tracking) echocardiographic parameters measured in patients with PDB and controls matched for age, weight, height and history of hypertension but without metabolic bone disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This multicentre case–control study included all patients with PDB referred to the Federico II and Siena Universities, Italy, from March 2019 to October 2022. During the same time, we enrolled at least one control for each patient, matched for age, sex, body mass index (BMI) and history of hypertension.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-nine patients with PDB and 115 healthy controls were enrolled in this study. All patients with PDB were treated with zoledronic acid at the time of diagnosis. Compared with controls, on standard echocardiography, patients with PDB showed a high prevalence of aortic and mitral valve calcifications and/or sclerosis, reduced left ventricular (LV) ejection fraction, stroke volume, cardiac output, increased interventricular septum thickness, posterior wall thickness, LV mass index, relative wall thickness, relative diastolic wall thickness, <i>E</i>/<i>e</i>′ ratio and systemic vascular resistance. Using speckle-tracking echocardiography, patients with PDB showed a lower global longitudinal strain and global myocardial work efficiency than controls. There was no relationship between the PDB activity and extent and severity of cardiac abnormalities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, the myocardial function and structure were impaired in patients with PDB. Additionally, PDB was associated with early subclinical myocardial damage.</p>\u0000 </section>\u0000 </div>","PeriodicalId":196,"journal":{"name":"Journal of Internal Medicine","volume":"297 6","pages":"630-641"},"PeriodicalIF":9.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/joim.20069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The yin–yang between clonal hematopoiesis of indeterminate potential and autoimmune diseases","authors":"Zachary Brady,&nbsp;Valeria Visconte","doi":"10.1111/joim.20091","DOIUrl":"10.1111/joim.20091","url":null,"abstract":"&lt;p&gt;The article by Wu et al. [&lt;span&gt;1&lt;/span&gt;] in the &lt;i&gt;Journal of Internal Medicine&lt;/i&gt; investigates the relation between clonal hematopoiesis of indeterminate potential (CHIP) and autoimmune diseases. The reason behind such relation might be attributed to changes in the immune system occurring with advanced age.&lt;/p&gt;&lt;p&gt;Indeed, CHIP is common in the elderly and asymptomatic. Individuals with CHIP have an increased risk of hematologic malignancies and chronic inflammatory diseases, such as cardiovascular disease [&lt;span&gt;2, 3&lt;/span&gt;]. The latter has been associated to enhanced production of proinflammatory cytokines and accelerated atherosclerosis. More recently, studies have found associations between CHIP and multiple autoimmune diseases; specifically, large CHIP clones (&gt;10% or &gt;15%) were associated with an increased risk of seropositive rheumatoid arthritis (RA) and, to a lesser extent, RA [&lt;span&gt;4&lt;/span&gt;]. Of note is that 60% of patients with the notable hemato-immunoinflammatory VEXAS syndrome have CHIP [&lt;span&gt;5&lt;/span&gt;]. Observations from studies of Behçet's disease, a chronic inflammatory immune-mediated disorder, indicate that some extent of inflammation is associated with CHIP emergence [&lt;span&gt;6&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Wu et al. [&lt;span&gt;1&lt;/span&gt;] set out to address the interplay between CHIP and autoimmune diseases. To do so, the authors analyzed data collected from whole blood-derived exome sequencing (WES) of 456,692 UK Biobank participants after exclusion of (a) individuals with hematologic malignancies, (b) individuals with more than 10 third-degree relatives, (c) heterozygous outliers, and (d) participants with a baseline autoimmune disease. Overall, 19 immune-mediated inflammatory diseases were selected (Addison's disease, ankylosing spondylitis, coeliac disease, type 1 diabetes, Graves’ disease, Crohn's disease, ulcerative colitis, multiple sclerosis, myasthenia gravis, pernicious anemia, polymyalgia rheumatica, primary biliary cholangitis, psoriasis, RA, Sjögren's syndrome, systemic lupus erythematosus, systemic sclerosis, vasculitis, and vitiligo). Association between CHIP (with a variant allele frequency [VAF] more than (a) 2%, (b) 10%, and (c) specific CHIP mutation) was analyzed. In total, 58 CHIP genes were included.&lt;/p&gt;&lt;p&gt;Overall, 17,433 (3.82%) individuals had any CHIP (&lt;i&gt;DNMT3A&lt;/i&gt; [2.40%] with p.R882H being the most common mutation, &lt;i&gt;TET2&lt;/i&gt; [0.47%], &lt;i&gt;ASXL1&lt;/i&gt; variants [0.25%], spliceosomal genes [0.11%], and &lt;i&gt;PPM1D&lt;/i&gt; [0.11%] variants). More than one CHIP mutation was detected in 6.10% of individuals. Specific CHIP mutations were associated with different autoimmune diseases. A large part of the study focuses on making inflammation the central node between CHIP and autoimmune disorders. However, as per today, this connection is still very vague and rather inconclusive due to the high number of inflammatory markers possibly involved in the process and the inability to assess all of them.&lt;/p&gt;&lt;p&gt;A point of discussion rem","PeriodicalId":196,"journal":{"name":"Journal of Internal Medicine","volume":"297 6","pages":"558-559"},"PeriodicalIF":9.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/joim.20091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related cardiovascular disease in Down syndrome: A population-based matched cohort study","authors":"Annie Pedersen,&nbsp;Anna Skarin Nordenvall,&nbsp;Giorgio Tettamanti,&nbsp;Ann Nordgren","doi":"10.1111/joim.20093","DOIUrl":"10.1111/joim.20093","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Life expectancy for individuals with Down syndrome (DS) has increased dramatically. To improve detection and prevention, the risk of age-related cardiovascular disease in this population needs to be better defined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a population-based matched cohort study. Through the National Patient Register (NPR) and/or the Medical Birth Register, we identified all individuals born in Sweden between 1946 and 2000 with a diagnosis of DS. Each individual with DS was matched to 50 comparators by sex, birth year, and county of birth. Data on ischemic and hemorrhagic stroke, acute myocardial infarction (AMI), and covariates indicating cardiovascular risk were retrieved from the NPR. Associations between DS and cardiovascular outcomes were estimated using Cox proportional hazards models. We also assessed the influence of cardiovascular risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included 5155 individuals with DS, of which 55% were male. The median age at the end of follow-up was 35 in the DS population and 42 among the comparisons. DS was associated with increased risk of ischemic stroke (hazard ratios [HR] 4.41, 95% confidence intervals [CI] 3.53–5.52) and hemorrhagic stroke (HR 5.14, 95% CI 3.84–6.89). The overall risk of AMI was similar in DS and comparators but increased in young individuals with DS. The risk of ischemic stroke was elevated in individuals with DS with selected atherosclerotic (HR 12.67, 95% CI 7.04–22.78) as well as embolic (HR 10.35, 95% CI 6.69–16.01) risk factors, as compared to comparators without risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Individuals with DS were at increased risk of cardiovascular outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":196,"journal":{"name":"Journal of Internal Medicine","volume":"297 6","pages":"683-692"},"PeriodicalIF":9.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/joim.20093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse effects of obesity on overall health, quality of life, and related physical health metrics: A cross-sectional and longitudinal study from the All of Us Research Program","authors":"Zhiqi Yao,&nbsp;Beverly G. Tchang,&nbsp;Kacey Chae,&nbsp;Michael Albert,&nbsp;Jeanne M. Clark,&nbsp;Michael J. Blaha","doi":"10.1111/joim.20083","DOIUrl":"10.1111/joim.20083","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Population-level adverse effects of obesity beyond commonly considered chronic conditions need to be characterized to understand its overall burden.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the cross-sectional associations between obesity and self-reported status of overall health, quality of life, pain, fatigue, ability of physical activity, and the risks of developing chronic pain syndrome, chronic fatigue syndrome, fibromyalgia, and insomnia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using data from the All of Us Research Program (the United States), we included participants with a body mass index (BMI) ≥18.5 kg/m² and available Overall Health Survey or electronic health records. Cross-sectional analyses of self-reported variables were conducted using multivariable logistic and linear regression models. Cox proportional-hazard models were used to assess risks for incident outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 323,640 participants (60.3% were female, mean age: 51.3 years), 20.7%, 11.0%, and 9.5% were with Classes I, II, and III obesity, respectively. Higher BMI categories were correlated with worse health metrics, with Class III obesity exhibiting the greatest disparities. Among those with Class III obesity, 9.6% (vs. 3.2% for normal weight) reported poor overall health, 28.3% (vs. 13.2%) reported severe pain, and 11.8% (vs. 8.4%) had prevalent insomnia. Graded associations were observed across high BMI categories, with Class III obesity showing the strongest effects. Compared with normal weight, in Class III obesity, the odds ratio (95% CI) was 3.82 (3.69–3.96) for fair/poor overall health, 3.93 (3.71–4.17) for severe pain, and 3.13 (2.98–3.29) for severely limited physical activity; the hazard ratio (95% CI) was 2.83 (2.36–3.40) for fibromyalgia and 1.53 (1.41–1.65) for insomnia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Obesity imposes a substantial burden on broad aspects of well-being in the US population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":196,"journal":{"name":"Journal of Internal Medicine","volume":"297 6","pages":"657-671"},"PeriodicalIF":9.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated lipoprotein(a) and progression of aortic stenosis measured by Doppler echocardiography: A population-based cohort study","authors":"Jonas Brinck,&nbsp;Karin Littmann,&nbsp;Daniel Eriksson Hogling,&nbsp;Linnea Widman,&nbsp;Kenneth Caidahl,&nbsp;Maria Eriksson,&nbsp;Jonas Johnson,&nbsp;Karolina Szummer,&nbsp;Magnus Bäck","doi":"10.1111/joim.20095","DOIUrl":"10.1111/joim.20095","url":null,"abstract":"&lt;p&gt;Elevated lipoprotein(a) (Lp(a)) is a dyslipoproteinaemia that causes atherosclerotic cardiovascular disease and calcified aortic valve stenosis (AS) [&lt;span&gt;1, 2&lt;/span&gt;]. AS develops over decades and can lead to valve obstruction requiring an aortic valve procedure. Both genetic variations in the LPA gene and an elevated plasma Lp(a) level are associated with an increased incidence of AS [&lt;span&gt;3, 4&lt;/span&gt;]. Measurement of peak aortic jet velocity (&lt;i&gt;V&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt;; m/s) with Doppler echocardiography is used to assess and monitor AS in clinical routine. In the ASTRONOMER trial, a limited number of participants (&lt;i&gt;n&lt;/i&gt; = 220) with mild-to-moderate AS (initial &lt;i&gt;V&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt; ≥ 2.5 m/s) who underwent repeated echocardiography exhibited faster &lt;i&gt;V&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt; progression with elevated Lp(a) [&lt;span&gt;5-7&lt;/span&gt;]. Similar faster haemodynamic progression at higher Lp(a) levels was reported in 129 subjects with AS (initial &lt;i&gt;V&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt; ≥ 2.0 m/s) from the SATIRE trial and Ring of Fire study [&lt;span&gt;8&lt;/span&gt;]. However, the impact of Lp(a) on AS progression in an unselected population has remained unexplored. The aim of the present study was to determine the effect of elevated plasma Lp(a) on AS progression measured as &lt;i&gt;V&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt; by repeated Doppler echocardiography in a large cohort with and without AS at any stage.&lt;/p&gt;&lt;p&gt;We performed an observational retrospective cohort study by linking two databases of individuals who had had their plasma Lp(a) level measured 2003–2017 (&lt;i&gt;n&lt;/i&gt; = 23,398) and who had ≥2 Doppler echocardiography &lt;i&gt;V&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt; measurements with ≥6 months of interval 2003–2018 (&lt;i&gt;n&lt;/i&gt; = 9889) in the clinical routine in Region Stockholm, Sweden (Fig. S1). Lp(a) was analysed using accredited laboratory methods, reporting values in nmol/L or mg/dL as previously described [&lt;span&gt;9&lt;/span&gt;]. Participants were subdivided into three Lp(a) strata defined as low (&lt;70 nmol/L or &lt;30 mg/dL), intermediate (70–169 nmol/L or 30–69 mg/dL) and high (≥170 nmol/L or ≥70 mg/dL). Transthoracic Doppler echocardiography was performed at Karolinska University Hospital using standard equipment. The current European Society of Cardiology guidelines recommendation on AS management in relation to AS progression is based on the change in &lt;i&gt;V&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt;, measured in m/s/year, which was calculated in the present study as the difference between the first and the last Doppler measurement divided by the time interval. Individuals who underwent aortic valve replacement (AVR) were excluded if the procedure was performed before the first echocardiography and censored if undergoing AVR during the observational period. The individuals’ cardiovascular status was specified by the International Classification of Diseases diagnoses. Differences between individuals in Lp(a) strata were compared using the Kruskal–Wallis test, Dunn's post hoc test and unbalanced adjusted analysis of covariance with ranked transformed","PeriodicalId":196,"journal":{"name":"Journal of Internal Medicine","volume":"298 1","pages":"46-48"},"PeriodicalIF":9.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/joim.20095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonal hematopoiesis of indeterminate potential and risk of immune thrombocytopenia","authors":"Qianwei Liu,&nbsp;Tove Wästerlid,&nbsp;Karin E. Smedby,&nbsp;Huiwen Xue,&nbsp;Erik Boberg,&nbsp;Fang Fang,&nbsp;Xinyuan Liu","doi":"10.1111/joim.20092","DOIUrl":"10.1111/joim.20092","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Clonal hematopoiesis of indeterminate potential (CHIP) might contribute to the pathogenesis of immune thrombocytopenia (ITP) through immune dysfunction or impairment of megakaryopoiesis and platelet formation. However, little is known about subsequent risk of ITP among individuals with CHIP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the risk of ITP among individuals with CHIP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We investigated the association of CHIP with risk of ITP by a prospective cohort study, including 466,064 participants in the UK Biobank, during 2006 to 2022. CHIP was ascertained based on data of whole exome sequencing. Incident ITP was identified in inpatient hospital records and death register. Cox regression models were utilized to estimate risk of ITP associated with CHIP. We also performed subgroup analyses by CHIP mutations (<i>DNMT3A</i>, <i>TET2</i>, <i>ASXL1</i>, <i>SRSF2</i>, and <i>JAK2</i>).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 14,466 and 451,598 individuals with and without CHIP, respectively. We identified 34 and 390 cases of ITP among the CHIP group and the reference group, respectively. CHIP was associated with an increased risk of ITP (hazard ratio [HR] 2.33, 95% confidence interval [CI]: 1.64–3.32). Subgroup analysis revealed that the heightened risk of ITP was greatest in CHIP with <i>JAK2</i> mutation (HR 54.31, 95% CI: 17.39–169.59), followed by CHIP with <i>SRSF2</i> (HR 20.11, 95% CI: 8.27–48.87), <i>TET2</i> (HR 4.00, 95% CI: 2.34–6.83), or <i>DNMT3A</i> (HR 1.95, 95% CI: 1.16–3.27) mutation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CHIP was associated with an increased risk of being diagnosed with ITP, particularly for CHIP with <i>JAK2</i> or <i>SRSF2</i> mutation. These findings call for clinical awareness of the risk of ITP among individuals with CHIP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":196,"journal":{"name":"Journal of Internal Medicine","volume":"297 6","pages":"672-682"},"PeriodicalIF":9.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes","authors":"David Rizo-Roca,&nbsp;John D. Henderson,&nbsp;Juleen R. Zierath","doi":"10.1111/joim.20090","DOIUrl":"10.1111/joim.20090","url":null,"abstract":"<p>Cardiometabolic diseases—including Type 2 diabetes and obesity—remain leading causes of global mortality. Recent advancements in metabolomics have facilitated the identification of metabolites that are integral to the development of insulin resistance, a characteristic feature of cardiometabolic disease. Key metabolites, such as branched-chain amino acids (BCAAs), ceramides, glycine, and glutamine, have emerged as valuable biomarkers for early diagnosis, risk stratification, and potential therapeutic targets. Elevated BCAAs and ceramides are strongly associated with insulin resistance and Type 2 diabetes, whereas glycine exhibits an inverse relationship with insulin resistance, making it a promising therapeutic target. Metabolites involved in energy stress, including ketone bodies, lactate, and nicotinamide adenine dinucleotide (NAD⁺), regulate insulin sensitivity and metabolic health, with ketogenic diets and NAD⁺ precursor supplementation showing potential benefits. Additionally, the novel biomarker <i>N</i>-lactoyl-phenylalanine further underscores the complexity of metabolic regulation and its therapeutic potential. This review underscores the potential of metabolite-based diagnostics and precision medicine, which could enhance efforts in the prevention, diagnosis, and treatment of cardiometabolic diseases, ultimately improving patient outcomes and quality of life.</p>","PeriodicalId":196,"journal":{"name":"Journal of Internal Medicine","volume":"297 6","pages":"584-607"},"PeriodicalIF":9.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/joim.20090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota development across the lifespan: Disease links and health-promoting interventions","authors":"Ida Schoultz,&nbsp;Marcus J. Claesson,&nbsp;Maria Gloria Dominguez-Bello,&nbsp;Frida Fåk Hållenius,&nbsp;Peter Konturek,&nbsp;Katri Korpela,&nbsp;Martin Frederik Laursen,&nbsp;John Penders,&nbsp;H. Roager,&nbsp;Tommi Vatanen,&nbsp;Lena Öhman,&nbsp;Maria C. Jenmalm","doi":"10.1111/joim.20089","DOIUrl":"10.1111/joim.20089","url":null,"abstract":"<p>The gut microbiota plays a pivotal role in human life and undergoes dynamic changes throughout the human lifespan, from infancy to old age. During our life, the gut microbiota influences health and disease across life stages. This review summarizes the discussions and presentations from the symposium “Gut microbiota development from infancy to old age” held in collaboration with the Journal of Internal Medicine. In early infancy, microbial colonization is shaped by factors such as mode of delivery, antibiotic exposure, and milk-feeding practices, laying the foundation for subsequent increased microbial diversity and maturation. Throughout childhood and adolescence, microbial maturation continues, influencing immune development and metabolic health. In adulthood, the gut microbiota reaches a relatively stable state, influenced by genetics, diet, and lifestyle. Notably, disruptions in gut microbiota composition have been implicated in various inflammatory diseases—including inflammatory bowel disease, Type 1 diabetes, and allergies. Furthermore, emerging evidence suggests a connection between gut dysbiosis and neurodegenerative disorders such as Alzheimer's disease. Understanding the role of the gut microbiota in disease pathogenesis across life stages provides insights into potential therapeutic interventions. Probiotics, prebiotics, and dietary modifications, as well as fecal microbiota transplantation, are being explored as promising strategies to promote a healthy gut microbiota and mitigate disease risks. This review focuses on the gut microbiota's role in infancy, adulthood, and aging, addressing its development, stability, and alterations linked to health and disease across these critical life stages. It outlines future research directions aimed at optimizing the gut microbiota composition to improve health.</p>","PeriodicalId":196,"journal":{"name":"Journal of Internal Medicine","volume":"297 6","pages":"560-583"},"PeriodicalIF":9.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/joim.20089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic options for human papillomavirus-positive tonsil and base of tongue cancer","authors":"Mark Zupancic,&nbsp;Ourania N. Kostopoulou,&nbsp;Linda Marklund,&nbsp;Tina Dalianis","doi":"10.1111/joim.20088","DOIUrl":"10.1111/joim.20088","url":null,"abstract":"<p>The incidences of human papillomavirus-positive (HPV⁺) tonsillar and base tongue squamous cell carcinomas (TSCC and BOTSCC) have increased in recent decades. Notably, HPV⁺ TSCC and BOTSCC have a significantly better prognosis than their HPV-negative counterparts when treated with current surgical options, radiotherapy, or intensified chemoradiotherapy. However, a cure is not achieved in 20% of patients with HPV⁺ TSCC/BOTSCC. Meanwhile, cured patients often present with severe chronic side effects. This necessitates novel tailored alternatives, such as targeted therapy, immune checkpoint inhibitors (ICIs), and treatment de-escalation, together with better follow-up. Current precision medicine therefore focuses on detecting predictive and driver cancer genes to better stratify patient treatment, provide those with poor prognostic markers targeted therapy, and select those with favorable markers for de-escalated therapy. Moreover, detecting cell-free HPV DNA (cfHPV DNA) in plasma before and after treatment has been attempted to improve follow-up. In this context, this perspective discusses the significance of optimally defining HPV⁺ status, which requires HPV DNA and p16^INKa overexpression, using prognostic markers, such as high CD8⁺ T-cell counts and HPV E2 mRNA expression, tumor size, and following cfHPV DNA for patient selection for specific therapies. Clinical trials with ICI with/without chemotherapy, targeted therapy with specific inhibitors—such as phosphoinositide 3-kinase and fibroblast growth factor receptor inhibitors—or immune therapy with various HPV-based vaccines for treating recurrences have yielded promising results.</p>","PeriodicalId":196,"journal":{"name":"Journal of Internal Medicine","volume":"297 6","pages":"608-629"},"PeriodicalIF":9.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/joim.20088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}