Oral abstracts最新文献_第9页

003 Autoimmune encephalitis antibody biomarkers: frequency, age and sex associations 自身免疫性脑炎抗体生物标志物:频率、年龄和性别相关性

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.3

Amy Kunchok, V. Lennon, C. Klein, E. Flanagan, D. Dubey, A. Zekeridou, A. McKeon, S. Pittock

{"title":"003 Autoimmune encephalitis antibody biomarkers: frequency, age and sex associations","authors":"Amy Kunchok, V. Lennon, C. Klein, E. Flanagan, D. Dubey, A. Zekeridou, A. McKeon, S. Pittock","doi":"10.1136/bmjno-2021-anzan.3","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.3","url":null,"abstract":"Objective To determine the frequency, age and sex associations for autoimmune encephalitis antibody biomarkers (AE-Abs). Methods There were 42032 patients tested in the Mayo Clinic Neuroimmunology Laboratory between January 2018-December 2019 for AE-Abs in serum and/or cerebrospinal fluid (CSF) including; NMDA-R-IgG, AMPA-R-IgG, GABAB-R-IgG, CASPR2-IgG, LGI1-IgG, GAD65-IgG, CRMP5-IgG, amphiphysin-IgG, PCA1/2/Tr-IgGs, ANNA1/2/3-IgGs, GFAP-α-IgG, mGluR1-IgG, DPPX-IgG, MOG-IgG1, were examined to determine frequency of antibody positivity. Age and sex associations were examined using multivariable logistic regression. Results Adult serum analysis (22,472 patients; 56% female) revealed 814 (4%) were positive: NMDA-R-IgG (25%) > GAD65-IgG (22%) > LGI1-IgG (21%) > others. Of children (5,649; 50% female), 250 (4%) were positive: NMDA-R-IgG (53%) > MOG-IgG1 (32%) > GAD65-IgG (7%) > others. Adult CSF analysis (18,745 patients; 54% female) revealed 709 (4%) were positive; NMDA-R-IgG (45%) > GAD65-IgG (19%) > LGI1-IgG (13%) > others. Of children (5136; 50% female), 276 (5%) were positive: NMDA-R-IgG (90%) > GAD65-IgG (7%) > others. Age 65 years was associated with GABAB-R-IgG, LGI1-IgG, CASPR2-IgG and ANNA1-IgG (OR=7.33, 14.98, 3.67, 14.53, p Conclusion The most frequently detected were NMDA-R-IgG, LGI1-IgG, GAD65-IgG and MOG-IgG1. Age and sex associations may suggest paraneoplastic, endocrinological or aging influences on neurological autoimmunity.","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"500 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76335823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

005 Psoriasis in multiple sclerosis: an Australian prevalence study 2005银屑病在多发性硬化症:澳大利亚流行病学研究

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.5

Varitsara Mangkorntongsakul, Olivia A. Charlton, K. Phan, Ariadna Fontes, J. Parratt, G. Herkes, Saxon D. Smith

{"title":"005 Psoriasis in multiple sclerosis: an Australian prevalence study","authors":"Varitsara Mangkorntongsakul, Olivia A. Charlton, K. Phan, Ariadna Fontes, J. Parratt, G. Herkes, Saxon D. Smith","doi":"10.1136/bmjno-2021-anzan.5","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.5","url":null,"abstract":"Background Multiple Sclerosis (MS) is an immune-mediated, demyelinating disease of the central nervous system.1 Although severe psoriasis and psoriasiform dermatitis have been noted in MS patients, the prevalence of psoriasis in these populations is uncertain and has not been explored in the Australian population. Objectives A pilot study to estimate the prevalence of psoriasis in MS cohorts in the Australian population. Methods A survey was conducted on 82 MS patients aged 18 and above who attended MS clinics in 2018. Results Data was recorded for 82 patients. The mean age was 48 years for the entire cohort and 48.0 years (SD ±11.30) for patients diagnosed with psoriasis. The observed prevalence of psoriasis in MS patients was 12.19% however, the true prevalence is likely to be much higher as various symptoms of psoriasis were reported by a much larger proportion of MS patients. Of the 72 cases without psoriasis, various skin symptoms that were reported were intermittent irritation (for at least 6 months) or erythematous rash (35.4%), seasonal skin changes (39.0%) and thickened scaly skin behind ears and scalps (18.3%). Moreover, 18.3% had flaky, peeling or scaly skin while 24.4% experienced dandruff; 17.1% reported nail changes, and 13.4% reported a family history of psoriasis. The study also showed that combined psoriasis and eczema was relatively common at 3.7%. Conclusions In this pilot study there is a high prevalence of psoriasis in patients with MS suggesting an immunopathological association between the two diseases and indicates that further studies should be done to elucidate common mechanisms,and the nature of this phenotype. Reference Montalban X, Tintore M, Swanton J, Barkhof F, Fazekas F, Filippi M, et al. MRI criteria for MS in patients with clinically isolated syndromes. Neurology 2010;74(5):427–34.","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81444509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

015 Gut microbiota and nutritional profiles of Parkinson’s disease patients 帕金森氏症患者的肠道微生物群和营养状况

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.15

M. Lubomski, Xiangnan Xu, A. Holmes, Samuel Mueller, J. Yang, C. Sue, R. Davis

{"title":"015 Gut microbiota and nutritional profiles of Parkinson’s disease patients","authors":"M. Lubomski, Xiangnan Xu, A. Holmes, Samuel Mueller, J. Yang, C. Sue, R. Davis","doi":"10.1136/bmjno-2021-anzan.15","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.15","url":null,"abstract":"Objectives Imbalances in the composition of the gut microbiome (GM) from Parkinson’s disease (PD) patients have been reported previously. Collectively, the limited literature indicates a reduction in short-chain fatty-acid–producing bacteria that negatively influence colonic permeability and inflammation. We investigated GM composition in association with various clinical features and nutritional data in a large cross-sectional Australian PD cohort, to determine whether short-chain fatty-acid–producing bacteria representation in the GM was altered in association with clinical or nutritional differences between PD patients and controls. Methods Clinical outcome measures derived from PD-validated questionnaires and stool samples were collected from 103 PD patients and 81 spousal healthy controls (HCs). GM composition, determined from 16S amplicon sequencing of the V3-V4 region of stool bacterial DNA, was compared between groups and with clinical outcome measures. Results We identified significant compositional differences in the GM profiles of PD patients compared to HCs, across order, family and genus taxonomic levels. Multiple taxa were associated with a variety of clinical PD characteristics. Predictive models using GM profiles were developed to identify PD and were improved by incorporating nutritional data. Conclusions We identified notable differences in microbial diversity and GM composition in PD patients compared to HCs that, along with nutritional data, enabled the development of predictive modelling to identify PD. These findings further support the GM as a potentially useful biomarker of PD pathophysiology.","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84969819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

O-013 Acute carotid artery stenting versus balloon angioplasty for tandem occlusions: a systematic review and meta-analysis 急性颈动脉支架置入术与球囊血管成形术治疗串联闭塞:系统回顾和荟萃分析

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/NEURINTSURG-2021-SNIS.13

C. Zevallos, M. Farooqui, D. Quispe-Orozco, A. Mendez‐Ruiz, A. Dajles, A. Garg, M. Patterson, O. Zaidat, S. Ortega‐Gutierrez

引用次数: 0

001 Neurological manifestations of coronavirus disease 2019: a comprehensive review 2019冠状病毒病的神经学表现:综合综述

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.1

J. Fanning, Samuel F. Huth, Sung-Min Cho, C. Robba, D. Highton, D. Battaglini, Judith Bellapart-Rubio, J. Suen, G. Bassi, F. Taccone, Rakesh C. Arora, Glenn Whitman, J. Fraser

{"title":"001 Neurological manifestations of coronavirus disease 2019: a comprehensive review","authors":"J. Fanning, Samuel F. Huth, Sung-Min Cho, C. Robba, D. Highton, D. Battaglini, Judith Bellapart-Rubio, J. Suen, G. Bassi, F. Taccone, Rakesh C. Arora, Glenn Whitman, J. Fraser","doi":"10.1136/bmjno-2021-anzan.1","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.1","url":null,"abstract":"Background There is growing evidence that SARS-Cov-2 infection is associated with severe neurological complications. Understanding the nature and prevalence of these neurologic manifestations is essential for identifying higher-risk patients and projecting demand for ongoing resource utilisation. This review and meta-analysis report the neurologic manifestations identified in hospitalised COVID-19 patients and provide a preliminary estimate of disease prevalence. Methods MEDLINE, Embase and Scopus were searched for studies reporting the occurrence of neurological complications in hospitalised COVID-19 patients. Results A total of 2207 unique entries were identified and screened, among which 14 cohort studies and 53 case reports were included, reporting on a total of 8,577 patients. Central nervous system manifestations included ischemic stroke (n=226), delirium (n=79), intracranial haemorrhage (ICH, n=57), meningoencephalitis (n=13), seizures (n=3), and acute demyelinating encephalitis (n=2). Peripheral nervous system manifestations included Guillain-Barre Syndrome (n=21) and other peripheral neuropathies (n=3). The pooled period prevalence of ischemic stroke from identified studies was 1.3% [95%CI: 0.9% – 1.8%, 102/7715] in all hospitalised COVID-19 patients, and 2.8% [95%CI: 1.0% - 4.6%, 9/318] among COVID-19 patients admitted to ICU. The pooled prevalence of ICH was estimated at 0.4% [95%CI: 0%-0.8%, 6/1006]. Conclusions The COVID-19 pandemic exerts a substantial neurologic burden which may have residual effects on patients and healthcare systems for years. Low quality evidence impedes the ability to accurately predict the magnitude of this burden. Robust studies with standardised screening and case definitions are required to improve understanding of this disease and optimise treatment of individuals at higher risk for neurologic sequelae.","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75946475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

041 Cognitive impairment in late onset epilepsy 041迟发性癫痫的认知障碍

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.41

Xin Zhang, A. Nikpour, R. Ahmed

{"title":"041 Cognitive impairment in late onset epilepsy","authors":"Xin Zhang, A. Nikpour, R. Ahmed","doi":"10.1136/bmjno-2021-anzan.41","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.41","url":null,"abstract":"Objective Late onset, unprovoked epilepsy patients with cognitive impairment can have complex pathophysiology.1 Our objective was to study the characteristics and contributors of cognitive impairment in this group; and how patients with dementia could be differentiated from late onset epilepsy patients. Methods Twenty-six patients with epilepsy, onset after 50 years of age, with new cognitive complaints and 26 patients with clinically diagnosed Alzheimer’s Disease (AD) were recruited. These participants had comprehensive neuropsychological and neuroimaging assessments. A subset of 17 participants from the Epilepsy group underwent longitudinal neuropsychological assessment. Results In the Epilepsy group, the neuropsychological profile of cognitive impairment was consistent with the foci and severity of seizure activity in 46% of participants; subcortical microvascular change in 15%; mood disturbance in 15%; medication in 15%; alcohol in 4% and AD in 4%. Compared with the Epilepsy group, the AD group had a lower Addenbrookes Cognitive Examination III (ACE-III) score (79.3±10.8 versus 87.5±6.5, p=0.01); specifically in the attention, memory and visuospatial subdomains (p=0.004, p=0.002 and p=0.02) but not fluency and language subdomains (p>0.05); and lower scores on additional assessments of naming, visuospatial and executive function (p≤ 0.001). The AD group had more abnormal metabolism in the temporal, parietal and occipital lobes than the Epilepsy group (p=0.02, p=0.006 and p=0.005). Conclusion Patients with late onset epilepsy and cognitive complaints rarely have dementia diagnosed at their first neuropsychological assessment and tend to have milder cognitive impairment than patients with AD. The two groups can be differentiated by their neuropsychological and FDG-PET profiles. Reference Sen A, Capelli V, Husain M. Cognition and dementia in older patients with epilepsy. Brain 2018;141(6):1592–1608.","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82097493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

011 Worsening longitudinal reaction time trajectories using the MSReactor computerised battery predicts confirmed EDSS progression 使用MSReactor计算机化电池的纵向反应时间轨迹恶化预测确认的EDSS进展

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.11

D. Merlo, J. Stankovich, C. Bai, T. Kalincik, M. Gresle, J. Lechner-Scott, T. Kilpatrick, M. Barnett, B. Taylor, D. Darby, H. Butzkueven, A. Walt

{"title":"011 Worsening longitudinal reaction time trajectories using the MSReactor computerised battery predicts confirmed EDSS progression","authors":"D. Merlo, J. Stankovich, C. Bai, T. Kalincik, M. Gresle, J. Lechner-Scott, T. Kilpatrick, M. Barnett, B. Taylor, D. Darby, H. Butzkueven, A. Walt","doi":"10.1136/bmjno-2021-anzan.11","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.11","url":null,"abstract":"Objectives To identify and validate longitudinal reaction time trajectories in relapsing remitting multiple sclerosis using a computerised cognitive battery and latent class mixed modelling, and to assess the association between reaction time trajectories and disability progression. Methods Participants serially completed web-based computerised reaction time tasks measuring psychomotor speed, visual attention and working memory. Testing sessions were completed 6-monthly with the option of additional home based testing. Participants who completed at least three testing sessions over a minimum of 180 days were included in the analysis. Longitudinal reaction times were modelled using Latent Class Mixed Models to group individuals sharing similar latent characteristics. Models were tested for consistency using a cross-validation approach. Inter-class differences in the probability of reaction time worsening and the probability of 6-month confirmed disability progression were assessed using survival analysis. Results A total of 460 relapsing remitting multiple sclerosis patients were included. For each task of the MSReactor computerised cognitive battery, the optimal model comprised of 3 latent classes. All tasks could identify a group with high probability of reaction time slowing. The visual attention and working memory tasks could identify a group of participants who were 3.7 and 2.6 times more likely to experience a 6-month confirmed disability progression, respectively. Participants could be classified into predicted cognitive trajectories after just 5 tests with between 64% and 89% accuracy. Conclusion Latent class modelling of longitudinal cognitive data collected by the MSReactor battery identified a group of patients with worsening reaction times and increased risk of disability progression.","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"177 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89267383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

O-008 Endovascular embolization vs. surgery for ruptured intracranial aneurysms: a propensity-matched study of 2,740 patients in the TriNetX analytics network 血管内栓塞与手术治疗颅内动脉瘤破裂:TriNetX分析网络中2740例患者的倾向匹配研究

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/neurintsurg-2021-snis.8

A. Nia, R. Lall, P. Kan, V. Srinivasan

引用次数: 0

024 Andersen-Tawil syndrome: multi-system deep phenotyping of a large UK cohort 安徒生- tawil综合征:一个大型英国队列的多系统深度表型分析

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.24

V. Vivekanandam, M. Hanna, E. Matthews

{"title":"024 Andersen-Tawil syndrome: multi-system deep phenotyping of a large UK cohort","authors":"V. Vivekanandam, M. Hanna, E. Matthews","doi":"10.1136/bmjno-2021-anzan.24","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.24","url":null,"abstract":"Background Andersen-Tawil Syndrome (ATS) is a rare channelopathy caused by mutations in the KCNJ2 gene that encodes the ubiquitously expressed Kir2.1 potassium channel. Methods In our paper, we describe key findings in a large UK cohort of 52 patients, pertinent to the diagnosis and management of ATS. We report a new point prevalence of 0.105 per 100 000 (increased from 0.08 per 100 000). Results While ATS has historically been considered a triad of episodic weakness, cardiac arrhythmias and dysmorphic features, we show that there is considerable variability to this phenotype. Pure cardiac or muscle phenotypes may exist. The absence of dysmorphic features does not exclude the diagnosis. Similarly, a normal long exercise test was seen in five patients. Importantly, we identify that the phenotype includes a significant risk of cardiac morbidity and mortality with 13% of our cohort requiring cardiac defibrillator or pacemaker insertion and an additional 23% reporting syncope. Syncope has been recently associated with an increased risk of life threatening arhythmic events in this cohort. Severe fixed myopathy was seen in a quarter of our cohort with 14% requiring a wheelchair or gait aid. Conclusions This is the largest multi-system study in ATS and provides key clinical insights to improve diagnosis, as well as management recommendations to address the potential for severe muscle weakness and cardiac morbidity and mortality.","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"171 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75455675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

O-003 Adequate lateral compression is a strong independent predictor of aneurysm occlusion and retreatment after endovascular treatment with WEB 充分的侧压迫是动脉瘤闭塞和血管内治疗后再治疗的一个强有力的独立预测因素

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/neurintsurg-2021-snis.3

J. D. Almandoz, Y. Kayan, A. Copelan, J. Scholz

引用次数: 0