Oral abstracts最新文献_第8页

027 Effect of inter-hospital transfer in patients undergoing endovascular thrombectomy in the early and late time window [27]早、晚时间窗内行血管内取栓术患者转院的影响

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.27

L. Edwards, Christopher Blair, D. Cordato, N. Manning, A. Cheung, J. Wenderoth, C. Cappelen-Smith

引用次数: 0

020 Real-time capture of patient-reported outcomes using a digital platform – a pilot study 020使用数字平台实时捕获患者报告的结果-一项试点研究

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.20

W. D'Souza, N. Lawn, M. Kiley, J. Frasca, E. Whitham, U. Seneviratne, L. Gillinder, Patrick Carney, F. Goodarzy, A. Partovi

{"title":"020 Real-time capture of patient-reported outcomes using a digital platform – a pilot study","authors":"W. D'Souza, N. Lawn, M. Kiley, J. Frasca, E. Whitham, U. Seneviratne, L. Gillinder, Patrick Carney, F. Goodarzy, A. Partovi","doi":"10.1136/bmjno-2021-anzan.20","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.20","url":null,"abstract":"Objectives To demonstrate proof of concept/feasibility of a novel digital platform using real-time capture of patient-reported outcomes for real-world research involving patients with epilepsy. Methods The phone app collects multi-faceted patient-reported outcomes including seizure frequency, medication side effects, mood, anxiety, quality of life and cognition along with voice and digital images. Patients are invited through a national consortium of 18 adult epilepsy centres in Australia. The patient-reported information potentially allows feedback to their treating specialists and tertiary centre in near real-time, along with deidentified aggregation across all participating centres for comparison. Currently, more than 40 patients are enrolled. We present the outcomes of one patient, with the longest-running data points. The new platform was developed by KeyLead Health TM, Melbourne Australia. Results The results report a single patient’s composite scores for mood, sleep, cognition seizures and medication side-effects from the first 1.5 months. Conclusions Our digital phone platform has the potential to facilitate the more effective and efficient capture of longitudinal data enhancing real-world research data integrity along with patient and specialist engagement. Table: Patient reported outcomes for single patient captured using digital phone app date 4/1 7/1 10/1 15/1 20/1 1/2 15/2 18/2 Side effects 4.5 3.8 3.4 3.4 3.4 3.4 3.3 3.8 Memory 9 1 7 5 5 6 7 6 Seizures 3 0 0 1 1 1 2 0 Reaction time 7.7 7.1 12.4 7.0 7.7 7.7 7.9 6.7 Mood 17 16 15 15 12 15 18 16 Sleep 12 6 8 4 3 10 8 5","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"420 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77781387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

029 High Sensitivity Troponin in Acute Ischaemic Stroke Study (TACIS) 高敏感性肌钙蛋白在急性缺血性卒中中的应用研究(TACIS)

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.29

Andrew P Hannaford, Michael Hayes, J. Worthington, T. Ang, Nimalin Harinesan

{"title":"029 High Sensitivity Troponin in Acute Ischaemic Stroke Study (TACIS)","authors":"Andrew P Hannaford, Michael Hayes, J. Worthington, T. Ang, Nimalin Harinesan","doi":"10.1136/bmjno-2021-anzan.29","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.29","url":null,"abstract":"Objective We designed a multi-centre prospective cohort study to explore the hypothesis that early acutely elevated high sensitivity troponin (hsT) is associated with cardioembolic stroke (CES) Methods Ischaemic strokes across three hospitals underwent hsTroponin testing and 2 blinded clinicians classified patients as CES, NCE (Non Cardioembolic) or ESUS by ESUS criteria. Characteristics included baseline NIHSS, renal function, hypertension, diabetes, smoking, ischaemic heart disease, past stroke and congestive cardiac failure. The odds of positive hsT for CES Vs NCE and ESUS Vs NCE were modelled with step-wise addition of patient characteristics. Results 194 ischaemic stroke cases were included, with a mean age of 71 years and a 57:43 male:female ratio. 65 had a positive hsTroponin, which was associated with older age, hypertension, cardiac failure, coronary disease, an eGFR Conclusions An elevated hs troponin after acute ischaemic stroke is independently associated with a cardioembolic mechanism. High sensitivity cardiac troponin was not significantly associated with ESUS after adjusting for confounders, suggesting that a cardio-embolic cause may not be the dominant mechanism in this group.","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"198 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79990187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

014 Visualising the topographic pattern of tau deposition in patients with progressive supranuclear palsy using PI2620-PET [14]利用PI2620-PET观察进行性核上性麻痹患者tau沉积的地形模式

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.14

Lucy E Vivash, Hui Tang, K. Bertram, T. O’Brien

{"title":"014 Visualising the topographic pattern of tau deposition in patients with progressive supranuclear palsy using PI2620-PET","authors":"Lucy E Vivash, Hui Tang, K. Bertram, T. O’Brien","doi":"10.1136/bmjno-2021-anzan.14","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.14","url":null,"abstract":"Objectives The accumulation of tau in the basal ganglia and later cerebellum and frontal cortex is a key pathogenic mechanism in Progressive Supranuclear Palsy (PSP). The ability to detect tau in the living brain has the potential to revolutionise the diagnosis of PSP and other tauopathies, and to monitor the effectiveness of therapeutic interventions targeting tau-based mechanisms. This study investigates the use of a new tau-specific PET radiotracer, PI-2620, as a tool for visualising tau in the living brain. Methods Ten patients with PSP (age 62-75 years, 6 male) underwent a 60 minute dynamic PET scan with PI2620 (185MBq). The dynamic PET data was processed in to a single parametric image of binding potential (BP) using the simplified reference tissue model and the corpus callosum as the reference region. Results Visual inspection of the images showed clear uptake in the basal ganglia nuclei. BP was highest in pallidum (1.99), putamen (1.67), thalamus (1.63), substantia nigra (1.62), cerebellum (1.6) and caudate (1.55), compared to 1.2-1.5 across the cortical regions. Higher BP in the basal ganglia nuclei were associated with higher scores on the PSPRS (putamen, r=0.77, p=0.01). Conclusion PI2620-PET shows promising potential as a technique for specifically imaging and quantitating the topographic pattern of tau distribution in patients with PSP. Further studies are needed to evaluate its use as a diagnostic and treatment monitoring tool for PSP and other tauopathies.","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83262441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

018 Optimising selection for epilepsy surgery 018优化癫痫手术选择

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.18

Anthony Khoo, J. Tisi, Shahidul Mannan, A. O'Keeffe, Josemir W Sander, J. Duncan

{"title":"018 Optimising selection for epilepsy surgery","authors":"Anthony Khoo, J. Tisi, Shahidul Mannan, A. O'Keeffe, Josemir W Sander, J. Duncan","doi":"10.1136/bmjno-2021-anzan.18","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.18","url":null,"abstract":"Objective To determine reasons for adult patients with drug-resistant focal epilepsy who undergo presurgical evaluation not proceeding with surgery and identify factors that influence this decision. Methods We analyzed demographic, imaging and electroclinical data on 617 consecutive patients brought to the Queen Square presurgical epilepsy MDT between January 2015 and December 2019. Multivariable logistic regression was performed to identify predictors of not proceeding with surgery, using comparative data from a prospectively-followed cohort of individuals who had epilepsy surgery at the same centre over an identical 5-year period. Results A definitive decision not to proceed with surgery was made in 315 (51%) cases. Common reasons behind this were an inability to localise the epileptogenic zone (n=104), multifocal epilepsy (n=74) and patients’ decisions not to proceed with intracranial EEG (n=50) or surgery (n=39). Learning disability (OR: 2.35; 95% CI 1.07-5.16), normal MRI (OR: 6.68; 95% CI 3.71-12.05), extratemporal epilepsy (OR: 2.93; 95% CI 1.82-4.71) and bilateral seizure onset zones (OR 3.05; 95% CI 1.41-6.61) were independent predictors of not having surgery. Probability of having surgery in those with normal MRI and extratemporal epilepsy was Conclusions Although underutilized, epilepsy surgery is only appropriate for selected individuals with drug-resistant focal epilepsy. A predictive model based on demographic, imaging and electroclinical data can help determine those unlikely to be suitable for surgery and aid the decision to refer for more extensive or invasive evaluation.","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80886270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

008 Disease reactivation after cessation of disease-modifying therapy in relapsing-remitting multiple sclerosis 008复发缓解型多发性硬化症患者停止改善疾病治疗后疾病再激活

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.8

I. Roos, C. Malpas, E. Leray, K. Buzzard, O. Skibina, J. Lechner-Scott, P. Mccombe, M. Slee, E. Butler, R. Macdonell, A. Walt, S. Hodgkinson, M. Barnett, S. Vucic, S. Vukusic, H. Butzkueven, T. Kalincik

{"title":"008 Disease reactivation after cessation of disease-modifying therapy in relapsing-remitting multiple sclerosis","authors":"I. Roos, C. Malpas, E. Leray, K. Buzzard, O. Skibina, J. Lechner-Scott, P. Mccombe, M. Slee, E. Butler, R. Macdonell, A. Walt, S. Hodgkinson, M. Barnett, S. Vucic, S. Vukusic, H. Butzkueven, T. Kalincik","doi":"10.1136/bmjno-2021-anzan.8","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.8","url":null,"abstract":"Objectives To evaluate the rate of return of disease activity after cessation of multiple sclerosis (MS) disease-modifying therapy. Methods This was a retrospective cohort study from two large observational MS registries: MSBase and OFSEP. Patients with relapsing-remitting MS who had ceased a disease-modifying therapy and were followed up for the subsequent 12-months were included in the analysis. The primary study outcome was annualised relapse rate in the 12 months after disease-modifying therapy discontinuation stratified by patients who did, and did not, commence a subsequent therapy. The secondary endpoint was the predictors of first relapse and disability accumulation after treatment discontinuation. Results 18 029 eligible treatment discontinuation epochs were identified for seven therapies. Rates of relapse started to increase 2-months after natalizumab cessation. Commencement of a subsequent therapy within 2-4 months reduced the magnitude of disease reactivation. After discontinuation of fingolimod, rates of relapse increased overall, and stabilised faster in patients who started a new therapy within 1-2 months. Magnitude of disease reactivation for other therapies was low, but reduced further by commencement of another treatment 1-10 months after treatment discontinuation. Predictors of relapse were higher relapse rate in the year before cessation, female sex, younger age and higher EDSS. Commencement of a subsequent therapy reduced both the risk of relapse (HR 0.76, CI 0.72-0.81) and disability accumulation (0.73, 0.65-0.80). Conclusion Understanding the rate of disease reactivation after discontinuing different MS immunotherapies will help guide optimal wash-out times for therapeutic agents during treatment sequencing.","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86233032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

033 COVID:19 the epicentre of neurological events in the human brain 2019冠状病毒病:人类大脑神经事件的中心

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.33

N. Parsons, F. D’Aprano, A. Outsikas, A. Parish, F. Toomey, S. Advani, G. Poudel

引用次数: 0

O-016 Aspiration thrombectomy for acute ischemic stroke patients presenting after 6 hours O-016急性缺血性脑卒中患者6小时后出现的吸入性血栓切除术

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/neurintsurg-2021-snis.16

A. Hassan, J. Fifi, O. Zaidat

引用次数: 0

038 Resolving infectious meningitis in uganda with metagenomics and host transcriptomics 038利用宏基因组学和宿主转录组学解决乌干达传染性脑膜炎

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/bmjno-2021-anzan.38

P. Ramachandran, A. Ramesh, F. Creswell, A. Wapniarski, C. Quinn, M. Rutakingirwa, Ananta Bandigwala, E. Kagimu, KT Kandole, K. Zorn, L. Tugume, J. Kasibante, K. Ssebambulidde, Micheal Okirwoth, N. Bahr, A. Musubire, A. Lyden, P. Serpa, G. Castañeda, S. Caldera, C. Langelier, E. Crawford, D. Boulware, D. Meya, M. Wilson

{"title":"038 Resolving infectious meningitis in uganda with metagenomics and host transcriptomics","authors":"P. Ramachandran, A. Ramesh, F. Creswell, A. Wapniarski, C. Quinn, M. Rutakingirwa, Ananta Bandigwala, E. Kagimu, KT Kandole, K. Zorn, L. Tugume, J. Kasibante, K. Ssebambulidde, Micheal Okirwoth, N. Bahr, A. Musubire, A. Lyden, P. Serpa, G. Castañeda, S. Caldera, C. Langelier, E. Crawford, D. Boulware, D. Meya, M. Wilson","doi":"10.1136/bmjno-2021-anzan.38","DOIUrl":"https://doi.org/10.1136/bmjno-2021-anzan.38","url":null,"abstract":"Objectives Tuberculous meningitis(TBM) is a common cause of meningitis in sub-Saharan Africa. CSF PCR with GeneXpert RIF/MTB Ultra is only 70% sensitive for detection of definite/probable TBM. Many infections can mimic TBM. Metagenomic next generation sequencing(mNGS) can detect the whole diversity of infectious microbes, but can be insensitive to TB in CSF. We assessed whether leveraging CSF mNGS to identify infections combined with a machine learning classifier(MLC), based on host transcriptomic data generated by mNGS, could enhance diagnostic accuracy for TBM. Methods Prospectively enrolled 347 HIV-infected Ugandan adults with subacute meningitis: RNA/DNA libraries were made from CSF and deep sequenced. Non-human sequences were interrogated to identify pathogens. A host transcriptomic MLC was developed from human RNA transcripts using 70 cases. The MLC and mNGS reporting thresholds were then tested on 108 blinded cases within the cohort. Results mNGS was 75% concordant(27/36) for detecting TB in definite TBM cases and 59% concordant(30/51) in definite/probable TBM combined. 3 TB and 3 non-TB pathogens were detected in the probable TBM group. In the possible TBM/indeterminant groups, mNGS identified 3 cases of TBM and 17 other pathogens. The combined mNGS and host-MLC displayed 83.3%(5/6) sensitivity, 86.8%(59/68) specificity, with an area under the ROC curve of 0.83(p=0.009). Conclusion mNGS identified an array of infectious TBM mimics, including many treatable and vaccine preventable pathogens. mNGS was 75% concordant with definite TBM. We further enhanced the sensitivity of the CSF mNGS assay by developing the first CSF-based host MLC to discriminate between TBM and its mimics","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89934592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

O-010 Racial disparity in mechanical thrombectomy utilization: multicenter registry results from 2016–2020 机械取栓使用的种族差异:2016-2020年的多中心注册结果

Oral abstracts Pub Date : 2021-08-01 DOI: 10.1136/NEURINTSURG-2021-SNIS.10

A. Wallace, D. Gibson, K. Asif, D. Sahlein, S. Warach, T. Malisch, M. LaMonte

引用次数: 0