Oral abstracts最新文献

{"title":"O002/#43 Randomized phase 3 study of lenvatinib plus pembrolizumab for advanced endometrial cancer (aec): subgroup analysis of patients with DNA mismatch repair deficient (DMMR) tumors","authors":"V. Makker, N. Colombo, A. Casado Herráez, A. Santin, E. Colomba, D. Miller, K. Fujiwara, S. Pignata, Sri Banerjee, B. Monk, K. Ushijima, R. Penson, R. Kristeleit, M. Fabbro, M. Orlando, H. Mackay, M. Ren, R. Orlowski, L. Dutta, D. Lorusso","doi":"10.1136/ijgc-2021-igcs.2","DOIUrl":"https://doi.org/10.1136/ijgc-2021-igcs.2","url":null,"abstract":"","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78985034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O017/#15 Efficacy and safety of niraparib maintenance treatment in platinum-sensitive recurrent ovarian cancer after shorter or longer chemotherapy: a post hoc subgroup analysis","authors":"Y. Gao, X. Wu, J. Zhu, R. Yin, J. Yang, J. Liu, J. Wang, L. Wu, Z. Liu, D. Wang, G. Lou, Hang Yang, Q. Zhou, B. Kong, Y. Huang, L. Chen, G. Li, R. An, T. Tan, J. Dong","doi":"10.1136/ijgc-2021-igcs.17","DOIUrl":"https://doi.org/10.1136/ijgc-2021-igcs.17","url":null,"abstract":"","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81195979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O001/#331 Empower-cervical 1/GOG-3016/ENGOT-CX9: results of phase 3 trial of cemiplimab vs investigator’s choice chemotherapy in recurrent/metastatic cervical carcinoma","authors":"K. Tewari, B. Monk, I. Vergote, A. Miller, A. de Melo, H. Kim, Y. Kim, A. Lisyanskaya, V. Samouélian, D. Lorusso, F. Damian, C-L. Chang, E. Gotovkin, Shin-ichiro Takahashi, D. Ramone, J. Pikiel, J. Li, M. Mathias, M. Fury, A. Oaknin","doi":"10.1136/ijgc-2021-igcs.1","DOIUrl":"https://doi.org/10.1136/ijgc-2021-igcs.1","url":null,"abstract":"","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76692310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O004/#393 Does intensive follow-up improve overall survivalin endometrial cancer patients? Results from the totem randomized controlled trial","authors":"P. Zola, G. Ciccone, R. Angioli, C. Terranova, E. Piovano, L. Fuso, D. di Cuonzo, E. Peirano, A. Perrone, V. Mandato, L. Zavallone, F. Chiudinelli, R. Berretta, S. Loda, S. Greggi, M. Adorni, E. Busato, G. Comerci, M. Fambrini, A. Ferrero","doi":"10.1136/ijgc-2021-igcs.4","DOIUrl":"https://doi.org/10.1136/ijgc-2021-igcs.4","url":null,"abstract":"","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91472932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O013/#573 Tisotumab vedotin (TV) + bevacizumab or pembrolizumab or carboplatin in recurrent/metastatic cervical cancer (R/MCC): phase 1B/2 engot-CX8/GOG-3024/innovaTV 205 study dose-escalation results","authors":"B. Monk, T. Van Gorp, D. Lorusso, R. Eilish O’Cearbhaill, A. Westermann, Sri Banerjee, D. Collins, J. Klat, K. Madsen, J. Baurain, A. Jackson, I. Boere, S. Pignata, E. Gort, J. Moroney, I. Soumaoro, CM Andreassen, L. Nicacio, C. Gennigens, I. Vergote","doi":"10.1136/ijgc-2021-igcs.13","DOIUrl":"https://doi.org/10.1136/ijgc-2021-igcs.13","url":null,"abstract":"","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89542097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12 Comparison of slow vs. rapid ajmaline infusion protocol for the diagnosis of brugada syndrome (BrS): ten year experience of the Northern Ireland inherited cardiac conditions service (NI ICC)","authors":"HM Sulaiman, P. Brennan, H. Connolly, J. McOsker, T. Jardine, A. Miur","doi":"10.1136/heartjnl-2021-ics.12","DOIUrl":"https://doi.org/10.1136/heartjnl-2021-ics.12","url":null,"abstract":"12 Table 1 Demographics of patients by ajmaline challenge protocol Group A: Slow protocol (1mg/kg over 10 minutes) Group B: Rapid protocol (1mg/kg over 5 minutes) p-value No of tests, n (%) 251 (61%) 163 (39%) p=0.61 (ns) Age (mean ± sd) years 40 ± 16 43 ± 15 p=0.09 (ns) Gender (male: female) 136 : 115 75 : 88 p=0.10 (ns) Indications: a) Family History of BrS b) Family history of SADS/SUD c) History of OOHCA d) ECG abnormality e) Unexplained syncope 105 78 17","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75328949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"13 Long-term safety outcomes of patients implanted with subcutaneous implantable cardioverter defibrillators","authors":"N. Starr, S. Esmonde, N. McKEAG, E. Chew","doi":"10.1136/heartjnl-2021-ics.13","DOIUrl":"https://doi.org/10.1136/heartjnl-2021-ics.13","url":null,"abstract":"","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79311839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"8 Stent optimization using optical coherence tomography and its prognostic implications after percutaneous coronary intervention","authors":"H. Rai, F. Harzer, T. Otsuka, Y. Abdelwahed, P. Antuña, F. Blachutzik, T. Koppara, L. Räber, D. Leistner, F. Alfonso, H. Nef, M. Seguchi, A. Aytekin, E. Xhepa, S. Kufner, S. Cassese, K. Laugwitz, R. Byrne, A. Kastrati, M. Joner","doi":"10.1136/heartjnl-2021-ics.8","DOIUrl":"https://doi.org/10.1136/heartjnl-2021-ics.8","url":null,"abstract":"","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89960562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5 Comparison of next generation P2Y12 inhibitors to clopidogrel in patients with acute coronary syndrome: an analysis from the British cardiovascular intervention society database of 382,361 ‘real-world’ patients","authors":"S. Saluja, H. Contractor, F. Mannan, Jadav Sarma, S. Garg, S. Anderson","doi":"10.1136/heartjnl-2021-ics.5","DOIUrl":"https://doi.org/10.1136/heartjnl-2021-ics.5","url":null,"abstract":"genes DSG2, DSC2 and JUP. Conclusion Predictive testing has potentially allowed up to 789 genotype-negative individuals (and their offspring) to be reassured and discharged from long term cardiac follow-up. Our data suggests adult females are more forthcoming for predictive testing than their male counterparts. The absence of testing for several cardiomyopathy genes suggests low frequency or low penetrance of these variants in the Irish population. The large size of families in our cohort represents an opportunity to develop gene penetrance and genotype-phenotype correlation data to assist in clinical management of genotype-positive individuals.","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77566833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"19 4 year results of the cardiology trainee feedback project","authors":"N. Fitzpatrick, B. McAdam, J. Crowley, B. McNeill, R. Murphy, B. Dalton","doi":"10.1136/heartjnl-2021-ics.19","DOIUrl":"https://doi.org/10.1136/heartjnl-2021-ics.19","url":null,"abstract":"Background The Higher Specialist Training (HST) Scheme is run by the Royal College of Physicians (RCPI) overseen by the Irish Board for Training in Cardiovascular Medicine (IBTCM). The stated aim of the scheme is to provide doctors upon completion, with the necessary skills and knowledge to practice competently, professionally and independently as cardiology specialists. In order to inform dialogue surrounding improvements to the training scheme, those enrolled have been surveyed annually over the past 4 years to gage their views regarding the following domains - trainer/trainee interaction, access to training, procedural training, service commitments and training, research and audit, training program structure, gender balance, future career planning and location, quality of life and in the past year the impact of the Covid- 19 pandemic on training. Methods For the past 4 years, the second author surveyed trainees in training years 1-4 through the medium of an online questionnaire. Trainees were asked to respond to a range of questions pertaining to the domains of interest listed above, predominantly indicating their level of agreement with a statement in the format of a 5 point Likert scale. Results The response rate to the survey was excellent and averaged at 65% over the four years. Individual years ranged from 52% to a high of 82%. Even in the year with the lowest response (52%) a significant proportion of the trainees were represented. Overall trainees are happy with the training scheme with 88% saying they would recommend the training scheme. When asked if a trainee encountered significant challenges in accessing training - CT/MRI, followed by Adult Congenital Heart Disease and Electrophysiology were most frequently identified. Interest in dual accreditation was low, with 77% of respondents saying they did not intend to purse dual accreditation. Approximately half (47%) of respondents felt that their year spent doing General Internal Medicine (GIM) enhanced their training experience. 46% of respondents felt they have a poor or very poor work-life-balance, but 72% indicated that they had a very good or good quality of life. Future career planning: 83% of trainees indicated definitely or probably when asked if planning to work in Ireland after completion of training. However, when in 2018, a small number of trainees on overseas out of program experience were asked the same question a smaller proportion of respondents indicated that they wished to work in Ireland. In relation to gender - 28% of respondents were female, in keeping with prior work published by the authors in 2017 showing a 7:3 gender ratio overall for trainees between 1998 and 2017. To address the gender balance respondents felt that changes to the training scheme(63%) and work practices (72%) would be needed. Covid-19 had a marked affect on training, with 94% of trainees responding that it adversely affected their training. Conclusion This 4 year study of the Irish cardiology t","PeriodicalId":19692,"journal":{"name":"Oral abstracts","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76968480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}