5 Comparison of next generation P2Y12 inhibitors to clopidogrel in patients with acute coronary syndrome: an analysis from the British cardiovascular intervention society database of 382,361 ‘real-world’ patients

genes DSG2, DSC2 and JUP. Conclusion Predictive testing has potentially allowed up to 789 genotype-negative individuals (and their offspring) to be reassured and discharged from long term cardiac follow-up. Our data suggests adult females are more forthcoming for predictive testing than their male counterparts. The absence of testing for several cardiomyopathy genes suggests low frequency or low penetrance of these variants in the Irish population. The large size of families in our cohort represents an opportunity to develop gene penetrance and genotype-phenotype correlation data to assist in clinical management of genotype-positive individuals.