Osaka city medical journal最新文献_第8页

Surgical resection for ruptured aneurysm of middle colic artery caused by segmental arterial mediolysis: a case report. 节段性动脉介质溶解所致中结肠动脉瘤破裂的手术切除1例。

Osaka city medical journal Pub Date : 2010-12-01

Yushi Fujiwara, Masashi Takemura, Kayo Yoshida, Keiichiro Morimura, Takeshi Inoue

{"title":"Surgical resection for ruptured aneurysm of middle colic artery caused by segmental arterial mediolysis: a case report.","authors":"Yushi Fujiwara, Masashi Takemura, Kayo Yoshida, Keiichiro Morimura, Takeshi Inoue","doi":"","DOIUrl":"","url":null,"abstract":"Aneurysm of the middle colic artery is very uncommon. In this report, we describe a case of a ruptured aneurysm of the middle colic artery caused by segmental arterial mediolysis and its successful management by surgical resection. A 60-year-old Japanese man was admitted to our institution for the treatment of a ruptured aneurysm of the branch of the superior mesenteric artery suspected by computed tomography. Angiography revealed multiple wide and narrow mural irregularities and some aneurysms in the middle colic artery without extravasation. Transcatheter arterial embolization could not be accomplished because of difficulty in catheterization. Since radiological findings of the patient indicated worsening of the aneurysm, surgical resection was performed. Histopathological findings of the resected specimen were consistent with those of segmental arterial mediolysis. In cases where curative embolization cannot be accomplished, surgical resection is required. However, in a non-ruptured aneurysm, healing occurs gradually. Therefore, if the vital parameters of the patient are stable, conservative observation can be recommended.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"56 2","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29792992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sentinel lymph node biopsy in conjunctival malignant melanoma at the lacrimal caruncle: a case report. 泪痈处结膜恶性黑色素瘤前哨淋巴结活检1例。

Osaka city medical journal Pub Date : 2010-06-01

Hisashi Motomura, Michiharu Sakamoto, Yoko Maruyama, Teruichi Harada, Masamitsu Ishii

{"title":"Sentinel lymph node biopsy in conjunctival malignant melanoma at the lacrimal caruncle: a case report.","authors":"Hisashi Motomura, Michiharu Sakamoto, Yoko Maruyama, Teruichi Harada, Masamitsu Ishii","doi":"","DOIUrl":"","url":null,"abstract":"Background: Conjunctival malignant melanoma (CMM) is so rare that there are no certain guidelines for its treatment. Factors influencing its prognosis include region of onset, tumor thickness, lymph node metastasis, and distant metastasis. Whether regional lymph node metastasis is present or not is one of the most powerful factors for predicting recurrence in and survival of patients with CMM.Methods: A 72-year-old man with conjunctival malignant melanoma at the lacrimal caruncle was underwent sentinel lymph node (SLN) biopsy by preoperative lymphoscintigraphy and intraoperative vital blue mapping.Results: A blue-dyed node could be identified in the superficial lobe of the parotid gland. A split half of the cropped SLN was immediately submitted to rapid pathological examination. After confirming no metastasis, it was decided not to perform lymph node dissection. The final diagnosis was pT3N0M0. Neither recurrence nor distant metastasis has been observed for 7 years after the operation.Conclusions: We were able to evaluate N (lymph node metastasis) in the TNM classification accurately. SLN may facilitate N classification and decisions regarding employment of appropriate lymph node dissection as well as combined therapy after operation.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"56 1","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29334679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Right subclavian artery aneurysm: report of a case. 右锁骨下动脉瘤1例。

Osaka city medical journal Pub Date : 2010-06-01

Manabu Motoki, Toshihiro Fukui, Toshihiko Shibata, Yasuyuki Sasaki, Hidekazu Hirai, Yosuke Takahashi, Shigefumi Suehiro

引用次数: 0

S-allylcysteine is effective as a chemopreventive agent against porcine serum-induced hepatic fibrosis in rats. s -丙氨酸半胱氨酸是一种有效的化学预防剂，可预防猪血清诱导的大鼠肝纤维化。

Osaka city medical journal Pub Date : 2009-12-01

Hiroji Shinkawa, Shigekazu Takemura, Yukiko Minamiyama, Shintaro Kodai, Takuma Tsukioka, Mayuko Osada-Oka, Shoji Kubo, Shigeru Okada, Shigefumi Suehiro

{"title":"S-allylcysteine is effective as a chemopreventive agent against porcine serum-induced hepatic fibrosis in rats.","authors":"Hiroji Shinkawa, Shigekazu Takemura, Yukiko Minamiyama, Shintaro Kodai, Takuma Tsukioka, Mayuko Osada-Oka, Shoji Kubo, Shigeru Okada, Shigefumi Suehiro","doi":"","DOIUrl":"","url":null,"abstract":"Background: Hepatic fibrosis is a chronic progressive disorder with a poor prognosis for which no definitive treatment exists. S-allylcysteine (SAC), an ingredient of aged garlic extract, is known to have antioxidant and hepatoprotective effects. The aim of this study was to investigate the antifibrotic effects of SAC in the liver.Methods: Hepatic fibrosis was induced in male Wistar rats by porcine serum (PS) intraperitoneal injection. SAC (0.15% of basal diet) or N-acetylcysteine (NAC, 0.45% of basal diet) was orally administered for 12 weeks. Liver damage was assessed by the levels of plasma alanine aminotransferase (ALT), hepatic lipid peroxides (LPO), and hepatic total thiols 12 weeks after first PS injection. Area of fibrosis was examined by Azan-Mallory staining. Hydroxyproline content of liver were assessed as an index of collagen content. Liver was examined for expression of alpha-smooth muscle actin (alpha-SMA) as a marker of hepatic stellate cell (HSC) activation.Results: There were no significant differences in levels of plasma ALT, hepatic LPO, or hepatic total thiols among the groups. PS significantly increased area of fibrosis and hydroxyproline content in the liver. SAC and NAC each markedly attenuated the development ofhepatic fibrosis. SAC and NAC markedly suppressed the PS-induced increase in alpha-SMA expressions.Conclusions: Oral administration of SAC reduced PS-induced hepatic fibrosis in rats via inhibition of HSC activation. SAC could provide a new therapeutic strategy for hepatic fibrosis.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"55 2","pages":"61-9"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28658914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity of agricultural chemicals in Daphnia magna. 农用化学品对大水蚤的毒性研究。

Osaka city medical journal Pub Date : 2009-12-01

Ken-ichi Matsumoto, Mamoru Hosokawa, Koichi Kuroda, Ginji Endo

{"title":"Toxicity of agricultural chemicals in Daphnia magna.","authors":"Ken-ichi Matsumoto, Mamoru Hosokawa, Koichi Kuroda, Ginji Endo","doi":"","DOIUrl":"","url":null,"abstract":"Background: Daphnia magna is a useful aquatic organism for testing ecological toxicities of environmental pollutants. However, there were only a few studies on agricultural chemicals using these organisms.Methods: We investigated acute and subchronic toxicities of 30 agricultural chemicals commonly used in Japan in D. magna. Acute toxicity of the agricultural chemicals was determined using the concentrations yielding 50% immobility of D. magna after 24 hr and 48 hr exposure as end points. D. magna was cultivated with the chemical and algae until the first brood production. Lethal toxicity and the number of survival broods were determined within 13 days.Results: All insecticides among the agricultural chemicals exhibited the strongest acute toxicity (LC50 from 0.00053 to 0.037 mg/L). More than 50% of the herbicides and fungicides did not exhibit acute toxicity at 10 mg/L. Chlornitrofen, pencycuron, and fenitrothion showed significantly lower LC50 values at 8 days than at 24 hr and 48 hr. Isoprothiolane, flutolanil, and thiophanatemethyl significantly delayed the first brood at concentrations less than half of those for LC50 (8 days). Thiobencarb, iprodione, flutolanil, mepronil, and thiophanatemethyl significantly reduced the size of the first brood at concentrations less than half of those for LC50 (8 days).Conclusions: In this study, chlornitrofen, pencycuron, and fenitrothion were suggested to have slow-acting toxicity. Also, thiobencarb, iprodione, flutolanil, mepronil, and thiophanatemethyl were suggested to have parthenogenetic toxicity.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"55 2","pages":"89-97"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28658917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of oral administration of GABA on temperature regulation in humans during rest and exercise at high ambient temperature. 口服GABA对人体在高温环境下休息和运动时体温调节的影响。

Osaka city medical journal Pub Date : 2009-12-01

Taiki Miyazawa, Takashi Kawabata, Takashi Suzuki, Daiki Imai, Takeshi Hamamoto, Takahiro Yoshikawa, Toshiaki Miyagawa

{"title":"Effect of oral administration of GABA on temperature regulation in humans during rest and exercise at high ambient temperature.","authors":"Taiki Miyazawa, Takashi Kawabata, Takashi Suzuki, Daiki Imai, Takeshi Hamamoto, Takahiro Yoshikawa, Toshiaki Miyagawa","doi":"","DOIUrl":"","url":null,"abstract":"Background: Centric administration of gamma-aminobutyric acid (GABA) has been implicated to affect temperature regulation in animals during rest or under anesthesia. However, there are few reports concerning the effects of the oral administration of GABA on temperature regulation in humans during rest and exercise. In order to clarify the effects and underlying mechanisms, we measured several parameters related to temperature regulation of humans during rest and exercise at high ambient temperature (35 degrees C).Methods: On two occasions, eight endurance-trained men rested for 20 min and cycled at 65% VO2peak for 30 min. In control trial (trial-C), subjects drank the sample which was a sports drink of 200 mL (placebo) before the rest period. In another trial (trial-G), subjects drank the sample which was a sports drink containing 1000 mg of GABA (GABA drink) before the rest period.Results: In trial-G, the plasma GABA concentrations were maintained higher than those in trial-C during the experiment. An increase of esophageal temperature during rest and exercise was inhibited in trial-G. Sweat rate, and plasma catecholamine concentrations during exercise were inhibited in trial-G.Conclusions: Esophageal temperature inhibition is suggested to be induced by the suppression of cold-sensitive neurons during rest, and the inhibition of plasma catecholamine concentrations caused by the GABA-induced attenuation of the sympathetic nervous system during exercise.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"55 2","pages":"99-108"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28658918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and pathological features of ascending testis. 升睾丸的临床与病理特征。

Osaka city medical journal Pub Date : 2009-12-01

Tatsuyuki Yoshida, Koichi Ohno, Yoshiki Morotomi, Tetsuro Nakamura, Takashi Azuma, Hiroto Yamada, Hiroaki Hayashi, Shigefumi Suehiro

{"title":"Clinical and pathological features of ascending testis.","authors":"Tatsuyuki Yoshida, Koichi Ohno, Yoshiki Morotomi, Tetsuro Nakamura, Takashi Azuma, Hiroto Yamada, Hiroaki Hayashi, Shigefumi Suehiro","doi":"","DOIUrl":"","url":null,"abstract":"Background: The clinical features and principles of surgery of the Ascending Testis (AT), in which the testis ascends from the scrotum with age, are controversial. We selected AT that met the treatment guidelines and examined the clinical features and principles of surgery.Methods: We retrospectively reviewed the medical charts of 12 AT and 530 Congenital Undescended Testis (CUDT) patients to investigate the statistics of AT among all CUDT, the side of the maldescent, the associated disorders, and the clinical course. The patients were compared in terms of testicular volume (TV), mean tubular diameter (MTD), and testicular fertility index (TFI) between the AT group and the CUDT group.Results: AT was observed in 2.2% of all CUDT patients: 10 had left AT and 2 had bilateral AT. Among the 12 AT patients, 8 patients had associated disorders. The TV, MTD, and TFI of 7 AT and 7 CUDT were 0.74 +/- 0.20 and 0.77 +/- 0.59 cm3, 38.7 +/- 3.7 and 35.9 +/- 9.1 microm, and 0.19 +/- 0.07 and 0.11 +/- 0.11, respectively.Conclusions: In order to examine the clinical features of AT, it is essential to strictly rule out CUDT and retractile testis. In our study, the clinical features are that AT is a rare disorder, occurs more frequently on the left side, and many patients with AT have associated disorders. Since AT causes histological damage equivalent to that caused by CUDT, we should perform orchidopexy for patients with AT immediately after diagnosis.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"55 2","pages":"81-7"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28658916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphatidylinositol 3-kinase/Akt pathway regulates inflammatory mediators-induced calcification of human vascular smooth muscle cells. 磷脂酰肌醇3-激酶/Akt通路调控炎症介质诱导的人血管平滑肌细胞钙化。

Osaka city medical journal Pub Date : 2009-12-01

Hirokazu Okazaki, Atsushi Shioi, Kaname Hirowatari, Hidenori Koyama, Shinya Fukumoto, Eiji Ishimura, Yoshiki Nishizawa

{"title":"Phosphatidylinositol 3-kinase/Akt pathway regulates inflammatory mediators-induced calcification of human vascular smooth muscle cells.","authors":"Hirokazu Okazaki, Atsushi Shioi, Kaname Hirowatari, Hidenori Koyama, Shinya Fukumoto, Eiji Ishimura, Yoshiki Nishizawa","doi":"","DOIUrl":"","url":null,"abstract":"Background: Vascular calcification is a clinically significant component of atherosclerosis and may be promoted by inflammatory stimuli. Phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway is involved in the regulation of cell metabolism, survival, migration, and inflammatory responses in various cell types.Methods: In this study, we investigated the roles of PI3K/Akt signaling pathway in human vascular smooth muscle cell (HVSMC) calcification induced by the inflammatory mediators (IM) including interferon-gamma, tumor necrosis factor-alpha, oncostatin M, and 1alpha,25-dihydroxyvitamin D3.Results: Pharmacological inhibition of PI3K with wortmannin dose-dependently increased IM-induced HVSMC calcification. IM-induced expression of alkaline phosphatase (ALP) in HVSMC was also augmented by wortmannin, while wortmannin did not induce apoptosis of HVSMCs in the presence or absence of IM. Moreover, wortmannin inhibited Akt activation in HVSMC by shortterm exposure to IM. Overexpression of wild-type or dominant-negative forms of Akt significantly attenuated or enhanced IM-induced ALP expression in HVSMC, respectively. Furthermore, suppression of Akt with siRNA significantly intensified IM-induced ALP expression in HVSMC.Conclusions: These data suggest that PI3K/Akt pathway may play an inhibitory role in IM-induced HVSMC calcification through regulating ALP expression.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"55 2","pages":"71-80"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28658915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffusion-weighted magnetic resonance imaging in tubo-ovarian abscess: a case report. 卵巢输卵管脓肿的扩散加权磁共振成像1例。

Osaka city medical journal Pub Date : 2009-12-01

Tohru Takeshita, Teruhisa Ninoi, Kunihiko Doh, Shigeo Hashimoto, Yuichi Inoue

引用次数: 0

Intracerebroventricular administration of leptin increases anxiety-like behavior in female rats after semi-starvation--implications for anxiety in eating disorders. 脑室内给药瘦素增加半饥饿后雌性大鼠的焦虑样行为——对饮食失调焦虑的影响

Osaka city medical journal Pub Date : 2009-06-01

Tsuneo Yamauchi, Koki Inoue, Shinichi Iwasaki, Tomohiro Muramatsu, Teruaki Hayashi, Nosuo Kiriike

{"title":"Intracerebroventricular administration of leptin increases anxiety-like behavior in female rats after semi-starvation--implications for anxiety in eating disorders.","authors":"Tsuneo Yamauchi, Koki Inoue, Shinichi Iwasaki, Tomohiro Muramatsu, Teruaki Hayashi, Nosuo Kiriike","doi":"","DOIUrl":"","url":null,"abstract":"Background: Patients with eating disorders often exhibit abnormal eating conditions like food restriction, adipocyte and body weight reduction, and pathologic anxiety-like behavior. The role of leptin, which is recognized as an adipocyte-derived hormone, on anxiety-like behavior in eating disorders is still unclear.Methods: We investigated the role of leptin on anxiety-like behavior with or without semi-starvation using the elevated plus-maze test in adolescent female rats. In our first experiment, anxiety-like behavior was evaluated with the elevated plus-maze test 30 min after intracerebroventricular administration of 3 microg of leptin or vehicle. In our second experiment, the rats were allowed access to food for only 2 hr each day for 7 days. Then, leptin or vehicle was administered to the rats after the last 2 hr feeding period, and anxiety-like behaviors were evaluated in the same way as in the first experiment.Results: In the first experiment, there was no difference between the anxiety-like behaviors observed after leptin administration and those seen after vehicle administration. Under the conditions of semi-starvation, however, the percentage of time spent in the open arms in the rats given leptin was lower than that in rats given vehicle.Conclusions: These results suggest that leptin administration causes anxiety-like behavior only after semistarvation. Leptin might play an important role in pathologic anxiety-like behavior in eating disorders.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"55 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28454366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0