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Effect of tetracyclines in organotypic cocultures using human gingival epithelial cells and human periodontal ligament fibroblasts 四环素对牙龈上皮细胞和牙周韧带成纤维细胞器官型共培养的影响
Oral Therapeutics and Pharmacology Pub Date : 2007-04-01 DOI: 10.11263/JSOTP1982.26.19
Morito Suzuki
{"title":"Effect of tetracyclines in organotypic cocultures using human gingival epithelial cells and human periodontal ligament fibroblasts","authors":"Morito Suzuki","doi":"10.11263/JSOTP1982.26.19","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.19","url":null,"abstract":"The effects of tetracyclines in organotypic cocultures using human gingival epithelial cells (NDUSD-1 cells) and human periodontal ligament fibroblasts (Pelt cells) were investigated. The organotypic cocultures were treated with tetracycline (TC) or minocycline (MINO) at 10-300ƒÊM for 1 week and multilayered epithelial cells were examined by hematoxylin-eosin staining and immunohistochemistry. Treatment with TC at 30ƒÊM did not affect multilayer formation of epithelial cells, but the formation was inhibited by treatment with TC at 100ƒÊM or more. Treatment with MINO at 10ƒÊM did not affect the multilayer formation, but the formation was inhibited by treatment with MINO at 30 ƒÊM or more. These values were greater than their MIC90 concentrations for periodontopathic bacteria, including Porphyromonas gingivalis, Prevotella intermedia, and Actinobacillus actinomycetemcomitans. These results suggested that topical administration of TC or MINO to the periodontal pocket at their MIC90 concentration for periodontopathic bacteria would have few adverse effects on the growth of the periodontal ligament.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"19-27"},"PeriodicalIF":0.0,"publicationDate":"2007-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between the analgesic and antipyretic effects of aspirin and salicylic acid concentration in rabbits 阿司匹林与水杨酸浓度对家兔镇痛解热作用的相关性研究
Oral Therapeutics and Pharmacology Pub Date : 2006-12-01 DOI: 10.11263/JSOTP1982.25.73
J. Yamane, Naoto Sato, Hidehiko Okada, M. Hori, Akihiko Gunji, Kosuke Hakozaki, A. Fujii
{"title":"Correlation between the analgesic and antipyretic effects of aspirin and salicylic acid concentration in rabbits","authors":"J. Yamane, Naoto Sato, Hidehiko Okada, M. Hori, Akihiko Gunji, Kosuke Hakozaki, A. Fujii","doi":"10.11263/JSOTP1982.25.73","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.73","url":null,"abstract":"In order to clarify the correlation between the analgesic and antipyretic effects of aspirin and salicylic acid concentration, a jaw-opening reflex test and pyrogenic test were performed under the presence of aspirin, and the corresponding plasma concentration of salicylic acid was measured using rabbits. The analgesic effect of aspirin determined by jaw-opening reflex was significantly dependent on plasma level. The antipyretic effect of aspirin obtained by the pyrogenic test was also significantly dependent on plasma level. A closer correlation was demonstrated between the integral antipyretic effect and integral plasma level of salicylic acid.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"73-79"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allergic reactions to drugs 药物过敏反应
Oral Therapeutics and Pharmacology Pub Date : 2006-12-01 DOI: 10.11263/JSOTP1982.25.80
D. Mohri, K. Shimazu, K. Ohura
{"title":"Allergic reactions to drugs","authors":"D. Mohri, K. Shimazu, K. Ohura","doi":"10.11263/JSOTP1982.25.80","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.80","url":null,"abstract":"Rashes due to drugs may be relatively mild such as erosions like canker sores, erythema papula, urticarial rashes, and fixed drug eruption, or they may be quite severe as with Stevens-Johnson syndrome or toxic epidermal necrolysis (Lyell syndrome). Since severe drug eruptions and rashes can affect internal organs in addition to skin and mucosa and can result in permanent disabilities, they must be diagnosed and treated as soon as possible. The vital elements of effective diagnosis are to clearly grasp which types of reactions are the most severe and to quickly identify the reactions which may become serious or threatening. We have found in our own practice that the most serious types of drug erosions and rashes are those that affect the whole body. There is a possibility that a very serious case may develop if an erosion of the oral mucosa spreads out beyond the region of the lip where the mucosa changes to skin or if erythema of the epidermis quickly spreads and red spots grow together over a relatively large area. The treatment is to immediately stop taking all suspect drugs and begin a rigorous course of steroids.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"80-87"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do probiotic bacteria improve human oral microbiota 益生菌能改善人类口腔微生物群吗
Oral Therapeutics and Pharmacology Pub Date : 2006-12-01 DOI: 10.11263/JSOTP1982.25.61
N. Maeda, T. Ohshima, K. Hojo, N. Taketomo
{"title":"Do probiotic bacteria improve human oral microbiota","authors":"N. Maeda, T. Ohshima, K. Hojo, N. Taketomo","doi":"10.11263/JSOTP1982.25.61","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.61","url":null,"abstract":"The term •eprobiotics•f is defined as •eliving microorganisms that exhibit beneficial effects for health based on improvement of balance of indigenous microbiota.•f Several strains of Lactobacillus and Bifidobacterium, and a certain yogurt are included in this definition. Probiotics have been developed for use in the prevention of intestinal infections, and the treatment of antibiotic-associated diarrhea and intestinal malfunction. Recently, the use of probiotics has come to exert a wide range of different effects such as the suppression of Helicobacter pylori, and the prevention of allergic disease. Moreover, evidence for the clinical effectiveness of probiotics has been reported in their use for the prevention and treatment of dental caries and periodontal diseases. For example, the administration of a dairy product containing L. rhamnosus appeared to reduce the risk of dental caries in a randomized, double-blind, placebo-controlled trial. This trial demonstrated reduced levels of dental caries and lower mutans streptococcal counts in probiotics patients after seven months of administration. From the viewpoint of periodontal diseases, it has been suggested that L. salivarius decrease the risk of periodontal disease by eliminating black-pigmented anaerobic rods (BPARs) which have been suspected of playing a role in periodontal disease. Yogurt may suppress the number of mutans streptococci in saliva and improve halitosis. However, there is little available information about the use of probiotics in dentistry. In addition, the role of indigenous Lactobacillus and Bifidobacterium on oral health, the adhesion of probiotics in the human oral cavity, and the mechanisms of probiotics against cariogenic and periodontopathogenic bacteria have not been clarified. In this review, the authors would like to address the possible use and problem of probiotics in dentistry.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"699 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Two cases of mandibular osteomyelitis caused by Actinomyces 放线菌所致下颌骨骨髓炎2例
Oral Therapeutics and Pharmacology Pub Date : 2006-08-01 DOI: 10.11263/JSOTP1982.25.47
Hiroyuki Nagashima, K. Asada, Hideo Yamamoto, A. Nakayama, Kenichi Yamaguchi, Y. Nakagawa, K. Ishibashi
{"title":"Two cases of mandibular osteomyelitis caused by Actinomyces","authors":"Hiroyuki Nagashima, K. Asada, Hideo Yamamoto, A. Nakayama, Kenichi Yamaguchi, Y. Nakagawa, K. Ishibashi","doi":"10.11263/JSOTP1982.25.47","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.47","url":null,"abstract":"Actinomycosis is a infectious disease that is characterized by chronic granulomatous and suppurative lesions often caused by Actinomyces israelii. Nowadays, the diagnosis may be difficult because the number of patients with typical symptoms has decreased, and there is a low success rate in culturing the microorganism. In this paper, two cases of osteomyelitis of the mandible caused by infection with Actinomyces are reported. Radiography and CT of these cases revealed bone destruction, and Gram stain of direct smears of pus obtained by extraoral incision showed Gram-positive bacteria with branching filaments.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Studies on anti-periodontitis ointment TCPS (Tetracycline Presteron) paste 抗牙周炎软膏TCPS(四环素普雷斯顿酮)膏剂的研究
Oral Therapeutics and Pharmacology Pub Date : 2006-08-01 DOI: 10.11263/JSOTP1982.25.39
A. Ueno, Masayoshi Tsunekawa
{"title":"Studies on anti-periodontitis ointment TCPS (Tetracycline Presteron) paste","authors":"A. Ueno, Masayoshi Tsunekawa","doi":"10.11263/JSOTP1982.25.39","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.39","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11263/JSOTP1982.25.39","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dental treatment of a patient with multiple drug allergies under general anesthesia 全身麻醉下多种药物过敏患者的牙科治疗
Oral Therapeutics and Pharmacology Pub Date : 2006-08-01 DOI: 10.11263/JSOTP1982.25.35
Kiyomi Kurihara, Hiroto Saito, T. Shirota, M. Nagumo, S. Yoshimura
{"title":"Dental treatment of a patient with multiple drug allergies under general anesthesia","authors":"Kiyomi Kurihara, Hiroto Saito, T. Shirota, M. Nagumo, S. Yoshimura","doi":"10.11263/JSOTP1982.25.35","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.35","url":null,"abstract":"We performed tooth extraction and dental treatment in a patient with multiple drug allergies. The patient was a 29-year-old female with a past medical history of anaphylaxis to local anesthesia; she also had multiple drug allergies to antimicrobial agents and anti-inflammatory agents. Treatments were performed under general anesthesia without local anesthesia or anti-inflammatory agents, and were completed without an immediate anaphylatic reaction, although vomiting, abdominal pain, diarrhea, and hoarse voice were noted after transfer from the operation room. Intraoperative and postoperative blood pressure and pulse rate were stable, and the eosinophil count, histamine, and C3, C4, and IgE complement levels were normal before and after treatment. The result suggested that performing tests using allergy indices before and after treatment and performing treatment in expectation of possible anaphylatic reaction enable safe dental treatment in patients with multiple drug allergies.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"35-38"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of intractable chronic osteomyelitis of the mandible accompanied with pathologic fracture and tardive dyskinesia 下颌骨顽固性慢性骨髓炎伴病理性骨折及迟发性运动障碍1例
Oral Therapeutics and Pharmacology Pub Date : 2006-04-01 DOI: 10.11263/JSOTP1982.25.1
K. Noda, J. Nomura, Y. Matsumura, S. Yanase, M. Sekida, T. Tagawa
{"title":"A case of intractable chronic osteomyelitis of the mandible accompanied with pathologic fracture and tardive dyskinesia","authors":"K. Noda, J. Nomura, Y. Matsumura, S. Yanase, M. Sekida, T. Tagawa","doi":"10.11263/JSOTP1982.25.1","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.1","url":null,"abstract":"A case of severe chronic osteomyelitis of the mandible accompanied with fracture of the mandibular angle and tardive dyskinesia in a 78-year-old male is reported. As treatment with intravenous antibiotics or decortication was not effective, intra-arterial infusion of the antibiotics was performed. This therapy was very effective without complication. In our case, as the patient had had tardive dyskinesia in the past, it was considered that the severe chronic osteomyelitis was closely related to chronic tendoperiotitis caused by muscular overuse.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2006-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11263/JSOTP1982.25.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Differentiation of the expression of A2a adenosine receptor in macrophage cell lines RAW264 巨噬细胞系RAW264中A2a腺苷受体表达的分化
Oral Therapeutics and Pharmacology Pub Date : 2006-04-01 DOI: 10.11263/JSOTP1982.25.8
Kyoko Watanabe, S. Shirasu, Kiyoshi Daito, M. Motoyama, Yoshitomo Ogawa, K. Nakai, K. Ohura, M. Daito
{"title":"Differentiation of the expression of A2a adenosine receptor in macrophage cell lines RAW264","authors":"Kyoko Watanabe, S. Shirasu, Kiyoshi Daito, M. Motoyama, Yoshitomo Ogawa, K. Nakai, K. Ohura, M. Daito","doi":"10.11263/JSOTP1982.25.8","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.8","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"8-16"},"PeriodicalIF":0.0,"publicationDate":"2006-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11263/JSOTP1982.25.8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A simple method of obtaining lingual mucosal cells with a toothbrush for DNA extraction 一种用牙刷提取舌粘膜细胞进行DNA提取的简单方法
Oral Therapeutics and Pharmacology Pub Date : 2006-04-01 DOI: 10.11263/JSOTP1982.25.17
Y. Imamura, Pao‐Li Wang, T. Kuno, J. Otogoto, T. Fujii, N. Ota
{"title":"A simple method of obtaining lingual mucosal cells with a toothbrush for DNA extraction","authors":"Y. Imamura, Pao‐Li Wang, T. Kuno, J. Otogoto, T. Fujii, N. Ota","doi":"10.11263/JSOTP1982.25.17","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.17","url":null,"abstract":"In the post-genomic era, it is necessary to gain a better understanding of the relationship between genes and oral disease. For example, single nucleotide polymorphisms (SNPs) are the most common form of DNA sequence variation and searching for SNPs covers many genes. To perform genetic testing such as testing for SNPs, DNA samples need to be obtained from patients. In the near future, genetic testing will become widespread as a chair-side procedure in general practice. It would be optimal to use a method that results in minimum bodily injury and that does not cause anxiety to patients. Here, we report a simple method of obtaining lingual mucosal cells with a toothbrush for extraction of DNA samples.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"17-21"},"PeriodicalIF":0.0,"publicationDate":"2006-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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