Open Journal of Epidemiology最新文献

{"title":"Prevalence and Clinical Relevance of <i>Schistosoma mansoni</i> Co-Infection with <i>Mycobacterium tuberculosis</i>: A Systematic Literature Review.","authors":"Bocar Baya,&nbsp;Bourahima Kone,&nbsp;Amadou Somboro,&nbsp;Ousmane Kodio,&nbsp;Anou Moise Somboro,&nbsp;Bassirou Diarra,&nbsp;Fah Gaoussou Traore,&nbsp;Drissa Kone,&nbsp;Mama Adama Traore,&nbsp;Mahamadou Kone,&nbsp;Antieme Georges Togo,&nbsp;Yeya Sadio Sarro,&nbsp;Almoustapha Maiga,&nbsp;Mamoudou Maiga,&nbsp;Yacouba Toloba,&nbsp;Souleymane Diallo,&nbsp;Robert L Murphy,&nbsp;Seydou Doumbia","doi":"10.4236/ojepi.2023.131008","DOIUrl":"https://doi.org/10.4236/ojepi.2023.131008","url":null,"abstract":"<p><p>Tuberculosis disease stands for the second leading cause of death worldwide after COVID-19, most active tuberculosis cases result from the reactivation of latent TB infection through impairment of immune response. Several factors are known to sustain that process. <i>Schistosoma mansoni</i>, a parasite of the helminth genus that possesses switching power from an immune profile type Th1 to Th2 that favors reactivation of latent TB bacteria. The aim of the study was to assess the prevalence of the co-infection between the two endemic infections. Systematic literature was contacted at the University Clinical Research Center at the University of Sciences, Techniques, and Technologies of Bamako in Mali. Original articles were included, and full texts were reviewed to assess the prevalence and better understand the immunological changes that occur during the co-infection. In total, 3530 original articles were retrieved through database search, 53 were included in the qualitative analysis, and data from 10 were included in the meta-analysis. Prevalence of the co-infection ranged from 4% to 34% in the literature. Most of the articles reported that immunity against infection with helminth parasite and more specifically <i>Schistosoma mansoni</i> infection enhances latent TB reactivation through Th1/Th2. In sum, the impact of <i>Schistosoma mansoni</i> co-infection with <i>Mycobacterium tuberculosis</i> is under-investigated. Understanding the role of this endemic tropical parasite as a contributing factor to TB epidemiology and burden could help integrate its elimination as one of the strategies to achieve the END-TB objectives by the year 2035.</p>","PeriodicalId":19578,"journal":{"name":"Open Journal of Epidemiology","volume":"13 1","pages":"97-111"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9106043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Religion and “Zero-Dose” Vaccination Status in Children Aged 12 to 23 Months in Benin and Togo: “Evidence of Demographic and Health Survey and Multiple Indicator Cluster Surveys”","authors":"Nyulelen Toyi Mangbassim, Alphonse Kpozehouen, Jacques Zinsou Saizonou, Nicolas Gaffan, Aissata Ba Sidibe, Marie Therese Guigui, Yaovi Temfan Toke, Dadja Essoya Landoh, Assima-Essodom Kalao","doi":"10.4236/ojepi.2023.134023","DOIUrl":"https://doi.org/10.4236/ojepi.2023.134023","url":null,"abstract":"Introduction: The relationship between religion and health has been a topic of interest in the past, and in recent years it has become increasingly visible in the social, behavioural, and health sciences. This work aims to study the influence of religion on the “zero-dose” vaccination status of children aged 12 - 23 months in Benin and Togo. Methods: This was a cross-sectional study which consisted in carrying out secondary analyzes using the databases of the most recent editions of the Demographic and Health Surveys in Benin and the Multiple Indicator Cluster Surveys (MICS) in Togo. We extracted data concerning the vaccination status (“1 = zero-dose”, “0 = vaccinated”) of the children, the religious affiliation of the head of the household or the mother and other variables related to the child, the mother, the household and the environment. By means of a logistic regression, the adjusted effect of the religious affiliation of the head of the household or of the mother on the vaccination status at “zero-dose” was determined. Results: A total of 2430 and 933 children were respectively included in the study on behalf of Benin and Togo. The prevalence of “zero-dose” vaccination status in children aged 12 - 23 months was 33.91% (95% CI = 31.67 - 36.23) in Benin and this prevalence was 26.88% (95% CI = 23.50 - 30.55) in Togo. In Benin, there is no evidence in favour of the influence of the religious affiliation of the mother on the “zero-dose” vaccination status of children. In Togo, children living in households whose head was Muslim (ORa = 3.44; 95% CI = 1.29 - 9.13) were more likely to be “zero-dose” than those coming from households run by individuals with no religious beliefs. Conclusion: Further research is needed to understand the basis for the excess risk of “zero-dose” vaccination status in children that appears to be associated with the Muslim religion.","PeriodicalId":19578,"journal":{"name":"Open Journal of Epidemiology","volume":"358 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135610495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Full Vaccination of Children Aged 12 to 23 Months in the Commune of Thiomby (Kaolack/Senegal)","authors":"Boubacar Gueye, Oumar Bassoum, Ndéye Marième Diagne, Martial Coly Bop, Alioune Badara Tall, Abdoul Aziz Ndiaye, Cheikh Tacko Diop, Papa Gallo Sow, Ousseynou Ka, Ibrahima Seck","doi":"10.4236/ojepi.2023.134021","DOIUrl":"https://doi.org/10.4236/ojepi.2023.134021","url":null,"abstract":"Introduction: Data on the complete vaccination of children in rural areas and the factors associated with it are poorly known. Knowledge of these factors is necessary for the adoption of effective vaccination strategies. The aim of our study was to determine the proportion of children aged 12 to 23 months fully vaccinated before the age of 12 months in the commune of Thiomby and to identify associated factors. Methods: A descriptive and analytical cross-sectional study was conducted from 15 January to 15 February 2020 in Thiomby among of children aged 12 to 23 months and their mothers/caregivers. The sampling was carried out in two-step clusters. Bivariate analysis was done with Epi-Info version 7.2.2.16. Results: The sample included 380 mothers/caregivers with children aged on average 24.7 years. Among them, 93.2% were housewives, 29.4% had attended school and 12.8% had a monthly income of more than 100,000 CFA francs. In total, 296 children were fully inoculated i.e. 77.9% of children aged 12 - 23 months had received all the appropriate vaccines by the age of 12 months. In addition, 42% of mothers and babysitters had a good level of knowledge about vaccination (benefits, side effects, etc.). The primary source of information for mothers about vaccination was the midwife, with 88 percent of women being informed through this channel. The age of mothers less than or equal to 30 years would significantly reduce (p < 0.05) the probability of fully vaccinating children. On the other hand, mothers’ education, good level of knowledge and receipt of vaccination advice during antenatal and postnatal consultations significantly increases the probability of children being fully vaccinated before the age of 12 months. Conclusion: Factors such as a good level of knowledge of mothers and access to information through midwives during prenatal and postnatal consultations contribute to an improvement in complete vaccination coverage among children aged 12 to 23 months.","PeriodicalId":19578,"journal":{"name":"Open Journal of Epidemiology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135446861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Antimicrobial Susceptibility Status of Gram-Negative and Gram-Positive Bacteria on Handheld Shopping Trolleys and Baskets in Supermarkets in Ndola, Zambia","authors":"Shivangi Patel, Victor Daka, Steward Mudenda, Mulemba Samutela, Misheck Chileshe, Warren Chanda, Imukusi Mutanekelwa, Ephraim Chikwanda, Titus Haakonde, Tobela Mudenda, Scott Matafwali, Samson Mwale, Ruth Lindizyani Mfune","doi":"10.4236/ojepi.2023.134018","DOIUrl":"https://doi.org/10.4236/ojepi.2023.134018","url":null,"abstract":"Background: Supermarkets are a place visited by individuals with different health conditions daily where microbiological contaminants through touch onto fomites such as trolleys and baskets can be passed on to other people hence potentially spreading infectious diseases. This study aimed to investigate the presence of Gram-negative and Gram-positive bacteria on handheld shopping trolleys and baskets and their antimicrobial susceptibility status against commonly used antibiotics in Zambia. Methods: A cross-sectional study was conducted. Trolleys and basket handles were swabbed and standard microbiological methods were used to identify the bacteria and disc diffusion to determine their antimicrobial susceptibility status. Data was collected from December 2021 to April 2022. Data was analysed using IBM Statistical Package for Social Sciences (SPSS) Version 22. Results: Twenty-eight percent of the 200 total samples were found to be culture-positive and predominant isolates were Staphylococcus aureus (17.3%), Pseudomonas species (4.5%), Escherichia coli (2%), Corynebacterium species (2%), Staphylococcus species (1.5%) and Enterobacter aerogenes (0.5%). Staphylococcus aureus showed the most resistance to azithromycin (17%) followed by ciprofloxacin (2.8%), nitrofurantoin (2.8%) and chloramphenicol (2.8%). Escherichia coli showed 100% resistance to amoxicillin, cloxacillin and ampicillin, 75% resistance to ciprofloxacin and the least resistance to azithromycin (25%) while it was susceptible to nitrofurantoin. Staphylococcus species, Corynebacterium species, Enterobacter aerogenes and Pseudomonas species showed no resistance to any antibiotics. Conclusion: The study showed the presence of microorganisms with considerable antimicrobial resistance to antibiotics in Zambia on trolley and basket handles indicating the need for more initiatives to address proper hygiene in public environmental sites for better infection prevention and control.","PeriodicalId":19578,"journal":{"name":"Open Journal of Epidemiology","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Variations in Mortality after Liver Transplantation: Retrospective Investigation of Potential Risk Factors Using Propensity Score","authors":"Rana A. Almousa, Mohamed M. Shoukri","doi":"10.4236/ojepi.2023.134019","DOIUrl":"https://doi.org/10.4236/ojepi.2023.134019","url":null,"abstract":"Objective: We aim to detect over-time variations in mortality of liver transplant recipients stratified by the period of transplant. Since this is a retrospective investigation, bias reduction caused by possible confounding effects can be achieved by using propensity score weighting in a multivariate logistic regression model. Methods: Medical charts of all adult liver transplant recipients (n = 250) who were transplanted in three periods 2005-2009, 2010-2014 and 2015-2019 were retrospectively reviewed. The following recipient factors were analyzed: recipients and donors’ ages, sex, renal impairment, body mass index (BMI), presence of bacterial or viral infections, MELD (Model for end-stage diseases). Multivariate logistic model adjusted by Propensity Scores (PS) was used to identify the effect of the risk factors on mortality, and death within five years, in the targeted time frame. Patient outcomes are recorded as; (patient status = 1 if dead, or patient status = 0 if alive). Results: Meld score, recipient age, and renal impairments were shown to be predictors of mortality in transplanted patients. Multivariate regression model was used to identify the significance of the specified risk factors, followed by pairwise comparisons between periods. Pairwise comparisons between periods using logistic regression weighted by the inverse propensity score, correcting for the possible confounding effect of measured covariates showed that the death rate is significantly reduced in subsequent periods as compared to the initial period. Conclusions: The clinical implications of these findings are the ability to stratify patients at high risk of posttransplant death by planning more intensive and accurate management for them.","PeriodicalId":19578,"journal":{"name":"Open Journal of Epidemiology","volume":"156 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135446657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for Precancerous Cervical Lesions in Women of Reproductive Age in the Kara Region of Togo in 2022","authors":"Gatibe Yendu-Suglpak Gnatou, Zézé Onivogui, Latame Komla Adoli, Fifonsi Adjidossi Gbeasor-Komlanvi, Arnold Junior Sadio, Yao Rodion Konu, Martin Kouame Tchankoni, Wendpouiré Ida Carine Zida-Compaore, Amegnona Agbonon, Didier Koumavi Ekouevi","doi":"10.4236/ojepi.2023.134022","DOIUrl":"https://doi.org/10.4236/ojepi.2023.134022","url":null,"abstract":"Introduction: Worldwide, cervical cancer is the 4th most common cancer in women and is a public health problem. The objective of this study was to estimate the prevalence of precancerous cervical lesions and to describe its associated factors among women of reproductive age in the Kara region of Togo. Methods: A cross-sectional study was conducted from March 6 to 14, 2022 in 11 health centers in Kara. Data were collected using a standardized questionnaire and screening for precancerous cervical lesions was performed by visual inspection of the cervix, after application of 5% acetic acid and Lugol’s. Logistic regression analysis was performed to describe factors associated with precancerous lesions. Results: A total of 728 women with a median age of 36, interquartile range [31 - 41] were enrolled. The prevalence of precancerous cervical lesions was 3.9%, 95% confidence interval (95% CI: [2.6 - 5.4]. Factors associated with the presence of precancerous lesions were age at first sexual intercourse ≥ 18 years (adjusted odds ratio (aOR = 3.67; 95% CI [1.17 - 18.4]) and being a sex worker (aOR = 8.14; 95% CI [1.96 - 27.1]). HIV infection was not associated with the presence of precancerous lesions. Conclusion: The results of this study underscore the importance of intensifying cervical cancer screening efforts in resource-limited countries for better management. These efforts should prioritize vulnerable populations such as female sex workers.","PeriodicalId":19578,"journal":{"name":"Open Journal of Epidemiology","volume":"156 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135446856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Factors Associated with Psychoactive Substance Misuse among Heavy Goods Vehicle Drivers in Cotonou, Benin","authors":"Yolaine Glèlè-Ahanhanzo, Nouriat Mohammed, Donatien Daddah, Nicolas Gaffan, Lamidhi Salami, Alphonse Kpozehouen","doi":"10.4236/ojepi.2023.134020","DOIUrl":"https://doi.org/10.4236/ojepi.2023.134020","url":null,"abstract":"Introduction: In Benin, Heavy Goods Vehicle (HGV) drivers play an essential role in the logistics chain, facilitating the transportation of goods within the country or between other countries in the sub-region. HGV drivers are professionals who experience adverse working conditions, exposing them to risky behaviours, including Psychoactive Substance (PAS) misuse, leading to particularly severe road accidents. This study aimed to determine the prevalence of PAS misuse among HGV drivers and identify associated factors in Cotonou, Benin. Materials and Methods: We conducted a cross-sectional survey involving HGV drivers at parking areas in Cotonou from 26 March to 10 April 2023. The dependent variable was the PAS misuse by HGV drivers, and the independent variables were related to their socio-demographic characteristics, health status and lifestyle habits, and professional characteristics. Data analysis involved determining the prevalence of PAS misuse with a 95% Confidence Interval (95% CI). Subsequently, we identified factors associated with PAS misuse among the participants using multivariate logistic regression. We presented the final regression results as adjusted odds ratios (aOR) with 95% CI. Results: The study included 425 HGV drivers. Among them, 53 (12.47%, 95% CI = 9.64 - 15.98) were misusing PAS. Compared to drivers aged 35 and older, those aged under 25 (aOR = 10.67, 95% CI = 3.56 - 32.03) and those aged 25 to 34 (aOR = 3.47, 95% CI = 1.37 - 8.82) had higher odds of PAS misuse. Drivers with a primary education were less likely (aOR = 0.43, 95% CI = 0.19 - 0.97) to misuse PAS than those with no formal education. Drivers suffering from cardiovascular diseases were also three times more likely (aOR = 3.08, 95% CI = 1.08 - 8.81) to misuse PAS than others. The odds of PAS misuse were also higher among drivers who reported taking breaks than those claiming not to (aOR = 3.11, 95% CI = 1.57 - 6.18). Conclusion: Driving under the influence of PAS is a risk factor for road accidents, associated with other factors highlighted in this study. Addressing these factors in prevention strategies through integrated approaches could lead to more effective results.","PeriodicalId":19578,"journal":{"name":"Open Journal of Epidemiology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135446867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus Disease-2019 Conspiracy Theories are Alive and Breathing on the Internet","authors":"John E. Boos","doi":"10.17140/epoj-7-126","DOIUrl":"https://doi.org/10.17140/epoj-7-126","url":null,"abstract":"The more detailed origin stories of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the coronavirus disease2019 (COVID-19) vaccines are both unknown to the layperson. These unknowns serve as opportunities for misinformation messaging to the layperson. How did pharmaceutical companies create a vaccine within a matter of months to a year for a relatively new virus? Were aborted fetal cells used to make the COVID vaccines? What if there are long-term side COVID-19 vaccine effects not yet known to scientists and the public? While the internet, without a fact-checker and combined with opportunity and individual attitudes and information preferences, may flourish with misinformation and conspiracy theories. Scientists have a professional duty to publish evidence-based data in all pursuits, but recently the scientific community has spent much time educating the public in hopes of neutralizing many of the COVID fallacies we see every day on social media.","PeriodicalId":19578,"journal":{"name":"Open Journal of Epidemiology","volume":"387 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75149265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unintended Effects of Coronavirus Disease-2019","authors":"James M. Wesson","doi":"10.17140/epoj-7-e003","DOIUrl":"https://doi.org/10.17140/epoj-7-e003","url":null,"abstract":"As of this writing: “Globally, as of 4:22 pm CEST, 25 May 2022, there have been 524,339,768 confirmed cases of coronavirus disease-2019 (COVID-19), including 6,281,260 deaths, reported to World Health Organization (WHO). As of 23 May 2022, a total of 11,752,954,673 vaccine doses have been administered”","PeriodicalId":19578,"journal":{"name":"Open Journal of Epidemiology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87063561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigations of PM2.5 Long-term Exposure and Subclinical Atherosclerosis in Women: An Overview","authors":"Lei Zhu, Samar R. El Khoudary, J. Adibi, A. Youk, E. Talbott","doi":"10.17140/epoj-7-129","DOIUrl":"https://doi.org/10.17140/epoj-7-129","url":null,"abstract":"Background/Aim Evidence demonstrates that coronary artery calcification (CAC) is a biological marker for cardiovascular disease (CVD) risk prediction. Acute cardiovascular effects of temporary and chronic environmental particle exposures sensitive to ≤2.5 micrometers in diameter (here termed “PM2.5”) have been well-studied. However, there is less information on the long-term effects of PM2.5 exposures on the earlier pre-clinical stage of CVD, especially in women (in whom it is also established experience frequent cardiovascular late- and under-diagnoses). This phase of pre-diagnosis pathological activity is classified as subclinical atherosclerosis (SCA) unless and until a patient meets established clinical diagnostic criteria. In this systematic review, we summarize reported associations of long-term PM2.5 and SCA exposure, with investigators placing an emphasis on gender differences in any documented associations. Methods We conducted a comprehensive literature review for articles published from 2007 to 2022 that reported associations of long-term PM2.5 and SCA and evaluated each study with areas of particular focus including study designs, populations at risk, and exposure measures. Results Investigations representing four cohorts yielded equivocal findings related to long-term PM2.5 exposure and CAC. Three cohorts reported positive associations between long-term PM2.5 and CAC development/progression. Two studies supported a strongly positive associations among women or postmenopausal women for PM2.5 on CAC. Studies, however, evaluating PM2.5 exposure associations with carotid intima-media thickness (another biomarker of SCA), reflect increases in both men and women with ↑ PM2.5 levels but reporting no gender differences in PM2.5 exposure and this measure of SCA. Conclusion Our study identifies important gaps in current knowledge synthesis including different methods of PM2.5 estimation and linkage, a lack of consensus of what constitutes long-term air pollution, and the selection of important covariates and intermediate variables. Our aim is to outline best practices going forward in the investigation of PM2.5 long-term exposure and SCA in women","PeriodicalId":19578,"journal":{"name":"Open Journal of Epidemiology","volume":"552 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77221876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}