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Preparation of new mono- and bis-amide derivatives of L-isoleucine via amidation of carboxyl and amino groups 羧基和氨基酰胺化制备新的L-异亮氨酸单酰胺和双酰胺衍生物
IF 1.7
Organic Communications Pub Date : 2021-09-19 DOI: 10.25135/acg.oc.112.21.07.2139
R. Erenler, Murat Sünkür, S. Aydin, Tarık Aral, B. Dag
{"title":"Preparation of new mono- and bis-amide derivatives of L-isoleucine via amidation of carboxyl and amino groups","authors":"R. Erenler, Murat Sünkür, S. Aydin, Tarık Aral, B. Dag","doi":"10.25135/acg.oc.112.21.07.2139","DOIUrl":"https://doi.org/10.25135/acg.oc.112.21.07.2139","url":null,"abstract":"","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2021-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45412254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Synthesis of novel salicylic acid-pyrrolone conjugates and investigation of their cytotoxic and genotoxic effects in Allium cepa root tip cells 水杨酸-吡咯酮偶联物的合成及其对洋葱根尖细胞的细胞毒性和遗传毒性研究
IF 1.7
Organic Communications Pub Date : 2021-09-19 DOI: 10.25135/acg.oc.111.21.06.2118
M. Gümüş, Selin Can, H. Eroğlu, İ. Koca
{"title":"Synthesis of novel salicylic acid-pyrrolone conjugates and investigation of their cytotoxic and genotoxic effects in Allium cepa root tip cells","authors":"M. Gümüş, Selin Can, H. Eroğlu, İ. Koca","doi":"10.25135/acg.oc.111.21.06.2118","DOIUrl":"https://doi.org/10.25135/acg.oc.111.21.06.2118","url":null,"abstract":"","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":"1 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2021-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41364409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, characterization, crystal structure and bioactivities of novel enamine and pyrrole derivatives endowed with acetylcholinesterase, α-glycosidase and human carbonic anhydrase inhibition effects 具有乙酰胆碱酯酶、α-糖苷酶和人碳酸酐酶抑制作用的新型烯胺和吡咯衍生物的合成、表征、晶体结构和生物活性
IF 1.7
Organic Communications Pub Date : 2021-06-22 DOI: 10.25135/acg.oc101.21.04.2029
I. Gülçin, A. Maharramov, M. Kurbanova, Parham Taslimi, Yeliz Demir, E. Huseyinov, A. Sujayev, S. Alwasel, A. Safarova
{"title":"Synthesis, characterization, crystal structure and bioactivities of novel enamine and pyrrole derivatives endowed with acetylcholinesterase, α-glycosidase and human carbonic anhydrase inhibition effects","authors":"I. Gülçin, A. Maharramov, M. Kurbanova, Parham Taslimi, Yeliz Demir, E. Huseyinov, A. Sujayev, S. Alwasel, A. Safarova","doi":"10.25135/acg.oc101.21.04.2029","DOIUrl":"https://doi.org/10.25135/acg.oc101.21.04.2029","url":null,"abstract":"","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2021-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44846115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Click chemistry: a fascinating method of connecting organic groups 点击化学：连接有机基团的迷人方法
IF 1.7
Organic Communications Pub Date : 2021-06-22 DOI: 10.25135/acg.oc.100.21.03.2006
T. Ozturk, Bibi Amna
{"title":"Click chemistry: a fascinating method of connecting organic groups","authors":"T. Ozturk, Bibi Amna","doi":"10.25135/acg.oc.100.21.03.2006","DOIUrl":"https://doi.org/10.25135/acg.oc.100.21.03.2006","url":null,"abstract":"","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2021-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48411375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Knoevenagel condensation reaction catalysed by agro-waste extract as a greener solvent catalyst 农业废弃物提取物作为绿色溶剂催化剂催化Knoevenagel缩合反应
IF 1.7
Organic Communications Pub Date : 2021-03-26 DOI: 10.25135/ACG.OC.99.21.01.1948
Krishnappa B Badiger, Kantharaju Kamanna
{"title":"Knoevenagel condensation reaction catalysed by agro-waste extract as a greener solvent catalyst","authors":"Krishnappa B Badiger, Kantharaju Kamanna","doi":"10.25135/ACG.OC.99.21.01.1948","DOIUrl":"https://doi.org/10.25135/ACG.OC.99.21.01.1948","url":null,"abstract":"This paper present a novel Knoevenagel reaction protocol for the condensation of aromatic/heteroaromatic aldehydes with malononitrile to give α, β–unsaturated benzylidene derivatives. The main focus of this work is to reveal the usability of agro-waste extracts as a catalyst in the Knoevenagel condensation. The present protocol proceeds efficiently for various substituted aromatic and heterocyclic aldehydes in the Knoevenagel reactions. In addition, the present method describes direct isolation of the formed products without using organic solvent extraction gave good yields product.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2021-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41844410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity 一种新型吩噻嗪衍生物的微波合成及其细胞毒活性研究
IF 1.7
Organic Communications Pub Date : 2020-12-26 DOI: 10.25135/acg.oc.86.20.10.1853
Cenk A Andac
{"title":"Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity","authors":"Cenk A Andac","doi":"10.25135/acg.oc.86.20.10.1853","DOIUrl":"https://doi.org/10.25135/acg.oc.86.20.10.1853","url":null,"abstract":"Herein, a facile procedure for microwave synthesis and NMR characterization of phenothiazine derivatives 10-(3-hydroxypropyl)-2-(methylsulphanyl)-10H-phenothiazine (3) (25% yield) and 1-[3-(2-methylsulfanyl-10H-phenothiazine-10-yl)-propyl]pyrimidine-2,4-(1H,3H)-dione (6) (67% yield) is described. After successful microwave synthesis steps, MTT cytotoxicity experiments gave rise to greater anticancer effect of compound 6 in MCF-7 human breast adenocarcinoma cell line (IC50= 1.35 µM) as compared to literature values for tamoxifen (IC50= 8.3 µM) and doxorubicin (IC50= 27 µM).","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44717527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Synthesis of ɣ-glutamyl β-cyanoalanine precursor 谷氨酰β-氰丙氨酸前体的合成
IF 1.7
Organic Communications Pub Date : 2020-12-26 DOI: 10.25135/acg.oc.89.20.05.1660
Sule Un, R. Altundas, A. Gören
{"title":"Synthesis of ɣ-glutamyl β-cyanoalanine precursor","authors":"Sule Un, R. Altundas, A. Gören","doi":"10.25135/acg.oc.89.20.05.1660","DOIUrl":"https://doi.org/10.25135/acg.oc.89.20.05.1660","url":null,"abstract":"The synthesis of precursors of neurotoxic ɣ-glutamyl β-cyanoalanine was developed starting from L-Serine via through the preparation of b-cyanoalanine and glutamyl units. Coupling of these two intermediates gave methyl ester of ɣ-glutamyl β-cyanoalanine precursor.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45103958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient one-pot three-component synthesis of 2H-indazole [2,1-b]phthalazine-1,6,11(13H)-triones at room temperature 室温下一锅三组分高效合成2h -茚唑[2,1-b]酞嗪-1,6,11(13H)-三酮
IF 1.7
Organic Communications Pub Date : 2020-12-26 DOI: 10.25135/acg.oc.85.20.08.1768
Parshuram M. Pisal, V. T. Kamble, Dr. Ravi Varala, Pradip B. Gujarathi
{"title":"Efficient one-pot three-component synthesis of 2H-indazole [2,1-b]phthalazine-1,6,11(13H)-triones at room temperature","authors":"Parshuram M. Pisal, V. T. Kamble, Dr. Ravi Varala, Pradip B. Gujarathi","doi":"10.25135/acg.oc.85.20.08.1768","DOIUrl":"https://doi.org/10.25135/acg.oc.85.20.08.1768","url":null,"abstract":"Tetrabutylammonium bromide (TBAB) and cesium carbonate (Cs2O3) catalyzed, one-pot three-component synthesis of 2H-indazole[2,1b]phthalazine-1,6,11(13H)-triones was developed at room temperature in ethanol. Both electron donating and withdrawing groups are compatible under the optimized reaction parameters.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46973524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cycloaddition reactions of 4-phenyl-3H-1,2,4-triazole-3,5(4H)-dione (PTAD) and 4-methyl-3H-1,2,4-triazole-3,5(4H)-dione (MTAD): A short review 4-苯基- 3h -1,2,4-三唑-3,5(4H)-二酮(PTAD)和4-甲基- 3h -1,2,4-三唑-3,5(4H)-二酮(MTAD)的环加成反应综述
IF 1.7
Organic Communications Pub Date : 2020-12-26 DOI: 10.25135/acg.oc.88.20.11.1870
N. Korol, M. Slivka, O. Holovko-Kamoshenkova
{"title":"Cycloaddition reactions of 4-phenyl-3H-1,2,4-triazole-3,5(4H)-dione (PTAD) and 4-methyl-3H-1,2,4-triazole-3,5(4H)-dione (MTAD): A short review","authors":"N. Korol, M. Slivka, O. Holovko-Kamoshenkova","doi":"10.25135/acg.oc.88.20.11.1870","DOIUrl":"https://doi.org/10.25135/acg.oc.88.20.11.1870","url":null,"abstract":"The sources, describing cycloaddition reactions with the participation of 4-phenyl-3H-1,2,4-triazole-3,5(4H)-dione (PTAD) and 4-methyl-3H-1,2,4-triazole-3,5(4H)-dione (MTAD) were reviewed from the middle 1970s and they are mentioned in chronological order. It was noted that the most investigated are Diels-Alder reactions and cycloaddition to a few cyclic mono- and dienes. Stereochemistry of obtained products are also described.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48346142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, anticancer activities and molecular modeling studies of some 2-aminonaphtho[2,3-d][1,3]thiazole-4,9-dione derivatives 一些2-氨基萘[2,3-d][1,3]噻唑-4,9-二酮衍生物的合成、抗癌活性及分子模型研究
IF 1.7
Organic Communications Pub Date : 2020-12-26 DOI: 10.25135/acg.oc.91.20.11.1913
Hülya Yanık, Sümeyra Ayan, A. Akdemir, Ö. Erdoğan, C. B. Ustundag, O. Cevik, Ozgur Yilmaz
{"title":"Synthesis, anticancer activities and molecular modeling studies of some 2-aminonaphtho[2,3-d][1,3]thiazole-4,9-dione derivatives","authors":"Hülya Yanık, Sümeyra Ayan, A. Akdemir, Ö. Erdoğan, C. B. Ustundag, O. Cevik, Ozgur Yilmaz","doi":"10.25135/acg.oc.91.20.11.1913","DOIUrl":"https://doi.org/10.25135/acg.oc.91.20.11.1913","url":null,"abstract":"Quinones, especially 1,4-naphthoquinones, are one of the most significant and widely distributed phytochemical groups in nature. 1,4-Naphthoquinones and their synthetic derivatives are found to possess remarkable cytotoxic activities. In this study, a series of 2-aminonaphtho[2,3-d][1,3]thiazole-4,9-dione derivatives were synthesized and their structures were verified with spectral analysis. In vitro cytotoxic activities of the synthesized compounds were evaluated by using MTT assay against MKN-45 (Human Gastric cancer), MDA-MB-231 (Human Breast cancer) and HeLa (Human Cervical cancer) cell lines. Among the synthesized compounds, 3d inhibited MDA-MB-cell proliferation with an IC50 value of 0.276 µM. Compound 3a inhibited HeLa and MKN-45 cell proliferation with IC50 values of 0.336 µM and 8.769 µM, respectively. Compound 3b inhibited HELA cell proliferation with an IC50 value of 0.269 µM. Molecular docking results suggest that the ligands may bind to the hDNA TopoIIβ binding pocket and partially exert their effects. These results propose that 2-aminonaphtho[2,3-d]thiazole-4,9-dion core has important biological effects and further explorations are worthwhile.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46107876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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