Organic Communications最新文献

{"title":"Microwave-assisted one-pot synthesis of tetrahydrobenzo[b]pyrans in the presence of WEWFPA and their electrochemical studies","authors":"Kantharaju Kamanna, Krishnappa B Badiger, Lokesh Koodlur Sannegowda","doi":"10.25135/acg.oc.124.2111.2263","DOIUrl":"https://doi.org/10.25135/acg.oc.124.2111.2263","url":null,"abstract":": The present work described one-pot three-component synthesis of tetrahydro benzo[b]pyran derivatives using Water Extract of Watermelon Fruit Peel Ash (WEWFPA) as a inexpensive grener catalyst. The title compounds were synthesized via the condensation reaction of aromatic aldehyde, dimedone, and ethyl cyanoacetate under microwave irradiation in agro-waste solvent medium and ethanol as a co-solvent. The developed method is simple, rapidity, high yields, pure, low cost, mild reaction condition, evading use of toxic metals and solvent, and the catalyst reusability are the main advantages. The resulting products were isolated by simple workup and recrystallization gave pure compounds. Further, the oxidation and reduction potential of the selected tetrahydrobenzo[b]pyran derivatives were studied using cyclic voltammetry.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":"1 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41496290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potassium ferrocyanide promoted an efficient synthesis of benzoxazoles and benzothiazoles under solvent free condition","authors":"Vishal A. Patil, Dhanshri V. Patil, Sachin Potdar","doi":"10.25135/acg.oc.121.2110.2242","DOIUrl":"https://doi.org/10.25135/acg.oc.121.2110.2242","url":null,"abstract":"","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44711813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural, spectroscopic, Hirshfeld surface and DFT approach of 3,9-dibromophenanthrene","authors":"O. Çakmak, C. Ersanli, Kıymet Berkil Akar, N. Karaoğlan","doi":"10.25135/acg.oc.119.2109.2213","DOIUrl":"https://doi.org/10.25135/acg.oc.119.2109.2213","url":null,"abstract":"","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42142771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acyl glucopyranosides: Synthesis, PASS Predication, Antifungal Activities, and Molecular Docking","authors":"M. Matin, A. Sanaullah, M. Rahman, S. Nayeem","doi":"10.25135/acg.oc.120.2201.2307","DOIUrl":"https://doi.org/10.25135/acg.oc.120.2201.2307","url":null,"abstract":"","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49657790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mandelic acid: an efficient and green organo-catalyst for synthesis of 2,4,5-trisubstituted Imidazoles under solvent free condition","authors":"Ramesh S. Ghogare","doi":"10.25135/acg.oc.118.22.01.2341","DOIUrl":"https://doi.org/10.25135/acg.oc.118.22.01.2341","url":null,"abstract":"","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41965462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review on repurposing of approved medicine in the management of COVID-19 infection","authors":"Umang Shah, Darshini Patel, Arya Patel, Sandip Patel, Mehul Patel, Ashish D. Patel, Swayamprakash Patel, N. Solanki, Nilesh Pandey","doi":"10.25135/acg.oc.117.2110.2244","DOIUrl":"https://doi.org/10.25135/acg.oc.117.2110.2244","url":null,"abstract":"The SARS-CoV-2 virus, accountable for the COVID-19 pandemic, is now sweeping the globe. As a result, as this disease resists testing and adoption of new treatments, repositioning existing medications may provide a quick and appealing method with established safety, features, and dose used. They are not, however, specific or focused. However, numerous medications have been studied for their efficacy and safety in treatment of COVID-19, with the majority currently undergoing clinical trials. The goal is to rapidly expand novel preventative and therapeutic medications, as well as to apply preventive methods such as early patient identification, isolation, and treatment. Moreover, reducing transmission through physical contact is also important. In the fight against this dangerous disease, finding the proper treatment is crucial. This article summarizes several anti-malarial, anti-parasitic, monoclonal antibodies, immunosuppressant, and immunomodulating agents in clinical trials for COVID-19. The purpose of this article is to evaluate and explore the potential roles of several medications now utilized in COVID-19.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44780445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel naphthalene-1,5-diamine containing urea/thiourea derivatives – Promising antimicrobial agents","authors":"R. M. N. Kalla, L. Venkataramana, C. Venkataramaiah, K. Kumari, M. Varalakshmi, C. Naga Raju","doi":"10.25135/acg.oc.115.2111.2257","DOIUrl":"https://doi.org/10.25135/acg.oc.115.2111.2257","url":null,"abstract":"A pioneering class of urea/thiourea derivatives of naphthalene-1,5-diamine was synthesized in excellent yields (89-96%) by one-pot procedure via treatments with phenyl isocyanates or phenyl isothiocyanates. All the constructed derivatives were evaluated for antimicrobial activity using in vitro and in silico methods. The obtained results showed that, all the titled compounds displayed the most significant antibacterial activity against grampositive and gram-negative bacteria namely B. substilis, B. sphaerius, S. aureus, P. aeruginosa, K. aerogenes, C. violaceum and antifungal activity against A.Niger, C. tropicum, R. oryzae, F. moniliforme and C. lunata when compared with the standard drugs such as ciproflaxacin and clotrimazole. Among all, the compounds 2c, 2e and 3d, 3e displayed higher content of antimicrobial activity akin to the rest of the compounds due to the presence of fluoro substitution on aromatic ring. Furthermore, molecular docking studies provided support to the in vitro studies. Four of the synthesized compounds, 4-fluorophenyl, 3-trifluoromethylphenyl, 4-chlorophenyl exhibited significant binding modes and were the best target ligands as they fitted more stably into the DNA gyrase binding pocket. Henceforth, it is suggested that, the fabricated urea/thiourea derivatives of naphthalene-1,5-diamine would stand as the prosperous antimicrobial drug candidates for further studies.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2021-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47477985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The computational screening of inhibitor for black fungus and white fungus by D-glucofuranose derivatives using in silico and SAR study","authors":"A. Kumer, Unesco Chakma, M. Matin, S. Akash, Debashis Howlader, Akhel Chandro","doi":"10.25135/acg.oc.116.2108.2188","DOIUrl":"https://doi.org/10.25135/acg.oc.116.2108.2188","url":null,"abstract":"Black fungus is the foremost life-threatening disease during the SARS-CoV-2 affected patients and spreading quickly in the region of the subcontinent of India although there was no prescribed proper medication. As the D-glucofuranose and its derivatives are reported to show strong antifungal activity, this study has been designed with them for their computational investigation. Firstly, the overall prediction of activity spectra for substances (PASS) value illustrates a good probability to be active(Pa) and probability to be inactive (Pi) value. Next, pharmacokinetics parameters including drug-likeness and Lipinski's rules, absorption, distribution, metabolism, excretion, and toxicity (ADMET) parameters, and overall quantum calculation of computational approaches by Density Functional Theory (DFT) have gradually been performed to analyze quantum calculations. After the analysis of docking score, it is found at -9.4 kcal/mol, -7.5 kcal/mol, -7.8 kcal/mol, -8.5 kcal/mol against the strain of black fungus protein strains Mycolicibacterium smegmatis, Mucor lusitanicus, Rhizomucor mien, and white fungus protein Candida Auris, Aspergillus luchuensis and Candida albicans. Next, the molecular dynamics of docked complexes have been performed to check their stability in biological systems with water ranging 100 ns calculating the Root Mean Square Deviation (RMSD) and Root Mean Square Fluctuation (RMSF) where the minimum RMSD and RMSF value indicated the higher stable configuration of docked complexes. These compounds have perfectly matched all the pharmacokinetics criteria to be a good drug candidate against both black and white fungus, and they are non-carcinogenic, low solubility, low toxic for both aquatic and non-aquatic. In addition, the quantum calculation using DFT conveys the strongest support and information about their chemical stability and biological significance. Finally, it could be concluded that the carboxylic group and methyl group in the benzene ring causes higher binding affinity against black and white fungus protein strain through the formation of hydrogen and hydrophobic bonds.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2021-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46660924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis and antimicrobial screening of some new thienopyrimidines","authors":"M. Tolba, M. Sayed, A. K. Kamal El‐dean, R. Hassanien, Mostafa Ahmed, S. A. Abdel-Raheem","doi":"10.25135/acg.oc.114.2109.2214","DOIUrl":"https://doi.org/10.25135/acg.oc.114.2109.2214","url":null,"abstract":"Heterocyclic compounds play an important role in our life due to their biological importance in the struggle of microorganisms. Herein, a series of novel hybrid compounds of thienopyrimidine with triazine and pyrimidine scaffolds were synthesized starting from difunctionalized compound 5-amino-4-phenyl-2-(p-tolylamino)thieno[2,3d]pyrimidine-6-carbonitrile (1). Moreover, the diazotization of compound 1 with sodium nitrite in an acidic medium gave the chloro-triazine compound 2 which was subjected to the nucleophilic substitution of chlorine atom with different nucleophiles delivered compounds 3a-5c. Furthermore, the reaction of compound 1 with carbon disulfide led to the formation of dithione derivative 6 which was alkylated with ethyl chloroacetate to give compound 7, on the other hand, the reaction of compound 1 with phenyl isothiocyanate produced 4-imino-3,9-diphenyl-7-(p-tolylamino)-3,4dihydropyrimido[4',5':4,5]thieno [2,3-d]pyrimidine-2(1H)-thione (8), while acylation of the amino group in compound 1 with acetic anhydride gave compound 9. All synthesized compounds were characterized by elemental and spectral analysis techniques (IR, H NMR, C NMR, Mass spectroscopy). Furthermore, the synthesized compounds were tested for their antimicrobial activity against different strains of bacteria and fungi, and the results obtained showed good to moderate activity with almost all the strains.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2021-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47386603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of reactor configurations on the Suzuki cross-coupling reaction using a carrageenan-based RhCl3 catalyst","authors":"A. Wolfson, Oshrat Levy‐Ontman, Eduart Arbit, Sivan Leviev","doi":"10.25135/acg.oc.113.2108.2189","DOIUrl":"https://doi.org/10.25135/acg.oc.113.2108.2189","url":null,"abstract":"RhCl3 was heterogenized into an iota-carrageenan polysaccharide support, and the effect of various reactor configurations on catalyst performance in a Suzuki cross-coupling reaction was studied. It was found that performing the reaction in a high-volume, well-agitated, mechanically mixed high volume reactor, or circulating the reaction mixture through the catalyst, which was placed in a tabular reactor, yielded higher product yields in comparison to magnetically stirring or shaking. In addition, the catalyst was also successfully recycled in all the systems. Moreover, the reaction solution in each reactor configuration did not contain any traces of rhodium, while elemental composition of the iota-based rhodium catalyst, ἰ-RhCl3, following the first and the second cycle in the glass tubular reactor was similar to the fresh ἰ-RhCl3 catalyst, demonstrating the high xerogel stability.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48720711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}