OncoTargets and therapy最新文献

筛选
英文 中文
A Multidisciplinary Approach to Improve the Management of Immune-Checkpoint Inhibitor-Related Pneumonitis. 改善免疫检查点抑制剂相关肺炎管理的多学科方法。
IF 2.7 4区 医学
OncoTargets and therapy Pub Date : 2024-08-22 eCollection Date: 2024-01-01 DOI: 10.2147/OTT.S470892
Monica Valente, Maura Colucci, Virginia Vegni, Valentina Croce, Cristiana Bellan, Giulia Rossi, Giulia Gibilisco, Francesco Frongia, Raffaella Guazzo, Claudia Ghiribelli, Elena Bargagli, Vinno Savelli, Matteo Ravara, Tommaso Sani, Elena Simonetti, Michele Maio, Luana Calabrò, Anna Maria Di Giacomo
{"title":"A Multidisciplinary Approach to Improve the Management of Immune-Checkpoint Inhibitor-Related Pneumonitis.","authors":"Monica Valente, Maura Colucci, Virginia Vegni, Valentina Croce, Cristiana Bellan, Giulia Rossi, Giulia Gibilisco, Francesco Frongia, Raffaella Guazzo, Claudia Ghiribelli, Elena Bargagli, Vinno Savelli, Matteo Ravara, Tommaso Sani, Elena Simonetti, Michele Maio, Luana Calabrò, Anna Maria Di Giacomo","doi":"10.2147/OTT.S470892","DOIUrl":"10.2147/OTT.S470892","url":null,"abstract":"<p><strong>Purpose: </strong>Treatment with immune-checkpoint inhibitors (ICIs) can be associated with a wide spectrum of immune-related adverse events (irAEs). Among irAEs, immune-mediated pneumonitis (im-PN) is a rare but potentially life-threatening side effect. TPrompt multidisciplinary diagnosis and effective management of im-PN may be essential to avoid severe complications and allowing resumation of therapy.</p><p><strong>Patients and methods: </strong>We collected a case series of skin (melanoma, cutaneous squamous cell carcinoma-CSCC), lung, and mesothelioma cancer patients (pts), treated with ICI at the Center for Immuno-Oncology University Hospital of Siena, Italy, and diagnosed with im-PN. Clinical and radiologic data were thoroughly collected, as well as bronchoalveolar lavage (BAL) samples; im-PN was graded using CTCAE v. 5.0. Radiological patterns were reported according to the <i>F</i>leischner Society classification.</p><p><strong>Results: </strong>From January 2014 to February 2023, 1004 patients with melanoma (522), CSCC (42), lung (342) or mesothelioma (98) were treated with ICI (619 monotherapy; 385 combination). Among treated patients, 24 (2%) developed an im-PN and 58% were symptomatic. Im-PN were classified as grades G1 (10) and G2 (14). Prompt steroid treatment led to complete resolution of im-PN in 21 patients, with a median time to resolution of 14 weeks (range: 0.4-51). Twelve patients resumed ICI therapy once fully-recovered and 2 experienced a recurrence that completely resolved with steroids after resumption of treatment. Three radiologic patterns were identified: organizational pneumonia-like (67%), pulmonary eosinophilia (29%), and hypersensitivity pneumonitis (4%). Furthermore, BAL analysis performed in 8 (33%) patients showed an inflammatory lymphocytic infiltrate, predominantly consisting of foam cell-like macrophage infiltrates in 6 cases. Notably, transmission electron microscopy evaluation performed in 2 patients revealed a scenario suggestive of a drug-mediated toxicity.</p><p><strong>Conclusion: </strong>Im-PN is a rare but challenging side effect of ICI therapy, with variable time of onset and with heterogeneous clinical and radiological presentations. A multidisciplinary assessment is mandatory to optimize the clinical management of im-PN.</p>","PeriodicalId":19534,"journal":{"name":"OncoTargets and therapy","volume":"17 ","pages":"673-681"},"PeriodicalIF":2.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TRIM31 Promotes Glioma Proliferation and Invasion Through Activating NF-κB Pathway [Retraction]. TRIM31 通过激活 NF-κB 通路促进胶质瘤的增殖和侵袭 [撤回]。
IF 2.7 4区 医学
OncoTargets and therapy Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI: 10.2147/OTT.S491281
{"title":"TRIM31 Promotes Glioma Proliferation and Invasion Through Activating NF-κB Pathway [Retraction].","authors":"","doi":"10.2147/OTT.S491281","DOIUrl":"https://doi.org/10.2147/OTT.S491281","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.2147/OTT.S183625.].</p>","PeriodicalId":19534,"journal":{"name":"OncoTargets and therapy","volume":"17 ","pages":"671-672"},"PeriodicalIF":2.7,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
G-Protein-Signaling Modulator 2 Expression and Role in a CD133+ Pancreatic Cancer Stem Cell Subset [Retraction]. G 蛋白信号调节器 2 在 CD133+ 胰腺癌干细胞亚群中的表达和作用 [撤回]。
IF 2.7 4区 医学
OncoTargets and therapy Pub Date : 2024-08-14 eCollection Date: 2024-01-01 DOI: 10.2147/OTT.S491280
{"title":"G-Protein-Signaling Modulator 2 Expression and Role in a CD133<sup>+</sup> Pancreatic Cancer Stem Cell Subset [Retraction].","authors":"","doi":"10.2147/OTT.S491280","DOIUrl":"https://doi.org/10.2147/OTT.S491280","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.2147/OTT.S187670.].</p>","PeriodicalId":19534,"journal":{"name":"OncoTargets and therapy","volume":"17 ","pages":"667-668"},"PeriodicalIF":2.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
circHIPK3 Promotes Cell Proliferation and Migration of Gastric Cancer by Sponging miR-107 and Regulating BDNF Expression [Retraction]. circHIPK3 通过疏导 miR-107 和调控 BDNF 表达促进胃癌细胞增殖和迁移 [撤回]。
IF 2.7 4区 医学
OncoTargets and therapy Pub Date : 2024-08-14 eCollection Date: 2024-01-01 DOI: 10.2147/OTT.S491282
{"title":"circHIPK<sub>3</sub> Promotes Cell Proliferation and Migration of Gastric Cancer by Sponging miR-107 and Regulating BDNF Expression [Retraction].","authors":"","doi":"10.2147/OTT.S491282","DOIUrl":"https://doi.org/10.2147/OTT.S491282","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.2147/OTT.S226300.].</p>","PeriodicalId":19534,"journal":{"name":"OncoTargets and therapy","volume":"17 ","pages":"669-670"},"PeriodicalIF":2.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11330851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of Sintilimab and Anlotinib for Metastatic Osteosarcoma: A Case Report. 辛替利单抗和安罗替尼联合治疗转移性骨肉瘤:病例报告
IF 2.7 4区 医学
OncoTargets and therapy Pub Date : 2024-08-13 eCollection Date: 2024-01-01 DOI: 10.2147/OTT.S464678
Gaoyan Tang, Qianqian Zhang, Fengxia Wang, Hua Zhang, Yuanling Qi
{"title":"Combination of Sintilimab and Anlotinib for Metastatic Osteosarcoma: A Case Report.","authors":"Gaoyan Tang, Qianqian Zhang, Fengxia Wang, Hua Zhang, Yuanling Qi","doi":"10.2147/OTT.S464678","DOIUrl":"10.2147/OTT.S464678","url":null,"abstract":"<p><strong>Background: </strong>As one of the most common types of primary bone sarcomas in adolescents and young adults, osteosarcoma has a high probability of local invasion and distant metastasis with a poor prognosis.</p><p><strong>Case presentation: </strong>Here, we report the case of a 34-year-old patient with advanced metastatic osteosarcoma. Considering the high expression of PD-L1 and the inability of the patient to tolerate chemotherapy, anti-PD-1 antibody (sintilimab 200 mg, q3w) and anti-angiogenesis drug (anlotinib 8 mg D1-14, q3w) were administered. The metastatic lesions were treated with local radiotherapy. The patient obtained an 11.7-month-sustained remission period, and he also enjoyed a better quality of life.</p><p><strong>Conclusion: </strong>This case demonstrates that sintilimab plus anlotinib may be a feasible treatment regimen for osteosarcoma patients.</p>","PeriodicalId":19534,"journal":{"name":"OncoTargets and therapy","volume":"17 ","pages":"661-665"},"PeriodicalIF":2.7,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Icariin Mitigates the Growth and Invasion Ability of Human Oral Squamous Cell Carcinoma via Inhibiting Toll-Like Receptor 4 and Phosphorylation of NF-κB P65 [Retraction] 淫羊藿苷通过抑制Toll-Like Receptor 4和NF-κB P65磷酸化减轻人口腔鳞状细胞癌的生长和侵袭能力 [撤回]
IF 4 4区 医学
OncoTargets and therapy Pub Date : 2024-08-08 DOI: 10.2147/ott.s490273
Ke Lei, Bing Ma, Ping Shi, Che Jin, Tan Ling, Longjiang Li, Xiangyi He, Lunchang Wang
{"title":"Icariin Mitigates the Growth and Invasion Ability of Human Oral Squamous Cell Carcinoma via Inhibiting Toll-Like Receptor 4 and Phosphorylation of NF-κB P65 [Retraction]","authors":"Ke Lei, Bing Ma, Ping Shi, Che Jin, Tan Ling, Longjiang Li, Xiangyi He, Lunchang Wang","doi":"10.2147/ott.s490273","DOIUrl":"https://doi.org/10.2147/ott.s490273","url":null,"abstract":"Retraction for the article Icariin Mitigates the Growth and Invasion Ability of Human Oral Squamous Cell Carcinoma via Inhibiting Toll-Like Receptor 4 and Phosphorylation of NF-&kappa;B P65","PeriodicalId":19534,"journal":{"name":"OncoTargets and therapy","volume":"1 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141930506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiR-181c-5p Mitigates Tumorigenesis in Cervical Squamous Cell Carcinoma via Targeting Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) [Retraction] MiR-181c-5p通过靶向糖原合成酶激酶3β相互作用蛋白(GSKIP)缓解宫颈鳞状细胞癌的肿瘤发生 [撤稿]
IF 4 4区 医学
OncoTargets and therapy Pub Date : 2024-08-08 DOI: 10.2147/ott.s490276
Niuniu Li, Chun Cheng, Tieyan Wang
{"title":"MiR-181c-5p Mitigates Tumorigenesis in Cervical Squamous Cell Carcinoma via Targeting Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) [Retraction]","authors":"Niuniu Li, Chun Cheng, Tieyan Wang","doi":"10.2147/ott.s490276","DOIUrl":"https://doi.org/10.2147/ott.s490276","url":null,"abstract":"Retraction for the article MiR-181c-5p Mitigates Tumorigenesis in Cervical Squamous Cell Carcinoma via Targeting Glycogen Synthase Kinase 3&beta; Interaction Protein (GSKIP)","PeriodicalId":19534,"journal":{"name":"OncoTargets and therapy","volume":"12 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141930505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Down-Regulation of ZEB1 by miR-199a-3p Overexpression Restrains Tumor Stem-Like Properties and Mitochondrial Function of Non-Small Cell Lung Cancer [Retraction] miR-199a-3p过表达对ZEB1的下调抑制了非小细胞肺癌的肿瘤干样特性和线粒体功能 [撤稿]
IF 4 4区 医学
OncoTargets and therapy Pub Date : 2024-08-07 DOI: 10.2147/ott.s490275
Juan Bai, Wen-Yu Jiao
{"title":"Down-Regulation of ZEB1 by miR-199a-3p Overexpression Restrains Tumor Stem-Like Properties and Mitochondrial Function of Non-Small Cell Lung Cancer [Retraction]","authors":"Juan Bai, Wen-Yu Jiao","doi":"10.2147/ott.s490275","DOIUrl":"https://doi.org/10.2147/ott.s490275","url":null,"abstract":"Retraction for the article Down-Regulation of ZEB1 by miR-199a-3p Overexpression Restrains Tumor Stem-Like Properties and Mitochondrial Function of Non-Small Cell Lung Cancer","PeriodicalId":19534,"journal":{"name":"OncoTargets and therapy","volume":"91 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141930507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Efficacy and Safety of Apatinib and Anlotinib in Advanced Non-Small Cell Lung Cancer. 阿帕替尼和安罗替尼治疗晚期非小细胞肺癌的有效性和安全性
IF 2.7 4区 医学
OncoTargets and therapy Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI: 10.2147/OTT.S468932
Xiao Wei, Yun Zhao, Wenyue Yan, Qigang Dai, Hui Wu, Yang Miao, Lei Huang, Qing Liu, Xuyao Zhang, Hongxia Wang, Yanan Liu, Linlin Zhang
{"title":"The Efficacy and Safety of Apatinib and Anlotinib in Advanced Non-Small Cell Lung Cancer.","authors":"Xiao Wei, Yun Zhao, Wenyue Yan, Qigang Dai, Hui Wu, Yang Miao, Lei Huang, Qing Liu, Xuyao Zhang, Hongxia Wang, Yanan Liu, Linlin Zhang","doi":"10.2147/OTT.S468932","DOIUrl":"10.2147/OTT.S468932","url":null,"abstract":"<p><strong>Background: </strong>Anlotinib and apatinib, both vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs), are clinically established in the treatment of advanced non-small cell lung cancer (NSCLC) in China, with anlotinib emerging as a standard treatment strategy. This study was conducted to evaluate the efficacy and safety of apatinib and anlotinib, and to compare their differences in treating patients with advanced NSCLC.</p><p><strong>Patients and methods: </strong>We retrospectively analyzed the data of patients with advanced NSCLC treated with apatinib or anlotinib at a hospital in Eastern China from January 2017 to December 2021. The primary endpoint was progression-free survival (PFS), while secondary endpoints included objective response rate (ORR), disease control rate (DCR), overall survival (OS), and safety profile.</p><p><strong>Results: </strong>A total of 145 patients were included in this study. Median PFS (mPFS) was 3.53 months for the apatinib group and 5.3 months for the anlotinib group (HR = 0.59, 95% CI: 0.41-0.84; P = 0.004), and median OS (mOS) was 7.6 months versus 15.6 months (HR = 0.68, 95% CI: 0.46-1.00; P = 0.048), which all showed significant differences after adjusting for confounders (P < 0.05). Subgroup analysis revealed that the presence or absence of bone metastases significantly influenced PFS in both treatment groups. The ORR was 3.03% in the anlotinib group versus 10.13% in the apatinib group (P = 0.12), the DCR was 72.73% versus 51.90% (P = 0.21). No unanticipated adverse events (AEs) were observed. The incidence of grade 3-4 AEs was significantly higher in the apatinib group (31.65% vs 13.64%, P < 0.05).</p><p><strong>Conclusion: </strong>Anlotinib demonstrated greater efficacy and safety compared to apatinib in the treatment of advanced NSCLC, particularly in patients with bone metastases and EGFR(-).</p>","PeriodicalId":19534,"journal":{"name":"OncoTargets and therapy","volume":"17 ","pages":"629-642"},"PeriodicalIF":2.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Function and Therapeutic Potential of Non-Coding RNA in Ameloblastoma. 非编码 RNA 在母细胞瘤中的功能和治疗潜力
IF 2.7 4区 医学
OncoTargets and therapy Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI: 10.2147/OTT.S474038
Xu Huang, Feihan Gu, Mingyu Zhao, Wenkai Huang, Wenjia Han, Ran Chen, Yuanyin Wang
{"title":"Function and Therapeutic Potential of Non-Coding RNA in Ameloblastoma.","authors":"Xu Huang, Feihan Gu, Mingyu Zhao, Wenkai Huang, Wenjia Han, Ran Chen, Yuanyin Wang","doi":"10.2147/OTT.S474038","DOIUrl":"10.2147/OTT.S474038","url":null,"abstract":"<p><p>Ameloblastoma (AB) is a common odontogenic tumor that develops in the mouth. Despite its benign nature, AB exhibits significant invasiveness leading to tumor metastasis and high postoperative recurrence rates. Studies have shown a relationship between the occurrence and development of various tumors and non-coding RNA (ncRNA). NcRNA, transcribed from the genomes of mammals and other complex organisms, are often products of alternative splicing and processing into smaller products. MicroRNA (miRNA), circular RNA (circRNA), and long non-coding RNA (lncRNA) are the main types of ncRNA. NcRNA play increasingly significant roles in the pathogenesis of human cancers, regulating their occurrence and progression as oncogenes or tumor suppressors. They are involved in tumor development and progression through alternative splicing of pre-mRNA, transcriptional regulation, mRNA stability, protein translation, and chromatin remodeling and modification. The importance of ncRNA in AB has received significant attention in recent years. However, the biological functions and mechanisms of ncRNA in AB remain largely unknown. In this review, we not only explore the functions and roles of ncRNA in AB, but also describe and envision their potential functional roles as biomarkers in AB diagnosis. In particular, we highlight the potential of miR-29a as a molecular marker for diagnosis and therapy. As promising novel therapeutic targets, the biological functions of ncRNA need further study, which is indispensable.</p>","PeriodicalId":19534,"journal":{"name":"OncoTargets and therapy","volume":"17 ","pages":"643-653"},"PeriodicalIF":2.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信