Oncoscience最新文献_第7页

Lactate dehydrogenase A inhibition by small molecular entities: steps in the right direction. 乳酸脱氢酶A的小分子实体抑制:正确方向的步骤。

Oncoscience Pub Date : 2020-09-09 eCollection Date: 2020-09-01 DOI: 10.18632/oncoscience.519

Btissame El Hassouni, Marika Franczak, Mjriam Capula, Christian M Vonk, Valentina M Gomez, Ryszard T Smolenski, Carlotta Granchi, Godefridus J Peters, Filippo Minutolo, Elisa Giovannetti

引用次数: 11

Pharmacogenomics based precision medicine in gastroesophageal cancers: way to move forward? 基于药物基因组学的胃食管癌精准医学:如何向前发展?

Oncoscience Pub Date : 2020-09-09 eCollection Date: 2020-11-01 DOI: 10.18632/oncoscience.520

Shrunjal Shah, Sarbajit Mukherjee

引用次数: 0

Eradication of CSCs: the roadmap for curing cancer. 根除csc:治疗癌症的路线图。

Oncoscience Pub Date : 2020-09-09 eCollection Date: 2020-09-01 DOI: 10.18632/oncoscience.516

Simona Romano, Elena Cesaro, Martina Tufano, Maria Fiammetta Romano

{"title":"Eradication of CSCs: the roadmap for curing cancer.","authors":"Simona Romano, Elena Cesaro, Martina Tufano, Maria Fiammetta Romano","doi":"10.18632/oncoscience.516","DOIUrl":"https://doi.org/10.18632/oncoscience.516","url":null,"abstract":"Cancer treatment failure mostly involves the insensitivity of a small, heterogeneous fraction of cancer cells within the tumor mass, endowed with extraordinary plasticity and the ability to self-renew and metastasize [1, 2]. These cells, termed cancer stem cells (CSCs) are, in general, resistant to conventional anti-cancer treatments [1, 2]. Radioand chemotherapy can even result in the enrichment of this cell subset [1, 2]. A cancer research ambition of the last decades is to develop therapies that target the dynamic nature of CSCs and hamper the potential of non-CSCs to switch to CSC-like cells. Several strategies to target CSC-supporting pathways, that are currently under investigation in clinical trials, include impairment of mitochondria, either biogenesis and the metabolism, particularly the oxidative phosphorylation system; contrasting angiogenesis; redirect the CSC genetic program with epigenetic modulators [3]. A caveat is, however, emerging because of the intraand intertumoral diversity of CSCs and the not negligible toxicity of the molecular inhibitors that undermine the success of CSC-targeted approaches [3]. CSCs have a special immunoediting capacity, a process that leads the immune system to play cooperative roles in tumorigenesis and metastasis. Recent findings show that genes active in the embryo, like Sox2, Oct4, Hippo/ YAP [4], and members of the stemness-associated Wntsignaling pathway [5] contribute to immune evasion of CSC through transcriptional activation of PDL1 expression while disarming dendritic cells. It is worth noting that CSC-enriched subpopulations often show prominent aspects of epithelial-to-mesenchymal transition (EMT) [2]. Inherent cellular plasticity and chronic inflammatory signals associated with mesenchymal differentiation of cancer cells contribute to immune escape through multiple routes, particularly, Research Perspective","PeriodicalId":19508,"journal":{"name":"Oncoscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38606988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does the natural product, honokiol, have value in the battle against osimertinib resistance? 天然产物，本木酚，在对抗奥西替尼耐药性的战斗中有价值吗?

Oncoscience Pub Date : 2020-09-09 eCollection Date: 2020-09-01 DOI: 10.18632/oncoscience.517

Karin A Vallega, Shi-Yong Sun

引用次数: 0

Genomic landscape of inflammatory breast cancer identifies potential actionable genetic alterations. 炎性乳腺癌的基因组图谱确定了潜在的可操作的基因改变。

Oncoscience Pub Date : 2020-06-30 eCollection Date: 2020-07-01 DOI: 10.18632/oncoscience.515

François Bertucci, Steven Van Laere, Daniel Birnbaum

引用次数: 1

Sacituzumab govitecan: a promising antibody-drug conjugate for the treatment of poorly differentiated endometrial cancer. Sacituzumab govitecan:一种治疗低分化子宫内膜癌的有前途的抗体-药物结合物。

Oncoscience Pub Date : 2020-06-08 eCollection Date: 2020-09-01 DOI: 10.18632/oncoscience.514

Emily M Webster, Burak Zeybek, Joan Tymon-Rosario, Alessandro D Santin

引用次数: 3

Fragile site instability: measuring more than breaks. 易碎站点不稳定:测量不止断裂。

Oncoscience Pub Date : 2020-06-08 eCollection Date: 2020-09-01 DOI: 10.18632/oncoscience.513

Irina Waisertreiger, Jacqueline Barlow

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引用次数: 1

RNA Binding Protein LIN28B: a prime time player shaping neuroblastoma aggression and metastasis. RNA结合蛋白LIN28B:形成神经母细胞瘤侵袭和转移的主要参与者。

Oncoscience Pub Date : 2020-06-08 eCollection Date: 2020-07-01 DOI: 10.18632/oncoscience.512

Dongdong Chen, Robert W Schnepp

引用次数: 0

A highway to carcinogenesis: the role of IQGAP1, a signaling scaffolding protein, in head and neck cancer development. 通往癌变的高速公路:信号支架蛋白IQGAP1在头颈癌发展中的作用

Oncoscience Pub Date : 2020-06-07 eCollection Date: 2020-07-01 DOI: 10.18632/oncoscience.511

Tao Wei, Paul F Lambert

引用次数: 2

Improving therapy in metastatic uveal melanoma by understanding prior failures. 通过了解先前的失败案例改进转移性葡萄膜黑色素瘤的治疗。

Oncoscience Pub Date : 2020-06-01 eCollection Date: 2020-05-01 DOI: 10.18632/oncoscience.510

Daniel J Olson, Jason J Luke

引用次数: 0