Open Access Journal of Clinical Trials最新文献

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Pediatric clinical trials: a US perspective 儿科临床试验:美国视角
IF 1.2
Open Access Journal of Clinical Trials Pub Date : 2014-11-26 DOI: 10.2147/OAJCT.S48506
M. Oelstrom, Margo L Hoover-Regan
{"title":"Pediatric clinical trials: a US perspective","authors":"M. Oelstrom, Margo L Hoover-Regan","doi":"10.2147/OAJCT.S48506","DOIUrl":"https://doi.org/10.2147/OAJCT.S48506","url":null,"abstract":"(unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php Open Access Journal of Clinical Trials 2014:6 127–138 Open Access Journal of Clinical Trials Dovepress","PeriodicalId":19500,"journal":{"name":"Open Access Journal of Clinical Trials","volume":"6 1","pages":"127-138"},"PeriodicalIF":1.2,"publicationDate":"2014-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/OAJCT.S48506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68414327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Randomized controlled trial to evaluate the effect of canola oil on blood vessel function in peripheral arterial disease: rationale and design of the Canola-PAD Study 评价菜籽油对外周动脉疾病患者血管功能影响的随机对照试验:菜籽油- pad研究的基本原理和设计
IF 1.2
Open Access Journal of Clinical Trials Pub Date : 2014-10-25 DOI: 10.2147/OAJCT.S70576
J. Enns, P. Zahradka, Randolph P Guzman, Alanna Baldwin, Brendon Foot, Carla G. Taylor
{"title":"Randomized controlled trial to evaluate the effect of canola oil on blood vessel function in peripheral arterial disease: rationale and design of the Canola-PAD Study","authors":"J. Enns, P. Zahradka, Randolph P Guzman, Alanna Baldwin, Brendon Foot, Carla G. Taylor","doi":"10.2147/OAJCT.S70576","DOIUrl":"https://doi.org/10.2147/OAJCT.S70576","url":null,"abstract":"License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php Open Access Journal of Clinical Trials 2014:6 117–125 Open Access Journal of Clinical Trials Dovepress","PeriodicalId":19500,"journal":{"name":"Open Access Journal of Clinical Trials","volume":"6 1","pages":"117-125"},"PeriodicalIF":1.2,"publicationDate":"2014-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/OAJCT.S70576","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68415352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A gender-medicine post hoc analysis (MetaGeM) project to test sex differences in previous observational studies in different diseases: methodology 性别医学事后分析(MetaGeM)项目,以测试先前不同疾病观察性研究中的性别差异:方法学
IF 1.2
Open Access Journal of Clinical Trials Pub Date : 2014-10-13 DOI: 10.2147/OAJCT.S67914
D. Colombo, G. Bellia, D. Vassellatti, E. Zagni, S. Sgarbi, S. Rizzoli
{"title":"A gender-medicine post hoc analysis (MetaGeM) project to test sex differences in previous observational studies in different diseases: methodology","authors":"D. Colombo, G. Bellia, D. Vassellatti, E. Zagni, S. Sgarbi, S. Rizzoli","doi":"10.2147/OAJCT.S67914","DOIUrl":"https://doi.org/10.2147/OAJCT.S67914","url":null,"abstract":"Only recently has medical research begun to understand the importance of taking sex into account, recognizing that symptoms and responses to medical treatment may be very different between males and females. However, the analyses provided by the pharmaceutical industry to regulatory authorities often do not present safety and efficacy data by sex. Novartis has started a gender-medicine project called MetaGeM, which includes nine observational studies sponsored by Novartis Farma, Italy; conducted in Italy between 2002 and 2013 in a range of different clinical areas. The MetaGeM project aims to analyze and describe by means of post hoc analyses and meta-analyses, clinical outcomes, therapeutic approaches, and safety data of these studies, by sex: PSYCHAE; GENDER ATTENTION in psoriasis; Synergy in psoriatic arthritis; ICEBERG in HBsAg carriers; SURF and CETRA in liverand renal transplanted patients, respectively; DEEP in Parkinson’s disease; and EVOLUTION and AXEPT in Alzheimer’s disease. The present paper describes the methodology of the MetaGeM project.","PeriodicalId":19500,"journal":{"name":"Open Access Journal of Clinical Trials","volume":"6 1","pages":"111-116"},"PeriodicalIF":1.2,"publicationDate":"2014-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/OAJCT.S67914","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68415116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Clinical trial design in the era of comparative effectiveness research 比较有效性研究时代的临床试验设计
IF 1.2
Open Access Journal of Clinical Trials Pub Date : 2014-10-03 DOI: 10.2147/OAJCT.S39758
Anke C. Winter, G. Colditz
{"title":"Clinical trial design in the era of comparative effectiveness research","authors":"Anke C. Winter, G. Colditz","doi":"10.2147/OAJCT.S39758","DOIUrl":"https://doi.org/10.2147/OAJCT.S39758","url":null,"abstract":": Clinical trials are one of the key study designs in the evolving field of comparative effectiveness research. Evaluating the effectiveness of interventions in real-world settings is complex and demands a rethinking of the traditional clinical trial approach as well as transformation of the clinical trial landscape. Novel strategies and refinement of existing approaches have been proposed to generate evidence that can guide health care stakeholders in their decision process. The purpose of this review is to discuss clinical trial design approaches in the era of comparative effectiveness research. We will focus on aspects relevant to the type of clinical trial, study population and recruitment, randomization process, outcome measures, and data collection.","PeriodicalId":19500,"journal":{"name":"Open Access Journal of Clinical Trials","volume":"6 1","pages":"101-110"},"PeriodicalIF":1.2,"publicationDate":"2014-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/OAJCT.S39758","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68414058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Randomized controlled trial of a positive affect intervention to reduce stress in people newly diagnosed with HIV; protocol and design for the IRISS study 积极影响干预减轻新诊断艾滋病毒感染者压力的随机对照试验IRISS研究的方案和设计
IF 1.2
Open Access Journal of Clinical Trials Pub Date : 2014-09-22 DOI: 10.2147/OAJCT.S64645
J. Moskowitz, A. Carrico, M. Cohn, Larissa G. Duncan, Cori Bussolari, Kristin Layous, J. Hult, A. Brousset, P. Cotten, Stephanie Maurer, Martha Pietrucha, M. Acree, J. Wrubel, Mallory O. Johnson, F. Hecht, S. Folkman
{"title":"Randomized controlled trial of a positive affect intervention to reduce stress in people newly diagnosed with HIV; protocol and design for the IRISS study","authors":"J. Moskowitz, A. Carrico, M. Cohn, Larissa G. Duncan, Cori Bussolari, Kristin Layous, J. Hult, A. Brousset, P. Cotten, Stephanie Maurer, Martha Pietrucha, M. Acree, J. Wrubel, Mallory O. Johnson, F. Hecht, S. Folkman","doi":"10.2147/OAJCT.S64645","DOIUrl":"https://doi.org/10.2147/OAJCT.S64645","url":null,"abstract":"License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php Open Access Journal of Clinical Trials 2014:6 85–100 Open Access Journal of Clinical Trials Dovepress","PeriodicalId":19500,"journal":{"name":"Open Access Journal of Clinical Trials","volume":"6 1","pages":"85-100"},"PeriodicalIF":1.2,"publicationDate":"2014-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/OAJCT.S64645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68415085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Evolution of the clinical trial landscape in Asia Pacific 亚太地区临床试验格局的演变
IF 1.2
Open Access Journal of Clinical Trials Pub Date : 2014-07-29 DOI: 10.2147/OAJCT.S57060
Shourav. Yathindranath, A. Kureishi, Simranjit Singh, Spencer Yeow, G. Geng, K. Wai, Audrey Ho, Elvira Zenaida Lansang, Ken J Lee
{"title":"Evolution of the clinical trial landscape in Asia Pacific","authors":"Shourav. Yathindranath, A. Kureishi, Simranjit Singh, Spencer Yeow, G. Geng, K. Wai, Audrey Ho, Elvira Zenaida Lansang, Ken J Lee","doi":"10.2147/OAJCT.S57060","DOIUrl":"https://doi.org/10.2147/OAJCT.S57060","url":null,"abstract":"License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php Open Access Journal of Clinical Trials 2014:6 75–84 Open Access Journal of Clinical Trials Dovepress","PeriodicalId":19500,"journal":{"name":"Open Access Journal of Clinical Trials","volume":"6 1","pages":"75-84"},"PeriodicalIF":1.2,"publicationDate":"2014-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/OAJCT.S57060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68414862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Between- and within-patient n -level response surface pathway design in dose-finding studies 剂量研究中患者间和患者内n水平反应面通路设计
IF 1.2
Open Access Journal of Clinical Trials Pub Date : 2014-07-03 DOI: 10.2147/OAJCT.S57955
Sagita Dewi, Veronica Kristiansen, S. lindkær-Jensen, S. Larsen
{"title":"Between- and within-patient n -level response surface pathway design in dose-finding studies","authors":"Sagita Dewi, Veronica Kristiansen, S. lindkær-Jensen, S. Larsen","doi":"10.2147/OAJCT.S57955","DOIUrl":"https://doi.org/10.2147/OAJCT.S57955","url":null,"abstract":"Background: The most commonly used escalation methods in dose-finding studies have obvious weaknesses, and the Bayesian approach is difficult for clinicians to understand and to apply. The study aims were to introduce and assess the performance of clinically based response surface pathway (RSP) design for dose-finding studies, exemplified by one between-patient study, one within-patient study, and simulation studies. Methods: The between-patient study consisted of 15 women suffering from stage IV breast cancer, while the within-patient study consisted of seven female dogs with metastatic mammary cancer. The studies were conducted to determine the maximum tolerated dose (MTD) of a new anticancer agent named BP-C1 using three-level RSP designs. Adjustment of the dose from one design level to the next was based on a k -adjustment factor estimated to ensure coverage of the entire predefined dose window. Patient sequences with an equal number of patients as design levels were included in the between-patient design, whereas the same patients were included in all the design levels in the within-patient design. Results: Four of the five patient sequences in the between-patient study and all seven dogs in the within-patient study reached the upper limit of the dose windows without any increase in toxicity. The MTD of BP-C1 was thus found to be higher than the predefined cumulative dose window for both patient groups. In all three scenarios, the RSP design estimated MTDs better than the traditional 3 + 3 design; however, the toxicity rates were found to be higher when the target MTD was under the starting dose. Conclusion: The RSP designs do not need an assumed statistical model, and may be useful in estimating MTD, using a minimal sample size. The k -adjustment factor ensures complete dose window coverage and the design utilizes more information by allowing multinomial outcomes. Phase I studies are conducted sequentially, allocating dose levels to patients based on the observed toxicity effect from previous patients or treatment periods.","PeriodicalId":19500,"journal":{"name":"Open Access Journal of Clinical Trials","volume":"6 1","pages":"63-74"},"PeriodicalIF":1.2,"publicationDate":"2014-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/OAJCT.S57955","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68414935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Safety and tolerability of an intravenously administered alpha1-proteinase inhibitor at an increased infusion rate: a novel, randomized, placebo-masked, infusion rate-controlled, crossover study in healthy adults 增加输注速率时静脉注射α - 1蛋白酶抑制剂的安全性和耐受性:一项新的、随机、安慰剂掩盖、输注速率控制的健康成人交叉研究
IF 1.2
Open Access Journal of Clinical Trials Pub Date : 2014-06-23 DOI: 10.2147/OAJCT.S62754
L. Ngo, A. Haeberle, J. Dyck-Jones, D. Gelmont, L. Yel
{"title":"Safety and tolerability of an intravenously administered alpha1-proteinase inhibitor at an increased infusion rate: a novel, randomized, placebo-masked, infusion rate-controlled, crossover study in healthy adults","authors":"L. Ngo, A. Haeberle, J. Dyck-Jones, D. Gelmont, L. Yel","doi":"10.2147/OAJCT.S62754","DOIUrl":"https://doi.org/10.2147/OAJCT.S62754","url":null,"abstract":"License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php Open Access Journal of Clinical Trials 2014:6 55–61 Open Access Journal of Clinical Trials Dovepress","PeriodicalId":19500,"journal":{"name":"Open Access Journal of Clinical Trials","volume":"6 1","pages":"55-61"},"PeriodicalIF":1.2,"publicationDate":"2014-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/OAJCT.S62754","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68414778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TrAnsFOrM: a novel study design to evaluate the effect of everolimus on long-term outcomes after kidney transplantation TrAnsFOrM:一项评估依维莫司对肾移植术后长期预后影响的新研究
IF 1.2
Open Access Journal of Clinical Trials Pub Date : 2014-06-10 DOI: 10.2147/OAJCT.S63058
J. Pascual, T. Srinivas, S. Chadban, F. Citterio, F. Oppenheimer, H. Tedesco, M. Henry, C. Legendre, Y. Watarai, C. Sommerer, P. Lee, J. Hexham, Gaohong Dong, P. Bernhardt, F. Vincenti
{"title":"TrAnsFOrM: a novel study design to evaluate the effect of everolimus on long-term outcomes after kidney transplantation","authors":"J. Pascual, T. Srinivas, S. Chadban, F. Citterio, F. Oppenheimer, H. Tedesco, M. Henry, C. Legendre, Y. Watarai, C. Sommerer, P. Lee, J. Hexham, Gaohong Dong, P. Bernhardt, F. Vincenti","doi":"10.2147/OAJCT.S63058","DOIUrl":"https://doi.org/10.2147/OAJCT.S63058","url":null,"abstract":"Two well defined, modifiable risk factors for kidney allograft failure are acute rejection and poor graft function at one year post-transplant. Regulatory bodies and expert panels in the USA and Europe have recognized that both acute rejection and one-year graft function should be assessed when evaluating immunosuppressive regimens. TRANSFORM (Clinicaltrials.gov NCT01950819) is one of the first trials to adopt this approach and the first that applies a novel combined clinically meaningful endpoint to take the first step towards changing the paradigm for immunosuppression in kidney transplant patients. Everolimus with reduced-exposure calcineurin inhibitor (CNI) therapy is a strategy designed to reduce the risk of chronic nephrotoxicity and other dose-dependent complications associated with CNI therapy. In TRANSFORM, de novo kidney transplant patients are randomized to everolimus with reduced-exposure CNI, or mycophenolic acid with standard-exposure CNI, both with induction therapy and maintenance steroids. The primary endpoint is a composite of treated biopsy-proven acute rejection or estimated glomerular filtration rate ,50 mL/min/1.73 m 2 at month 12 post-transplant, which is expected to be sensitive both to the effects of acute and chronic allograft rejection and nephrotoxic side effects of immunosuppressive therapies. The construct of this endpoint allows the integration of a continuous outcome (graft function) with a logistic outcome (rejection). The trial uses a randomized, multicenter, open-label, two-arm design. After completion of a 2-year core study, patients enter a further 3-year prospective observational study. By capturing follow-up to 5 years, TRANSFORM will provide substantial data on the incidence of graft loss, graft dysfunction, cancer, cardiovascular events, and other patient-relevant outcomes. TRANSFORM will determine whether de novo CNI reduction with an everolimus-based regimen achieves short-term outcomes compared with standard CNI. As the largest clinical trial undertaken to date in kidney transplantation, recruiting more than 2,000 patients, and with extended follow-up to 5 years, TRANSFORM will provide critical data required to help maximize long-term outcomes.","PeriodicalId":19500,"journal":{"name":"Open Access Journal of Clinical Trials","volume":"6 1","pages":"45-54"},"PeriodicalIF":1.2,"publicationDate":"2014-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/OAJCT.S63058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68414891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Study design and patient recruitment for the Japan Polyp Study 日本息肉研究的研究设计和患者招募
IF 1.2
Open Access Journal of Clinical Trials Pub Date : 2014-05-21 DOI: 10.2147/OAJCT.S62272
Y. Sano, T. Fujii, T. Matsuda, Y. Oda, S. Kudo, M. Igarashi, H. Iishi, K. Kaneko, K. Hotta, N. Kobayashi, Yuichiro Yamaguchi, K. Kobayashi, H. Ishikawa, Y. Murakami, T. Shimoda, T. Fujimori, Y. Ajioka, H. Taniguchi, H. Ikematsu, K. Konishi, Yutaka Saito, S. Yoshida
{"title":"Study design and patient recruitment for the Japan Polyp Study","authors":"Y. Sano, T. Fujii, T. Matsuda, Y. Oda, S. Kudo, M. Igarashi, H. Iishi, K. Kaneko, K. Hotta, N. Kobayashi, Yuichiro Yamaguchi, K. Kobayashi, H. Ishikawa, Y. Murakami, T. Shimoda, T. Fujimori, Y. Ajioka, H. Taniguchi, H. Ikematsu, K. Konishi, Yutaka Saito, S. Yoshida","doi":"10.2147/OAJCT.S62272","DOIUrl":"https://doi.org/10.2147/OAJCT.S62272","url":null,"abstract":"License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php Open Access Journal of Clinical Trials 2014:6 37–44 Open Access Journal of Clinical Trials Dovepress","PeriodicalId":19500,"journal":{"name":"Open Access Journal of Clinical Trials","volume":"6 1","pages":"37-44"},"PeriodicalIF":1.2,"publicationDate":"2014-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/OAJCT.S62272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68414700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
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