比较有效性研究时代的临床试验设计

IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Anke C. Winter, G. Colditz
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引用次数: 5

摘要

临床试验是不断发展的比较疗效研究领域的关键研究设计之一。在现实环境中评估干预措施的有效性是复杂的,需要重新思考传统的临床试验方法以及临床试验环境的转变。提出了新的战略和改进现有方法,以产生可以指导卫生保健利益攸关方决策过程的证据。本综述的目的是讨论在比较疗效研究时代的临床试验设计方法。我们将重点关注与临床试验类型、研究人群和招募、随机化过程、结果测量和数据收集相关的方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical trial design in the era of comparative effectiveness research
: Clinical trials are one of the key study designs in the evolving field of comparative effectiveness research. Evaluating the effectiveness of interventions in real-world settings is complex and demands a rethinking of the traditional clinical trial approach as well as transformation of the clinical trial landscape. Novel strategies and refinement of existing approaches have been proposed to generate evidence that can guide health care stakeholders in their decision process. The purpose of this review is to discuss clinical trial design approaches in the era of comparative effectiveness research. We will focus on aspects relevant to the type of clinical trial, study population and recruitment, randomization process, outcome measures, and data collection.
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来源期刊
Open Access Journal of Clinical Trials
Open Access Journal of Clinical Trials MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.90
自引率
0.00%
发文量
2
审稿时长
16 weeks
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