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Journal of Heterocyclic Chemistry最新文献

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An Efficient and Regioselective Route Towards Novel 1,2,3-Triazole (Isoxazole)-Linked 1,3-Thiazolidine Hybrids via a Copper-Catalyzed Alkyne-Azide Reaction 铜催化炔叠氮化反应制备1,2,3-三唑（异恶唑）- 1,3-噻唑烷杂化物的高效和区域选择性途径
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2025-08-15 DOI: 10.1002/jhet.70070
Fausto M. Güiza, Julia M. Urbiña, Andres F. Yepes, Arnold R. Romero Bohórquez
{"title":"An Efficient and Regioselective Route Towards Novel 1,2,3-Triazole (Isoxazole)-Linked 1,3-Thiazolidine Hybrids via a Copper-Catalyzed Alkyne-Azide Reaction","authors":"Fausto M. Güiza,&nbsp;Julia M. Urbiña,&nbsp;Andres F. Yepes,&nbsp;Arnold R. Romero Bohórquez","doi":"10.1002/jhet.70070","DOIUrl":"https://doi.org/10.1002/jhet.70070","url":null,"abstract":"<div>\u0000 \u0000 <p>A clean and highly regioselective three-step synthetic procedure to obtain two new series of novel 1,3-thiazolidine/1,2,3-triazole hybrids (<b>3a–r</b> and <b>5a–f</b>) based on the copper-catalyzed alkyne-azide reaction (CuAAC) was developed. The key intermediaries, the 3-propioloyl-thiazolidine-4-carboxylic acid methyl esters (<b>2a–e</b>) and methyl 3-propargyl-thiazolidine-4-carboxylic acid methyl ester (<b>4</b>) were easily prepared from the corresponding thiazolidine-4-carboxylic acid methyl esters (<b>1a–e</b>), which were previously obtained from L-(+)-cysteine and some aromatic and aliphatic aldehydes with subsequent acylation reaction activated by carbodiimide with propiolic acid or the respective alkylation reaction using propargyl bromide. In addition, one new thiazolidine/isoxazole hybrid (<b>6a</b>) was also obtained through 1,3-dipolar cycloaddition reaction with the same click chemistry approach. All of the molecular hybrids reported here are promising models for future pharmacological studies, particularly for the development of cancer drugs, with a special focus on in vitro prostate cancer models.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 10","pages":"1228-1244"},"PeriodicalIF":2.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Cellular Evaluation of Some Oxepino- and Pyranoxanthone Derivatives as Antitumor Agents: A Comparative Study 一些抗肿瘤药物奥西皮诺和吡喃氧蒽酮衍生物的合成和细胞评价：比较研究
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2025-08-13 DOI: 10.1002/jhet.70057
Manisha Kundu, Shyamasankar Mandal, Shyamal K. Das, Solanki Sarkar, Arunima Biswas, Shital K. Chattopadhyay
{"title":"Synthesis and Cellular Evaluation of Some Oxepino- and Pyranoxanthone Derivatives as Antitumor Agents: A Comparative Study","authors":"Manisha Kundu,&nbsp;Shyamasankar Mandal,&nbsp;Shyamal K. Das,&nbsp;Solanki Sarkar,&nbsp;Arunima Biswas,&nbsp;Shital K. Chattopadhyay","doi":"10.1002/jhet.70057","DOIUrl":"https://doi.org/10.1002/jhet.70057","url":null,"abstract":"<div>\u0000 \u0000 <p>A set of six hitherto unknown oxepinoxanthone derivatives has been prepared for cellular evaluation in view of the known and impressive anticancer potential of some pyranoxanthone derivatives. A set of three structurally similar pyranoxanthone derivatives has also been prepared for a direct comparison of biological activity associated with a change in ring size, from six to seven, if any. Evaluation of their anticancer properties was attempted in three different cancer cell lines, such as HPV, cervical cancer cell line HeLa, hormone-responsive breast cancer cell line MCF7, and lung cancer cell line A549, as many of the naturally occurring pyranoxanthones have shown effective activity against these cell lines. The oxepinoxanthone derivatives <b>15</b>, <b>16</b>, and <b>18</b> showed significant anticancer effects (selectivity index &gt; 1–1.5), increasing reactive oxygen species generation, leading to apoptotic DNA laddering and nuclear blebbing. Though the pyran analogues <b>21</b> and <b>23</b> showed cytotoxicity in MCF7 and A549 cell lines, they also showed poor selectivity indices against breast cancer, cervical cancer, and lung cancer.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 10","pages":"1129-1139"},"PeriodicalIF":2.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in the Chemistry of Morita–Baylis–Hillman (MBH) Carbonates: A Review Morita-Baylis-Hillman （MBH）碳酸盐化学研究进展
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2025-08-13 DOI: 10.1002/jhet.70058
Rabia Ashraf, Ameer Fawad Zahoor, Sajjad Ahmad, Syed Makhdoom Hussain, Bushra Parveen, Samreen Gul Khan, Usman Nazeer, Asim Mansha, Aijaz Rasool Chaudhry, Ahmad Irfan
{"title":"Recent Advances in the Chemistry of Morita–Baylis–Hillman (MBH) Carbonates: A Review","authors":"Rabia Ashraf,&nbsp;Ameer Fawad Zahoor,&nbsp;Sajjad Ahmad,&nbsp;Syed Makhdoom Hussain,&nbsp;Bushra Parveen,&nbsp;Samreen Gul Khan,&nbsp;Usman Nazeer,&nbsp;Asim Mansha,&nbsp;Aijaz Rasool Chaudhry,&nbsp;Ahmad Irfan","doi":"10.1002/jhet.70058","DOIUrl":"https://doi.org/10.1002/jhet.70058","url":null,"abstract":"<div>\u0000 \u0000 <p>Morita-Baylis-Hillman carbonates are a versatile and emerging class of organic precursors, utilized in various organic transformations as a main reagent, yielding intricate functionalized moieties. These carbonates facilitate the synthesis of various bioactive entities, natural products, and other valuable compounds. MBH carbonates combined with other substrates such as phenolates, oxindole-chromones, enamino maleimides, isoquinolines, sulfones, cyclic ketimines/imines, and perfluoroalkyls, and so forth via substitution and annulation reactions provide valuable organic compounds. This review highlights the recent synthetic applications of these organic carbonates in the synthesis and functionalization of oxindoles, pyrazoles, quinolines, and organofluorides, and so forth.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 10","pages":"1171-1217"},"PeriodicalIF":2.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient Synthetic Strategies for Highly Functionalized Pyrazole Including an Amidine Skeleton Based on Trichloroacetamidine, Alkynes, and Hydrazonoyl Chlorides 高功能化吡唑的高效合成策略，包括基于三氯乙脒、炔和肼酰氯的脒骨架
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2025-08-13 DOI: 10.1002/jhet.70023
Manijeh Nematpour
{"title":"Efficient Synthetic Strategies for Highly Functionalized Pyrazole Including an Amidine Skeleton Based on Trichloroacetamidine, Alkynes, and Hydrazonoyl Chlorides","authors":"Manijeh Nematpour","doi":"10.1002/jhet.70023","DOIUrl":"https://doi.org/10.1002/jhet.70023","url":null,"abstract":"<div>\u0000 \u0000 <p>The synthesis of functionalized pyrazole-4-carboximidamide with appropriate yields through a novel four-component reaction from alkynes, hydrazonoyl chlorides, trichloroacetonitrile, and various anilines is a remarkable achievement in heterocycle chemistry. This strategy offers a direct and efficient route to access different pyrazoles with amidine substitution from readily available starting materials. The use of copper (I) as a catalyst, in DMF solvent, without adding a ligand, and with the help of ultrasonic conditions for 50 min at room temperature highlights the importance of transition metal catalysis in this process. The combination of available starting materials, mild reaction conditions, catalytic systems, and ease of purification procedures contributes to the attractiveness of this method for the synthesis of diverse new substituted pyrazoles, including an amidine skeleton.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 10","pages":"1104-1110"},"PeriodicalIF":2.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary Trends in the Greener Synthetic Approaches Towards Quinoline Derivatives 喹啉衍生物绿色合成方法的当代趋势
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2025-08-13 DOI: 10.1002/jhet.70054
Babita,  Kanika, Richa Srivastava
{"title":"Contemporary Trends in the Greener Synthetic Approaches Towards Quinoline Derivatives","authors":"Babita,&nbsp; Kanika,&nbsp;Richa Srivastava","doi":"10.1002/jhet.70054","DOIUrl":"https://doi.org/10.1002/jhet.70054","url":null,"abstract":"<div>\u0000 \u0000 <p>Quinoline derivatives represent a major family of N-containing heterocyclic compounds with various biological properties and a major role in medicinal and material chemistry. Traditional strategies for the preparation of quinolines typically rely on toxic reagents, dangerous by-products, and energy-demanding processes that represent substantial environmental and economic loss. Toward sustainable and efficient alternatives, green synthesis methods are developed that use environmentally friendly solvents, catalysts, and energy-saving techniques (microwave-assisted synthesis, solvent-free reactions, green solvents, biocatalysis, photocatalysis, nanocatalysis, ultrasonication, and catalyst-free synthesis). This review provides a broad overview of recent advancements in the green synthesis of quinoline derivatives, highlighting their potential to revolutionize conventional practices and contribute to sustainable development goals. The synthesis of quinoline derivatives has been covered in a number of reports, but most of them focus on either conventional or green methods independently. We present both approaches in a single, comparative framework in this review. The work aims to give researchers a clearer, more balanced understanding of the current methods and to support the exploration of more effective and environmentally friendly synthetic routes by describing their respective advantages, disadvantages, and practical challenges.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 10","pages":"1140-1170"},"PeriodicalIF":2.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel 5-(Trifluoromethyl)-1,2,4-Oxadiazole Substituted Benzamide Derivatives Containing 5-(Trifluoromethyl)-1,2,4-Oxadiazole Moiety: Design, Synthesis, Anti-Rust and In Silico Study 新型含5-（三氟甲基）-1,2,4-恶二唑取代苯甲酰胺衍生物：设计、合成、防锈及硅研究
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2025-08-13 DOI: 10.1002/jhet.70055
Chen-Hao Fu, Jian Wang, You-Chang Wei, Cheng-Xia Tan, Tian-Ming Xu, Li-Jing Min, Ning-Jie Wu, Xing-Hai Liu
{"title":"Novel 5-(Trifluoromethyl)-1,2,4-Oxadiazole Substituted Benzamide Derivatives Containing 5-(Trifluoromethyl)-1,2,4-Oxadiazole Moiety: Design, Synthesis, Anti-Rust and In Silico Study","authors":"Chen-Hao Fu,&nbsp;Jian Wang,&nbsp;You-Chang Wei,&nbsp;Cheng-Xia Tan,&nbsp;Tian-Ming Xu,&nbsp;Li-Jing Min,&nbsp;Ning-Jie Wu,&nbsp;Xing-Hai Liu","doi":"10.1002/jhet.70055","DOIUrl":"https://doi.org/10.1002/jhet.70055","url":null,"abstract":"<div>\u0000 \u0000 <p>Trifluoromethyloxadiazole compounds (TFMO) are a class of anti-rust disease targeting histone deacetylases inhibitors (HDACs). In this paper, a series of 5-(trifluoromethyl)-1,2,4-oxadiazole substituted benzamide derivatives containing 5-(trifluoromethyl)-1,2,4-oxadiazole moiety were designed and synthesized. Anti-rust bioassay results showed some of them possessed excellent activities against <i>Puccinia sorghi</i> at 200 mg/L. Furthermore, the structure–activity relationship was established using in silico methods, and the most active compound binding mode was carried out based on the crystal structure of human HDAC1, human HDAC4, and human HDAC6. This work provided an excellent fungicide against rust for further optimization.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 10","pages":"1119-1128"},"PeriodicalIF":2.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthetic Approaches to Imidazo[1,2-a]indole,2,3-dihydro-1H-imidazo[1,2-a]-indoles and Benzo[4,5]imidazo[1,2-a]indole Derivatives: A Comprehensive Review 咪唑[1,2- A]吲哚、2,3-二氢- 1h -咪唑[1,2- A]-吲哚和苯并[4,5]咪唑[1,2- A]吲哚衍生物的合成方法综述
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2025-08-12 DOI: 10.1002/jhet.70026
Elizabeth J. Diana, Thomas V. Mathew
{"title":"Synthetic Approaches to Imidazo[1,2-a]indole,2,3-dihydro-1H-imidazo[1,2-a]-indoles and Benzo[4,5]imidazo[1,2-a]indole Derivatives: A Comprehensive Review","authors":"Elizabeth J. Diana,&nbsp;Thomas V. Mathew","doi":"10.1002/jhet.70026","DOIUrl":"https://doi.org/10.1002/jhet.70026","url":null,"abstract":"<div>\u0000 \u0000 <p>Imidazo[1,2-a]indoles, 2,3-dihydro-1<i>H</i>-imidazo[1,2-a]-indoles and benzo[4,5]imidazo[1,2-a]indoles are rare yet valuable classes of nitrogen-containing heterocycles, offering diverse applications in pharmaceutical development and advanced materials research. Despite their potential medicinal applications, efficient synthesis methods for these substances remain limited. This review provides an in-depth analysis of emerging synthetic approaches for imidazo[1,2-a]indoles and benzo[4,5]imidazo[1,2-a]indoles, including metal-catalyzed and metal-free methods, as well as metal-catalyzed synthesis of 2,3-dihydro-1<i>H</i>-imidazo[1,2-a]indoles, offering valuable insights into effective synthetic strategies.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 10","pages":"1087-1103"},"PeriodicalIF":2.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of New [1,3]Selenazolo[5,4-d]Pyrimidine Derivatives as Purine-Like Selenium-Containing Heterocycles 新型类嘌呤类含硒杂环[1,3]硒偶氮[5,4-d]嘧啶衍生物的合成
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2025-08-12 DOI: 10.1002/jhet.70033
Effat Vatankhah, Hossein Eshghi, Ali Shiri
{"title":"Synthesis of New [1,3]Selenazolo[5,4-d]Pyrimidine Derivatives as Purine-Like Selenium-Containing Heterocycles","authors":"Effat Vatankhah,&nbsp;Hossein Eshghi,&nbsp;Ali Shiri","doi":"10.1002/jhet.70033","DOIUrl":"https://doi.org/10.1002/jhet.70033","url":null,"abstract":"<div>\u0000 \u0000 <p>In the research, we presented a method for synthesizing selenium-containing heterocyclic compounds. One of the key structures in this project is the derivative of 7-methyl-2-(alkylthio)-5-(amino-1-yl)-[1,3]selenazolo[5,4-<i>d</i>]pyrimidine (<b>3a-i</b>). These are synthesized in one step using the treatment of precursor 2,4-dichloro-6-methylpyrimidin-5-amine (<b>1</b>) with selenium and sodium borohydride in ethanol to obtain the compound, which subsequently reacts with carbon disulfide in pyridine to form 5-chloro-7-methyl-[1,3]selenazolo[5,4-d]pyrimidine-2(1H)-thione (<b>2</b>). This is then treated with various alkyl halides under reflux conditions in ethanol to yield various derivatives (<b>3a-i</b>). A mixture of 5-chloro-7-methyl-2-(alkylthio)-[1,3]selenazolo[5,4-<i>d</i>]pyrimidine (<b>3a-i</b>) and various primary and secondary amines is refluxed in ethanol to prepare the corresponding nucleophilic substituted products, 2-(alkylsulfanyl)-7-methyl-5-(morpholin-4-yl)-[1,3]selenazolo[5,4-<i>d</i>]pyrimidines (<b>4a-i</b>) in good yields.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 10","pages":"1111-1118"},"PeriodicalIF":2.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of New [1,2,5]Chalсogenadiazoles Fused With Pyridine Skeleton and Their Reactions With Neutral C-Nucleophiles 新型[1,2,5]氯代硫代二唑吡啶骨架的合成及其与中性c -亲核试剂的反应
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2025-08-07 DOI: 10.1002/jhet.70053
Alexey K. Fedorenko, Victoria V. Ivanova, Alexey M. Starosotnikov, Mikhail E. Minyaev, Maxim A. Bastrakov
{"title":"Synthesis of New [1,2,5]Chalсogenadiazoles Fused With Pyridine Skeleton and Their Reactions With Neutral C-Nucleophiles","authors":"Alexey K. Fedorenko,&nbsp;Victoria V. Ivanova,&nbsp;Alexey M. Starosotnikov,&nbsp;Mikhail E. Minyaev,&nbsp;Maxim A. Bastrakov","doi":"10.1002/jhet.70053","DOIUrl":"https://doi.org/10.1002/jhet.70053","url":null,"abstract":"<div>\u0000 \u0000 <p>Reactions of [1,2,5]oxa- and [1,2,5]selenadiazolo[3,4-c]pyridines with neutral carbon nucleophiles such as indoles, pyrrole, polyphenols, and CH-acids have been studied. All reactions proceed under mild conditions. As a result, a number of complex molecules containing structurally diverse fragments were synthesized, and subsequent oxidative aromatization has been demonstrated.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 10","pages":"1080-1086"},"PeriodicalIF":2.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Simple, Economical, and Green Protocol for the Synthesis of Benzyl-Quinoline Analogues by Grinding 一种简单、经济、绿色的研磨法合成苯基喹啉类似物方案
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2025-08-07 DOI: 10.1002/jhet.70052
Bathala Balaramudu, Chunduri Venkata Rao, Adapaka Venkateswara Rao, Suresh Maddila, Lalu Venigalla, Mohamed A. Nassan, Mohamed Mohamed Soliman
{"title":"A Simple, Economical, and Green Protocol for the Synthesis of Benzyl-Quinoline Analogues by Grinding","authors":"Bathala Balaramudu,&nbsp;Chunduri Venkata Rao,&nbsp;Adapaka Venkateswara Rao,&nbsp;Suresh Maddila,&nbsp;Lalu Venigalla,&nbsp;Mohamed A. Nassan,&nbsp;Mohamed Mohamed Soliman","doi":"10.1002/jhet.70052","DOIUrl":"https://doi.org/10.1002/jhet.70052","url":null,"abstract":"<div>\u0000 \u0000 <p>A solvent-free, mechanochemical synthesis of benzyl-quinoline analogues is reported via a one-pot multicomponent reaction of substituted aldehydes, benzyl-3-oxobutanoate, 5-methylcyclohexane-1,3-dione, and ammonium acetate. Urea serves as an eco-friendly catalyst, enabling high yields (93%–97%) within 30 min under grinding conditions. This method eliminates column chromatography, reduces waste, and avoids toxic solvents or harsh conditions, offering a cost-effective and sustainable approach to quinoline derivatives.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 10","pages":"1074-1079"},"PeriodicalIF":2.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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