Oncotarget最新文献_第9页

Retraction: Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis. 收缩：纤颤蛋白1由Aurora-A诱导，但受BRCA2抑制，可促进卵巢癌转移。

Oncotarget Pub Date : 2026-01-06 DOI: 10.18632/oncotarget.28860

Ziliang Wang, Yang Liu, Lili Lu, Lina Yang, Sheng Yin, Yan Wang, Zihao Qi, Jiao Meng, Rongyu Zang, Gong Yang

引用次数: 0

Retraction: Sodium fluoride induces apoptosis in mouse splenocytes by activating ROS-dependent NF-κB signaling. 缩回：氟化钠通过激活ros依赖性NF-κB信号通路诱导小鼠脾细胞凋亡。

Oncotarget Pub Date : 2026-01-06 DOI: 10.18632/oncotarget.28849

Huidan Deng, Ping Kuang, Hengmin Cui, Qin Luo, Huan Liu, Yujiao Lu, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao

引用次数: 0

Retraction: JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells. 回顾：JARID1B通过PTEN/AKT信号通路促进肝癌细胞转移和上皮间质转化。

Oncotarget Pub Date : 2026-01-06 DOI: 10.18632/oncotarget.28847

Bo Tang, Guangying Qi, Fang Tang, Shengguang Yuan, Zhenran Wang, Xingsi Liang, Bo Li, Shuiping Yu, Jie Liu, Qi Huang, Yangchao Wei, Run Zhai, Biao Lei, Hongping Yu, Xingyuan Jiao, Songqing He

引用次数: 0

Retraction: QKI5mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis. 回顾：qki5介导的组蛋白变体macroH2A1的选择性剪接调节胃癌的发生。

Oncotarget Pub Date : 2026-01-06 DOI: 10.18632/oncotarget.28866

Feng Li, Ping Yi, Jingnan Pi, Lanfang Li, Jingyi Hui, Fang Wang, Aihua Liang, Jia Yu

引用次数: 0

Retraction: Long noncoding RNA XIST is a prognostic factor in colorectal cancer and inhibits 5-fluorouracil-induced cell cytotoxicity through promoting thymidylate synthase expression. 撤回：长链非编码RNA XIST是结直肠癌的预后因素，通过促进胸苷酸合成酶的表达抑制5-氟尿嘧啶诱导的细胞毒性。

Oncotarget Pub Date : 2026-01-06 DOI: 10.18632/oncotarget.28897

Yang Xiao, Usenko Alexander Yurievich, Smorzhevskyi Valentyn Yosypovych

引用次数: 0

Editorial Note: Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on β-catenin. 编者按：钙黄蛋白外溢的人结肠癌细胞具有丰富的自我更新能力，并依赖于β-连环蛋白。

Oncotarget Pub Date : 2026-01-06 DOI: 10.18632/oncotarget.28903

Joshua E Allen, Wafik S El-Deiry

引用次数: 0

Gut feeling: Microbes at the heart of cancer therapy. 直觉：微生物是癌症治疗的核心。

Oncotarget Pub Date : 2026-01-06 DOI: 10.18632/oncotarget.28919

Uzma Saqib, Sakina Ratlamwala, Monika Pandey, Krishnan Hajela

引用次数: 0

Tumor infiltrating lymphocyte (TIL) therapy for treating the solid tumors: Challenges and future perspectives. 肿瘤浸润淋巴细胞（TIL）治疗实体瘤：挑战和未来展望。

Oncotarget Pub Date : 2026-01-06 DOI: 10.18632/oncotarget.28883

Sharma Bhartendra, Kaur Sukhbir, Sharma Vikas, Soni Sanjay

引用次数: 0

COVID vaccination and post-infection cancer signals: Evaluating patterns and potential biological mechanisms. COVID - 19疫苗接种和感染后癌症信号：评估模式和潜在的生物学机制

Oncotarget Pub Date : 2026-01-03 DOI: 10.18632/oncotarget.28824

Charlotte Kuperwasser, Wafik S El-Deiry

{"title":"COVID vaccination and post-infection cancer signals: Evaluating patterns and potential biological mechanisms.","authors":"Charlotte Kuperwasser, Wafik S El-Deiry","doi":"10.18632/oncotarget.28824","DOIUrl":"10.18632/oncotarget.28824","url":null,"abstract":"A growing number of peer-reviewed publications have reported diverse cancer types appearing in temporal association with COVID-19 vaccination or infection. To characterize the nature and scope of these reports, a systematic literature search from January 2020 to October 2025 was conducted based on specified eligibility criteria. A total of 69 publications met inclusion criteria: 66 article-level reports describing 333 patients across 27 countries, 2 retrospective population-level investigations (Italy: ~300,000 cohort, and Korea: ~8.4 million cohort) quantified cancer incidence and mortality trends among vaccinated populations, and one longitudinal analysis of ~1.3 million US miliary service members spanning the pre-pandemic through post-pandemic periods. Most of the studies documented hematologic malignancies (non-Hodgkin's lymphomas, cutaneous lymphomas, leukemias), solid tumors (breast, lung, melanoma, sarcoma, pancreatic cancer, and glioblastoma), and virus-associated cancers (Kaposi and Merkel cell carcinoma). Across reports, several recurrent themes emerged: (1) unusually rapid progression, recurrence, or reactivation of preexisting indolent or controlled disease, (2) atypical or localized histopathologic findings, including involvement of vaccine injection sites or regional lymph nodes, and (3) proposed immunologic links between acute infection or vaccination and tumor dormancy, immune escape, or microenvironmental shifts. The predominance of case-level observations and early population-level data demonstrates an early phase of potential safety-signal detection. These findings underscore the need for rigorous epidemiologic, longitudinal, clinical, histopathological, forensic, and mechanistic studies to assess whether and under what conditions COVID-19 vaccination or infection may be linked with cancer.","PeriodicalId":19499,"journal":{"name":"Oncotarget","volume":"17 ","pages":"1-29"},"PeriodicalIF":0.0,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypothesis: HPV E6 and COVID spike proteins cooperate in targeting tumor suppression by p53. 假设：HPV E6和COVID刺突蛋白协同p53靶向肿瘤抑制。

Oncotarget Pub Date : 2026-01-03 DOI: 10.18632/oncotarget.28823

Wafik S El-Deiry

{"title":"Hypothesis: HPV E6 and COVID spike proteins cooperate in targeting tumor suppression by p53.","authors":"Wafik S El-Deiry","doi":"10.18632/oncotarget.28823","DOIUrl":"10.18632/oncotarget.28823","url":null,"abstract":"Human Papilloma Virus (HPV) is a causative agent in several cancers including cervical cancer, head and neck cancer, anal cancer, penile, vulvar and vaginal cancers. HPV through its virus-encoded protein E6 and the cellular E6-Associated Protein (E6-AP) target the tumor suppressor p53 protein for degradation thereby contributing to cancer development after HPV infection. As viruses cause cancer, the author previously hypothesized that SARS-COV-2 virus may be associated with cancer. More recent insights on the present hypothesis have come from studies suggesting (1) Spike protein of SARS-COV-2 may suppress p53 function, (2) cancer has been associated with mRNA vaccines that produce Spike, and (3) a case mentioned by Dr. Patrick Soon Shiong of a patient who survived HPV-associated head and neck cancer, but the tumor recurred after COVID mRNA vaccination including with liver metastases. Thus, the present hypothesis is that virally encoded proteins such as HPV-E6 or SARS-COV-2 Spike may cooperate in suppressing host defenses including tumor suppressor mechanisms involving p53. The hypothesis can be further explored through epidemiologic and laboratory studies.","PeriodicalId":19499,"journal":{"name":"Oncotarget","volume":"17 ","pages":"30-33"},"PeriodicalIF":0.0,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0