Oléagineux, Corps gras, Lipides最新文献

{"title":"Rapeseed oil and magnesium manipulations affect the seizure threshold to kainate in mice","authors":"N. Pagès, P. Maurois, P. Bac, J. Vamecq","doi":"10.1051/OCL.2011.0414","DOIUrl":"https://doi.org/10.1051/OCL.2011.0414","url":null,"abstract":"We have previously shown that the drop in N-methyl-D-aspartate (NMDA)-induced seizure threshold caused by nutritional magnesium deprivation responded well to the w-3 polyunsaturated fatty acid (PUFA) alpha-linolenate (ALA) (5% rapeseed oil) diet when compared to w-6 PUFA diet. In the present work, kainate-induced seizures are shown to be also exacerbated by magnesium deprivation. ALA diet better attenuates this seizure exacerbation when compared to the non-ALA diet. The reversion of the drop in kainate seizure threshold induced in these conditions by magnesium administration was, however, better under the non-ALA diet in comparison with the ALA diet. Taken as a whole, present data indicate that kainate like NMDA brain injury is attenuated by ALA diet. On the other hand, the relative failure of ALA diet to potentiate reversion induced by magnesium might suggest that magnesium and ALA protections are not additive.","PeriodicalId":19493,"journal":{"name":"Oléagineux, Corps gras, Lipides","volume":"2 1","pages":"314-316"},"PeriodicalIF":0.0,"publicationDate":"2011-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89873325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early behavior and development are influenced by the n-6 and n-3 status in prematures","authors":"B. Strandvik, C. Lundqvist-Persson, K. Sabel","doi":"10.1051/OCL.2011.0416","DOIUrl":"https://doi.org/10.1051/OCL.2011.0416","url":null,"abstract":"In a cohort of premature infants, consecutively included in the study at birth and followed to 18 months of age, the neonatal status of essential fatty acids and longchain polyunsaturated fatty acids (LCPUFA) were investigated and correlated to the development at 40 and 44 weeks gestational age and at 3, 6, 10 and 18 months corrected age. The diet reported by the mothers contained low EFA, 98% had an intake ) of the developmental scores. This was only an observational study, and it cannot be excluded that the highly negative influence of n- 6 fatty acids was an effect of the low intake of n-3 fatty acids, which in the context of the changes generally seen in Western diet imply urgent need for larger studies.","PeriodicalId":19493,"journal":{"name":"Oléagineux, Corps gras, Lipides","volume":"7 1","pages":"297-300"},"PeriodicalIF":0.0,"publicationDate":"2011-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75308898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Ciliary Neurotrophic Factor (CNTF) and hypothalamic control of energy homeostasis","authors":"C. Vacher, O. Couvreur, Elsa Basire, A. Aubourg, D. Crépin, F. Berthou, Nicolas Vicaire, M. Taouis","doi":"10.1051/OCL.2011.0399","DOIUrl":"https://doi.org/10.1051/OCL.2011.0399","url":null,"abstract":"Cytokines play an important role in energy-balance regulation. Notably leptin, an adipocyte-secreted cytokine, regulates the activity of hypothalamic neurons that are involved in the modulation of appetite. Leptin decreases appetite and stimulates weight loss in rodents. Unfortunately, numerous forms of obesity in humans seem to be resistant to leptin action. The ciliary neurotrophic factor (CNTF) is a neurocytokine that belongs to the same family as leptin and that was originally characterized as a neurotrophic factor that promotes the survival of a broad spectrum of neuronal cell types and that enhances neurogenesis in adult rodents. It presents the advantage of stimulating weight loss in humans, despite the leptin resistance. Moreover, the weight loss persists several weeks after the cessation of treatment. Hence, CNTF has been considered as a promising therapeutic tool for the treatment of obesity and has prompted intense research aimed at identifying the cellular and molecular mechanisms underlying its potent anorexigenic properties. It has been found that CNTF shares signaling pathways with leptin and is expressed in the arcuate nucleus (ARC), a key hypothalamic region controlling food intake. Endogenous CNTF may also participate in the control of energy balance. Indeed, its expression in the ARC is inversely correlated to body weight in rats fed a high-sucrose diet. Thus hypothalamic CNTF may act, in some individuals, as a protective factor against weight gain during hypercaloric diet and could account for individual differences in the susceptibility to obesity.","PeriodicalId":19493,"journal":{"name":"Oléagineux, Corps gras, Lipides","volume":"1 1","pages":"263-266"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91316954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different dietary omega-3 sources during pregnancy and DHA in the developing rat brain","authors":"C. Childs, A. Fear, S. Hoile, P. Calder","doi":"10.1051/OCL.2011.0391","DOIUrl":"https://doi.org/10.1051/OCL.2011.0391","url":null,"abstract":"The essential n-3 fatty acid α-linolenic acid (ALA) can be converted into eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) under the action of desaturase and elongase enzymes. Human studies have demonstrated that females convert a higher proportion of ALA into EPA and DHA than males. We have demonstrated that when fed upon an ALA rich diet, female rats have a significantly higher EPA content of plasma and liver lipids than males. When fetal tissues were collected, it was observed that pups from dams fed the ALA rich diet had a comparable brain DHA status to those from dams fed on a salmon-oil based diet, indicating that conversion of ALA to DHA during pregnancy was efficient, and that DHA accumulated in a tissue-specific manner. Similar efficacy of dietary ALA in women during pregnancy would mean that plant n-3 fatty acids would be useful alternatives to preformed EPA and DHA.","PeriodicalId":19493,"journal":{"name":"Oléagineux, Corps gras, Lipides","volume":"31 1","pages":"259-262"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86076697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Needs in omega 3 and ocular pathologies","authors":"L. Bretillon, E. Simon, N. Acar, O. Berdeaux, A. Bron, C. Creuzot-Garcher","doi":"10.1684/OCL.2011.0407","DOIUrl":"https://doi.org/10.1684/OCL.2011.0407","url":null,"abstract":"Life expectancy at birth has regularly increased decade after decade, especially since the beginning of the 20th century: 15 years have been gained over the past 50 years. Changes in living and dietary habits during this time period have been associated with the development of various pathologies which represent a growing socioeconomic burden. Among age-related disorders, ocular diseases are the second most prevalent ones after 65 years. Age-related Macular Degeneration (AMD) is the leading cause of visual impairment after the age of 50 years. Age is the prominent risk factor for AMD and is accompanied with both endogenous (including genetics) and environmental factors, such as smoking habits and dietary factors (diet rich in cholesterol and saturated fatty acids). AMD is characterized by the loss of cells at the most central area of the retina, called macula. The neural retina is a highly structured neurosensory tissue that is responsible for the transduction pathway. The transduction pathway is initiated in photoreceptors where the light stimulus is coded into an electrical signal. This signal is transmitted to neighboured neurons and transferred to the brain via the optic nerve. The retinal pigment epithelium (RPE) is the cellular and metabolic interface between the neural retina and choriocapillaris through Bruch’s membrane. The close association between RPE and photoreceptors is one of the factors that promote the efficacy of RPE to, in the one hand, provide nutrients and oxygen to photoreceptors and, in the other hand, eliminate the metabolic debris originating from shedding of the outer segments. Epidemiological data suggest that dietary habits privileging the consumption of omega- 3 long chain polyunsaturated fatty acids participate to prevent from the development of AMD (). The mechanisms underlying the effects of omega-3 fatty acids remain unclear until now. The purpose of the present paper is to give a review on the role, metabolism and effects of omega 3 fatty acids in the retina.","PeriodicalId":19493,"journal":{"name":"Oléagineux, Corps gras, Lipides","volume":"34 1","pages":"279-283"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84608833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"α-linolenic omega-3 fatty acid for stroke protection: from brain preconditioning paradigm to nutrition","authors":"N. Blondeau","doi":"10.1051/OCL.2011.0389","DOIUrl":"https://doi.org/10.1051/OCL.2011.0389","url":null,"abstract":"Stroke is the third leading cause of death, due to its high incidence, the severity of the insult, and lack of treatment options. The only therapeutic is restoration of cerebral blood flow achieved by recombinant tissue plasminogen activator treatment, but only approximately 5% of patients receive it. In addition, therapeutics aimed at achieving neuroprotection by blocking the ischemic cascade, as identified in numerous preclinical studies, failed in clinical trials. This failure in translation from experimental models to clinical trials led to a re-evaluation of properties which would constitute the ‘‘best-in class’’ therapeutics to be used against stroke. Given that neuroprotection appears ineffective per se, an emerging direction is to identify therapies, probably combinatorial in nature, which protect the whole neurovascular unit and target timedependent neurotoxic mechanisms. Molecules that activate complex cellular signaling cascades that render the brain resistant to subsequent ischemia, known as preconditioners, offer a novel perspective in stroke protection. Preconditioning elicits complex endogenous neuroprotective responses that act by pleiotropic mechanisms to block death pathways, promote survival pathways and increase resistance. In addition to chemical preconditioners, natural/endogenous compounds such as adenosine, glutamate, lysophospholipids, and omega-3 polyunsaturated fatty acids have been demonstrated to be excellent preconditioners. Consequently, a major new concept in preconditioning to combat stroke is introduced, which is preconditioning achieved through supplementation of an essential item in diet or as a nutraceutical. Several epidemiologic studies suggested a beneficial effect of a seafood/omega-3-enriched diet in cerebral diseases, but the omega-3-induced protective mechanisms are still poorly identified. This review highlights how α-linolenic acid (ALA), the omega-3 polyunsaturated fatty acid precursor, protects the brain from in vivo and in vitro models of stroke, thus potentially fulfilling the goal of identifying the ‘‘best-in class’’ therapeutics against stroke. Also described is the surprising pleiotric nature of ALA in protecting neurons, vasodilating brain arteries and stimulating neuroplasticity. Importantly, feasibility of delivery has been demonstrated, since ALA supplementation can be achieved through modification of the daily diet, for which prevention of stroke-induced mortality and cerebral damage has been confirmed. Therefore evaluating ALA as an interesting preconditioner against stroke represents a novel and extremely relevant concept in the context of nutraceutical and functional food development.","PeriodicalId":19493,"journal":{"name":"Oléagineux, Corps gras, Lipides","volume":"10 1","pages":"271-278"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81282807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EPA but not DHA appears to be responsible for the efficacy of omega-3 LC-PUFA supplementation in depression: evidence from an updated meta-analysis of randomized controlled trials","authors":"J. Martins","doi":"10.1684/OCL.2011.0402","DOIUrl":"https://doi.org/10.1684/OCL.2011.0402","url":null,"abstract":"Background: Epidemiological and case-control data suggest that increased dietary intake of omega-3 long-chain polyunsaturated fatty acids (v 3L C-PUFA) may be of benefit in depression. However, the results of randomized controlled trials are mixed and controversy exists as to whether either eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) or both are responsible for the reported benefits. Objective: To update a recently published meta-analysis (Martins JG, J Am Coll Nutr, 2009; 28: 525-42) of double-blind, placebo-controlled, randomized controlled trials examining the effect of v 3L C-PUFA supplementation where depressive symptoms were a reported outcome. The differential effectiveness of EPA versus DHA has been reassessed through meta-regression and subgroup analyses. Design: Studies were selected using the PubMed database on the basis of the following criteria: i) randomized design; ii) placebo controlled; iii) use of an v 3L C-PUFA preparation containing DHA, EPA or both where the relative amounts of each fatty acid could be quantified; and iv) reporting sufficient statistics on scores of a recognizable measure of depressive symptoms. Results: 370 studies wereidentified (22/01/2011) of which35 metthe aboveinclusion criteria(7 additional to Martins JG, 2009) and were therefore included for analysis. Using a random effects model, overall standardized mean depression scores were reduced in response to v 3L C-PUFA supplementation as compared with placebo (standardized mean difference = -0.230, 95% CI = -0.361 to -0.099, p = 0.001). However, significant heterogeneity and evidence of publication bias was present. Meta-regression studies showed a significant effect of EPA:DHA ratio on therapeutic efficacy. Subgroup analyses showed significant effects for: i) baseline debression; ii) diagnostic category (bipolar disorder and major depression showing significant improvement with v 3L C- PUFA supplementation versus mildtomoderate depression, perinatal depression, chronic fatigue and non-clinical populations not); iii) therapeutic as opposed to preventative intervention; iv) adjunctive treatment and to a lesser extent monotherapy; and v) supplement type. Symptoms of depression were not significantly reduced in 2 studies using pure DHA of algal origin (standardized mean difference = -0.111, 95% CI = -0.590 to 0.368, p = 0.649), in 3 studies using a mixture of DHA and EPA ethyl esters (standardized mean difference = -0.027, 95% CI = -0.200 to 0.147, p = 0.764), or in 7 studies using fish oil triglyceride supplements containing greater than 50% DHA (standardized mean difference = 0.027, 95% CI = -0.148 to 0.202, p = 0.763). In contrast, symptoms of depression were significantly reduced in 13 studies using fish oil triglyceride supplements containing greater than 50% EPA (standardized mean difference = -0.513, 95% CI = -0.840 to -0.185, p = 0.002) and in 10 studies using pure EPA ethyl ester (standardized mean difference = -0.360, 95% CI = -0.597 to","PeriodicalId":19493,"journal":{"name":"Oléagineux, Corps gras, Lipides","volume":"142 ","pages":"188-198"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72556281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi nutrient concept to enhance synapse formation and function: science behind a medical food for Alzheimer’s disease","authors":"J. Sijben, Martijn C. de Wilde, R. Wieggers, M. Groenendijk, P. Kamphuis","doi":"10.1051/OCL.2011.0410","DOIUrl":"https://doi.org/10.1051/OCL.2011.0410","url":null,"abstract":"Alzheimer’s Disease (AD) is the leading cause of dementia. Epidemiological studies suggest that AD is linked with poor status of nutrients including DHA, B-vitamins and the vitamins E and C. Ongoing neurodegeneration, particularly synaptic loss, leads to the classical clinical features of AD namely, memory impairment, language deterioration, and executive and visuospatial dysfunction. The main constituents of neural and synaptic membranes are phospholipids. Supplemenation of animals with three dietary precursors of phospholipids namely, DHA, uridine monophosphate and choline, results in increased levels of brain phospholipids, synaptic proteins, neurite outgrowth, dendritic spines formation (i.e. the anatomical precursors of new synapses) and an improvement in learning and memory. Other nutrients act as co-factors in the synthesis pathway of neuronal membranes. For example B-vitamins are involved in methylation processes, thereby enhancing the availability of choline as a synaptic membrane precursor. A multi-nutrient concept that includes these nutrients may improve membrane integrity, thereby influencing membrane-dependent processes such as receptor function and amyloid precursor protein (APP) processing, as shown by reduced amyloid production and amyloid β plaque burden, as well as toxicity. Together, these insights provided the basis for the development of a medical food for patients with AD, Souvenaid® , containing a specific combination of nutrients (Fortasyn™ Connect) and designed to enhance synapse formation in AD. The effect of Souvenaid on memory and cognitive performance was recently assessed in a proof-of-concept study, SOUVENIR I, with 212 drug-naive mild AD patients (MMSE 20-26). This proof-of-concept study demonstrated that oral nutritional supplementation with Souvenaid® for 12 weeks improves memory in patients with mild AD. To confirm and extend these findings, we have designed and initiated three additional studies. Two of these studies will be completed in 2011; Souvenir II, a 24-week European study, with 259 drug-naive mild AD patients (MMSE≥20) and S-Connect, another 24-week study, with 527 mild-tomoderate AD patients (MMSE 14-24) using AD medication conducted in the US. The third is the EU-funded LipiDiDiet study, a 24-month study, which will enrol 300 people with prodromal AD to assess the effect on memory performance.","PeriodicalId":19493,"journal":{"name":"Oléagineux, Corps gras, Lipides","volume":"19 1","pages":"267-270"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76039827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging plasma docosahexaenoic acid (dha) incorporation into the brain in vivo, as a biomarker of brain DHA: Metabolism and neurotransmission","authors":"S. Rapoport, Epolia Ramadan, M. Basselin","doi":"10.1051/OCL.2011.0396","DOIUrl":"https://doi.org/10.1051/OCL.2011.0396","url":null,"abstract":"Docosahexaenoic acid (DHA) is critical for normal brain structure and function, and its brain concentration depends on dietary DHA content and hepatic conversion from its dietary derived n-3 precursor, a-linolenic acid (α-LNA). We developed an in vivo method in rats using quantitative autoradiography to image incorporation into brain of unesterified plasma DHA, and showed that the incorporation rate equals the rate of brain metabolic DHA consumption. Thus, quantitative imaging of DHA incorporation from plasma into brain can be used as a biomarker of brain DHA metabolism and neurotransmission. The method has been extended to humans with the use of positron emission tomography (PET). Furthermore, imaging in unanesthetized rats using DHA incorporation as a biomarker in response to N-methyl-D-aspartate (NMDA) administration confirms that regional DHA signaling is independent of extracellular calcium, and likely mediated by a calcium-independent phospholipase A2 (iPLA2). Studies in mice in which iPLA2-VIA (β) was knocked out confirmed that this enzyme is critical for baseline and muscarinic cholinergic signaling involving DHA.","PeriodicalId":19493,"journal":{"name":"Oléagineux, Corps gras, Lipides","volume":"1 1","pages":"246-250"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82890640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alteration of brain insulin and leptin signaling promotes energy homeostasis impairment and neurodegenerative diseases","authors":"M. Taouis","doi":"10.1051/OCL.2011.0405","DOIUrl":"https://doi.org/10.1051/OCL.2011.0405","url":null,"abstract":"The central nervous system (CNS) controls vital functions, by efficiently coordinating peripheral and central cascades of signals and networks in a coordinated manner. Historically, the brain was considered to be an insulin-insensitive tissue. But, new findings demonstrating that insulin is present in different regions of themammalian brain, in particular the hypothalamus and the hippocampus. Insulin acts through specific receptors and dialogues with numerous peptides, neurotransmitters and adipokines such as leptin. The cross-talk between leptin and insulin signaling pathways at the hypothalamic level is clearly involved in the control of energy homeostasis. Both hormones are anorexigenic through their action on hypothalamic arcuate nucleus by inducing the expression of anorexigenic neuropetides such as POMC (pro-opiomelanocortin, the precursor of aMSH) and reducing the expression of orexigenic neuropeptide such as NPY (Neuropeptide Y). Central defect of insulin and leptin signaling predispose to obesity (leptin-resistant state) and type-2 diabetes (insulin resistant state). Obesity and type-2 diabetes are associated to deep alterations in energy homeostasis control but also to other alterations of CNS functions as the predisposition to neurodegenerative diseases such as Alzheimer’s disease (AD). AD is a neurodegenerative disorder characterized by distinct hallmarks within the brain. Postmortem observation of AD brains showed the presence of parenchymal plaques due to the accumulation of the amyloid beta (AB) peptide and neurofibrillary tangles. These accumulations result from the hyperphosphorylation of tau (a mictrotubule-interacting protein). Both insulin and leptin have been described to modulate tau phosphorylation and therefore in leptin and insulin resistant states may contribute to AD. The concentrations of leptin and insulin cerebrospinal fluid are decreased type2 diabetes and obese patients. In addition, the concentration of insulin in the cerebrospinal fluid of AD patients is diminished.Taken together, these data clearly links deficiency of leptin and insulin signaling to both alterations of energy homeostasis control and predisposition to AD. Furthermore, environment changes leading to insulin and leptin-resistance may promote these defects, such as high fat diet.","PeriodicalId":19493,"journal":{"name":"Oléagineux, Corps gras, Lipides","volume":"49 1","pages":"251-254"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85805421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}