Hellenic Journal of Obstetrics and Gynecology最新文献

{"title":"Von Willebrand factor in follicular fluid in women undergoing IVF/ICSI: a “ghost” associated with oocyte and embryo quality","authors":"G. Partsinevelos, D. Mavrogianni, Evagelia Dimitroulia, V. Dinopoulou, D. Loutradis, P. Drakakis","doi":"10.33574/hjog.0093","DOIUrl":"https://doi.org/10.33574/hjog.0093","url":null,"abstract":"Introduction: The purpose of the present study to determine the presence of Von Willebrand factor (vWF) in the follicular fluid of women undergoing IVF/ICSI and to investigate the association of its concentration with oocyte and embryo quality. Methods: We conducted a prospective observational study based in women undergoing in vitro fertilization treatment. vWF concentrations in follicular fluid samples collected during transvaginal oocyte retrieval were measured using an enzyme-linked immunosorbent assay (Elisa). They were also analyzed by the VIDAS® vWF method for confirmation of the results. The latter is an automated quantitative test for the measurement of vWF in human plasma, using the ELFA technique (enzyme-linked fluorescent assay). vWF concentrations were correlated to oocyte and embryo quality. Results: Contrary to previous reports, vWF was determined in follicular fluid. A higher percentage of good quality oocytes were found in the presence of lower vWF follicular fluid levels. Similarly, better quality embryos were derived from oocytes retrieved from follicles with lower vWF follicular fluid levels. Conclusions: Contrary to existing evidence to date, vWF was found in the follicular fluid of women undergoing IVF/ICSI treatment. In addition, the quality of oocytes and embryos was adversely related to vWF follicular fluid levels. In fact, a better outcome of IVF/ICSI treatment was suggested when the levels of vWF in follicular fluid were low. In this context, vWF follicular fluid levels could be used as a prognostic factor for oocyte and embryo quality.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129689979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luteal phase pregnancy after mirena coil insertion for intrauterine septum resection","authors":"N. Citeroni, Rifat Syed","doi":"10.33574/hjog.2163","DOIUrl":"https://doi.org/10.33574/hjog.2163","url":null,"abstract":"This report is of an unusual case of an intrauterine singleton pregnancy with a Mirena Coil (IUS) in situ following an elective hysteroscopic intrauterine septum resection for treatment of primary subfertility in a 27-year-old female. The patient elected to continue with the pregnancy and underwent additional monitoring via ultrasound. A caesarean section was undertaken at 39-weeks gestation and a healthy male infant was born. The Mirena coil was recovered intraoperative and was visualised in the placental membranes. Pregnancy occurring with Mirena coil insertion as an adjunct to hysteroscopic septum resection in our case is an unusual clinical scenario with no management recommendations and limited recorded outcomes. Therefore, this case demonstrates potential management of such a case and learning points for intrauterine septum excision in the context of primary subfertility.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126738676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of epigenetic factors in descendants from Assisted Reproductive Techniques (ART)","authors":"V. Pergialiotis, A. Prodromidou, E. Dimitroulia, D. Loutradis","doi":"10.33574/hjog.2164","DOIUrl":"https://doi.org/10.33574/hjog.2164","url":null,"abstract":"Altogether, Assisted Reproductive Techniques (ART) are likely to cause some epigenetic changes in the offspring, which might consist the molecular basis of complex characteristics and diseases. The present review contributes a large biochemical dataset of a well-defined group of pre- pubertal in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) conceived children in order to detect the potential effect in the offspring’s health. Additionally, the relevant usefulness of metabolomics and proteomics are also investigated. The outcomes indicate early insulin resistance in ICSI-offspring which can set the basis for further research in the field so as to identify the respective pathophysiological pathways and mechanisms of action. The data support that metabolomics may unravel metabolic variances before they become clinically or biochemically evident, underlining its utility in the ART research.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133423454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What brings adolescents to the Obstetrics and Gynaecology Emergency Department of a General Hospital","authors":"M. Litos, V. Triantafyllidi, D. Vasileiadou, E. Papamargaritis, C. Sofoudis, K. Bakalianou","doi":"10.33574/hjog.2162","DOIUrl":"https://doi.org/10.33574/hjog.2162","url":null,"abstract":"Introduction: Paediatric & Adolescent Gynaecology is a special field and also part of the everyday practice. This paper studies the problems adolescent females present with at the Obstetrics & Gynaecology (O&G) Emergency Department (ED). Material and Methods: Data regarding adolescent females that were examined at the O&G ED over one year (2018) were extracted from the records of Konstantiopouleio General Hospital, Athens, Greece. Results: Of the 1534 women that attended O&G ED over one year, 111 were under 19 years old (7%). Of the 83 gynaecological cases, the presenting symptom was pelvic pain in 54 (65%), irregular vaginal bleeding in 11(13%), urinary tract symptoms in 11(13%), vaginal discomfort in 3 (4%) and others in 4 (5%). In 39 (47%) no urgent gynaecological pathology was detected. There were 11 cases (13%) of ovarian cysts, 10 of urinary tract infection (12%), 7 (8%) of other surgical pathology, 6 (8%) of first trimester pregnancy complications and 10 others. Of the 28 pregnant adolescents, 10 complained of abdominal pain (36%), 6 of hyperemesis (21%), 5 of myometrial activity (18%), 4 of vaginal bleeding (14%). In 18 cases (64%) no acute medical condition was diagnosed, 4 were admitted in active labour (14%) and one with threatened delivery, two were referred to other specialties and three refused the examination. Conclusion: O&G emergency conditions in adolescent females are common and potentially serious. Healthcare professionals need to be aware and alert to the special needs of this significant and sensitive population group.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"2011 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127365763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of bilateral tubal ectopic pregnancy following intrauterine insemination","authors":"E. Tingi, Helena Misiura, M. Williams, S. Ajayi, S. Vitthala","doi":"10.33574/hjog.2165","DOIUrl":"https://doi.org/10.33574/hjog.2165","url":null,"abstract":"The incidence of unilateral ectopic pregnancy (EP) is 1-2% with the tubal EP being the commonest. Bilateral tubal pregnancy occurs 1 in every 750 to 1,850 EP following assisted reproductive technologies. We present a case of bilateral tubal EP in a 28 year old woman who underwent intrauterine insemination with donor sperm.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"294 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132914001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating multiple diagnostic tests: An application to cervical cancer","authors":"A. Veroniki, Sofia Tsokani, E. Paraskevaidis, D. Mavridis","doi":"10.33574/hjog.2161","DOIUrl":"https://doi.org/10.33574/hjog.2161","url":null,"abstract":"Systematic Reviews of diagnostic test accuracy (DTA) studies are increasingly comparing the accuracy of multiple tests to facilitate selection of the best performing test(s). Common approaches to compare multiple tests include multiple meta-analyses or meta-regression with the test type as a covariate. Within-study correlation between tests are typically not considered in these approaches. Several DTA network meta-analysis (DTA-NMA) models have been suggested to compare the accuracy of multiple index tests in a single model. Our aim was to identify all DTA-NMA methods for comparing the accuracy of multiple diagnostic tests. We conducted a methodological review of the DTA-NMA models. We searched PubMed, Web of Science, and Scopus from inception until the end of July 2019. Studies of any design published in English were eligible for inclusion. We also reviewed relevant unpublished material. The methods were applied in a network of 37 studies comparing human papillomavirus (HPV) DNA, mRNA, and cytology (ASCUS+/ LSIL+ threshold) for the diagnosis of invasive cervical cancer (CIN2+). We included 10 relevant studies, and identified four Bayesian hierarchical DTA-NMA methods including the 2×2 data table for each index test. Using CIN2+ as a case study, we applied the DTA-NMA methods to determine the most promising test, in terms of sensitivity and specificity. All models showed the mRNA test as the most accurate test followed by HPV DNA: relative sensitivity compared to the cytology test 1.36-1.39 and 1.33-1.35, respectively. However, both tests had similar or worse specificity than cytology (relative specificity range in mRNA 0.96-0.98 and in HPV-DNA 0.94-0.95). Both sensitivity and specificity of mRNA were associated with the highest uncertainty across all models (widest 95% credible intervals 0.68-0.97 and 0.74-0.94, respectively). Precision and estimation of between-study and within-study variability vary across models, which might be due to the differences in the key properties of the models. Different DTA-NMA methods may lead to different results. The choice of a DTA-NMA method for the comparison of multiple diagnostic tests may depend on the available data, e.g., threshold data, as well as on clinically-related factors.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"219 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124345006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Prophylaxis for Caesarean Delivery; A comparative study between different agents","authors":"Afroditi Ziogou, Ioannis Kokolakis, Fanourios Makrygiannakis, A. Makrigiannakis","doi":"10.33574/hjog.2160","DOIUrl":"https://doi.org/10.33574/hjog.2160","url":null,"abstract":"Antimicrobial prophylaxis is commonly used for pre-intra and post-operative caesarean delivery. Caesarean delivery is still the single most important risk factor for puerperal infection. Post-caesarean infections include wound infections, endomyometritis, bacteraemia, septic shock, septic pelvic vein thrombophlebitis, necrotising fasciitis, pelvic abscess, dehiscence of the wound or evisceration. The goal of antimicrobial prophylaxis is to put a stop to postoperative infection of the surgical site, the use of therapeutic antibiotics, additional surgical interventions, longer duration of hospital stay, to decrease postoperative infectious morbidity and mortality and the cost of postoperative health care. A post-caesarean wound infection detected prior to hospital discharge will lead to prolongation of hospital stay and will increase the hospitalisation costs and need of readmission. Both the American College of Obstetricians and Gynaecologists and the American Society of Health-Care System Pharmacists have introduced single-dose prophylactic protocols using a heterogeneity of agents (penicillins, cephalosporins, clindamycin and azithromycin). Women undergoing caesarean delivery have a greater risk of developing infection compared to women who have a vaginal birth by 5 to 20-fold. The use of prophylaxis in patients undergoing a low-risk Caesarean Delivery remains controversial.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"190 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116646297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of proactive strategies on pregnancy healthcare during the COVID-19 epidemic.","authors":"George Daskalakis, M. Theodora, S. Koura, D. Loutradis, V. Pergialiotis","doi":"10.33574/hjog.2092","DOIUrl":"https://doi.org/10.33574/hjog.2092","url":null,"abstract":"","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"174 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133944003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of meconium peritonitis due to bowel perforation diagnosed at anomaly scan at 20 weeks.","authors":"P. Sinha, S. Sibtain, H. Aoun","doi":"10.33574/hjog.2104","DOIUrl":"https://doi.org/10.33574/hjog.2104","url":null,"abstract":"Meconium peritonitis is a rare condition in a fetus which occurs due to perforation of the bowel in the antenatal period. It has serious neonatal consequences resulting in death if the diagnosis is delayed soon after delivery. However, its detection is difficult as the presentation is very variable. A case of meconium peritonitis and pseudocyst detected in a fetus at 33 weeks and 2 days of gestation is discussed regarding its diagnosis and management. Final diagnosis was made only after delivery and managed by surgery (bowel resection). The outcome after treatment was favourable because of the timely intervention.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122169277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking during pregnancy was negatively associated with physical fitness in childhood","authors":"Konstantinos D Tambalis, S. Mourtakos, Demosthenes D. Panagiotakos, L. Sidossis","doi":"10.33574/hjog.2047","DOIUrl":"https://doi.org/10.33574/hjog.2047","url":null,"abstract":"Background: To explore the potential relationship of several prenatal predictors with physical fitness (PF) components among children. Material and Methods: Α random sample of 5,125 dyads children (8 to 9 years old) and their mothers was evaluated. Mothers were asked to provide information contained in their medical booklets and pregnancy ultrasound records. With the use of a standardized questionnaire, telephone interviews were carried out for the collection of maternal factors in order to assess the potential association between several prenatal factors (preterm birth, maternal age, parity before, mode of delivery, gestational diabetes, hypertensive disorders of pregnancy, alcohol consumption and smoking during pregnancy) and child’s PF. Data from five PF tests were used to assess cardiorespiratory fitness (CRF), speed, and lower and upper body strength. Results: Children born to mothers with adequate physical activity (PA) levels during pregnancy, parity before and higher education presented higher performances in PF components (all p-values<0.05) in childhood. Also, mother’s smoking during pregnancy was unfavorably associated with CRF (b=-0.04), lower body strength (b=-0.02), upper body strength (b=-0.02), and speed (b=0.10), after adjusting for several covariates. Conclusion: Among prenatal factors considered, parity before, educational level and PA and smoking during pregnancy had an important influence on PF in childhood.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132929249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}