{"title":"Neuroprotective effect of selenomethionine in SH-SY5Y cells is enhanced by L-serine and its potential mechanism: an in vitro study","authors":"Ya‐Zhi Bai, Shuang‐Qing Zhang","doi":"10.1108/nfs-03-2026-0137","DOIUrl":"https://doi.org/10.1108/nfs-03-2026-0137","url":null,"abstract":"Purpose Selenium (Se) has the potential in the modulation of cognition in animal experiments and human studies, however, the exact mechanism still remains unclear. The purpose of this study aims to investigate neuroprotective effect of Se and its potential mechanism. Design/methodology/approach The authors hypothesized that selenoprotein expression and antioxidative ability of Se in neuronal cell lines are enhanced by L-serine, and the potential novel mechanism of Se on cognition might be associated with the regulation of de novo L-serine synthesis for selenoprotein synthesis. For the first time, the interaction of selenomethionine (SeMet) and L-serine was investigated by the evaluation of cell viability, selenoprotein expression and antioxidative ability in SH-SY5Y cells cultured in the specific culture medium (without L-serine and glycine). Findings Based on cell viability results, SeMet (0.001, 0.01 and 0.1 µM) and L-serine (0.01, 0.1, 1 and 5 µM) were used to treat SH-SY5Y cells for 48 h. L-serine upregulated the expression of four selenoproteins and an inverted U-shaped relationship existed between SeMet concentration and expression of four selenoproteins. SeMet decreased malondialdehyde and reactive oxygen species contents, as well as increased superoxide dismutase activity and glutathione level. Originality/value Neuroprotective effect of SeMet in SH-SY5Y cells was enhanced by L-serine and its mechanism might involve the de novo L-serine synthesis for selenoprotein expression.","PeriodicalId":19376,"journal":{"name":"Nutrition & Food Science","volume":"1 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ikuko Kato, Sai Shiva Bhaskar Emani, Raobo Xu, Xinmin Yin, Xiang Zhang, Maarten C Bosland, Seongho Kim
{"title":"Impact of one-year soy protein supplementation on serum metabolomic profiles: results from a randomized, placebo-controlled trial in prostate cancer patients.","authors":"Ikuko Kato, Sai Shiva Bhaskar Emani, Raobo Xu, Xinmin Yin, Xiang Zhang, Maarten C Bosland, Seongho Kim","doi":"10.1108/nfs-11-2024-0357","DOIUrl":"10.1108/nfs-11-2024-0357","url":null,"abstract":"<p><strong>Purpose –: </strong>This study aims to investigate global metabolomic effects of soy protein supplementation.</p><p><strong>Design/methodology/approach –: </strong>This study was designed as an exploratory study based on residual specimens from a randomized placebo-controlled trial. The authors investigated changes in serum metabolomic and lipidomic profiles of prostate cancer patients who were assigned to soy protein (19.2g/day, 41mg isoflavones, <i>n</i> = 10) or a casein-based placebo (19.8g/day <i>n</i> = 11) for up to one year following prostatectomy. A total of 63 serum samples collected at baseline, 6 and 12months were analyzed by untargeted, global metabolomics.</p><p><strong>Findings –: </strong>Partial least squares discriminant analysis, based on 493 polar metabolites and 4,706 lipids, showed clear separation of changes in metabolomic profiles between the soy and placebo groups. However, the only metabolite that was significantly different after multiple comparison adjustment was daidzein 4'-sulfate (<i>p</i> = 0.036). A few other metabolites/lipids were weakly associated with soy supplementation; betaine and C18-ceramide derivative increased and L-<i>α</i>-aminoadipic acid and a linolenic acid derivative decreased, compared with the placebo.</p><p><strong>Originality/value –: </strong>The present study demonstrates that physiologically relevant dietary levels of soy protein supplementation close to real-life levels of consumption lead to a shift in global metabolomic profiles.</p>","PeriodicalId":19376,"journal":{"name":"Nutrition & Food Science","volume":"56 4","pages":"689-702"},"PeriodicalIF":1.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ye Yue, Huasong Bai, Tong Liu, Shang Jia, Xiaohong Kou, Zhanzhong Wang
{"title":"The anti-inflammatory ability of n-3 PUFAs: optimization of compositions and concentrations in mouse hepatocytes","authors":"Ye Yue, Huasong Bai, Tong Liu, Shang Jia, Xiaohong Kou, Zhanzhong Wang","doi":"10.1108/nfs-11-2024-0376","DOIUrl":"https://doi.org/10.1108/nfs-11-2024-0376","url":null,"abstract":"Purpose This study aims to investigate the impact of the compositions and concentrations of α -linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are significant n-3 polyunsaturated fatty acids (n-3 PUFAs), on the anti-inflammatory properties of lipopolysaccharide (LPS)-stimulated mouse hepatocytes. Design/methodology/approach A mouse hepatocyte inflammation model was established using LPS to evaluate the anti-inflammatory effects of a combination therapy with EPA, ALA and DHA. Interleukin-10 (IL-10), lipoxin A4 (LXA4) and tumor necrosis factor-α(TNF- α ) were measured to evaluate the anti-inflammatory ability of hepatocytes. The compositions and concentrations of EPA, ALA and DHA were optimized by response surface methodology to obtain the best anti-inflammatory effect. Findings The optimal inflammatory model was established with 10 µg/mL LPS treatment for 24 h. Maximal cell viability was found at EPA concentration of 150 µM, ALA concentration of 400 µM and DHA concentration of 600 µM. The optimal concentrations of n-3 PUFAs for anti-inflammatory activity in mouse hepatocytes were obtained through single-factor experiments and response surface analysis, with EPA 141.41 µM, ALA 405.45 µM and DHA 551.76 µM. Under optimized conditions, the experimental results for TNF- α , IL-10 and LXA4 levels were close to the theoretical prediction, indicating that the mathematical model was extremely accurate and versatile. Originality/value This study systematically explored the specific effects of different ratios and concentrations of ALA, EPA and DHA on the anti-inflammatory ability of mouse hepatocytes, offering an experimental foundation for the advancement of novel anti-inflammatory medicines and nutritional supplements.","PeriodicalId":19376,"journal":{"name":"Nutrition & Food Science","volume":"55 4","pages":"753-771"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147910862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huasong Bai, Jiayi Yang, Ruixue Wang, Tong Liu, Zhanzhong Wang
{"title":"The enhancing effects and mechanisms of inositol and choline on antioxidant capacity of vitamin E using model established in mice hepatocytes","authors":"Huasong Bai, Jiayi Yang, Ruixue Wang, Tong Liu, Zhanzhong Wang","doi":"10.1108/nfs-06-2024-0208","DOIUrl":"https://doi.org/10.1108/nfs-06-2024-0208","url":null,"abstract":"Purpose This study aims to enhance the bioavailability and antioxidant function of vitamin E (VE) by combining it with inositol and choline, exploring their synergistic effects and underlying mechanisms. Design/methodology/approach An oxidative stress model in mouse hepatocytes was established using hydrogen peroxide to assess the antioxidant effects of combined VE, inositol and choline treatments. Cell viability, the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) and antioxidant enzymes, including superoxide dismutase (SOD) and catalase (CAT), were measured to evaluate protective effects. α -Tocopherol ( α -T) and α -tocopherol transfer protein ( α -TTP) levels were assessed to determine VE bioavailability. Transcriptome sequencing was conducted to identify gene expression changes and pathways impacted by the treatment. Findings An optimal oxidative stress model was established with 641 µM hydrogen peroxide for 6 h. The combination of 20 µM VE, 1.5 mM inositol and 0.3 mM choline significantly improved cell viability, reduced ROS and MDA levels and increased SOD and CAT activities, indicating enhanced antioxidant protection. In addition, α -T and α -TTP levels were higher with this combination, suggesting improved VE bioavailability. Transcriptome analysis revealed that the treatment modulated key pathways linked to inflammation, cancer and lipid metabolism, particularly impacting interleukin-17 and nuclear factor kappa-light-chain-enhancer of activated B cells signaling, cytokine interactions and the alcoholic liver disease pathway. Originality/value This study demonstrates a novel approach for improving VE’s bioavailability and effectiveness through its combination with inositol and choline, providing insights that could inform antioxidant therapies and liver health interventions.","PeriodicalId":19376,"journal":{"name":"Nutrition & Food Science","volume":"55 3","pages":"533-550"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147919462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leila Nikravan, Setayesh Zamanpour, Seyyed Mohammad Ali Noori
{"title":"Postbiotics: an innovative approach to increase shelf life and quality of foods","authors":"Leila Nikravan, Setayesh Zamanpour, Seyyed Mohammad Ali Noori","doi":"10.1108/nfs-06-2023-0138","DOIUrl":"https://doi.org/10.1108/nfs-06-2023-0138","url":null,"abstract":"Purpose The purpose of this paper is to provide an overview of the antimicrobial and antioxidant properties of postbiotics and the use of postbiotics to increase the shelf life and quality of food. Design/methodology/approach In this review paper, all articles from five electronic databases containing Google Scholar, Web of Science, PubMed, Scopus and Science Direct were considered and selected according to the purpose of the study. Findings In addition to improving food safety and increasing its shelf life, natural food preservation using biological preservatives also has a positive effect on improving consumer health. As a result, protection using natural antioxidants and antimicrobial agents seems essential. Postbiotics, having favorable characteristics such as nontoxicity, long shelf life and ease of standardization and transportation, are known as suitable antioxidant and antimicrobial, and there is an interest in making antioxidant and antimicrobial active films containing postbiotics to delay spoilage, increase the shelf life of perishable foods without changing their sensory characteristics. Originality/value Postbiotic refers to all soluble factors that are either secreted from living probiotic cells or released after cell lysis. These compounds include enzymes, peptides, polysaccharides, organic acids, teichoic acids and cell surface proteins, and their effects have been proven to improve some human and animal diseases. Probiotic bacteria must survive unfavorable conditions such as processing, storage, distribution, preparation and the digestive system to exert their health-giving effects, whereas their metabolites (postbiotics) have overcome these adverse conditions well and may be a good substitute for probiotics.","PeriodicalId":19376,"journal":{"name":"Nutrition & Food Science","volume":"47 29","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134902147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Local staples, and global solutions: optimizing the effect of traditional fermentation on heavy metals and mineral nutrients","authors":"Ekpor Anyimah-Ackah","doi":"10.1108/nfs-02-2023-0037","DOIUrl":"https://doi.org/10.1108/nfs-02-2023-0037","url":null,"abstract":"Purpose This study aims to examine the effect of traditional fermentation on gari’s total heavy metal and mineral nutrient content. Design/methodology/approach This study used a quantitative approach, descriptive-analytical design to baseline the risk of heavy metals and experimental design to assess the effect of traditional fermentation. Data were analyzed using descriptives, univariate and multivariate analysis. Findings Although gari is rich in mineral nutrients (total calcium 3.9 ± 0.1 g/kg, copper 5.5 ± 0.02 mg/kg, iron 97.1 ± 5.8 mg/kg, potassium 9.1 ± 0.29 g/kg and zinc 3.4 ± 0.11 mg/kg), the significant levels of heavy metals (total arsenic 1.2 ± 0.01, cadmium 2.5 ± 0.04, lead 1.7 ± 0.01, mercury 2.8 ± 0.01 and tin 1.7 ± 0.02 mg/kg) present are a cause for concern. The results further suggested that traditional fermentation has reductive effects on some heavy metals and stabilizing or concentrating effects on mineral nutrients. Research limitations/implications This paper provides evidence that traditional fermentation may have exploitable differential effects on heavy metal contaminants and mineral nutrients that should be further explored. Practical implications Thise study reports fermentation implications for mitigating food with high heavy metal contaminants with minimal nutrient loss. Originality/value This study fulfills an identified need to optimize traditional fermentation to ensure food safety and nutrient security.","PeriodicalId":19376,"journal":{"name":"Nutrition & Food Science","volume":" 62","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135340318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Meta-analysis of community-based interventions on fruits and vegetables consumption in adults","authors":"Masoumeh Jabbari, Nazli Namazi, Pardis Irandoost, Leila Rezazadeh, Nahid Ramezani-Jolfaie, Mina Babashahi, Samira Pourmoradian, Meisam Barati","doi":"10.1108/nfs-05-2023-0115","DOIUrl":"https://doi.org/10.1108/nfs-05-2023-0115","url":null,"abstract":"Purpose Despite the well-known positive effects of fruits and vegetables, their consumption in many countries is lower than those recommended. This study aims to systematically examine the effects of community-based interventions on fruits and vegetables consumption in adults. Design/methodology/approach To collect relevant publications, the authors searched electronic databases including PubMed/MEDLINE, Scopus and Web of Science from January 2000 to July 2021. Considering random models, this study analyzed the data using weighted mean differences (WMD) and 95% confidence intervals (CI). Findings Among 1,621 retrieved publications, 21 articles met the inclusion criteria. The overall effect size demonstrated that, at the end of the trials, the educational interventions increased the consumption of aggregated fruits and vegetables (WMD: 0.55 serving/day, 95%CI: 0.34, 0.77), and vegetables (WMD: 0.15, 95%CI: 0.09, 0.21, I2: 33.2%; p = 0.103) in the intervention groups, compared to the control groups. Practical implications The subgroup analyses that were based on the type of interventions (face-to-face education compared to online interventions), location (home-based compared to the other types of interventions) and duration (24 weeks and higher) of interventions, and accompanied financial support reduced between-group heterogeneity. An efficient interventional program on increasing fruits and vegetables consumption should be part of a multi-component project. Originality/value To the best of the authors’ knowledge, no systematic review and meta-analysis has provided a summary of the effects of community-based interventions on fruits and vegetables consumption in adult populations, and there is no fixed conclusion that could be drawn in this regard.","PeriodicalId":19376,"journal":{"name":"Nutrition & Food Science","volume":"12 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135875950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Consumption of packaged food and associated factors among adults aged 18–30 years: a cross-sectional study in Kerala","authors":"Thottasseri Haseena, Sibasis Hense, Prakash Babu Kodali, Kavumpurathu Raman Thankappan","doi":"10.1108/nfs-05-2023-0102","DOIUrl":"https://doi.org/10.1108/nfs-05-2023-0102","url":null,"abstract":"Purpose Literature on packaged food consumption and associated factors in Kerala is limited. This study aims to find out consumption pattern of packaged food and the factors associated with it among young adults in Kerala. Design/methodology/approach The authors conducted a cross-sectional survey among 384 young adults aged 18–30 years selected using multistage cluster sampling. Information on packaged food consumption and sociodemographic factors was collected using a structured, pre-tested interview schedule. Binary logistic regression analysis was done to find out the factors associated with packaged food consumption. Findings Among the participants, 85.7% (95% CI = 81.9%–88.9%) reported consuming packaged food at least once a week, and 45% (95% CI = 40.4%–50.3%) reported consuming packaged food more than two times a week. Individuals who were employed [adjusted odds ratio (AOR) = 1.71, 95% CI = 1.06–2.76], who consume packaged food without a fixed routine (AOR = 2.24, 95% CI = 1.18–4.28), those without previous attempts to reduce packaged food consumption (AOR = 3.45, 95% CI = 1.72–6.91) and those who preferred packaged food for their taste and flavor (AOR = 1.73, 95% CI = 1.09–2.74) had greater odds of consuming packaged food more than two times a week compared to their counterparts. Originality/value Packaged food is frequently consumed by more than 40% of young adults in Kerala. Efforts focused on individuals (such as building awareness and taxing packaged foods) are warranted to control packaged food consumption among young adults.","PeriodicalId":19376,"journal":{"name":"Nutrition & Food Science","volume":"57 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135219767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dietary and lifestyle indices for insulin resistance and nonalcoholic fatty liver disease","authors":"Aref Momeni, Soodeh Razeghi Jahromi, Mitra KazemiJahromi, Farshad Teymoori, Hossein Farhadnejad, Rouhollah Haghshenas","doi":"10.1108/nfs-11-2022-0369","DOIUrl":"https://doi.org/10.1108/nfs-11-2022-0369","url":null,"abstract":"Purpose The aim of the present study was to investigate the association of the empirical dietary index for insulin resistance (EDIR) and empirical lifestyle index for insulin resistance (ELIR) with the risk of nonalcoholic fatty liver disease (NAFLD) in Iranian adults. Design/methodology/approach In this case-control study, 120 cases of NAFLD and 240 controls aged ≥20 years were included. NAFLD was detected by a gastroenterologist using an ultrasonography test. The food frequency questionnaire was used to collect nutritional data and determine the score of EDIR in participants. ELIR was determined based on body mass index, physical activity and dietary pattern. The odds ratios (ORs) of NAFLD were reported across tertiles of EDIR and ELIR using a logistic regression test. Findings The mean±SD age and BMI of subjects were 41.8 ± 7.5 years and 27.4 ± 2.2 kg/m 2 , respectively. In the age and sex-adjusted model, the odds of NAFLD were increased across tertiles of ELIR (OR = 3.00; 95% CI: 1.63–5.55, P trend = 0.001). Also, based on the fully adjusted model, the odds of NAFLD were increased according to tertiles of ELIR (OR = 2.66; 95% CI: 1.38–5.10, P trend = 0.006). However, no significant association was found between the higher score of EDIR and odds of NAFLD based on the age and sex-adjusted model (OR = 1.18; 95% CI: 0.68–2.05, P trend = 0.52) and the multivariable-adjusted model (OR = 0.91; 95% CI: 0.48–1.70, P trend = 0.87). Originality/value To the best of the authors’ knowledge, this was the first study to examine the role of the insulinemic potential of diet and lifestyle in predicting NAFLD risk. Our findings suggested that a lifestyle with a higher score of ELIR was positively associated with NAFLD risk. However, a diet with a higher score of EDIR was not related to the odds of NAFLD.","PeriodicalId":19376,"journal":{"name":"Nutrition & Food Science","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135044207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bunga Astria Paramashanti, Yhona Paratmanitya, Ignasia Ika Kusumaningtyas, Tri Mei Khasana, Anafrin Yugistyowati, Tri Siswati
{"title":"Minimum dietary diversity and the concurrence of stunting and overweight among infants and young children in Yogyakarta, Indonesia","authors":"Bunga Astria Paramashanti, Yhona Paratmanitya, Ignasia Ika Kusumaningtyas, Tri Mei Khasana, Anafrin Yugistyowati, Tri Siswati","doi":"10.1108/nfs-02-2023-0042","DOIUrl":"https://doi.org/10.1108/nfs-02-2023-0042","url":null,"abstract":"Purpose This study aims to examine the association between minimum dietary diversity (MDD) and the concurrence of stunting and overweight (CSO) among children aged 6–23 months. Design/methodology/approach A cross-sectional study was conducted in Sedayu Subdistrict, Bantul District, Daerah Istimewa Yogyakarta. The authors assessed the concurrence of stunting (height-for-age Z -score below −2 standard deviations SD) and overweight/obesity (Body mass index BMI-for-age Z-score above +2 SD) among a total of 189 children aged 6–23 months as the primary outcome. The authors defined MDD as consuming at least four out of seven food groups using a single 24-h recall. The authors also included other covariates, including sociodemographic characteristics, exclusive breastfeeding history and complementary feeding practices. To identify the factors associated with CSO, this study conducted multiple logistic regression across the study variables using STATA 16.1. Findings In the adjusted model, children who met the MDD criterion were associated with a reduced risk of CSO (adjusted odds ratios [OR]: 0.14; 95%confidence interval CI: 0.03–2.43). Compared to boys, girls were more likely to experience CSO (adjusted OR: 5.23; 95%CI: 1.02–26.9). Middle economic status was a protective factor for CSO (adjusted OR: 0.10; 95%CI: 0.01–0.98). This study did not find a significant relationship between CSO and the child’s age, low birth weight, exclusive breastfeeding, energy intake, protein intake, parental education and parental occupation. Practical implications This study suggests future programs and policies that promote dietary diversity to reduce the risk of CSO. Originality/value This study reveals the association between MDD and the coexistence of stunting and overweight.","PeriodicalId":19376,"journal":{"name":"Nutrition & Food Science","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134883687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}