North American journal of medicine & science最新文献_第6页

Magnetic Resonance Spectroscopy of Adult Thalamic Glioblastoma Multiforme 成人多形性丘脑胶质母细胞瘤的磁共振波谱研究

North American journal of medicine & science Pub Date : 2012-01-31 DOI: 10.7156/V5I1P051

Peng Li, Yingru Liu, Rachael B. Rowswell-Turner, F. Esfahani

引用次数: 0

Novel Chromosomal Aberration as Evidence of Clonal Evolution in a Case of Relapsed Acute Myeloid Leukemia 新染色体畸变作为复发急性髓性白血病克隆进化的证据

North American journal of medicine & science Pub Date : 2012-01-31 DOI: 10.7156/V5I1P048

B. Bai, Z. Zuo, S. Cheong, B. Vo, E. Harper, D. Lovshe, Suxia Yang, C. Yin

{"title":"Novel Chromosomal Aberration as Evidence of Clonal Evolution in a Case of Relapsed Acute Myeloid Leukemia","authors":"B. Bai, Z. Zuo, S. Cheong, B. Vo, E. Harper, D. Lovshe, Suxia Yang, C. Yin","doi":"10.7156/V5I1P048","DOIUrl":"https://doi.org/10.7156/V5I1P048","url":null,"abstract":"Acute myeloid leukemia (AML) is a heterogeneous group of diseases with a multitude of molecular genetic aberrations and variable clinical outcome. Clonal chromosomal abnormalities have been identified in over 50% of AML cases, and have been regarded as one of the most important prognostic markers. We present a case of a 28-year-old Caucasian woman with AML without maturation, diploid karyotype, that was resistant to multiple chemotherapies and relapsed after matched unrelated stem cell transplantation. Conventional cytogenetic analysis performed on bone marrow specimens revealed 46,XX,t(2;16)(p21;p11.2),t(11;14)(p13;p11.2). The t(11;14)(p13;p11.2) was confirmed by fluorescence in situ hybridization using a whole chromosome paint probe for chromosome 11. Morphologically, the bone marrow was hypercellular with trilineage hypoplasia and 84% blasts. Flow cytometry analysis showed that the blasts were of myeloid immunophenotype. Molecular studies detected internal tandem duplication of the FLT3 gene and a mutation in exon 12 of the NPM1 gene. The patient then received monotherapy with AC220, achieved a brief remission, and died of relapsed disease 23 months after initial diagnosis. This is the first report of this novel clonal chromosome aberration as evidence of clonal evolution in AML. [N A J Med Sci. 2012;5(1):48-50.]","PeriodicalId":19338,"journal":{"name":"North American journal of medicine & science","volume":"360 1","pages":"048"},"PeriodicalIF":0.0,"publicationDate":"2012-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82637400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Adrenal Leiomyosarcoma: Case Report and Review of Literature 原发性肾上腺平滑肌肉瘤1例报告及文献复习

North American journal of medicine & science Pub Date : 2012-01-31 DOI: 10.7156/V5I1P058

F. Azzouni, G. Azabdaftari, M. Safwat, T. Schwaab

{"title":"Primary Adrenal Leiomyosarcoma: Case Report and Review of Literature","authors":"F. Azzouni, G. Azabdaftari, M. Safwat, T. Schwaab","doi":"10.7156/V5I1P058","DOIUrl":"https://doi.org/10.7156/V5I1P058","url":null,"abstract":"Primary adrenal leiomyosarcomas are rare and usually symptomatic at presentation. The presentation of a large adrenal mass should raise suspicion of adrenal leiomyosarcoma as a differential diagnosis. To our knowledge, primary adrenal leiomyosarcoma has been reported in 20 cases in the English literature. Here we describe a case of primary adrenal leiomyosarcoma in a 76-year-old Caucasian female. The patient complained of right upper quadrant abdominal pain for 2 months. Contrast-enhanced magnetic resonance imaging showed a heterogeneous 10.5 cm adrenal mass with a suspected inferior vena cava tumor thrombus without lymph node enlargement or distant metastasis. The patient underwent a right adrenalectomy, partial resection of the inferior vena cava and reconstruction of the inferior vena cava with a pericardial patch. Histopathologic examination was consistent with leiomyosarcoma. At 3 months postoperatively, a follow-up computed tomography scan of the chest, abdomen and pelvis without intravenous contrast was done that showed multiple bilateral pulmonary metastatic lesions, bilateral hilar and mediastinal lymphadenopathy, liver metastasis, a new mass at the head of the pancreas, and a new mass at the lower pole of the right kidney. The patient was deemed to be unfit for systemic chemotherapy, and was referred to the hospice service for palliative care. The patient died 4 months after surgery.","PeriodicalId":19338,"journal":{"name":"North American journal of medicine & science","volume":"03 1","pages":"58"},"PeriodicalIF":0.0,"publicationDate":"2012-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86090098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Molecular Diagnostics in Adult Acute Myeloid Leukemia 成人急性髓性白血病的分子诊断

North American journal of medicine & science Pub Date : 2012-01-31 DOI: 10.7156/V5I1P029

A. Svensson, Youjun Hu

引用次数: 1

Global Epidemiology of Hepatitis B Virus (HBV) Infection 乙型肝炎病毒(HBV)感染的全球流行病学

North American journal of medicine & science Pub Date : 2012-01-01 DOI: 10.7156/V4I1P007

E. Hwang, R. Cheung

{"title":"Global Epidemiology of Hepatitis B Virus (HBV) Infection","authors":"E. Hwang, R. Cheung","doi":"10.7156/V4I1P007","DOIUrl":"https://doi.org/10.7156/V4I1P007","url":null,"abstract":"Hepatitis B virus (HBV), a DNA virus with a human-only reservoir, is a worldwide public health problem. Hepatitis B is transmitted through parenteral or mucosal exposure to infected blood and body fluids. The mode of transmission is usually vertical or horizontal in highly endemic areas early in life, resulting in a high chronicity rate. In low endemic countries, transmission is usually in adulthood with self-limiting infection in most. The prevalence of chronic HBV infection is highly variable, ranging from 0.1% in the United States to 20-30% in some Pacific Island nations. There are an estimated 360 million people who are chronically infected, of whom almost one million people die annually of HBV-related liver disease. Chronic hepatitis B is the major cause of hepatocellular carcinoma in the world. Safe and effective HBV vaccines have been available since 1982. The implementation of effective vaccination programs has resulted in a significant decrease in the incidence of chronic hepatitis B infection. Nevertheless, hepatitis B remains an important cause of morbidity and mortality among the chronic carriers worldwide. Understanding the epidemiology of the disease is essential in developing programs to prevent and treat this global infection. [N A J Med Sci. 2011;4(1):7-13.]","PeriodicalId":19338,"journal":{"name":"North American journal of medicine & science","volume":"10 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86851609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 71

Prostatic Ductal Adenocarcinoma Exhibits More Advanced Histopathological Features than Acinar Adenocarcinoma 前列腺导管腺癌比腺泡腺癌表现出更高级的组织病理学特征

North American journal of medicine & science Pub Date : 2012-01-01 DOI: 10.7156/NAJMS.2012.054208

Hervé Huang, Frank Chen

引用次数: 5

Factors Associated with Colorectal Cancer Screening Among Cambodians, Vietnamese, Koreans and Chinese Living in the United States. 生活在美国的柬埔寨人、越南人、韩国人和中国人的结直肠癌筛查相关因素

North American journal of medicine & science Pub Date : 2012-01-01 DOI: 10.7156/v5i1p001

Grace X Ma, Min Qi Wang, Jamil Toubbeh, Yin Tan, Steven Shive, Dunli Wu

{"title":"Factors Associated with Colorectal Cancer Screening Among Cambodians, Vietnamese, Koreans and Chinese Living in the United States.","authors":"Grace X Ma, Min Qi Wang, Jamil Toubbeh, Yin Tan, Steven Shive, Dunli Wu","doi":"10.7156/v5i1p001","DOIUrl":"https://doi.org/10.7156/v5i1p001","url":null,"abstract":"<p><p>The purpose of this community-based participatory study was to identify factors associated with colorectal cancer (CRC) screening compliance and non-compliance among Cambodians, Vietnamese, Koreans and Chinese men and women 50 years and older living in the United States. A cross-sectional design was used in the study. The completed sample included 815 Asian Americans which included Cambodians (N=215), Vietnamese (N=195), Koreans (N=94) and Chinese (N=311). A 95-item questionnaire was developed and pilot tested for content validity and reliability. An in-person data collection approach was utilized and participants were given choice in responding in English or their native language. Of the 815 participants, 79.1% (N=645) reported never-screened, 7.9% (N=64), non-compliance, and 13.0% (N=106) compliance. Education was significantly associated with never-screened for CRC for Vietnamese and Chinese; employment status for Cambodians and Koreans; lack of health insurance for Cambodians, Korean and Chinese; English fluency and years lived in the U.S. for Vietnamese, Koreans, and Chinese. Less acculturated Asian Americans were more likely to be never screened, but differentially across ethnic subgroups. Barriers to screening included lack of knowledge, language, transportation, and time. Increased culturally-targeted public awareness and education programs are needed to improve CRC screening and compliance among high risk Asian American ethnic subgroups.</p>","PeriodicalId":19338,"journal":{"name":"North American journal of medicine & science","volume":"5 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521597/pdf/nihms360419.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31125972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Review of the Multi-Level Factors Contributing to Fruit and Vegetable Consumption in the US 影响美国果蔬消费的多层次因素综述

North American journal of medicine & science Pub Date : 2011-10-30 DOI: 10.7156/V4I4P232

Qi Zhang, B. L. Fu

引用次数: 6

Macrophage Polarization and Inflammation at the Interface of Cardiovascular Disease and Metabolism 巨噬细胞极化和炎症在心血管疾病和代谢的界面

North American journal of medicine & science Pub Date : 2011-10-30 DOI: 10.7156/V4I4P191

Zhuxia Shen, Mingxing Lu, S. Duan, Shengzhong Duan

引用次数: 7

Maternal Diabetes and Autism Spectrum Disorders in the Offspring: A Review of Epidemiological Evidence and Potential Biologic Mechanisms 母亲糖尿病和后代自闭症谱系障碍:流行病学证据和潜在生物学机制的综述

North American journal of medicine & science Pub Date : 2011-10-30 DOI: 10.7156/V4I4P217

K. Bowers, Cuilin Zhang

引用次数: 5