North American journal of medicine & science最新文献_第2页

Toward Best Practice in Using Molecular Diagnosis to Guide Medical Management, Are We There Yet? 用分子诊断指导医疗管理的最佳实践，我们到了吗?

North American journal of medicine & science Pub Date : 2014-10-01

Anne Chun-Hui Tsai, Xuezhong Liu

引用次数: 0

Hepatitis C Virus Mediated Hepatocellular Carcinoma: A Focused Review for a Time of Changing Therapeutic Options 丙型肝炎病毒介导的肝细胞癌:改变治疗选择的重点回顾

North American journal of medicine & science Pub Date : 2014-07-31 DOI: 10.7156/NAJMS.2014.0701008

Jesse M Civan, H. Hann

引用次数: 6

Folate Receptor Alpha Autoantibodies Modulate Thyroid Function in Autism Spectrum Disorder 叶酸受体α自身抗体调节自闭症谱系障碍患者的甲状腺功能

North American journal of medicine & science Pub Date : 2014-07-31 DOI: 10.7156/NAJMS.2014.0702053

R. Frye, J. M. Sequeira, E. Quadros, D. Rossignol

{"title":"Folate Receptor Alpha Autoantibodies Modulate Thyroid Function in Autism Spectrum Disorder","authors":"R. Frye, J. M. Sequeira, E. Quadros, D. Rossignol","doi":"10.7156/NAJMS.2014.0702053","DOIUrl":"https://doi.org/10.7156/NAJMS.2014.0702053","url":null,"abstract":"The folate receptor alpha (FRα) is essential for folate transportation across the blood-brain barrier and is closely associated with cerebral folate deficiency, a syndrome that commonly presents with autism spectrum disorder (ASD) features. FRα autoantibodies (FRAAs) interrupt FRα function and have a high prevalence in children with ASD. Since the FRα is also located on the thyroid, FRAAs could also interfere with thyroid function. Interestingly, ASD has been inconsistently associated with hypothyroidism. The aim of this study was to determine if thyroid dysfunction in ASD could be related to FRAAs. To this end we investigated the relationship between serum FRAA titers (both blocking and binding) and thyroid stimulating hormone (TSH) in 32 children with ASD. Blocking, but not binding, FRAAs were found to be related to TSH levels. Higher FRAAs were significantly correlated with higher TSH concentrations (r = 0.36, p = 0.025), while ASD children who were positive for blocking FRAAs demonstrated a significantly higher serum concentration of TSH than children who were negative for FRAAs (t(31) = 2.07, p = 0.02). These results are consistent with the notion that blocking FRAAs are associated with reduced thyroid function and suggest that thyroid function should be examined in children with ASD who are positive for the blocking FRAAs.","PeriodicalId":19338,"journal":{"name":"North American journal of medicine & science","volume":"44 1","pages":"053"},"PeriodicalIF":0.0,"publicationDate":"2014-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78971235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Eosinophilic Esophagitis Presenting as Complete Esophageal Desquamation: An Unusual Case of Chest Pain 嗜酸性粒细胞性食管炎表现为完全性食管脱屑:一例罕见的胸痛病例

North American journal of medicine & science Pub Date : 2014-07-31 DOI: 10.7156/NAJMS.2014.0702081

Kheng-Jim Lim, Lanjing Zhang, Anish Sheth

引用次数: 0

Study of the Application of Clinical Pathways in Varicella, Acute Bacillary Dysentery, Measles, Scarlet Fever, and Rubella 临床路径在水痘、急性细菌性痢疾、麻疹、猩红热、风疹中的应用研究

North American journal of medicine & science Pub Date : 2014-07-31 DOI: 10.7156/NAJMS.2014.0702063

Zhe Xu, E. Qin, Min Zhao, Weimin Nie, Zhi-ping Zhou, B. Tu, Weiwei Chen, B. Wu, Fei Wang, Jin Li

{"title":"Study of the Application of Clinical Pathways in Varicella, Acute Bacillary Dysentery, Measles, Scarlet Fever, and Rubella","authors":"Zhe Xu, E. Qin, Min Zhao, Weimin Nie, Zhi-ping Zhou, B. Tu, Weiwei Chen, B. Wu, Fei Wang, Jin Li","doi":"10.7156/NAJMS.2014.0702063","DOIUrl":"https://doi.org/10.7156/NAJMS.2014.0702063","url":null,"abstract":"In order to explore the clinical pathways that fit the actual situation of our country and department of infectious diseases, an analysis was performed to evaluate the effectiveness of clinical pathways for varicella, acute bacillary dysentery, measles, scarlet fever and rubella when compared with traditional standard medical care. Using a retrospective comparative study design, varicella, acute bacillary dysentery, measles, scarlet fever and rubella patients who were managed on a clinical pathway (clinical pathway group) were compared with a retrospective group of patients who received traditional medical care (control group) prior to the pathway's implementation. The following outcomes were measured: length of hospital stay, hospitalization costs. There was a significant reduction in the median hospitalization costs in the clinical pathway group patients in all five infectious diseases (P<0.05). The clinical pathway group's length of hospital stay for varicella, measles, acute bacillary dysentery and rubella were significantly shorter than the control group (P<0.05). The implementation of clinical pathways in varicella, acute bacillary dysentery, measles, scarlet fever and rubella might contribute to better quality of care and cost-effectiveness.","PeriodicalId":19338,"journal":{"name":"North American journal of medicine & science","volume":"100 1","pages":"063"},"PeriodicalIF":0.0,"publicationDate":"2014-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73623555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of the Natural History of Chronic Hepatitis C Infection 慢性丙型肝炎感染的自然史综述

North American journal of medicine & science Pub Date : 2014-07-31 DOI: 10.7156/NAJMS.2014.0701001

Julius M. Wilder, K. Patel

引用次数: 6

Anti-HBV Activities of Xanthones From Swertia Punicea Hemsl 獐牙菜口山酮抗hbv活性研究

North American journal of medicine & science Pub Date : 2014-07-31 DOI: 10.7156/NAJMS.2014.0702072

Xiu-qiao Zhang, Jiachun Chen, Feng-jiao Huang, L. Tian, Y. Tu

{"title":"Anti-HBV Activities of Xanthones From Swertia Punicea Hemsl","authors":"Xiu-qiao Zhang, Jiachun Chen, Feng-jiao Huang, L. Tian, Y. Tu","doi":"10.7156/NAJMS.2014.0702072","DOIUrl":"https://doi.org/10.7156/NAJMS.2014.0702072","url":null,"abstract":"We studied the effects of two xanthones compounds isolated from Swertia punicea Hemsl (from Geutianaceae), swertianolin (I) and bellidifolin (II), on Hepatitis B surface antigen (HBsAg) and e antigen (HBeAg) in cultured human hepatocellular carcinoma cell line (HepG 2 ). The HepG 2 cells were first cultured for 24h, various concentrations of these two xanthones were then added to the culture medium. The culture medium containing the two xanthones was exchanged once every 4 days. After 8 days, the cytotoxic activities of these two xanthones were assessed by cytopathic effect. The HepG 2 cells were then treated with the two compounds at a concentration of swertianolin (1.6, 3.1, 6.2, 12.5, 25 m g/ml) and bellidifolin (2.0, 3.9, 7.8, 25.5, 31.2 m g/ml). Four or eight days later, the culture medium was collected and the expression of HBsAg and HBeAg were determined by radioimmunoassay. Our results show that swertianolin can suppress the expression of HBeAg with IC 50 of 8.0 m g/ml, while bellidifolin can inhibit the expression of HBsAg with IC 50 of 13 m g/ml at the eighth days. The Therapeutic Index for swertianolin and bellidifolin are 6.2 and 6.8, respectively. Our findings suggest that swertianolin and bellidifolin have anti-HBV activities in vitro.","PeriodicalId":19338,"journal":{"name":"North American journal of medicine & science","volume":"46 1","pages":"072"},"PeriodicalIF":0.0,"publicationDate":"2014-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87904639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Validity of Fine Needle Aspiration Cytology in Diagnosis of Prostatic Lesions and Correlation with Trucut Biopsy 细针穿刺细胞学诊断前列腺病变的有效性及其与前列腺活检的相关性

North American journal of medicine & science Pub Date : 2014-07-31 DOI: 10.7156/NAJMS.2014.0702075

J. J. Thangaiah, K. Balachandran, U. Poothiode, S. Bhat

{"title":"Validity of Fine Needle Aspiration Cytology in Diagnosis of Prostatic Lesions and Correlation with Trucut Biopsy","authors":"J. J. Thangaiah, K. Balachandran, U. Poothiode, S. Bhat","doi":"10.7156/NAJMS.2014.0702075","DOIUrl":"https://doi.org/10.7156/NAJMS.2014.0702075","url":null,"abstract":"Prostate fine needle aspiration (FNA) is an easy-to-perform outpatient procedure requiring no expensive equipment or anesthesia. The aim of this study was to analyze the cytomorphology of prostatic lesions and to correlate the findings in cytology with that of the histopathological appearance. In doing so we also assessed the diagnostic accuracy of fine needle aspiration cytology and identified possible pitfalls. The study was carried out in 100 patients who underwent tru-cut biopsy in the department of Urology at Kottayam Medical College, India during the period spanning from March 2010 to March 2011. Fine needle aspiration cytology (FNAC) was done with Franzen needle and followed by tru-cut biopsy after which the results of both were compared. FNAC gave a benign diagnosis in 64 cases and identified a malignant pattern in 36 cases. The overall accuracy of FNAC in this series in diagnosing prostatic lesions was 97% with a sensitivity of 100% and specificity of 95.5%. This shows that FNAC prostate is a reliable, relatively painless tool, which can be used for the diagnosis of prostatic carcinoma, especially in patients with high risk complications such as bleeding and infections in whom a tru-cut biopsy is more invasive. In addition it is also cost-effective and may sample a larger area.","PeriodicalId":19338,"journal":{"name":"North American journal of medicine & science","volume":"63 1","pages":"075"},"PeriodicalIF":0.0,"publicationDate":"2014-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79685529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Management of HCV Treatment-related Side-effects, Toxicity, and Drug-interactions HCV治疗相关副作用、毒性和药物相互作用的管理

North American journal of medicine & science Pub Date : 2014-07-31 DOI: 10.7156/NAJMS.2014.0701033

PharmD Jenna K. Kawamoto, P. Smith, Agaf Steven-Huy B. Han

引用次数: 0

Clinical Evaluation of Chronic Hepatitis C and Indications for HCV Treatment 慢性丙型肝炎的临床评价及治疗适应症

North American journal of medicine & science Pub Date : 2014-07-31 DOI: 10.7156/NAJMS.2014.0701017

V. Sundaram, T. Tran

引用次数: 1