{"title":"Aneurysm Wall Enhancement Can Predict Rupture Point in Intracranial Aneurysms With Multiple Blebs.","authors":"Shunsuke Omodaka, Shin-Ichiro Sugiyama, Hiroyuki Sakata, Kenichi Funamoto, Takuhiro Yamaguchi, Kuniyasu Niizuma, Hidenori Endo","doi":"10.1227/neu.0000000000003134","DOIUrl":"https://doi.org/10.1227/neu.0000000000003134","url":null,"abstract":"<p><strong>Background and objectives: </strong>Ruptured aneurysms visualized by vessel wall MRI (VW-MRI) exhibit characteristic aneurysm wall enhancement (AWE). A secondary bulge of the aneurysmal wall, called a bleb, is often the site of rupture in ruptured aneurysms. We hypothesized that a higher degree of AWE would identify the rupture point in aneurysms with multiple blebs.</p><p><strong>Methods: </strong>AWE was quantitatively analyzed in consecutive ruptured intracranial aneurysms with multiple blebs (31 aneurysms with a total of 72 blebs) using VW-MRI. A 3-dimensional T1-weighted fast spin-echo sequence was obtained after contrast media injection, and the contrast ratio of the aneurysm wall against the pituitary stalk (CRstalk) was calculated as the AWE indicator. Bleb characteristics, including CRstalk and wall shear stress (WSS), were compared between ruptured and unruptured blebs. Odds ratios with 95% confidence intervals for ruptures were calculated by conditional logistic regression analysis.</p><p><strong>Results: </strong>Ruptured blebs had a higher CRstalk and lower WSS compared with unruptured blebs. CRstalk remained significantly associated with the bleb rupture status in the conditional logistic regression (adjusted odds ratio 3.9, 95% CIs 1.6-9.7).</p><p><strong>Conclusion: </strong>AWE is associated with the bleb rupture status independent of WSS. Contrast-enhanced VW-MRI may be a useful noninvasive tool for identifying the rupture point and guiding the treatment strategy.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurosurgeryPub Date : 2024-08-08DOI: 10.1227/neu.0000000000003132
Birra R Taha
{"title":"Evaluating Linear Heuristics for Ventricular Volume in Healthy Adults Using a Fully Automated Algorithm: Implications for Defining the Normal.","authors":"Birra R Taha","doi":"10.1227/neu.0000000000003132","DOIUrl":"https://doi.org/10.1227/neu.0000000000003132","url":null,"abstract":"<p><strong>Background and objectives: </strong>Linear metrics for ventricular volume play a large role in the rapid, approximate evaluation of ventricular volume. In this article, we automatically extract linear measures of ventricular volume to explore their correlation with lateral ventricular volume (LVV) in the healthy adult population and comprehensively define normal values.</p><p><strong>Methods: </strong>We automatically extract Evans' ratio (ER), Frontal-Occipital Horn Ratio (FOHR), and anteroposterior lateral ventricle index (ALVI) from an open MRI data set of healthy adults (https://brain-development.org/ixi-dataset/). Indices have been correlated with corresponding LVVs and lateral ventricular volumes divided by supratentorial brain volumes. Spearman rank correlation was used to compare strength of correlation.</p><p><strong>Results: </strong>ER shows correlation with lateral ventricle volume based on sex (r = 0.58; men, r = 0.65; women P < .001), including when controlling for supratentorial volume (r = 0.57; men, r = 0.63). ER did not profoundly correlate with age (r = 0.29, men; r = 0.35, women; P < .001) and seemed normally distributed around 0.25. ALVI showed strong correlation with LVV with only slight gender differences (r = 0.83, men; r = 0.84, women) and LVV to supratentorial cortical volume ratio (r = 0.9, men; r = 0.86, women). FOHR was also normally distributed around a value of 0.37 and showed moderate correlation with LVV (r = 0.68, men; r = 0.73, women) and LVV to supratentorial cortical volume ratio (r = 0.69, men; r = 0.74, women).</p><p><strong>Conclusion: </strong>ALVI is a newer index with strong correlation with LVV and has strong potential for clinical use. Both FOHR and ER show moderate correlation with LVV. Reference values for linear estimates of ventricular volume may help clinicians better identify patients with pathological ventriculomegaly.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurosurgeryPub Date : 2024-08-08DOI: 10.1227/neu.0000000000003144
Ashwin Kumaria
{"title":"Commentary: Gene Expression Changes Associated With Recurrence After Gross Total Resection of Newly Diagnosed World Health Organization Grade 1 Meningioma.","authors":"Ashwin Kumaria","doi":"10.1227/neu.0000000000003144","DOIUrl":"https://doi.org/10.1227/neu.0000000000003144","url":null,"abstract":"","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurosurgeryPub Date : 2024-08-08DOI: 10.1227/neu.0000000000003136
Li Ma, Samer S Hoz, Mohamed F Doheim, Ali Fadhil, Abdullah Sultany, Alhamza R Al-Bayati, Raul G Nogueira, Michael J Lang, Bradley A Gross
{"title":"Middle Meningeal Artery Embolization for \"Trial-Ineligible\" Chronic Subdural Hematomas.","authors":"Li Ma, Samer S Hoz, Mohamed F Doheim, Ali Fadhil, Abdullah Sultany, Alhamza R Al-Bayati, Raul G Nogueira, Michael J Lang, Bradley A Gross","doi":"10.1227/neu.0000000000003136","DOIUrl":"https://doi.org/10.1227/neu.0000000000003136","url":null,"abstract":"<p><strong>Background and objectives: </strong>The benefit of middle meningeal artery embolization (MMAE) in the treatment of chronic subdural hematoma (CSDH) has been recently demonstrated in a series of clinical trials. Whether MMAE benefits \"trial-ineligible\" patients remains elusive. We thus sought to explore the potential benefit of MMAE in neurologically stable (modified Rankin Scale ≤3) patients with \"trial-ineligible\" CSDHs because of large size: Thickness >15 mm and/or midline shift ≥5 mm.</p><p><strong>Methods: </strong>A prospectively maintained database was reviewed to identify trial-ineligible CSDHs undergoing standalone MMAE. Surgical rescue rate, hematoma resolution, and neurological deterioration after hematoma progression were evaluated and compared with trial-eligible counterparts. Effect sizes were adjusted for demographic, clinical, and radiological features using multivariable regression.</p><p><strong>Results: </strong>Of 150 standalone MMAE procedures, 92 (61%) were performed in \"trial-ineligible\" cases: 41% with CSDH thickness >15 mm, 21% with midline shift ≥5 mm, and 38% with both. The surgical rescue rate was 7.6% in the trial-ineligible cohort. Over a median follow-up of 62.5 days, 88.9% cases achieved satisfactory hematoma resolution (≥50% in thickness); 76% had satisfactory resolution at 90-day follow-up. Antithrombotic resumption was a risk factor for surgical rescue (adjusted odds ratio 9.64 [95% CI, 1.33-69.74]; P = .02). Surgical rescue and hematoma resolution did not significantly differ between trial-ineligible and trial-eligible cohorts (P = .87 for surgical rescue rate and P = .85 for hematoma resolution rate).</p><p><strong>Conclusion: </strong>This study emphasizes the considerable prevalence of potentially \"trial-ineligible\" patients with CSDHs because of large size that may still benefit from standalone MMAE.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurosurgeryPub Date : 2024-08-05DOI: 10.1227/neu.0000000000003133
Ramin A Morshed, Minh P Nguyen, Mark W Youngblood, Haley K Perlow, Calixto-Hope G Lucas, Akash J Patel, Joshua D Palmer, James P Chandler, Philip V Theodosopoulos, Stephen T Magill, William C Chen, David R Raleigh
{"title":"Gene Expression Changes Associated With Recurrence After Gross Total Resection of Newly Diagnosed World Health Organization Grade 1 Meningioma.","authors":"Ramin A Morshed, Minh P Nguyen, Mark W Youngblood, Haley K Perlow, Calixto-Hope G Lucas, Akash J Patel, Joshua D Palmer, James P Chandler, Philip V Theodosopoulos, Stephen T Magill, William C Chen, David R Raleigh","doi":"10.1227/neu.0000000000003133","DOIUrl":"https://doi.org/10.1227/neu.0000000000003133","url":null,"abstract":"<p><strong>Background and objective: </strong>Patients who undergo gross total resection (GTR) of Central Nervous System World Health Organization (WHO) grade 1 meningioma constitute a \"low-risk\" group, but some low-risk meningiomas can recur despite reassuring clinical and histological features. In this study, gene expression values in newly diagnosed WHO grade 1 meningiomas that had undergone GTR were evaluated for their association with recurrence.</p><p><strong>Methods: </strong>This was a retrospective, international, multicenter cohort study that included WHO grade 1 meningiomas that underwent GTR, as first treatment, based on postoperative magnetic resonance imaging. Normalized gene expression values from a previously validated 34-gene panel were evaluated for their association with recurrence. Kaplan-Meier, multivariable Cox proportional hazard analyses, and K-means clustering were performed to assess the association of genes of interest with recurrence and identify molecular subgroups among clinically and histologically low-risk meningiomas.</p><p><strong>Results: </strong>In total, 442 patients with WHO grade 1 meningiomas that underwent GTR and had available gene expression profiling data were included in the study. The median follow-up was 5.0 years (interquartile range 2.6-7.7 years), local recurrence occurred in 36 patients (8.1%), 5-year local freedom from recurrence was 90.5%, and median time to recurrence was 2.9 years (range 0.5-10.7 years). Eleven genes were associated with local recurrence, including lower expression of ARID1B, ESR1, LINC02593, PGR, and TMEM30B and higher expression of CDK6, CDKN2C, CKS2, KIF20A, PGK1, and TAGLN. Of these genes, PGK1 had the largest effect size. K-means clustering based on these 11 genes distinguished 2 molecular groups of clinically and histologically low-risk meningiomas with significant differences in local freedom from recurrence (hazard ratio 2.5, 95% CI 1.2-5.1, P = .016).</p><p><strong>Conclusion: </strong>Gene expression profiling may help to identify newly diagnosed WHO grade 1 meningiomas that have an elevated risk of recurrence despite GTR.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurosurgeryPub Date : 2024-08-05DOI: 10.1227/neu.0000000000003130
Yuanxuan Xia, Pritika Papali, Abdel-Hameed Al-Mistarehi, Landon J Hansen, Tej D Azad, A Karim Ahmed, Christian Meyer, John Gross, Majid Khan, Chetan Bettegowda, Debraj Mukherjee, Timothy Witham, Ali Bydon, Nicholas Theodore, Jean-Paul Wolinsky, Ziya Gokaslan, Sheng-Fu Larry Lo, Daniel Sciubba, Sang H Lee, Kristin J Redmond, Daniel Lubelski
{"title":"Outcomes After Definitive Surgery for Spinal and Sacral Chordoma in 101 Patients Over 20 Years.","authors":"Yuanxuan Xia, Pritika Papali, Abdel-Hameed Al-Mistarehi, Landon J Hansen, Tej D Azad, A Karim Ahmed, Christian Meyer, John Gross, Majid Khan, Chetan Bettegowda, Debraj Mukherjee, Timothy Witham, Ali Bydon, Nicholas Theodore, Jean-Paul Wolinsky, Ziya Gokaslan, Sheng-Fu Larry Lo, Daniel Sciubba, Sang H Lee, Kristin J Redmond, Daniel Lubelski","doi":"10.1227/neu.0000000000003130","DOIUrl":"https://doi.org/10.1227/neu.0000000000003130","url":null,"abstract":"<p><strong>Background and objectives: </strong>Spinal chordomas are primary bone tumors where surgery remains the primary treatment. However, their low incidence, lack of evidence, and late disease presentation make them challenging to manage. Here, we report the postoperative outcomes of a large cohort of patients after surgical resection, investigate predictors for overall survival (OS) and local recurrence-free survival (LRFS) times, and trend functional outcomes over multiple time periods.</p><p><strong>Methods: </strong>Retrospective review of all patients followed for spinal chordoma at a quaternary spinal oncology center from 2003 to 2023 was included. Data were collected regarding demographics, preoperative and perioperative management, and follow-up since initial definitive surgery. Primary outcomes were OS and LRFS, whereas secondary outcomes were functional deficits.</p><p><strong>Results: </strong>One hundred one patients had an average follow-up of 6.0 ± 4.2 years. At the time of census, 25/101 (24.8%) had experienced a recurrence and 10/101 (9.9%) had died. After surgery, patients experienced a significant decrease in pain over time, but rates of sensory deficits, weakness, and bowel/bladder dysfunction remained static. Tumors ≥100 cm3 (hazard ratio (HR) = 5.89, 95% CI 1.72-20.18, P = .005) and mobile spine chordomas (HR = 7.73, 95% CI 2.09-28.59, P = .002) are related to worse LRFS, whereas having neoadjuvant radiotherapy is associated with improved LRFS (HR = 0.09, 95% CI 0.01-0.88, P = .038). On the other hand, being age ≥65 years was associated with decreased OS (HR = 16.70, 95% CI 1.54-181.28, P = .021).</p><p><strong>Conclusion: </strong>Surgeons must often weigh the pros and cons of en bloc resection and sacrificing important but affected native tissues. Our findings can provide a benchmark for counseling patients with spinal chordoma. Tumors ≥100 cm3 appear to have a 5.89-times higher risk of recurrence, mobile spine chordomas have a 7.73 times higher risk, and neoadjuvant radiotherapy confers an 11.1 times lower risk for local recurrence. Patients age ≥65 years at surgery have a 16.70 times higher risk of mortality than those <65 years.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurosurgeryPub Date : 2024-08-01Epub Date: 2024-06-13DOI: 10.1227/neu.0000000000003045
Mohammad Sadegh Fallahi, Seyed Farzad Maroufi, Jason P Sheehan
{"title":"In Reply: Radiosurgery With Prior Embolization Versus Radiosurgery Alone for Intracranial Arteriovenous Malformations: A Systematic Review and Meta-Analysis.","authors":"Mohammad Sadegh Fallahi, Seyed Farzad Maroufi, Jason P Sheehan","doi":"10.1227/neu.0000000000003045","DOIUrl":"10.1227/neu.0000000000003045","url":null,"abstract":"","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurosurgeryPub Date : 2024-08-01Epub Date: 2024-06-13DOI: 10.1227/neu.0000000000003044
Shaopeng Chen
{"title":"Letter: Radiosurgery With Prior Embolization Versus Radiosurgery Alone for Intracranial Arteriovenous Malformations: A Systematic Review and Meta-Analysis.","authors":"Shaopeng Chen","doi":"10.1227/neu.0000000000003044","DOIUrl":"10.1227/neu.0000000000003044","url":null,"abstract":"","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurosurgeryPub Date : 2024-08-01Epub Date: 2024-03-21DOI: 10.1227/neu.0000000000002902
José Pedro Lavrador, Ana Mirallave-Pescador, Christos Soumpasis, Alba Díaz Baamonde, Jahard Aliaga-Arias, Asfand Baig Mirza, Sabina Patel, José David Siado Mosquera, Richard Gullan, Keyoumars Ashkan, Ranjeev Bhangoo, Francesco Vergani
{"title":"Transcranial Magnetic Stimulation-Based Machine Learning Prediction of Tumor Grading in Motor-Eloquent Gliomas.","authors":"José Pedro Lavrador, Ana Mirallave-Pescador, Christos Soumpasis, Alba Díaz Baamonde, Jahard Aliaga-Arias, Asfand Baig Mirza, Sabina Patel, José David Siado Mosquera, Richard Gullan, Keyoumars Ashkan, Ranjeev Bhangoo, Francesco Vergani","doi":"10.1227/neu.0000000000002902","DOIUrl":"10.1227/neu.0000000000002902","url":null,"abstract":"<p><strong>Background: </strong>Navigated transcranial magnetic stimulation (nTMS) is a well-established preoperative mapping tool for motor-eloquent glioma surgery. Machine learning (ML) and nTMS may improve clinical outcome prediction and histological correlation.</p><p><strong>Methods: </strong>This was a retrospective cohort study of patients who underwent surgery for motor-eloquent gliomas between 2018 and 2022. Ten healthy subjects were included. Preoperative nTMS-derived variables were collected: resting motor threshold (RMT), interhemispheric RMT ratio (iRMTr)-abnormal if above 10%-and cortical excitability score-number of abnormal iRMTrs. World Health Organization (WHO) grade and molecular profile were collected to characterize each tumor. ML models were fitted to the data after statistical feature selection to predict tumor grade.</p><p><strong>Results: </strong>A total of 177 patients were recruited: WHO grade 2-32 patients, WHO grade 3-65 patients, and WHO grade 4-80 patients. For the upper limb, abnormal iRMTr were identified in 22.7% of WHO grade 2, 62.5% of WHO grade 3, and 75.4% of WHO grade 4 patients. For the lower limb, iRMTr was abnormal in 23.1% of WHO grade 2, 67.6% of WHO grade 3%, and 63.6% of WHO grade 4 patients. Cortical excitability score ( P = .04) was statistically significantly related with WHO grading. Using these variables as predictors, the ML model had an accuracy of 0.57 to predict WHO grade 4 lesions. In subgroup analysis of high-grade gliomas vs low-grade gliomas, the accuracy for high-grade gliomas prediction increased to 0.83. The inclusion of molecular data into the model-IDH mutation and 1p19q codeletion status-increases the accuracy of the model in predicting tumor grading (0.95 and 0.74, respectively).</p><p><strong>Conclusion: </strong>ML algorithms based on nTMS-derived interhemispheric excitability assessment provide accurate predictions of HGGs affecting the motor pathway. Their accuracy is further increased when molecular data are fitted onto the model paving the way for a joint preoperative approach with radiogenomics.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurosurgeryPub Date : 2024-08-01Epub Date: 2024-03-21DOI: 10.1227/neu.0000000000002897
Eric J Lehrer, William G Breen, Raj Singh, Joshua D Palmer, Paul D Brown, Daniel M Trifiletti, Jason P Sheehan
{"title":"Hypofractionated Stereotactic Radiosurgery in the Management of Brain Metastases.","authors":"Eric J Lehrer, William G Breen, Raj Singh, Joshua D Palmer, Paul D Brown, Daniel M Trifiletti, Jason P Sheehan","doi":"10.1227/neu.0000000000002897","DOIUrl":"10.1227/neu.0000000000002897","url":null,"abstract":"<p><p>Stereotactic radiosurgery (SRS) is an important weapon in the management of brain metastases. Single-fraction SRS is associated with local control rates ranging from approximately 70% to 100%, which are largely dependent on lesion and postoperative cavity size. The rates of local control and improved neurocognitive outcomes compared with conventional whole-brain radiation therapy have led to increased adoption of SRS in these settings. However, when treating larger targets and/or targets located in eloquent locations, the risk of normal tissue toxicity and adverse radiation effects within healthy brain tissue becomes significantly higher. Thus, hypofractionated SRS has become a widely adopted approach, which allows for the delivery of ablative doses of radiation while also minimizing the risk of toxicity. This approach has been studied in multiple retrospective reports in both the postoperative and intact settings. While there are no reported randomized data to date, there are trials underway evaluating this paradigm. In this article, we review the role of hypofractionated SRS in the management of brain metastases and emerging data that will serve to validate this treatment approach. Pertinent articles and references were obtained from a comprehensive search of PubMed/MEDLINE and clinicaltrials.gov .</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}