Neurosurgery最新文献

筛选
英文 中文
Heparin-Binding Protein as a Diagnostic Biomarker for Healthcare-Associated Meningitis and Ventriculitis in Pediatric Patients. 肝素结合蛋白作为儿科患者医疗相关脑膜炎和脑室炎的诊断性生物标志物
IF 3.9 2区 医学
Neurosurgery Pub Date : 2025-06-13 DOI: 10.1227/neu.0000000000003505
Yueyue Kong, Jiahao Niu, Zhiming Liu, Wentao Zhou, Yongji Tian, Guangzhi Shi
{"title":"Heparin-Binding Protein as a Diagnostic Biomarker for Healthcare-Associated Meningitis and Ventriculitis in Pediatric Patients.","authors":"Yueyue Kong, Jiahao Niu, Zhiming Liu, Wentao Zhou, Yongji Tian, Guangzhi Shi","doi":"10.1227/neu.0000000000003505","DOIUrl":"https://doi.org/10.1227/neu.0000000000003505","url":null,"abstract":"<p><strong>Background and objectives: </strong>Early and accurate diagnosis of meningitis and ventriculitis after craniotomy is still quite challenging. The research aimed to examine if cerebrospinal fluid (CSF) heparin-binding protein (HBP) can enhance the accuracy in diagnosing healthcare-associated meningitis or ventriculitis in children compared with lactate and procalcitonin (PCT).</p><p><strong>Methods: </strong>Children with craniotomy for ventricular system tumors were eligible for this prospective observational cohort study. Heparin-binding protein, PCT, white blood cell count, glucose, protein, and lactate in CSF were tested when children were suspected of developing CSF infections, as were Gram staining and cultures.</p><p><strong>Results: </strong>Among 122 eligible participants, 116 with 279 samples were enrolled in the final analysis, including 71 children (142 samples) with healthcare-associated meningitis or ventriculitis as the infected group and 45 children (137 samples) with no CSF infections as the control group. Heparin-binding protein presented a substantially increased pattern in patients with postoperative meningitis or ventriculitis contrasted with control patients (180 [120-212] ng/mL in the infected group vs 12 [3-58] ng/mL in the controls). Heparin-binding protein achieved the highest area under the receiver operating characteristic curve of 0.93 (95% confidence interval, 0.91-0.96), a sensitivity of 89%, a specificity of 81%, a positive predictive value of 83%, and a negative predictive value of 87% with a cutoff value of >74 ng/mL, followed by lactate (0.90 [0.87-0.94]) and PCT (0.66 [0.60-0.73]). The protein was the only biomarker that elevated significantly in all culture-positive patients without the influence of empiric antibiotics.</p><p><strong>Conclusion: </strong>CSF HBP is a more accurate candidate biomarker superior to lactate and PCT for diagnosing healthcare-associated meningitis and ventriculitis among pediatric patients. Early HBP analysis of CSF in suspected patients may facilitate early detection of CSF infections.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural History of Sporadic Cerebral Cavernous Malformations by Zabramski Classification: Hemorrhage Risk and Functional Outcomes Over 5 Years. 散发性脑海绵状畸形的Zabramski分类的自然历史:出血风险和5年以上的功能结局。
IF 3.9 2区 医学
Neurosurgery Pub Date : 2025-06-13 DOI: 10.1227/neu.0000000000003565
Delal Bektas, Giuseppe Lanzino, Kelly D Flemming
{"title":"Natural History of Sporadic Cerebral Cavernous Malformations by Zabramski Classification: Hemorrhage Risk and Functional Outcomes Over 5 Years.","authors":"Delal Bektas, Giuseppe Lanzino, Kelly D Flemming","doi":"10.1227/neu.0000000000003565","DOIUrl":"https://doi.org/10.1227/neu.0000000000003565","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study aimed to investigate the clinical presentation, natural history, and long-term outcome of sporadic cerebral cavernous malformations (CCMs) based on initial Zabramski classification.</p><p><strong>Methods: </strong>A prospective cohort of 285 patients with sporadic CCMs was analyzed. Patients were classified into Zabramski Types I-IV based on diagnostic MRI. Clinical presentation, lesion size, location, and developmental venous anomaly presence were recorded. Prospective symptomatic hemorrhage (SH) (censored at first hemorrhage, surgery, or last follow-up) and functional outcomes were assessed using Kaplan-Meier and Cox regression analyses. Functional outcomes were measured with the modified Rankin Scale (mRS) at baseline, annually, and at the last follow-up.</p><p><strong>Results: </strong>The cohort included 58.9% women and 41.1% men, with a mean age at diagnosis of 44.5 years. Zabramski Types I-IV (n = 113, 125, 40, and 7, respectively) differed significantly in clinical presentation (P < .001). Type I lesions were symptomatic in 97.3%, Types II and III in 34.4% and 22.5%, respectively, while all Type IV lesions were asymptomatic. Type I lesions had the highest annual hemorrhage rate (13.9% per year) and a 5-year cumulative risk of 50.6%. Types II and III had lower rates (2.9% and 1.8%), whereas no hemorrhages occurred in Type IV lesions. At baseline, 70.8% of Type I patients had mRS ≥2, which decreased to 35.4% at the last follow-up. Type III lesions had favorable outcomes, with 7.5% of patients having mRS ≥2 at the last follow-up. Type IV lesions remained asymptomatic throughout. Severe SH significantly increased the odds of poor outcomes (mRS ≥3; P < .001), whereas Zabramski type was not predictive of outcomes after adjustment.</p><p><strong>Conclusion: </strong>Zabramski classification aids in stratifying hemorrhage risk and guiding management in CCMs. Severe SH is a critical determinant of functional outcomes, underscoring the need for comprehensive risk assessments and individualized patient care strategies.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Reply: Traumatic Vertebral Artery Injury After Subaxial Cervical Spine Injuries: Incidence, Risk Factors, and Long-Term Outcomes: A Population-Based Cohort Study. 答复:颈椎亚轴损伤后的创伤性椎动脉损伤:发病率、危险因素和长期结局:一项基于人群的队列研究。
IF 3.9 2区 医学
Neurosurgery Pub Date : 2025-06-13 DOI: 10.1227/neu.0000000000003573
Victor Gabriel El-Hajj, Ihab Ahmad Al-Rikabi, Victor E Staartjes, Adrian Elmi-Terander
{"title":"In Reply: Traumatic Vertebral Artery Injury After Subaxial Cervical Spine Injuries: Incidence, Risk Factors, and Long-Term Outcomes: A Population-Based Cohort Study.","authors":"Victor Gabriel El-Hajj, Ihab Ahmad Al-Rikabi, Victor E Staartjes, Adrian Elmi-Terander","doi":"10.1227/neu.0000000000003573","DOIUrl":"10.1227/neu.0000000000003573","url":null,"abstract":"","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":" ","pages":"e66"},"PeriodicalIF":3.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Reply: Arms Race Control Score Standardizes Residency Applicant Publication Assessment. 回复:军备竞赛控制分数标准化居留申请人出版评估。
IF 3.9 2区 医学
Neurosurgery Pub Date : 2025-06-13 DOI: 10.1227/neu.0000000000003578
Christian A Bowers, Maria Cielito Robles, Elad Levy, Michael M Covell, Michael Kogan
{"title":"In Reply: Arms Race Control Score Standardizes Residency Applicant Publication Assessment.","authors":"Christian A Bowers, Maria Cielito Robles, Elad Levy, Michael M Covell, Michael Kogan","doi":"10.1227/neu.0000000000003578","DOIUrl":"10.1227/neu.0000000000003578","url":null,"abstract":"","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":" ","pages":"e57-e59"},"PeriodicalIF":3.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy and Breastfeeding in Neurosurgery: A Pilot Cross-Sectional Study. 妊娠和母乳喂养在神经外科:一个试点横断面研究。
IF 3.9 2区 医学
Neurosurgery Pub Date : 2025-06-13 DOI: 10.1227/neu.0000000000003566
Olabisi Sanusi, Richard U Kalu, Eniola Otukoya, Jamila Godil, James Obayashi, Nathan Beird, Theresa Williamson, Brian V Nahed, Maria I Rodriguez
{"title":"Pregnancy and Breastfeeding in Neurosurgery: A Pilot Cross-Sectional Study.","authors":"Olabisi Sanusi, Richard U Kalu, Eniola Otukoya, Jamila Godil, James Obayashi, Nathan Beird, Theresa Williamson, Brian V Nahed, Maria I Rodriguez","doi":"10.1227/neu.0000000000003566","DOIUrl":"https://doi.org/10.1227/neu.0000000000003566","url":null,"abstract":"<p><strong>Background and objectives: </strong>There has been an increase in the recruitment of women into neurosurgery. Despite this, there is limited research on their childbearing experiences. This study explores the experiences and challenges of women in neurosurgery with a focus on preterm delivery and breastfeeding.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey (August-December 2023) of neurosurgery residents and faculty at American College of Graduate Medical Education-accredited programs collecting data on demographics, obstetric history, and breastfeeding experiences. Only participants who had themselves been pregnant were included in this analysis. The primary outcome was preterm delivery, while secondary outcomes were Neonatal Intensive Care Unit admission and length of breastfeeding. Univariate and multivariate logistic regression was performed with statistical significance set at a P-value <.05.</p><p><strong>Results: </strong>There were 49 participants who were eligible for this subanalysis. The mean age at first pregnancy was 32 years. Most (95.8%) intended to breastfeed for an average of 10.6 months with 54.3% reporting a gap between desired and achieved breastfeeding length. The mean achieved breastfeeding length was 8.5 months (± 6.02). Preterm delivery was significantly associated with requiring Neonatal Intensive Care Unit care (P = .019). The number of operative hours per week during the third trimester was not associated with preterm delivery (P = .401). On multivariate analysis, age (odds ratio [OR]: 1.11 95% CI: 1.011-1.22; P = .029) and having multiple children (OR: 11.28 95% CI: 1.2-104, P .033) were significantly associated with preterm delivery. With every 5-year increase in age, there is a 71% increased odd of preterm delivery (OR: 1.7, 95% CI 1.05-2.79).</p><p><strong>Conclusion: </strong>Our study shows a higher age at first pregnancy for women in neurosurgery and that an increase in age is associated with increased risk of preterm delivery. Larger studies are needed to identify and address barriers to childbearing in neurosurgery.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Reply: MicroRNA Analysis in Meningiomas With Different Degrees of Tissue Stiffness: A Potential Tool for Effective Preoperative Planning. 回复:不同组织僵硬程度脑膜瘤中的MicroRNA分析:有效的术前计划的潜在工具。
IF 3.9 2区 医学
Neurosurgery Pub Date : 2025-06-13 DOI: 10.1227/neu.0000000000003575
Milos Duba, Dagmar Al Tukmachi, Tetiana Samoilenko, Marek Vecera, Michaela Ruckova, Tereza Vankova, Lenka Radova, Milos Kerkovsky, Marek Dostal, Tereza Koprivova, Ivana Roskova, Andrej Mrlian, Ondrej Hrdy, Jaroslav Duba, Leos Kren, Martin Smrcka, Ondrej Slaby, Pavel Fadrus, Jiri Sana
{"title":"In Reply: MicroRNA Analysis in Meningiomas With Different Degrees of Tissue Stiffness: A Potential Tool for Effective Preoperative Planning.","authors":"Milos Duba, Dagmar Al Tukmachi, Tetiana Samoilenko, Marek Vecera, Michaela Ruckova, Tereza Vankova, Lenka Radova, Milos Kerkovsky, Marek Dostal, Tereza Koprivova, Ivana Roskova, Andrej Mrlian, Ondrej Hrdy, Jaroslav Duba, Leos Kren, Martin Smrcka, Ondrej Slaby, Pavel Fadrus, Jiri Sana","doi":"10.1227/neu.0000000000003575","DOIUrl":"10.1227/neu.0000000000003575","url":null,"abstract":"","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":" ","pages":"e54-e55"},"PeriodicalIF":3.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter: Arms Race Control Score Standardizes Residency Applicant Publication Assessment. 信:军备竞赛控制分数标准化居留申请人出版评估。
IF 3.9 2区 医学
Neurosurgery Pub Date : 2025-06-12 DOI: 10.1227/neu.0000000000003577
Sina Sadeghzadeh
{"title":"Letter: Arms Race Control Score Standardizes Residency Applicant Publication Assessment.","authors":"Sina Sadeghzadeh","doi":"10.1227/neu.0000000000003577","DOIUrl":"10.1227/neu.0000000000003577","url":null,"abstract":"","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":" ","pages":"e56"},"PeriodicalIF":3.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter: Importance of Signaling in the Neurosurgical Match. 信:信号在神经外科匹配中的重要性。
IF 3.9 2区 医学
Neurosurgery Pub Date : 2025-06-12 DOI: 10.1227/neu.0000000000003581
Antonio Dono, Ankush Chandra, Spiros L Blackburn, Jacques Morcos
{"title":"Letter: Importance of Signaling in the Neurosurgical Match.","authors":"Antonio Dono, Ankush Chandra, Spiros L Blackburn, Jacques Morcos","doi":"10.1227/neu.0000000000003581","DOIUrl":"10.1227/neu.0000000000003581","url":null,"abstract":"","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":" ","pages":"e63-e64"},"PeriodicalIF":3.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter: Nicotine Replacement Therapy During the Spinal Surgery Perioperative Period. 信:尼古丁替代疗法在脊柱手术围手术期。
IF 3.9 2区 医学
Neurosurgery Pub Date : 2025-06-12 DOI: 10.1227/neu.0000000000003580
Cara Borelli, Michael McGinity, Michael Gaub
{"title":"Letter: Nicotine Replacement Therapy During the Spinal Surgery Perioperative Period.","authors":"Cara Borelli, Michael McGinity, Michael Gaub","doi":"10.1227/neu.0000000000003580","DOIUrl":"10.1227/neu.0000000000003580","url":null,"abstract":"","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":" ","pages":"e67-e68"},"PeriodicalIF":3.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter: Traumatic Vertebral Artery Injury After Subaxial Cervical Spine Injuries: Incidence, Risk Factors, and Long-Term Outcomes: A Population-Based Cohort Study. 信:颈椎亚轴损伤后的创伤性椎动脉损伤:发病率、危险因素和长期结果:一项基于人群的队列研究。
IF 3.9 2区 医学
Neurosurgery Pub Date : 2025-06-12 DOI: 10.1227/neu.0000000000003571
Xianfa Zhang, Jing Wang
{"title":"Letter: Traumatic Vertebral Artery Injury After Subaxial Cervical Spine Injuries: Incidence, Risk Factors, and Long-Term Outcomes: A Population-Based Cohort Study.","authors":"Xianfa Zhang, Jing Wang","doi":"10.1227/neu.0000000000003571","DOIUrl":"10.1227/neu.0000000000003571","url":null,"abstract":"","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":" ","pages":"e65"},"PeriodicalIF":3.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信