NephrologyPub Date : 2025-03-01DOI: 10.1111/nep.70013
Claude J Renaud, Tricia Mae Wong, Muhamed Shamir Jaffar Hussein
{"title":"Practice and Outcome Trends of Peritoneal Dialysis in Chronic Kidney Disease Patients With Liver Cirrhosis and Chronic Heart Failure Complicated by Symptomatic Ascites-A Scoping Review.","authors":"Claude J Renaud, Tricia Mae Wong, Muhamed Shamir Jaffar Hussein","doi":"10.1111/nep.70013","DOIUrl":"https://doi.org/10.1111/nep.70013","url":null,"abstract":"<p><strong>Background: </strong>The rising growth of patients with end-stage kidney disease (ESKD) associated with chronic liver disease (CLD) and refractory chronic heart failure (CHF) associated with advanced chronic kidney disease (CKD) complicated by ascites presents serious renal replacement therapy (RRT) challenges. Haemodialysis is often poorly tolerated owing to increased hemodynamic instability, bleeding, and encephalopathy risks. Peritoneal dialysis (PD) has emerged as a promising alternative, but its adoption and efficacy are not consistently supported by existing literature, and there lacks guideline consensus.</p><p><strong>Methods: </strong>We thus used a scoping review approach to more accurately map the literature on PD practice and outcomes in this population.</p><p><strong>Results: </strong>We identified 18 observational studies involving 627 ESKD patients with CLD/ascites and 222 advanced CKD patients with CHF/ascites. We found practice patterns revealing higher adoption of PD for CLD/ascites in Asia, reflecting the heavier regional PD and viral hepatitis penetration, while there was unique usage for CHF in Western settings. Across contexts, PD demonstrated adaptability for diverse patient profiles. PD as urgent-start and incremental therapy enabled both long-term controlled paracentesis and dialysis while maintaining haemodynamic stability, optimal nutritional status and particularly in CHF improved symptom control, reduced hospitalisation, and lowered diuretics reliance. Mechanical complications were rare and typically manageable whilst peritonitis rates were comparable without impacting technique failure. Survival outcomes were also comparable or superior.</p><p><strong>Conclusions: </strong>Our findings add valuable insights to PD as a feasible and safe long-term RRT option across the ascitic CKD spectrum. Broader consensus is nonetheless needed on its expansion as a first-line therapy and bridge to both palliation and transplantation.</p>","PeriodicalId":19264,"journal":{"name":"Nephrology","volume":"30 3","pages":"e70013"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NephrologyPub Date : 2025-03-01DOI: 10.1111/nep.70009
Tsz-Wai Ho, Alison Lap-Tak Ma, Lawrence K Ma, Fiona Fung-Yee Lai, Kyle Ying-Kit Lin, Sze-Wa Wong, Justin Ming-Yin Ma, Pak-Chiu Tong, Wai-Ming Lai, Desmond Y H Yap, Eugene Yu-Hin Chan
{"title":"Long-Term Clinical Outcomes of Paediatric Kidney Transplantation in Hong Kong-A Territory-Wide Study.","authors":"Tsz-Wai Ho, Alison Lap-Tak Ma, Lawrence K Ma, Fiona Fung-Yee Lai, Kyle Ying-Kit Lin, Sze-Wa Wong, Justin Ming-Yin Ma, Pak-Chiu Tong, Wai-Ming Lai, Desmond Y H Yap, Eugene Yu-Hin Chan","doi":"10.1111/nep.70009","DOIUrl":"10.1111/nep.70009","url":null,"abstract":"<p><strong>Aim: </strong>To review the clinical characteristics and long-term outcomes of paediatric kidney transplants in Hong Kong.</p><p><strong>Method: </strong>A retrospective cohort study was carried out on all paediatric kidney transplant recipients managed in the Paediatric Nephrology Centre in Hong Kong from 2009 to 2020. All recipients were under 21 at the time of transplant, with a minimal follow-up period of 2 years.</p><p><strong>Results: </strong>Sixty-one patients (57.4% male; median age 13 years, IQR: 8.9-17.8) were followed for 6.4 years (IQR 4.3-9.6). The commonest causes of kidney failure were congenital abnormalities of the kidney and urinary tract (34.4%), followed by glomerular diseases (21.3%). 90.2% were deceased donor transplantation. Patient survival rates were 100%, 96.4%, and 96.4% at 1, 5, and 7 years, respectively, and the corresponding graft survival rates were 95.1%, 95.1%, and 89.9%. There were eight graft losses (13.1%). Rejection and chronic allograft nephropathy were the leading causes for graft loss after the first month. Donor age at or above 35 years and the presence of donor-specific antibodies with a history of antibody-mediated rejection (both p < 0.05) were associated with worse graft survival, while medication non-adherence was associated despite being marginally significant (p = 0.056). The rates of CMV syndrome and biopsy-proven BKV nephropathy were 19.7% and 13.1% respectively. 47.5% had short stature at the last follow-up.</p><p><strong>Conclusion: </strong>Our paediatric kidney transplantation outcomes are favourable and comparable to international benchmarks. Preferential allocation of young donors below 35 to paediatric recipients, reinforce immunosuppressant compliance and early detection of DSA with prompt treatment of ABMR may improve allograft outcomes in paediatric recipients.</p>","PeriodicalId":19264,"journal":{"name":"Nephrology","volume":"30 3","pages":"e70009"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NephrologyPub Date : 2025-03-01DOI: 10.1111/nep.70016
Shubham Kumar, Ahmad Neyazi, Rachana Mehta, Ranjana Sah
{"title":"Comment on: \"The Comprehensive Incidence and Risk Factors of Fracture in Kidney Transplant Recipients: A Meta-Analysis\".","authors":"Shubham Kumar, Ahmad Neyazi, Rachana Mehta, Ranjana Sah","doi":"10.1111/nep.70016","DOIUrl":"10.1111/nep.70016","url":null,"abstract":"","PeriodicalId":19264,"journal":{"name":"Nephrology","volume":"30 3","pages":"e70016"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reinsertion of Peritoneal Dialysis Catheter in a Patient With Nocardial Peritonitis and Tunnel Abscess.","authors":"Veenaa Manjari S, Rajeevalochana Parthasarathy, Sanjeev Nair, Deepak Kumar Selvanathan, Nikesh Gandhi","doi":"10.1111/nep.70014","DOIUrl":"https://doi.org/10.1111/nep.70014","url":null,"abstract":"<p><p>Nocardial peritonitis is rare and difficult to diagnose and treat in patients on continuous ambulatory peritoneal dialysis (CAPD). Nocardia-related PD peritonitis has high mortality. There is not much data on the reinsertion of peritoneal dialysis catheters after PD peritonitis. We describe a case of nocardial peritonitis associated with septic shock necessitating Tenckhoff catheter removal. After appropriate treatment with 7 months of trimethoprim-sulfamethoxazole, the PD catheter was reinserted. After 1 year, the patient continues to be on CAPD without recurrence.</p>","PeriodicalId":19264,"journal":{"name":"Nephrology","volume":"30 3","pages":"e70014"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health Related Quality of Life in Adult Patients With Primary Glomerular Diseases.","authors":"Amritesh Grewal, Bhavik Bansal, Arunkumar Subbiah, Dipankar Bhowmik, Sanjay Kumar Agarwal, Soumita Bagchi","doi":"10.1111/nep.70011","DOIUrl":"https://doi.org/10.1111/nep.70011","url":null,"abstract":"<p><strong>Background: </strong>There is a growing need to understand how glomerular diseases impact patients' ability to lead a healthy and productive life. We examined the Health-Related Quality of Life (HRQoL) in patients with primary glomerular diseases in India.</p><p><strong>Method: </strong>In a cross-sectional study, the Patient-Reported Outcomes Measurement Information System (PROMIS) 29v2.1 questionnaire was administered to adults with primary glomerular diseases at the renal clinic. Demographic and clinical data were collected from medical records. Quality of life domain scores were calculated for physical function, pain interference, fatigue, anxiety, sleep disturbance, depression, and ability to participate in social roles and activities. The composite score was derived to reflect the overall HRQoL. Univariable and multivariable linear regression models were run to assess demographic, socio-economic, and clinical predictors of overall and domain-specific quality of life.</p><p><strong>Results: </strong>Three hundred and one patients were included in the final analysis. 67.2% were male. Edema was present in 16.6% of participants, while 37.2% had recently taken steroids. Female sex (β = -5.3, 95% CI: -7.6 to -3.0, p < 0.001), eGFR < 60 mL/min/1.73 m<sup>2</sup> (β = -3.3, 95% CI: -5.6 to -0.96, p = 0.006) and obesity (β = -5.6, 95% CI: -9.5 to -1.8, p = 0.004) were independently associated with worse overall HRQoL and negatively affected most individual domains of HRQoL. Edema and steroid use impacted some individual domains but did not affect overall HRQoL. There was no association with education level and per capita income.</p><p><strong>Conclusion: </strong>These findings underscore the negative impact of female sex, lower eGFR, body weight, edema, and recent steroid intake on HRQoL in adults with primary glomerular diseases. The implications of these results extend to the optimisation of long-term care for patients by addressing their concerns and priorities.</p>","PeriodicalId":19264,"journal":{"name":"Nephrology","volume":"30 3","pages":"e70011"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Comprehensive Skin Gas Analysis of Substances Related to Uraemia in Patients With End-Stage Kidney Disease: A Pilot Study.","authors":"Toyohiro Hashiba, Hiroyasu Yamahara, Yosuke Hirakawa, Yasuo Yano, Yuka Yamada, Risa Hara, Hitoshi Tabata, Masaomi Nangaku","doi":"10.1111/nep.70020","DOIUrl":"10.1111/nep.70020","url":null,"abstract":"<p><p>Recent progress in gas-sensing technology has enabled the rapid collection and highly sensitive analysis of skin gases associated with body odour. Skin gases can be collected less invasively, more continuously, and less consciously than blood or urine. Patients with end-stage kidney disease (ESKD) have a characteristic uremic odour that fades after initiating kidney replacement therapy. We investigated the potential for objectively and quantitatively evaluating the factors underlying uraemia. Skin gases were collected using a passive flux sampler placed on the forearm, with peak intensities measured using gas chromatography-mass spectrometry (GC/MS). We investigated the changes in skin gases obtained from the haemodialysis (HD) group before and after the first HD session of patients undergoing incident dialysis and compared them between the ESKD groups (HD and non-HD) and the healthy group. Thermal desorption enabled the collection of volatile molecules for 20 min using GC/MS preprocessing. Amongst 137 volatile molecules collected from the HD group (N = 5), 16 were detected in all patients. Aldehydes and alkanes were detected more frequently, and four volatile molecules, including 6-methyl-5-hepten-2-one, were detected in all participants in the ESKD (N = 11) and healthy (N = 7) groups. Benzaldehyde and undecanal showed significantly higher intensities in the ESKD group. Additionally, five unidentified volatile molecules were undetectable after dialysis, suggesting an association with the uremic odour. A comprehensive skin gas analysis technique has enabled the identification of volatile molecules related to ESKD. With a short sampling time, skin gas analysis has potential applications in clinical testing and telemedicine.</p>","PeriodicalId":19264,"journal":{"name":"Nephrology","volume":"30 3","pages":"e70020"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NephrologyPub Date : 2025-03-01DOI: 10.1111/nep.70018
Minh Truong Do, Dung Trung Nghiem, Ha Thi Viet Dang, Dung Huu Nguyen, Thuy Thi An Nguyen, Nhu Thi Cao, Anh Trung Nguyen, Tuyen Gia Do
{"title":"Gender Differences in the Prevalence and Associated Factors of Sarcopenia Among Maintenance Haemodialysis Patients in Vietnam.","authors":"Minh Truong Do, Dung Trung Nghiem, Ha Thi Viet Dang, Dung Huu Nguyen, Thuy Thi An Nguyen, Nhu Thi Cao, Anh Trung Nguyen, Tuyen Gia Do","doi":"10.1111/nep.70018","DOIUrl":"https://doi.org/10.1111/nep.70018","url":null,"abstract":"<p><strong>Aim: </strong>The prevalence and associated factors of dialysis-related sarcopenia could vary greatly according to gender. This study aimed to determine the prevalence of sarcopenia in haemodialysis patients according to gender and to assess some factors related to sarcopenia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in maintenance haemodialysis patients. Muscle mass was measured after a dialysis session using bioelectrical impedance analysis. The Asian Working Group for Sarcopenia 2019 definition was applied to diagnose sarcopenia. Logistic regression analysis was applied to determine the associations between several factors and sarcopenia in each gender group.</p><p><strong>Results: </strong>Among 270 participants (50.7% males, age 52.4 ± 13.8), 47 males (34.3%) and 75 females (56.4%) had sarcopenia. According to multivariate logistic regression, the correlates in males were age (OR 1.035, 95% CI 1.001-1.070, p = 0.044), BMI (OR 0.704, 95% CI 0.582-0.852, p < 0.001), dialysis vintage (OR 1.084, 95% CI 1.019-1.153, p = 0.011) and low income (OR 2.49, 95% CI 1.09-5.65, p = 0.03). In females, age (OR 1.053, 95% CI 1.017-1.091, p = 0.003), BMI (OR 0.746, 95% CI 0.619-0.899, p = 0.002), dialysis vintage (OR 1.109, 95% CI 1.017-1.209, p = 0.019), poor nutritional status (OR 5.17, 95% 2.01-13.28, p = 0.001), and polypharmacy (OR 5.12, 95% CI 1.43-18.42, p = 0.012) were associated with sarcopenia.</p><p><strong>Conclusion: </strong>Our study showed that sarcopenia was common among haemodialysis patients, and female patients were more susceptible to sarcopenia. There are differences in gender-specific associated factors of sarcopenia.</p>","PeriodicalId":19264,"journal":{"name":"Nephrology","volume":"30 3","pages":"e70018"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Predictors of Major Adverse Cardiovascular Events in Renal Transplant Patients: A Systematic Review and Meta-Analysis.","authors":"Krisha Patel, Vlad Danaila, Shaun Khanna, Arunav Thakur, Aditya Bhat, Surjit Tarafdar","doi":"10.1111/nep.70015","DOIUrl":"https://doi.org/10.1111/nep.70015","url":null,"abstract":"<p><p>Adult patients with a prior renal transplantation are at increased risk of accelerated cardiovascular disease. This study aims to identify key clinical and biochemical predictors of major adverse cardiovascular events (MACEs) in this population. Understanding these predictors may improve risk stratification and enhance long-term outcomes for kidney transplant recipients. A systematic literature search of medical databases was performed using PRISMA principles to identify all relevant studies assessing clinical and biochemical parameters in adult patients with a prior renal transplantation (2000-2024; English only; PROSPERO registration CRD42024596207). Data for a range of clinical and biochemical parameters were individually extracted, and those with low heterogeneity were then meta-analysed using a random-effects model for overall effect size and assessed through standardised mean difference (SMD) and odds ratios (ORs). The primary outcomes assessed were fatal or non-fatal cardiovascular events occurring after renal transplantation during hospitalisation and up to 10 years post discharge. Of 506 screened studies, 17 peer-reviewed articles met inclusion criteria and included a total of 181,938 renal transplant patients. The key novel predictors of MACE included pre-transplant haemodialysis (OR 2.562, 95% CI = 1.585-4.139, p < 0.001) and delayed graft function (OR 2.113, 95% CI = 1.397-3.198, p < 0.001). Importantly, transplant from a living donor (OR 0.463, 95% CI = 0.393-0.546, p < 0.001) was a protective factor. Traditional cardiovascular risk factor profiles were all predictors of MACE events (p < 0.05). This study identified several traditional and novel predictors of cardiovascular events in patients with pre-existing renal transplantation. Early recognition of these high-risk clinical predictors should prompt more aggressive monitoring and treatment.</p>","PeriodicalId":19264,"journal":{"name":"Nephrology","volume":"30 3","pages":"e70015"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Characteristics of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Patients Proven by Muscle Biopsy and Its Relevance to Kidney Involvement.","authors":"Shunichiro Hanai, Yoshiaki Kobayashi, Moe Watanabe, Kojiro Ikeda, Soichiro Kubota, Nakako Tanaka-Mabuchi, Ryosuke Ito, Daiki Nakagomi","doi":"10.1111/nep.70021","DOIUrl":"https://doi.org/10.1111/nep.70021","url":null,"abstract":"<p><p>Muscle symptoms including myalgia are common in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Muscle biopsy (MB) is sometimes used in the diagnosis of AAV, but which AAV patients benefit from MB remains unclear. We retrospectively assessed the clinical characteristics of Japanese AAV patients who underwent MB and examined the relationship between MB showing positive results for muscular vasculitis and kidney involvement. We enrolled all 38 of the 118 patients with AAV who also underwent MB. Clinical characteristics and histopathological findings on kidney biopsies were assessed in patients with MB showing positive or negative results for muscular vasculitis. Among the 38 patients, 34 (89.5%) were diagnosed with microscopic polyangiitis, and 17 patients (44.7%) showed positive MB. Myalgia and edema of the lower extremities were observed in 12 MB-positive patients, higher proportions than seen in MB-negative patients (70.6% vs. 38.1%, p = 0.046 and 70.6% vs. 33.3%, p = 0.022, respectively). Kidney involvement was more frequent in MB-positive patients (70.6%) than in MB-negative patients (28.6%, p = 0.010). Twelve of the 38 patients with MB underwent kidney biopsy. Proportions of crescents or vascular fibrinoid necrosis were higher in MB-positive patients than in MB-negative patients (83% vs. 33% and 67% vs. 20%, respectively). Myalgia and edema of the lower extremities may offer a guide to the utility of MB. Glomerulonephritis should be considered when muscular vasculitis is confirmed by MB.</p>","PeriodicalId":19264,"journal":{"name":"Nephrology","volume":"30 3","pages":"e70021"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NephrologyPub Date : 2025-03-01DOI: 10.1111/nep.70019
Robert J Ellis, Christopher E Davies, Dominic Keuskamp, Benjamin Lazarus, Stephen P McDonald
{"title":"Kidney Failure due to Diabetic Kidney Disease Among Australians Aged ≤ 45 Years, 2000-2022: A Population-Based Geospatial Analysis.","authors":"Robert J Ellis, Christopher E Davies, Dominic Keuskamp, Benjamin Lazarus, Stephen P McDonald","doi":"10.1111/nep.70019","DOIUrl":"10.1111/nep.70019","url":null,"abstract":"<p><strong>Aim: </strong>Evaluate the area-level incidence of kidney failure due to diabetes among Australians aged ≤ 45 years.</p><p><strong>Methods: </strong>Using Australian registry and census data (2000-2022), incidence rates and prevalence of kidney failure (defined as commencing kidney replacement therapy) due to diabetes among people aged ≤ 45 years were compared by geographical region.</p><p><strong>Results: </strong>Incidence (per 100 000/year, 95% confidence interval) of kidney failure due to diabetes among people aged ≤ 45 years in Australia was 0.72 (0.68-0.77) in 2000-2011, and 1.13 (1.07-1.18) in 2012-2022 (incidence rate ratio [IRR] 1.56, 1.50-1.62). Between 2012 and 2022, there were 48 regions where the crude incidence of kidney failure due to diabetes was more than double the national average, the highest being 49.8 cases per 100 000 per year. Between 2012 and 2022, all jurisdictions had similar age-sex-adjusted point estimates for kidney failure incidence (range 0.78-1.48) except for the Northern Territory (15.8, 13.9-17.8). The most significant characteristics associated with the rate of incident kidney failure were residence in remote areas (IRR 13.9, 13.1-14.8, ref. major cities), socioeconomic disadvantage (IRR 2.96, 2.75-3.19, ref. advantaged areas), and Aboriginal and Torres Strait Islander ethnicity (IRR 24.2, 23.0-25.5). Between the eras, people born outside Australia had the largest increase in incident cases (IRR 2.47, 2.23-2.72) but had a lower overall incidence than those born in Australia (IRR 0.55, 0.52-0.59).</p><p><strong>Conclusion: </strong>In Australia, there was an increase in the incidence of kidney failure due to diabetes among people aged ≤ 45 years in the last two decades. There was a strong relationship between the risk of kidney failure and social determinants of health, including place of residence, socioeconomic status and Indigenous status.</p>","PeriodicalId":19264,"journal":{"name":"Nephrology","volume":"30 3","pages":"e70019"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}