Neuro-Ophthalmology最新文献

{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, John J. Chen, Hui-Chen Cheng, M. Vaphiades, Xiaojun Zhang","doi":"10.1080/01658107.2023.2216613","DOIUrl":"https://doi.org/10.1080/01658107.2023.2216613","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, John J. Chen, Hui-Chen Cheng, Michael S. Vaphiades, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, AL, USA; Department of Neurology, Ohio State University Medical Center, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China Characteristics of 110 Patients with Functional Visual Loss Sverdlichenko I, Brossard-Barbosa N, Micieli JA, Margolin E. Characteristics of 110 patients with functional visual loss. Am J Ophthalmol. 2023;250 171–176. Five to 15% of patients who present to a neuroophthalmology practice with a complaint of vision loss are diagnosed with functional visual loss (FVL). To complicate matters, as many as 53% of these patients are also diagnosed with a coexistent organic cause for their loss of vision. To identify the characteristics of patients with FVL, the authors reviewed the records of 110 patients who were diagnosed with FVL at university-affiliated neuroophthalmology clinics. The majority (73.8%) of patients were women with a mean age of 37 ± 15 years. The most common complaints were decreased vision (71.8%) followed by visual field defects (21.8%). In more than half of the patients the complaint was bilateral. Visual acuity improved in 95.9% of patients when tested with fogging and/or a bottom-up technique. The most common visual field defects were generalised depression (42.5%) followed by concentric constriction/tunnel vision (12.5%). Many patients had concurrent mental illness including depression (23.6%) and anxiety (22.7%) as well as other mental health conditions. A history of preceding trauma was present in 35% of patients. These patients incur considerable costs to the health care system. They averaged 4.6 health care visits with 3.7 of these being to medical specialists. They also averaged 2.2 neuroimaging studies in addition to other testing. The authors point out the fact that there can be considerable savings in terms of cost and patient anxiety if these patients are referred promptly for neuro-ophthalmological consultation. David Bellows GLP-1 Receptor Agonists: The Miracle Pill for IIH? Mitchell JL, Lyons HS, Walker JK, Yiangou A, Grech O, Alimajstorovic Z, et al. The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: A randomized clinical trial. Brain. 13 March 2023: awad003. doi: 10.1093/brain/awad003. Epub ahead of print. PMID: 36,907,221. Glucagon-like peptide-1 (GLP-1) receptor agonists are currently used as a treatment for diabetes and weight loss. The Birmingham, United Kingdom group previously sho","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76857006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could a Gout Attack Cause Non-Arteritic Anterior Ischaemic Optic Neuropathy?","authors":"Omer Karti, Dilek Top Karti, Pelin Kiyat, Tuncer Şak","doi":"10.1080/01658107.2023.2212759","DOIUrl":"10.1080/01658107.2023.2212759","url":null,"abstract":"<p><p>Non-arteritic anterior ischaemic optic neuropathy (NAION) is a common cause of optic neuropathy in individuals over the age of 50. While risk factors such as hypertension, diabetes, and hyperlipidaemia have been identified, recent literature suggests that new risk factors may be associated with NAION. This article reports a case of NAION that occurred concurrently with an acute gout attack in a 78-year-old male patient with no other systemic diseases. We suggest that gout may be a new potential risk factor for NAION as it has the potential to cause inflammation and vascular dysfunction, particularly during acute attacks. The case emphasises the importance of considering gout as a possible risk factor in the aetiology of NAION.</p>","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91305040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Cerebral Vasomotor Reactivity by Transcranial Doppler Ultrasound in Patients with Diabetic Retinopathy.","authors":"Aslı Yaman Kula, Çiğdem Deniz, Tuğçe Özdemir Gültekin, Muhammed Altinisik, Talip Asil","doi":"10.1080/01658107.2023.2212754","DOIUrl":"10.1080/01658107.2023.2212754","url":null,"abstract":"<p><p>The aim of this study was to assess the correlation between cerebral vasomotor reactivity (CVR) and the grade of diabetic retinopathy. A total of 43 diabetic patients with matched severity of diabetic retinopathy between their right and left eyes were included in this study. Diabetic retinopathy was graded in three groups. Right and left middle cerebral artery CVR was assessed by the breath-holding index (BHI) using transcranial Doppler ultrasound (TCD). The mean age of the patients was 56.51 ± 9.34 years with a mean duration of having diabetes mellitus of 14.49 ± 8.06 years. Diabetic retinopathy was graded as mild, moderately severe, and severe in 27.9%, 34.9%, and 37.2% of the patients, respectively. The grade of diabetic retinopathy was associated with the HbA1c level (<i>p</i> < .049), microalbuminuria (<i>p</i> < .024), and BHI (<i>p</i> = .001). In patients with severe diabetic retinopathy, the right-sided BHI was significantly lower as compared to those with mild or moderately severe retinopathy (<i>p</i> = .001 and <i>p</i> = .008, respectively). The left-sided BHI value in patients with severe diabetic retinopathy was significantly lower as compared to those with mild or moderately severe retinopathy (<i>p</i> = .001 and <i>p</i> = .012, respectively). In subjects with moderately severe diabetic retinopathy, both-sided BHI was significantly reduced compared to those with mild retinopathy (<i>p</i> = .001). Our results indicate that the grade of diabetic retinopathy was associated with impaired CVR.</p>","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9815289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moyamoya-Like Vasculopathy and Orbital Trauma: An Association.","authors":"Jonathan A Alexis, Jane Lock, Lay Kho, Andrew L Thompson, David A Prentice","doi":"10.1080/01658107.2023.2212756","DOIUrl":"10.1080/01658107.2023.2212756","url":null,"abstract":"<p><p>An Asian man in his 20s developed asymptomatic ipsilateral moyamoya-like vascular changes following orbital and head trauma. An ipsilateral traumatic optic neuropathy with extensive optic cupping ensued. The complex embryology of the ocular vascular development is reviewed as having a potential causative role in the intracranial carotid vasculopathy.</p>","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86796829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Manifestations After Acute Methanol Poisoning.","authors":"Maamouri Rym, Nabi Wijden, Maamouri Héla, Sassi Héla, Brahmi Nozha, Monia Cheour","doi":"10.1080/01658107.2023.2205926","DOIUrl":"10.1080/01658107.2023.2205926","url":null,"abstract":"<p><p>Acute methanol poisoning is first and foremost life-threatening. Otherwise, functional prognosis is mainly based on ocular impairment. In this case series we aimed to describe the ocular manifestations after acute methanol poisoning during an outbreak in Tunisia. The data from 21 patients (41 eyes) were analysed. All patients underwent a complete ophthalmological examination including visual fields, colour vision test and optical coherence tomography with evaluation of the retinal nerve fibre layer. Patients were classified into two groups. Group 1 included patients with visual symptoms and group 2 included patients with no visual symptoms. Ocular abnormalities were seen in 81.8% of patients with ocular symptoms. They included: optic neuropathy in 7 patients (63.6%); central retinal artery occlusion in 1 patient (9.1%); and central serous chorioretinopathy in 1 patient (9.1%). Mean blood methanol levels were significantly higher in patients without ocular symptoms (<i>p</i> = .03).</p>","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9811844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Jindahra, P. Macintosh, Collin M. McClelland, M. Vaphiades, Xiaojun Zhang","doi":"10.1080/01658107.2023.2201136","DOIUrl":"https://doi.org/10.1080/01658107.2023.2201136","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, Noel C. Y. Chan, John J. Chen, Hui-Chen Cheng, Panitha Jindahra, Peter W. MacIntosh, Collin McClelland, Michael S. Vaphiades, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong; Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology, Mahidol University, Bangkok, Thailand; Department of Ophthalmology, Illinois Ear and Eye Infirmary, Chicago, Illinois, USA; Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, Alexandria, USA; Department of Neurology, Ohio State University Medical Center, Columbus, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, Hebei, China Peripapillary Hyperreflective Ovoid Mass-Like Structures: Multimodal Imaging – A Review Jeffery RCH, Chen FK. Peripapillary hyperreflective ovoid mass-like structures: Multimodal imaging-A review. Clin Exp Ophthalmol. 2023;51:67–80. Prior to the establishment of the Optic Disk Drusen Consortium the ovoid peripapillary structures detected on optical coherence tomography (OCT) were felt to be buried optic disk drusen. These structures have since been redefined as peripapillary hyperreflective ovoid mass-like structures (PHOMS) and identified as a manifestation of axoplasmic stasis. The authors discuss the characteristic findings of PHOMS on multimodal OCT and review the literature pertaining to the co-existence of PHOMS with diseases other than optic disk drusen. These include papilloedema, anterior ischaemic optic neuropathy, tilted disk syndrome, inflammatory demyelinating disorders as well as retinal and orbital diseases. David Bellows Anti-Hypertensive Medications – Before Bed or Not? Labowsky MT, Rizzo III JF. The controversy of chronotherapy: Emerging evidence regarding bedtime dosing of antihypertensive medications in non-arteritic anterior ischaemic optic neuropathy. Semin Ophthalmol. 2023;38:99–104. This is a review article highlighting the marked conflict between therapeutic recommendations published in the ophthalmology and cardiology literature, with the former arguing against taking anti-hypertensive medications at bedtime to reduce risk of sequential non-arteritic anterior ischaemic optic neuropathy (NAION) while the latter arguing in favour of bedtime dosing to reduce the risk of cardiovascular disease (CVD). The observation of “blinding upon awakening” in patients with NAION has prom","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79995194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic Optic Neuritis Should Neither Be Defined as a Subtype nor an Early Sign of Multiple Sclerosis.","authors":"Siqian Wei, Yi Du, Wenjing Luo","doi":"10.1080/01658107.2023.2205931","DOIUrl":"10.1080/01658107.2023.2205931","url":null,"abstract":"","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9815288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Vision Loss and Visual Hallucinations in Subacute Sclerosing Panencephalitis: A Case Report.","authors":"Ravi Uniyal, Ravindra Kumar Garg, Hardeep Singh Malhotra, Neeraj Kumar, Shweta Pandey, Imran Rizvi, Amita Jain, Nidhi Tejan, Rupesh Singh Kirar","doi":"10.1080/01658107.2023.2194987","DOIUrl":"10.1080/01658107.2023.2194987","url":null,"abstract":"<p><p>We report an interesting case of visual loss and visual hallucinations in a 37-year-old man. He presented with decreased vision in both eyes and visual hallucinations for the last one and a half months. He also had multiple focal to bilateral tonic-clonic seizures. On examination, there was no perception of light rays in both eyes. Fundus examination revealed disc oedema with peripapillary small haemorrhages in both eyes. Initially, the discs were hyperaemic, which turned pale in the subsequent examination at 1 month. Magnetic resonance imaging (MRI) of the brain revealed T2 hyperintensities in periventricular white matter and right fronto-parietal-occipital gray matter. His electroencephalogram showed intermittent slowing. His cerebrospinal fluid (CSF) examination showed five cells (all lymphocytes), protein 50 mg/dl, sugar 76 mg/dl (corresponding blood sugar 90 mg/dl). His CSF specimen was positive for anti-measles IgG antibodies. In conclusion, acute vision loss can rarely be the presenting symptom and, therefore, SSPE should also be considered in differential diagnoses of acute vision loss in measles-endemic regions.</p>","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9817886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downbeat Nystagmus as a Presenting Manifestation of Neurolisteriosis in a Pregnant Woman.","authors":"Ritwik Ghosh, Moisés León-Ruiz, Sona Singh Sardar, Padavi Lalsing D, Julián Benito-León","doi":"10.1080/01658107.2023.2186431","DOIUrl":"10.1080/01658107.2023.2186431","url":null,"abstract":"<p><p>Listeria monocytogenes has tropism towards two immunologically \"privileged\" sites, the fetoplacental unit in pregnant women and the central nervous system (neurolisteriosis) in immunocompromised individuals. We report a case of neurolisteriosis in a previously asymptomatic pregnant woman from rural West Bengal, India, who presented with a subacute onset febrile illness with features of rhombencephalitis and a predominantly midline-cerebellopathy (slow and dysmetric saccades, florid downbeat nystagmus, horizontal nystagmus, and ataxia). With timely detection and the institution of prolonged intravenous antibiotic therapy, both the mother and the fetus were saved uneventfully.</p>","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9811846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, John J. Chen, Hui-Chen Cheng, P. Jindahra, Collin M. McClelland, M. Vaphiades, Xiaojun Zhang","doi":"10.1080/01658107.2023.2169555","DOIUrl":"https://doi.org/10.1080/01658107.2023.2169555","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, John J. Chen, Hui-Chen Cheng, Panitha Jindahra, Collin McClelland, Michael S. Vaphiades, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, MN, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology, Mahidol University, Bangkok, Thailand; Department of Ophthalmology, University of Minnesota, Minneapolis, MN, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, AL, USA; Department of Neurology, Ohio State University Medical Center, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China Oral fluorescein angiography for the diagnosis of papilloedema versus pseudopapilledema in children Elhusseiny AM, Fong JW, Hsu C, Grigorian F, Grigorian AP, Soliman MK, et al. Oral fluorescein angiography for the diagnosis of papilloedema versus pseudopapilledema in children. Am J Ophthalmol 2023;245: 8–13. This study was designed to determine if the use of oral fluorescein angiography is accurate and safe in differentiating papilloedema from pseudopapilloedema in paediatric patients. Two masked specialists (a paediatric ophthalmologist and retina specialist) reviewed the oral fluorescein angiogram images of 45 patients (90 eyes). They evaluated the optic discs and assigned them to three categories: leakage; no leakage; or “borderline” leakage of fluorescein, at least 30 minutes following ingestion of the medication. The determinations made by the masked observers were then compared with the final clinical diagnosis. There was excellent interobserver accordance in grading the images. Oral fluorescein angiography was found to be safe with no ocular, systemic or allergic reactions. The accuracy, however, was suboptimal with only 62 to 69% of images accurately differentiating papilloedema from pseudopapilloedema. However, the sensitivity at detecting leakage increased with the severity of disc swelling and the observers correctly identified papilloedema in 89% of patients who had Frisén grade 2 or 3 swelling. David Bellows Enhanced depth imaging may be the new gold standard for detecting optic disc drusen Youn S, Mfe B, Armstrong JJ, Fraser JA, Hamann S, Bursztyn L. Am J Ophthalmol. 11 December 2022: S0002-9394(22)00485–8. doi: 10.1016/j.ajo.2022. 12.004. Online ahead of print.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83042651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}