Nihon Kyobu Shikkan Gakkai zasshi最新文献_第7页

[Flutropium bromide was effective in relieving symptoms of lymphangioleiomyomatosis--a case report]. [氟托溴铵对缓解淋巴管平滑肌瘤病症状有效——1例报告]。

Nihon Kyobu Shikkan Gakkai zasshi Pub Date : 1997-11-01

M Baba, M Mikami, S Nakamura, J Takizawa, M Kawakami

引用次数: 0

[The effects of surfactant-TA on bleomycin-induced lung injury and lung fibroblast proliferation]. [表面活性剂- ta对博莱霉素诱导的肺损伤及肺成纤维细胞增殖的影响]。

Nihon Kyobu Shikkan Gakkai zasshi Pub Date : 1997-11-01 DOI: 10.11389/JJRS1963.35.1163

M. Ito, A. Suwabe, T. Suzuki, M. Tominaga, K. Takahashi

{"title":"[The effects of surfactant-TA on bleomycin-induced lung injury and lung fibroblast proliferation].","authors":"M. Ito, A. Suwabe, T. Suzuki, M. Tominaga, K. Takahashi","doi":"10.11389/JJRS1963.35.1163","DOIUrl":"https://doi.org/10.11389/JJRS1963.35.1163","url":null,"abstract":"We investigated whether artificial surfactant modified pulmonary fibrosis following the intratracheal administration of bleomycin (BLM 3.75 mg/kg) in rats. Twenty-four hours after the administration of bleomycin, the lungs were washed twice with surfactant-TA (S-TA, 1 mg/ml, 6 ml x 2 times), and replaced with 0.5 ml of 10 mg/ml S-TA. Fourteen days later the animals were sacrificed and the lungs were assayed for collagen content and pathologic changes. BLM-treated rats showed both increases in wet lung weights and lung collagen content, and a loss in body weights (due to lung injury and fibrosis), but these changes were significantly inhibited by the intratracheal administration of S-TA. In vitro studies demonstrated that S-TA inhibited lung fibroblast proliferation in a dose dependent manner (0.01-0.5 mg/ml). This inhibition was also seen in native rat lung surfactant and its protein and lipid components. However, S-TA, did not change the number of rat type II pneumocutes in culture, and likely protected type II cells from dedifferentiation. S-TA inhibited BLM-induced pulmonary fibrosis, probably by directly inhibiting lung fibroblast proliferation.","PeriodicalId":19255,"journal":{"name":"Nihon Kyobu Shikkan Gakkai zasshi","volume":"100 1","pages":"1163-72"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90341522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

[High levels of elastolytic activity in bronchoalveolar lavage fluid from a patient with idiopathic interstitial pneumonia]. [特发性间质性肺炎患者支气管肺泡灌洗液高水平的弹性溶解活性]。

Nihon Kyobu Shikkan Gakkai zasshi Pub Date : 1997-11-01 DOI: 10.11389/JJRS1963.35.1238

Hironobu Hamada, M. Sakatani, Michiho Nishioka, Masanori Akira, S. Yamamoto, Einosuke Ueda

引用次数: 1

[Serum soluble adhesion molecules in patients with sarcoidosis]. [结节病患者血清可溶性黏附分子研究]。

Nihon Kyobu Shikkan Gakkai zasshi Pub Date : 1997-11-01

H Mukae, J Ashitani, H Ihiboshi, H Taniguchi, S Matsukura, K Iida, J Kadota, S Kohno

引用次数: 0

[The relationship between a decrease in fat mass and serum levels of TNF-alpha in patients with chronic obstructive pulmonary disease]. [慢性阻塞性肺疾病患者脂肪量减少与血清tnf - α水平的关系]。

Nihon Kyobu Shikkan Gakkai zasshi Pub Date : 1997-11-01

C Yamamoto, T Yoneda, M Yoshikawa, A Fu, I Takenaka, A Kobayashi, I Okamura, Y Okamoto, K Tsukaguchi, N Narita

{"title":"[The relationship between a decrease in fat mass and serum levels of TNF-alpha in patients with chronic obstructive pulmonary disease].","authors":"C Yamamoto, T Yoneda, M Yoshikawa, A Fu, I Takenaka, A Kobayashi, I Okamura, Y Okamoto, K Tsukaguchi, N Narita","doi":"","DOIUrl":"","url":null,"abstract":"To investigate the relationship between malnutrition and TNF-alpha levels in patients with chronic obstructive pulmonary disease (COPD), we measured concentrations of TNF-alpha in serum from fifty four patients with stable COPD. The patients were divided into three groups, according to ideal body weight (IBW): group A, %IBW > or = 90; group B, 90 > %IBW > or = 80; group C, %IBW < 80. Serum TNF-alpha levels in group C were significantly higher than in group A (mean +/- SD; 3.00 +/- 0.43 pg/ml and 2.25 +/- 0.29 pg/ml, respectively, p < 0.0001), group B (2.41 +/- 0.47 pg/ml, p < 0.001), and healthy controls (2.33 +/- 0.30 pg/ml, p < 0.001) who were age- and %IBW-matched with patients in group C. Sixteen patients with COPD underwent body composition analysis by dual energy X-ray absorptiometry. Serum TNF-alpha levels in patients with COPD significantly correlated with fat mass (r = -0.67, p < 0.001). No association was observed between lean mass and serum TNF-alpha levels. These data suggest that TNF-alpha is involved with malnutrition in patients with COPD, and that TNF-alpha may cause a decrease in fat mass in patients with COPD.","PeriodicalId":19255,"journal":{"name":"Nihon Kyobu Shikkan Gakkai zasshi","volume":"35 11","pages":"1191-5"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20417497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The effects of surfactant-TA on bleomycin-induced lung injury and lung fibroblast proliferation]. [表面活性剂- ta对博莱霉素诱导的肺损伤及肺成纤维细胞增殖的影响]。

Nihon Kyobu Shikkan Gakkai zasshi Pub Date : 1997-11-01

M Ito, A Suwabe, T Suzuki, M Tominaga, K Takahashi

{"title":"[The effects of surfactant-TA on bleomycin-induced lung injury and lung fibroblast proliferation].","authors":"M Ito, A Suwabe, T Suzuki, M Tominaga, K Takahashi","doi":"","DOIUrl":"","url":null,"abstract":"We investigated whether artificial surfactant modified pulmonary fibrosis following the intratracheal administration of bleomycin (BLM 3.75 mg/kg) in rats. Twenty-four hours after the administration of bleomycin, the lungs were washed twice with surfactant-TA (S-TA, 1 mg/ml, 6 ml x 2 times), and replaced with 0.5 ml of 10 mg/ml S-TA. Fourteen days later the animals were sacrificed and the lungs were assayed for collagen content and pathologic changes. BLM-treated rats showed both increases in wet lung weights and lung collagen content, and a loss in body weights (due to lung injury and fibrosis), but these changes were significantly inhibited by the intratracheal administration of S-TA. In vitro studies demonstrated that S-TA inhibited lung fibroblast proliferation in a dose dependent manner (0.01-0.5 mg/ml). This inhibition was also seen in native rat lung surfactant and its protein and lipid components. However, S-TA, did not change the number of rat type II pneumocutes in culture, and likely protected type II cells from dedifferentiation. S-TA inhibited BLM-induced pulmonary fibrosis, probably by directly inhibiting lung fibroblast proliferation.","PeriodicalId":19255,"journal":{"name":"Nihon Kyobu Shikkan Gakkai zasshi","volume":"35 11","pages":"1163-72"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20417538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Flutropium bromide was effective in relieving symptoms of lymphangioleiomyomatosis--a case report]. [氟托溴铵对缓解淋巴管平滑肌瘤病症状有效——1例报告]。

Nihon Kyobu Shikkan Gakkai zasshi Pub Date : 1997-11-01 DOI: 10.11389/JJRS1963.35.1223

M. Baba, M. Mikami, S. Nakamura, J. Takizawa, M. Kawakami

引用次数: 0

[Nocturnal pulmonary hypertension in patients with obstructive sleep apnea associated with daytime pulmonary hypertension]. [阻塞性睡眠呼吸暂停伴日间肺动脉高压患者的夜间肺动脉高压]。

Nihon Kyobu Shikkan Gakkai zasshi Pub Date : 1997-11-01

J Kang, H Kimura, M Niijima, H Edo, H Sakabe, T Shinozaki, S Masuyama, O Okada, K Tatsumi, T Kuriyama

{"title":"[Nocturnal pulmonary hypertension in patients with obstructive sleep apnea associated with daytime pulmonary hypertension].","authors":"J Kang, H Kimura, M Niijima, H Edo, H Sakabe, T Shinozaki, S Masuyama, O Okada, K Tatsumi, T Kuriyama","doi":"","DOIUrl":"","url":null,"abstract":"We investigated the effect of state-specific changes associated with REM sleep on pulmonary artery pressure in patients with obstructive sleep apnea (OSAS). Six male patients with OSAS (age; 40 +/- 12 SD yrs, BMI; 39.0 +/- 8.6 kg/m2, AHI; 51.5 +/- 28.5) were examined throughout the night by polysomnography, while monitoring pulmonary artery pressure via right cardiac catheterization. All patients had pulmonary hypertension (PH) during periods of wakefulness, and their mean pulmonary artery pressure (PAPm) was 31.1 +/- 7.4 mmHg. PAPm was analyzed at two different points in each apneic episode. PAPbase was the baseline value when inspiratory effects during apnea were not elicited, and PAPpeak was the peak value observed just after the cessation of OSA. PAPpeak was higher in REM (56.3 +/- 12.4) than in NREM (41.4 +/- 6.9 mmHg; P < 0.01), and both values were significantly higher than those observed during periods of wakefulness. The magnitude of elevation of PAP (delta PAP; PAPpeak-PAPbase) in REM and NREM were 11.6 +/- 2.0 and 6.9 +/- 2.8 mmHg, respectively. Relative ratios in the response of PAP to a decrease in O2 desaturation (delta PAP/delta SpO2) showed almost the same value for REM (-0.57 +/- 0.27) and NREM sleep (-0.57 +/- 0.26 mmHg/%). The values of PAPm at SpO2 75% were significantly higher in REM than in NREM (48.7 +/- 11.2 vs. 41.6 +/- 6.2 mmHg). We conclude that transient pulmonary hypertension could be caused not only by hypoxia, but also by state-specific responses (which are unrelated to hypoxia) that occur during REM sleep.","PeriodicalId":19255,"journal":{"name":"Nihon Kyobu Shikkan Gakkai zasshi","volume":"35 11","pages":"1173-8"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20417494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The outcome of patients with mediastinal tumors detected by mass screening versus the outcome of those initially presentating with symptoms]. [通过大规模筛查发现的纵隔肿瘤患者的结果与最初出现症状的患者的结果]。

Nihon Kyobu Shikkan Gakkai zasshi Pub Date : 1997-11-01

T Maeno, H Satoh, H Ishikawa, T Naito, M Ohtsuka, S Hasegawa

引用次数: 0

[Pulmonary disease caused by Mycobacterium avium presenting as a solitary cavity with a thickened wall]. [由鸟分枝杆菌引起的肺部疾病，表现为壁增厚的孤立腔]。

Nihon Kyobu Shikkan Gakkai zasshi Pub Date : 1997-11-01

A Takamizawa, Y Kamijo, Y Yamazaki, K Kubo

引用次数: 0