Immuno-Oncology and Technology最新文献

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135P Isunakinra as monotherapy and combined with nivolumab for treatment-resistant advanced solid tumours: Exploratory effect data, tolerability, and pharmacokinetics from a dose escalation trial 135P Isunakinra 作为单药或与 nivolumab 联合治疗耐药晚期实体瘤:一项剂量递增试验的探索性疗效数据、耐受性和药代动力学
Immuno-Oncology and Technology Pub Date : 2023-12-01 DOI: 10.1016/j.iotech.2023.100607
C. Becerra, H. Olivecrona, M. de Château, S.A. Paulson
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引用次数: 0
154P Computer-aided drug design based on CLDN4 ligand and its biological evaluation in ovarian cancer 154P 基于 CLDN4 配体的计算机辅助药物设计及其在卵巢癌中的生物学评价
Immuno-Oncology and Technology Pub Date : 2023-12-01 DOI: 10.1016/j.iotech.2023.100665
Y. Xu, Y. Shen
{"title":"154P Computer-aided drug design based on CLDN4 ligand and its biological evaluation in ovarian cancer","authors":"Y. Xu, Y. Shen","doi":"10.1016/j.iotech.2023.100665","DOIUrl":"https://doi.org/10.1016/j.iotech.2023.100665","url":null,"abstract":"","PeriodicalId":192507,"journal":{"name":"Immuno-Oncology and Technology","volume":"156 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138621475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
198P Polarization of tumor-associated macrophages enhanced by 2-HP-β-cyclodextrin modified PLGA nanoparticles 198P 2-HP-β-环糊精修饰的聚乳酸(PLGA)纳米颗粒可增强肿瘤相关巨噬细胞的极化能力
Immuno-Oncology and Technology Pub Date : 2023-12-01 DOI: 10.1016/j.iotech.2023.100674
H.H. Yuan, H. Gui, L.Z. Li
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引用次数: 0
108P Real-world (RW) effectiveness and safety of adjuvant nivolumab (NIVO) in patients (pts) with melanoma in Belgium and Luxembourg: PRESERV MEL 108P 比利时和卢森堡黑色素瘤患者(pts)使用尼伐单抗(NIVO)辅助治疗的真实世界(RW)有效性和安全性:PRESERV MEL
Immuno-Oncology and Technology Pub Date : 2023-12-01 DOI: 10.1016/j.iotech.2023.100580
B. Neyns, L. Willemot, L. McDonald, H. Van Campenhout, G. Berchem, C. Jacobs, A. Rogiers, N. Blockx, A. Rorive
{"title":"108P Real-world (RW) effectiveness and safety of adjuvant nivolumab (NIVO) in patients (pts) with melanoma in Belgium and Luxembourg: PRESERV MEL","authors":"B. Neyns, L. Willemot, L. McDonald, H. Van Campenhout, G. Berchem, C. Jacobs, A. Rogiers, N. Blockx, A. Rorive","doi":"10.1016/j.iotech.2023.100580","DOIUrl":"https://doi.org/10.1016/j.iotech.2023.100580","url":null,"abstract":"","PeriodicalId":192507,"journal":{"name":"Immuno-Oncology and Technology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138626031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
184P Elevated baseline circulating IL-8 is associated with increased expression of the IMmotion myeloid gene signature (GS) in metastatic clear cell renal cell carcinoma (mRCC) patients (pts) treated with nivolumab (nivo) within the NIVOREN GETUG-AFU 26 study 184P 在 NIVOREN GETUG-AFU 26 研究中接受 nivolumab (nivo) 治疗的转移性透明细胞肾细胞癌(mRCC)患者(pts)中,基线循环 IL-8 升高与 IMmotion 髓系基因特征(GS)表达增加有关
Immuno-Oncology and Technology Pub Date : 2023-12-01 DOI: 10.1016/j.iotech.2023.100643
L. C. Ajuria, M. Naigeon, R. Flippot, C. Dalban, A. Desnoyer, N. Rioux-Leclercq, C. Sautes-Fridman, M. Meylan, Y. Vano, B. Beuselinck, S. Chouaib, C. de Oliveira, F. Tantot, B. Escudier, N. Chaput-Gras, L. Albiges
{"title":"184P Elevated baseline circulating IL-8 is associated with increased expression of the IMmotion myeloid gene signature (GS) in metastatic clear cell renal cell carcinoma (mRCC) patients (pts) treated with nivolumab (nivo) within the NIVOREN GETUG-AFU 26 study","authors":"L. C. Ajuria, M. Naigeon, R. Flippot, C. Dalban, A. Desnoyer, N. Rioux-Leclercq, C. Sautes-Fridman, M. Meylan, Y. Vano, B. Beuselinck, S. Chouaib, C. de Oliveira, F. Tantot, B. Escudier, N. Chaput-Gras, L. Albiges","doi":"10.1016/j.iotech.2023.100643","DOIUrl":"https://doi.org/10.1016/j.iotech.2023.100643","url":null,"abstract":"","PeriodicalId":192507,"journal":{"name":"Immuno-Oncology and Technology","volume":" 55","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138613937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
163MO Single-cell T cell dynamics induced by neoadjuvant nivolumab +/- ipilimumab in early triple negative breast cancer with tumor-infiltrating lymphocytes (BELLINI trial) 163MO 有肿瘤浸润淋巴细胞的早期三阴性乳腺癌患者的新辅助治疗 nivolumab +/- ipilimumab 诱导的单细胞 T 细胞动态(BELLINI 试验)
Immuno-Oncology and Technology Pub Date : 2023-12-01 DOI: 10.1016/j.iotech.2023.100622
O.I. Isaeva, I. Nederlof, M. de Graaf, B. Boeckx, J. Traets, I.A.M. Mandjes, K. Van De Vijver, M. Chelushkin, C. Drukker, M.V. Dongen, G.S. Sonke, S.C. Linn, C.U. Blank, K.E. de Visser, R. Salgado, L. Wessels, T.N. Schumacher, H. Horlings, D. Lambrechts, M. Kok
{"title":"163MO Single-cell T cell dynamics induced by neoadjuvant nivolumab +/- ipilimumab in early triple negative breast cancer with tumor-infiltrating lymphocytes (BELLINI trial)","authors":"O.I. Isaeva, I. Nederlof, M. de Graaf, B. Boeckx, J. Traets, I.A.M. Mandjes, K. Van De Vijver, M. Chelushkin, C. Drukker, M.V. Dongen, G.S. Sonke, S.C. Linn, C.U. Blank, K.E. de Visser, R. Salgado, L. Wessels, T.N. Schumacher, H. Horlings, D. Lambrechts, M. Kok","doi":"10.1016/j.iotech.2023.100622","DOIUrl":"https://doi.org/10.1016/j.iotech.2023.100622","url":null,"abstract":"","PeriodicalId":192507,"journal":{"name":"Immuno-Oncology and Technology","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138617133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
164P Disentangling the joint and distinct immunomodulation and vulnerability between KEAP1/NFE2L2 and SMARCA4 alterations in lung adenocarcinoma 164P 解读肺腺癌中 KEAP1/NFE2L2 和 SMARCA4 改变之间共同而独特的免疫调节和脆弱性
Immuno-Oncology and Technology Pub Date : 2023-12-01 DOI: 10.1016/j.iotech.2023.100623
A. Li, L. Luo, W. Du, K. Wu, Z. Yan, Z. Yu, L. Zhang, S. Hong
{"title":"164P Disentangling the joint and distinct immunomodulation and vulnerability between KEAP1/NFE2L2 and SMARCA4 alterations in lung adenocarcinoma","authors":"A. Li, L. Luo, W. Du, K. Wu, Z. Yan, Z. Yu, L. Zhang, S. Hong","doi":"10.1016/j.iotech.2023.100623","DOIUrl":"https://doi.org/10.1016/j.iotech.2023.100623","url":null,"abstract":"","PeriodicalId":192507,"journal":{"name":"Immuno-Oncology and Technology","volume":" 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138620768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
173P Depleting resident peritoneal macrophages is an effective treatment for peritoneal metastasized colorectal cancer 173P 消耗腹腔巨噬细胞是治疗腹膜转移性结直肠癌的有效方法
Immuno-Oncology and Technology Pub Date : 2023-12-01 DOI: 10.1016/j.iotech.2023.100632
J. Saris, A.Y. Li Yim, S. Bootsma, J. Verhoeff, J. Tuynman, M. Wildenberg, G. D'Haens, R. F. Fernandez, H. Khan, K. Lenos, J. G. Vallejo, L. Vermeulen, J. Grootjans
{"title":"173P Depleting resident peritoneal macrophages is an effective treatment for peritoneal metastasized colorectal cancer","authors":"J. Saris, A.Y. Li Yim, S. Bootsma, J. Verhoeff, J. Tuynman, M. Wildenberg, G. D'Haens, R. F. Fernandez, H. Khan, K. Lenos, J. G. Vallejo, L. Vermeulen, J. Grootjans","doi":"10.1016/j.iotech.2023.100632","DOIUrl":"https://doi.org/10.1016/j.iotech.2023.100632","url":null,"abstract":"","PeriodicalId":192507,"journal":{"name":"Immuno-Oncology and Technology","volume":"11 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138621336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
199P Scalable multiplexed image analysis across cancer types as part of the IMMUcan consortium 199P 作为 IMMUcan 联合体的一部分,对各种癌症类型进行可扩展的多路复用图像分析
Immuno-Oncology and Technology Pub Date : 2023-12-01 DOI: 10.1016/j.iotech.2023.100675
N. Eling, J. Dorier, S. Rusakiewicz, S. Tissot, P. Devanand, M. Daniel, S. Déglise, B. Palau Fernandez, J. Windhager, M. Możejko, K. Gogolewski, J. Krawczyk, A. Essabbar, V. Pancaldi, E. Szczurek, M. Morfouace, H.S. Hong, R. Liechti, B. Bodenmiller, D. Schulz
{"title":"199P Scalable multiplexed image analysis across cancer types as part of the IMMUcan consortium","authors":"N. Eling, J. Dorier, S. Rusakiewicz, S. Tissot, P. Devanand, M. Daniel, S. Déglise, B. Palau Fernandez, J. Windhager, M. Możejko, K. Gogolewski, J. Krawczyk, A. Essabbar, V. Pancaldi, E. Szczurek, M. Morfouace, H.S. Hong, R. Liechti, B. Bodenmiller, D. Schulz","doi":"10.1016/j.iotech.2023.100675","DOIUrl":"https://doi.org/10.1016/j.iotech.2023.100675","url":null,"abstract":"","PeriodicalId":192507,"journal":{"name":"Immuno-Oncology and Technology","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138622430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
177P The immune-microenvironment confers chemoresistance in breast cancer through activation of VEGFR2/STAT3/BIRC5 signaling 177P 免疫微环境通过激活血管内皮生长因子受体2/STAT3/BIRC5 信号传递赋予乳腺癌化疗抗药性
Immuno-Oncology and Technology Pub Date : 2023-12-01 DOI: 10.1016/j.iotech.2023.100636
B. Deswal, U. Bagchi, S. Kapoor
{"title":"177P The immune-microenvironment confers chemoresistance in breast cancer through activation of VEGFR2/STAT3/BIRC5 signaling","authors":"B. Deswal, U. Bagchi, S. Kapoor","doi":"10.1016/j.iotech.2023.100636","DOIUrl":"https://doi.org/10.1016/j.iotech.2023.100636","url":null,"abstract":"","PeriodicalId":192507,"journal":{"name":"Immuno-Oncology and Technology","volume":"22 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138624234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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