发布求助
文献互助 智能选刊 最新文献

Nucleosides & nucleotides最新文献

筛选
英文 中文
Stimulation of cytokine and nitric oxide production by acyclic nucleoside phosphonates. 无环核苷膦酸盐对细胞因子和一氧化氮产生的刺激。
Nucleosides & nucleotides Pub Date : 1999-04-01 DOI: 10.1080/15257779908041612
Z Zídek, D Franková, A Holý
{"title":"Stimulation of cytokine and nitric oxide production by acyclic nucleoside phosphonates.","authors":"Z Zídek,&nbsp;D Franková,&nbsp;A Holý","doi":"10.1080/15257779908041612","DOIUrl":"https://doi.org/10.1080/15257779908041612","url":null,"abstract":"<p><p>Several antiviral acyclic nucleotide analogues activate expression of genes for cytokines, such as TNF-alpha, IL-10 in macrophages and IFN-gamma in splenocytes. This is an underlying mechanism for substantially enhanced production of nitric oxide generated by IFN-gamma. More lipophilic prodrugs, bis-POM-PMEA and bis-POC-PMPA, are cytocidal for macrophages and thus inhibit nitric oxide formation.</p>","PeriodicalId":19222,"journal":{"name":"Nucleosides & nucleotides","volume":"18 4-5","pages":"959-61"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15257779908041612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21297866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Synthesis, anti-HIV activity and stability studies of 3'-azido-2',3'-dideoxythymidine 5'-fluorophosphate. 3'-叠氮-2'，3'-二脱氧胸腺嘧啶5'-氟磷酸盐的合成、抗hiv活性及稳定性研究。
Nucleosides & nucleotides Pub Date : 1999-04-01 DOI: 10.1080/15257779908041621
D Egron, A A Arzumanov, N B Dyatkina, A Krayevsky, J L Imbach, A M Aubertin, G Gosselin, C Périgaud
{"title":"Synthesis, anti-HIV activity and stability studies of 3'-azido-2',3'-dideoxythymidine 5'-fluorophosphate.","authors":"D Egron,&nbsp;A A Arzumanov,&nbsp;N B Dyatkina,&nbsp;A Krayevsky,&nbsp;J L Imbach,&nbsp;A M Aubertin,&nbsp;G Gosselin,&nbsp;C Périgaud","doi":"10.1080/15257779908041621","DOIUrl":"https://doi.org/10.1080/15257779908041621","url":null,"abstract":"<p><p>The synthesis, in vitro anti-HIV activity, and stability studies of AZT 5'-fluorophosphate (F-AZTMP) are reported. The present results demonstrate that such compound is a bioprecursor of its parent 5'-mononucleotide (AZTMP) but its biotransformation does not allow its selective intracellular delivery. Moreover, several attempts were carried out in order to improve the biological activity of this compound by the use of a SATE prodrug strategy.</p>","PeriodicalId":19222,"journal":{"name":"Nucleosides & nucleotides","volume":"18 4-5","pages":"983-4"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15257779908041621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21297874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Synthesis of new PMEA diphosphate mimics. 新型PMEA二磷酸模拟物的合成。
Nucleosides & nucleotides Pub Date : 1999-04-01 DOI: 10.1080/15257779908041629
W H Laux, C Périgaud, J L Imbach, G Gosselin
{"title":"Synthesis of new PMEA diphosphate mimics.","authors":"W H Laux,&nbsp;C Périgaud,&nbsp;J L Imbach,&nbsp;G Gosselin","doi":"10.1080/15257779908041629","DOIUrl":"https://doi.org/10.1080/15257779908041629","url":null,"abstract":"<p><p>We synthesized and characterized new diphosphate mimics of the acyclic nucleoside phosphonate PMEA [Adefovir, 9-(2-phosphonylmethoxyethyl)adenine].</p>","PeriodicalId":19222,"journal":{"name":"Nucleosides & nucleotides","volume":"18 4-5","pages":"1003-4"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15257779908041629","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21297876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
ddC- and 3TC-bis(SATE) monophosphate prodrugs overcome cellular resistance mechanisms to HIV-1 associated with cytidine kinase deficiency. ddC-和3TC-bis(SATE)单磷酸前药克服与胞苷激酶缺乏相关的HIV-1细胞耐药机制。
Nucleosides & nucleotides Pub Date : 1999-04-01 DOI: 10.1080/15257779908041600
B Gröschel, N Himmel, J Cinatl, C Périgaud, G Gosselin, J L Imbach, H W Doerr, J Cinatl
{"title":"ddC- and 3TC-bis(SATE) monophosphate prodrugs overcome cellular resistance mechanisms to HIV-1 associated with cytidine kinase deficiency.","authors":"B Gröschel,&nbsp;N Himmel,&nbsp;J Cinatl,&nbsp;C Périgaud,&nbsp;G Gosselin,&nbsp;J L Imbach,&nbsp;H W Doerr,&nbsp;J Cinatl","doi":"10.1080/15257779908041600","DOIUrl":"https://doi.org/10.1080/15257779908041600","url":null,"abstract":"<p><p>A 2',3'-dideoxycytidine (ddC)-resistant T-lymphoid cell line (MOLT-4/8rddC250), in which deoxycytidine kinase (dCK) gene-expression was decreased when compared with parental cells, has been selected. Cytotoxic and antiretroviral activity of ddC and 3TC was significantly lower in MOLT-4/8rddC250-than in parental MOLT-4/8 cells. ddC- and 3TC-bis(SATE)phosphotriesters completely overcame cellular resistance mechanisms and showed comparable both cytotoxic and antiretroviral activity in parental and ddC-resistant cells.</p>","PeriodicalId":19222,"journal":{"name":"Nucleosides & nucleotides","volume":"18 4-5","pages":"921-6"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15257779908041600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21297982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Evidence for cyclophosphate formation during hydrolysis of 3-methyl-cycloSal-PCVMP. 3-甲基-环盐- pcvmp水解过程中形成环磷酸盐的证据。
Nucleosides & nucleotides Pub Date : 1999-04-01 DOI: 10.1080/15257779908041606
A Lomp, C Meier, M Herderich, P Wutzler
{"title":"Evidence for cyclophosphate formation during hydrolysis of 3-methyl-cycloSal-PCVMP.","authors":"A Lomp,&nbsp;C Meier,&nbsp;M Herderich,&nbsp;P Wutzler","doi":"10.1080/15257779908041606","DOIUrl":"https://doi.org/10.1080/15257779908041606","url":null,"abstract":"<p><p>A hydrolysis study of 3-methyl-cycloSal-PCVMP 2 is described. Surprisingly, phosphotriester 5 released in this study not the expected PCVMP, but cycloPCVMP.</p>","PeriodicalId":19222,"journal":{"name":"Nucleosides & nucleotides","volume":"18 4-5","pages":"943-4"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15257779908041606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21297988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Potential inhibitors of HIV integrase. HIV整合酶的潜在抑制剂。
Nucleosides & nucleotides Pub Date : 1999-04-01 DOI: 10.1080/15257779908041539
C Mathé, V Nair
{"title":"Potential inhibitors of HIV integrase.","authors":"C Mathé,&nbsp;V Nair","doi":"10.1080/15257779908041539","DOIUrl":"https://doi.org/10.1080/15257779908041539","url":null,"abstract":"<p><p>In the search for inhibitors of HIV integrase, the enzyme involved in the integration of viral DNA into host DNA, we have synthesized and studied a number of analogs of the heterocyclic molecule, chloroquine.</p>","PeriodicalId":19222,"journal":{"name":"Nucleosides & nucleotides","volume":"18 4-5","pages":"681-2"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15257779908041539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21298255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Studies designed to increase the stability and antiviral activity (HCMV) of the active benzimidazole nucleoside, TCRB. 研究旨在提高活性苯并咪唑核苷(TCRB)的稳定性和抗病毒活性(HCMV)。
Nucleosides & nucleotides Pub Date : 1999-04-01 DOI: 10.1080/15257779908041486
L B Townsend, K S Gudmundsson, S M Daluge, J J Chen, Z Zhu, G W Koszalka, L Boyd, S D Chamberlain, G A Freeman, K K Biron, J C Drach
{"title":"Studies designed to increase the stability and antiviral activity (HCMV) of the active benzimidazole nucleoside, TCRB.","authors":"L B Townsend,&nbsp;K S Gudmundsson,&nbsp;S M Daluge,&nbsp;J J Chen,&nbsp;Z Zhu,&nbsp;G W Koszalka,&nbsp;L Boyd,&nbsp;S D Chamberlain,&nbsp;G A Freeman,&nbsp;K K Biron,&nbsp;J C Drach","doi":"10.1080/15257779908041486","DOIUrl":"https://doi.org/10.1080/15257779908041486","url":null,"abstract":"<p><p>The potent activity of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB) against Human Cytomegalovirus with the concomitant low cellular toxicity at concentrations that inhibit viral growth prompted considerable interest in this research area. This interest was moderated by the pharmacokinetic studies of TCRB in rats and monkeys that revealed the instability of TCRB in vivo. These studies suggested that the instability was due to a cleavage of the glycosidic bond in vivo which released the heterocycle (2,5,6-trichlorobenzimidazole) into the bloodstream. This prompted us to initiate synthetic studies designed to increase the stability of the glycosidic bond of TCRB and BDCRB. Several synthetic approaches to address this and other problems are presented.</p>","PeriodicalId":19222,"journal":{"name":"Nucleosides & nucleotides","volume":"18 4-5","pages":"509-19"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15257779908041486","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21298364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Synthesis and antiviral activities of 1,3-oxathiolanyl nucleosides with 5-hydroxymethyl substituent. 含5-羟甲基取代基1,3-草硫酰核苷的合成及抗病毒活性研究
Nucleosides & nucleotides Pub Date : 1999-04-01 DOI: 10.1080/15257779908041515
M W Chun, S P Choi, M J Kim, C J Bae, H R Moon, H D Kim, L S Jeong
{"title":"Synthesis and antiviral activities of 1,3-oxathiolanyl nucleosides with 5-hydroxymethyl substituent.","authors":"M W Chun,&nbsp;S P Choi,&nbsp;M J Kim,&nbsp;C J Bae,&nbsp;H R Moon,&nbsp;H D Kim,&nbsp;L S Jeong","doi":"10.1080/15257779908041515","DOIUrl":"https://doi.org/10.1080/15257779908041515","url":null,"abstract":"<p><p>Novel 1,3-oxathiolanyl pyrimidine nucleosides with 5-hydroxymethyl substituent were synthesized starting from D-mannose and evaluated for antiviral activities against HIV-1, HSV type 1,2 and HCMV.</p>","PeriodicalId":19222,"journal":{"name":"Nucleosides & nucleotides","volume":"18 4-5","pages":"615-6"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15257779908041515","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21298373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase. 癌症的基因治疗:用大肠杆菌嘌呤核苷磷酸化酶激活核苷前药。
Nucleosides & nucleotides Pub Date : 1999-04-01 DOI: 10.1080/15257779908041562
J A Secrist, W B Parker, P W Allan, L L Bennett, W R Waud, J W Truss, A T Fowler, J A Montgomery, S E Ealick, A H Wells, G Y Gillespie, V K Gadi, E J Sorscher
{"title":"Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase.","authors":"J A Secrist,&nbsp;W B Parker,&nbsp;P W Allan,&nbsp;L L Bennett,&nbsp;W R Waud,&nbsp;J W Truss,&nbsp;A T Fowler,&nbsp;J A Montgomery,&nbsp;S E Ealick,&nbsp;A H Wells,&nbsp;G Y Gillespie,&nbsp;V K Gadi,&nbsp;E J Sorscher","doi":"10.1080/15257779908041562","DOIUrl":"https://doi.org/10.1080/15257779908041562","url":null,"abstract":"<p><p>During the last few years, many gene therapy strategies have been developed for various disease targets. The development of anticancer gene therapy strategies to selectively generate cytotoxic nucleoside or nucleotide analogs is an attractive goal. One such approach involves the delivery of herpes simplex virus thymidine kinase followed by the acyclic nucleoside analog ganciclovir. We have developed another gene therapy methodology for the treatment of cancer that has several significant attributes. Specifically, our approach involves the delivery of E. coli purine nucleoside phosphorylase, followed by treatment with a relatively non-toxic nucleoside prodrug that is cleaved by the enzyme to a toxic compound. This presentation describes the concept, details our search for suitable prodrugs, and summarizes the current biological data.</p>","PeriodicalId":19222,"journal":{"name":"Nucleosides & nucleotides","volume":"18 4-5","pages":"745-57"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15257779908041562","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21299344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
Design and SAR study of a novel class of nucleotide analogues as potent anti-HCMV agents. 一类新的核苷酸类似物作为抗hcmv药物的设计和SAR研究。
Nucleosides & nucleotides Pub Date : 1999-04-01 DOI: 10.1080/15257779908041570
N Nguyen-Ba, L Chan, M Quimpère, N Turcotte, N Lee, H Mitchell, J Bédard
{"title":"Design and SAR study of a novel class of nucleotide analogues as potent anti-HCMV agents.","authors":"N Nguyen-Ba,&nbsp;L Chan,&nbsp;M Quimpère,&nbsp;N Turcotte,&nbsp;N Lee,&nbsp;H Mitchell,&nbsp;J Bédard","doi":"10.1080/15257779908041570","DOIUrl":"https://doi.org/10.1080/15257779908041570","url":null,"abstract":"<p><p>We have developed a novel class of 2-phosphonate 1,3-dioxolane nucleotide analogues, from which the guanine derivative displayed weak anti-HCMV activity. Further SAR studies led to the identification of both cis and trans guanine derivatives of tetrahydrofuran analogues as potent anti-HCMV agents, both in vitro and in vivo, compared to ganciclovir and HPMPC.</p>","PeriodicalId":19222,"journal":{"name":"Nucleosides & nucleotides","volume":"18 4-5","pages":"821-7"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15257779908041570","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21299351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信