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Proceedings of the ASGO 2022 7th International Workshop最新文献

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Single-Cell Transcriptomics Reveals Tissue Architecture in Ovarian Carcinosarcoma 单细胞转录组学揭示卵巢癌肉瘤的组织结构
Proceedings of the ASGO 2022 7th International Workshop Pub Date : 2021-10-26 DOI: 10.21203/rs.3.rs-986007/v1
Junfen Xu, Y. Cen, Weiguo Lu
{"title":"Single-Cell Transcriptomics Reveals Tissue Architecture in Ovarian Carcinosarcoma","authors":"Junfen Xu, Y. Cen, Weiguo Lu","doi":"10.21203/rs.3.rs-986007/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-986007/v1","url":null,"abstract":"\u0000 Background\u0000\u0000Ovarian carcinosarcoma (OCS) is one of rarest and most challenging histologic subtype of ovarian cancer. It features remarkable cellular heterogeneity. Using single-cell RNA sequencing, we characterize the cellular composition of the OCS and identify their molecular characteristics.\u0000Methods\u0000\u0000we applied single-cell RNA sequencing (scRNA-seq) to resected primary OCS for the in-depth analysis of tumor cells and the TME. Immunohistochemistry (IHC) staining was used for validation.\u0000Results\u0000\u0000Malignant epithelial and fibroblast cells displayed a high-degree of intratumoral heterogeneity. We revealed that certain epithelial cell subclusters had high levels of drug resistance scores and many active metabolic pathways. Furthermore, γδ T cells exhibited enriched IFNγ and IFNα response characteristics. Notably, we observed that macrophages were mainly M2-like macrophages with immunosuppressive properties. In addition, we found that the CD1A+/FCER1A+ DC cells were enriched with genes related to cytolytic effector pathway. Analyzing ligand-receptor interaction pairs between cell types, we identified broadly interacting cells and observed an interaction between the ANXA1+ epithelial population and FPR1+/FPR3+ myeloid cells.\u0000Conclusion\u0000\u0000Our findings provide a comprehensive single-cell transcriptomic landscape of human OCS and present a well-established resource for elucidating OCS diversity.","PeriodicalId":192166,"journal":{"name":"Proceedings of the ASGO 2022 7th International Workshop","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126858234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploiting DNA replication stress for sequential therapy with PARP and WEE1 inhibitors 利用DNA复制应激与PARP和WEE1抑制剂序次治疗
Proceedings of the ASGO 2022 7th International Workshop Pub Date : 1900-01-01 DOI: 10.3802/jgo.2022.33.s12
Yong Fang
{"title":"Exploiting DNA replication stress for sequential therapy with PARP and WEE1 inhibitors","authors":"Yong Fang","doi":"10.3802/jgo.2022.33.s12","DOIUrl":"https://doi.org/10.3802/jgo.2022.33.s12","url":null,"abstract":"","PeriodicalId":192166,"journal":{"name":"Proceedings of the ASGO 2022 7th International Workshop","volume":"35 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116645527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic performance of magnetic resonance imaging (MRI) in patients with operable cervical cancer: a retrospective analysis 磁共振成像(MRI)在可手术宫颈癌患者中的诊断性能:回顾性分析
Proceedings of the ASGO 2022 7th International Workshop Pub Date : 1900-01-01 DOI: 10.3802/jgo.2022.33.s14
Rohini V. Kulkarni, J. Thakkar, M. Thakur, K. Deodhar, Pabashi Poddar, A. Maheshwari
{"title":"Diagnostic performance of magnetic resonance imaging (MRI) in patients with operable cervical cancer: a retrospective analysis","authors":"Rohini V. Kulkarni, J. Thakkar, M. Thakur, K. Deodhar, Pabashi Poddar, A. Maheshwari","doi":"10.3802/jgo.2022.33.s14","DOIUrl":"https://doi.org/10.3802/jgo.2022.33.s14","url":null,"abstract":"","PeriodicalId":192166,"journal":{"name":"Proceedings of the ASGO 2022 7th International Workshop","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116228533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-world outcomes of niraparib treatment in patients with ovarian cancer: the first observational multicenter study in China 尼拉帕尼治疗卵巢癌患者的实际结果:中国首个多中心观察性研究
Proceedings of the ASGO 2022 7th International Workshop Pub Date : 1900-01-01 DOI: 10.3802/jgo.2022.33.s11
Jin Li, Jianhua Yang, H. Shou, Lin Zhang, Xiaohong Huang, X. Tang, Fei Zheng, Fang Liu, Xiaohua Wu
{"title":"Real-world outcomes of niraparib treatment in patients with ovarian cancer: the first observational multicenter study in China","authors":"Jin Li, Jianhua Yang, H. Shou, Lin Zhang, Xiaohong Huang, X. Tang, Fei Zheng, Fang Liu, Xiaohua Wu","doi":"10.3802/jgo.2022.33.s11","DOIUrl":"https://doi.org/10.3802/jgo.2022.33.s11","url":null,"abstract":"","PeriodicalId":192166,"journal":{"name":"Proceedings of the ASGO 2022 7th International Workshop","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122388242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significance of TCGA molecular classification in fertility-sparing treatment of endometrial cancer and atypical hyperplasia TCGA分子分型在子宫内膜癌及不典型增生保生育治疗中的意义
Proceedings of the ASGO 2022 7th International Workshop Pub Date : 1900-01-01 DOI: 10.3802/jgo.2022.33.s10
W. Yiqin, K. Nan, Liao Liwei, Wang Zhiqi, Z. Rong, Shen Danhua, Wang Jianliu
{"title":"Significance of TCGA molecular classification in fertility-sparing treatment of endometrial cancer and atypical hyperplasia","authors":"W. Yiqin, K. Nan, Liao Liwei, Wang Zhiqi, Z. Rong, Shen Danhua, Wang Jianliu","doi":"10.3802/jgo.2022.33.s10","DOIUrl":"https://doi.org/10.3802/jgo.2022.33.s10","url":null,"abstract":"","PeriodicalId":192166,"journal":{"name":"Proceedings of the ASGO 2022 7th International Workshop","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131583551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychosocial burden in women with positive human papillomavirus testing after abnormal cervical cytology: atypical squamous cells of undetermined significance (ASC-US) 宫颈细胞学异常后人乳头瘤病毒检测阳性妇女的社会心理负担:意义不明的非典型鳞状细胞(ASC-US)
Proceedings of the ASGO 2022 7th International Workshop Pub Date : 1900-01-01 DOI: 10.3802/jgo.2022.33.s2
Suwicha Chittithaworn, Ornthicha Suphattanaporn, Chompunoot Kongsawatvorakul, Krissada Paiwattananupant
{"title":"Psychosocial burden in women with positive human papillomavirus testing after abnormal cervical cytology: atypical squamous cells of undetermined significance (ASC-US)","authors":"Suwicha Chittithaworn, Ornthicha Suphattanaporn, Chompunoot Kongsawatvorakul, Krissada Paiwattananupant","doi":"10.3802/jgo.2022.33.s2","DOIUrl":"https://doi.org/10.3802/jgo.2022.33.s2","url":null,"abstract":"","PeriodicalId":192166,"journal":{"name":"Proceedings of the ASGO 2022 7th International Workshop","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127944870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A carrier as a gynecologic oncologist in an academic hospital in a developing country 发展中国家学术医院妇科肿瘤科医生的携带者
Proceedings of the ASGO 2022 7th International Workshop Pub Date : 1900-01-01 DOI: 10.3802/jgo.2022.33.s15
H. Nugroho
{"title":"A carrier as a gynecologic oncologist in an academic hospital in a developing country","authors":"H. Nugroho","doi":"10.3802/jgo.2022.33.s15","DOIUrl":"https://doi.org/10.3802/jgo.2022.33.s15","url":null,"abstract":"","PeriodicalId":192166,"journal":{"name":"Proceedings of the ASGO 2022 7th International Workshop","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123420785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and impact of PARPi monotherapy to subsequent platinum-based chemotherapy in BRCA1/2 mutant ovarian cancer patients with secondary platinum-sensitive relapse PARPi单药治疗BRCA1/2突变卵巢癌继发性铂敏感复发患者后续铂基化疗的疗效及影响
Proceedings of the ASGO 2022 7th International Workshop Pub Date : 1900-01-01 DOI: 10.3802/jgo.2022.33.s6
Song Kun, Yana Ma, H. Bu, B. Kong
{"title":"Efficacy and impact of PARPi monotherapy to subsequent platinum-based chemotherapy in BRCA1/2 mutant ovarian cancer patients with secondary platinum-sensitive relapse","authors":"Song Kun, Yana Ma, H. Bu, B. Kong","doi":"10.3802/jgo.2022.33.s6","DOIUrl":"https://doi.org/10.3802/jgo.2022.33.s6","url":null,"abstract":"","PeriodicalId":192166,"journal":{"name":"Proceedings of the ASGO 2022 7th International Workshop","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115492591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The randomized controlled trial on the efficacy of surgical debulking of metastatic lymph nodes in cervical cancer stage IIICr 宫颈癌IIICr期转移性淋巴结手术切除疗效的随机对照试验
Proceedings of the ASGO 2022 7th International Workshop Pub Date : 1900-01-01 DOI: 10.3802/jgo.2022.33.s13
Misi He, D. Zou
{"title":"The randomized controlled trial on the efficacy of surgical debulking of metastatic lymph nodes in cervical cancer stage IIICr","authors":"Misi He, D. Zou","doi":"10.3802/jgo.2022.33.s13","DOIUrl":"https://doi.org/10.3802/jgo.2022.33.s13","url":null,"abstract":"","PeriodicalId":192166,"journal":{"name":"Proceedings of the ASGO 2022 7th International Workshop","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128482527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A prospective multicenter cohort study comparing vNOTES and laparoscopic sentinel lymph node mapping for endometrial cancer 一项前瞻性多中心队列研究，比较vNOTES和腹腔镜前哨淋巴结定位对子宫内膜癌的影响
Proceedings of the ASGO 2022 7th International Workshop Pub Date : 1900-01-01 DOI: 10.3802/jgo.2022.33.s7
L. Deng, Keyao Chen, Y. Deng, S. Tang, Li-Qun Sun, Yanzhou Wang
{"title":"A prospective multicenter cohort study comparing vNOTES and laparoscopic sentinel lymph node mapping for endometrial cancer","authors":"L. Deng, Keyao Chen, Y. Deng, S. Tang, Li-Qun Sun, Yanzhou Wang","doi":"10.3802/jgo.2022.33.s7","DOIUrl":"https://doi.org/10.3802/jgo.2022.33.s7","url":null,"abstract":"","PeriodicalId":192166,"journal":{"name":"Proceedings of the ASGO 2022 7th International Workshop","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132997360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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