Neuroscience Research Communications最新文献_第7页

Differential regulation of map kinase isoforms by H2O2 in neuronal cells H2O2对神经元细胞中map激酶同种异构体的差异调节

Neuroscience Research Communications Pub Date : 2003-07-01 DOI: 10.1002/NRC.10077

Amandeep Gargi, Naresh Kumar, C. Dey

引用次数: 0

An antitoxidant formulation that induces differentiation of neuroblastoma in culture 一种在培养中诱导神经母细胞瘤分化的抗氧化制剂

Neuroscience Research Communications Pub Date : 2003-07-01 DOI: 10.1002/NRC.10082

Amy L. Hancock, E. Nakuci, R. Nicolosi, T. Shea

引用次数: 2

A NOS inhibitor aminoguanidine reduces zinc‐induced neuron loss in rat hippocampus NOS抑制剂氨基胍可减少锌诱导的大鼠海马神经元损失

Neuroscience Research Communications Pub Date : 2003-07-01 DOI: 10.1002/NRC.10080

F. Gokce, F. Bağırıcı, S. Kaplan, Ş. Demir, M. Ayyildiz, C. Marangoz

{"title":"A NOS inhibitor aminoguanidine reduces zinc‐induced neuron loss in rat hippocampus","authors":"F. Gokce, F. Bağırıcı, S. Kaplan, Ş. Demir, M. Ayyildiz, C. Marangoz","doi":"10.1002/NRC.10080","DOIUrl":"https://doi.org/10.1002/NRC.10080","url":null,"abstract":"There are many studies on zinc as a possible cause of neuronal hyperactivity and cell death. The present study was designed to investigate the changes in total pyramidal cell number of rat hippocampus after intracortical zinc sulphate (ZnSO4, 200 μg/kg, i.c.) and a nitric oxide synthase (NOS) inhibitor aminoguanidine (AG) administration. Animals were divided into three groups as control, zinc and the treatment (zinc+AG) groups. Each group was divided into two subgroups, as 7-day group and 15-day group. Zinc sulphate was injected intracortically into 2 mm lateral of Bregma. The same volume of saline (2μl) was given to the rats belonging to the control groups. Rats in the third group were given ZnSO4 + AG in the same injection point. Animals in the third group only received 100 mg/kg AG intraperitoneally twice a day for periods of 7 or 15 days. Total pyramidal neuron number was estimated using the optical fractionator method. The total number of pyramidal cells found in the left hippocampus was 653,468 ± 3,452 and 601,860 ± 3,348 in the control groups; 257,968 ± 1,277 and 250,555 ± 1,443 in the zinc groups; 382,519 ± 1,973 and 365,880 ± 2,658 in the treatment groups in 7-day post treatment and 15-day post treatment rats, respectively. \u0000 \u0000 \u0000 \u0000These results suggest that zinc has a neurotoxic effect on pyramidal neurons in rat hippocampus (p<0.05) and an inhibitor of nitric oxide synthase, AG, decreases cell loss (p<0.05). This shows that nitric oxide (NO) contributes to this type of neurotoxicity in the rat hippocampus and also suggests a possible therapeutic role for NOS inhibitor in neurodegenerative diseases.","PeriodicalId":19198,"journal":{"name":"Neuroscience Research Communications","volume":"70 1","pages":"53-62"},"PeriodicalIF":0.0,"publicationDate":"2003-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76446712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Vitamin D receptor expression in the embryonic rat brain 维生素D受体在胚胎大鼠脑中的表达

Neuroscience Research Communications Pub Date : 2003-07-01 DOI: 10.1002/NRC.10081

R. Burkert, J. Mcgrath, D. Eyles

引用次数: 47

Differential effects of depolarization on intracellular calcium concentration in wild type and dunce Drosophila neurons 去极化对野生型和迟钝型果蝇神经元细胞内钙浓度的差异影响

Neuroscience Research Communications Pub Date : 2003-07-01 DOI: 10.1002/NRC.10078

W. Alshuaib, M. Hasan, S. Cherian, M. Fahim

{"title":"Differential effects of depolarization on intracellular calcium concentration in wild type and dunce Drosophila neurons","authors":"W. Alshuaib, M. Hasan, S. Cherian, M. Fahim","doi":"10.1002/NRC.10078","DOIUrl":"https://doi.org/10.1002/NRC.10078","url":null,"abstract":"Utilizing Fura 2-AM fluorescence photometry, intracellular calcium concentration ∥[Ca2+]i) was measured in wild type and dunce cleavage-arrested Drosophila neurons under resting condition and in response to KCl induced depolarization. Following KCl application, peak [Ca2+]i was greater in dunce (424 ± 29 nM) than in wild type neurons (246 ± 21 nM). Half decay time was shorter in dunce (65 ± 5 sec) than in wild type neurons (84 ± 6 sec). In cadmium-containing and in calcium-free external solutions, KCl application did not lead to any changes in [Ca2+]i in wild type and dunce neurons. Thus, the source of increase in [Ca2+]i seems to be Ca2+ influx from outside. Treatment with nifedipine and nimodipine did not affect [Ca2+]i increase in response to KCl application. This indicates that both wild type and dunce neuronal Ca2+ channels are not sensitive to these dihydropyridines. Pretreatment of wild type neurons with dibutyryl cAMP for 1 hour, prior to depolarization by KCl, resulted in peak [Ca2+]i of 369 ± 27 nM which is similar to untreated dunce neurons. The present results suggest that cAMP is implicated in modulating Ca2+ channels leading to enhanced Ca2+ influx in dunce neurons. Calcium extrusion and/or calcium buffering systems are possibly enhanced in the dunce mutant compared to the wild type. This disturbance in homeostatis of cytosolic calcium concentration in dunce neurons may be implicated in defective learning and memory.","PeriodicalId":19198,"journal":{"name":"Neuroscience Research Communications","volume":"57 1","pages":"31-43"},"PeriodicalIF":0.0,"publicationDate":"2003-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85663681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New view on cerebellar cortical background activity in rat: simulation 大鼠小脑皮层背景活动的新认识:模拟

Neuroscience Research Communications Pub Date : 2003-05-01 DOI: 10.1002/NRC.10075

Aleksandar Kalauzi, M. Culic, L. Martac, G. Grbic, J. Saponjic, A. Jovanović, B. Janković, S. Spasic

引用次数: 4

Differential effects of dopamine on a potassium current in cultured rutabaga and wild-type Drosophila cells 多巴胺对培养芜菁和野生型果蝇细胞钾电流的差异影响

Neuroscience Research Communications Pub Date : 2003-05-01 DOI: 10.1002/NRC.10072

W. Alshuaib, M. V. Mathew, M. Hasan, M. Fahim

{"title":"Differential effects of dopamine on a potassium current in cultured rutabaga and wild-type Drosophila cells","authors":"W. Alshuaib, M. V. Mathew, M. Hasan, M. Fahim","doi":"10.1002/NRC.10072","DOIUrl":"https://doi.org/10.1002/NRC.10072","url":null,"abstract":"The rutabaga mutation which has a low intracellular cyclic adenosine monophosphate (cAMP) concentration is defective in short-term memory. The aim of this study was to compare modulation effects of dopamine on the delayed-rectifier potassium current (IKDR) in rutabaga and wild-type Drosophila neurons. The conventional whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IKDR was measured from cultured (2 days) wild-type and rutabaga neurons. IKDR was smaller in rutabaga neurons (373 ± 38 pA) than in wild-type neurons (519 ± 40 pA) but there was no difference in IKDR activation in wild-type inactivation between the two genotypes. We examined the effects of dopamine on IKDR in wild-type and rutabaga neurons. IKDR was measured from neurons before and after addition of dopamine to the external solution. Dopamine application reduced IKDR in wild-type neurons but did not significantly affect IKDR in rutabaga neurons (single-cell studies). In the presence of dopamine there was no difference in IKDR between wild-type (344 ± 29 pA) and rutabaga (338 ± 27pA) neurons (population studies). These results indicate that dopamine differentially affects the delayed-rectifier channel in wild-type and rutabaga neurons. This can alter neuronal excitability in rutabaga and may affect the processing of neural signals necessary for learning and memory.","PeriodicalId":19198,"journal":{"name":"Neuroscience Research Communications","volume":"23 1","pages":"175-187"},"PeriodicalIF":0.0,"publicationDate":"2003-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85204678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Lysine 445 is a molecular indicator of subunit‐specific AMPA receptor binding domains 赖氨酸445是亚基特异性AMPA受体结合域的分子指标

Neuroscience Research Communications Pub Date : 2003-05-01 DOI: 10.1002/NRC.10069

J. S. S. Sikes, T. Verdoorn

引用次数: 0

The neurotoxic effect of iron on pyramidal cell number in rat hippocampus: a stereological study 铁对大鼠海马锥体细胞数量的神经毒性作用:一项体视学研究

Neuroscience Research Communications Pub Date : 2003-05-01 DOI: 10.1002/NRC.10070

M. O. Bostanci, F. Bağırıcı, A. Korkmaz

引用次数: 7

Response properties of cat striate neurons to simulated optic flow stimuli 猫纹状神经元对模拟光流刺激的响应特性

Neuroscience Research Communications Pub Date : 2003-05-01 DOI: 10.1002/NRC.10074

Baowang Li, Bing-chuan Li, Yao Chen, Y. Diao

引用次数: 0